JP2011512817A5 - - Google Patents
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- Publication number
- JP2011512817A5 JP2011512817A5 JP2010548830A JP2010548830A JP2011512817A5 JP 2011512817 A5 JP2011512817 A5 JP 2011512817A5 JP 2010548830 A JP2010548830 A JP 2010548830A JP 2010548830 A JP2010548830 A JP 2010548830A JP 2011512817 A5 JP2011512817 A5 JP 2011512817A5
- Authority
- JP
- Japan
- Prior art keywords
- clostridium difficile
- binds
- isolated antibody
- protein
- acetylmuramoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000193163 Clostridioides difficile Species 0.000 claims 2
- 241000423301 Clostridioides difficile 630 Species 0.000 claims 2
- 101710189354 Putative N-acetylmuramoyl-L-alanine amidase Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3227008P | 2008-02-28 | 2008-02-28 | |
| PCT/US2009/035050 WO2009108652A1 (en) | 2008-02-28 | 2009-02-25 | Antibodies to clostridium difficile spores and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011512817A JP2011512817A (ja) | 2011-04-28 |
| JP2011512817A5 true JP2011512817A5 (enExample) | 2012-04-12 |
Family
ID=41016450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548830A Pending JP2011512817A (ja) | 2008-02-28 | 2009-02-25 | クロストリジウム・ディフィシル胞子に対する抗体及びその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8697374B2 (enExample) |
| EP (1) | EP2271366A4 (enExample) |
| JP (1) | JP2011512817A (enExample) |
| KR (1) | KR20100126760A (enExample) |
| CN (1) | CN101980723A (enExample) |
| AU (1) | AU2009219358A1 (enExample) |
| BR (1) | BRPI0906060A2 (enExample) |
| CA (1) | CA2714720A1 (enExample) |
| WO (1) | WO2009108652A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102388064A (zh) * | 2009-03-27 | 2012-03-21 | 高裘企业公司 | 用于筛选与使用拮抗孢子-表面交互作用的化合物的组合物与方法 |
| CN102533867A (zh) * | 2010-12-10 | 2012-07-04 | 西北民族大学 | 一种艰难梭菌a毒素的类毒素的制备方法 |
| US10295535B2 (en) * | 2011-04-29 | 2019-05-21 | Techlab, Inc. | Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease |
| US20120276059A1 (en) | 2011-04-29 | 2012-11-01 | Techlab, Inc. | Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease |
| EP2755681B1 (en) * | 2011-09-15 | 2018-06-27 | Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center | IMMUNOTHERAPY AND DIAGNOSIS OF MUCORMYCOSIS USING CotH |
| WO2013038156A1 (en) * | 2011-09-16 | 2013-03-21 | Ucb Pharma S.A. | Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile |
| CA2856085C (en) | 2011-11-18 | 2020-06-30 | National Research Council Of Canada | Clostridium difficile lipoteichoic acid and uses thereof |
| CN102590515B (zh) * | 2012-01-13 | 2014-07-30 | 张春华 | 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体 |
| RU2628305C2 (ru) | 2012-03-02 | 2017-08-15 | Регенерон Фармасьютиказ, Инк. | Человеческие антитела к токсинам clostridium difficile |
| US9133527B2 (en) * | 2012-05-11 | 2015-09-15 | Techlab, Inc. | Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027 |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| BR112015004629A2 (pt) * | 2012-09-19 | 2017-11-21 | Novartis Ag | polipeptídeos de clostridium difficile como vacinas |
| JP2016501877A (ja) * | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| CN105555309A (zh) * | 2013-04-19 | 2016-05-04 | 英穆伦有限公司 | 治疗和/或预防艰难梭菌相关疾病的方法和组合物 |
| WO2015150493A1 (en) * | 2014-04-01 | 2015-10-08 | Institut Pasteur | Predictive value of clostridium difficile-specific immune response for recurrence and disease outcome |
| WO2015191419A2 (en) | 2014-06-09 | 2015-12-17 | 3M Innovative Properties Company | Assay devices and method of detecting a target analyte |
| US20180000793A1 (en) | 2015-02-06 | 2018-01-04 | Ernesto Abel-Santos | Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis |
| US20190059860A1 (en) * | 2015-09-21 | 2019-02-28 | 4C Diagnostics Ltd. | Stool specimen collecting, sampling and diagnosing means and methods thereof |
| JP2022535131A (ja) | 2019-06-05 | 2022-08-04 | リブ・プロセス・インコーポレイテッド | クロストリジウム・ディフィシル菌に対するアプタマー |
| CN111948388B (zh) * | 2020-08-18 | 2022-03-22 | 山东农业大学 | 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用 |
| EP4398890A4 (en) | 2021-09-09 | 2025-07-30 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The Univ Of Nevada Las Ve | C. Difficile Spore Germination Inhibitors |
| CN119751687B (zh) * | 2024-12-26 | 2025-09-26 | 杭州医学院 | 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US4530833A (en) | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4533630A (en) | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| GB8426464D0 (en) | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
| US4863852A (en) | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
| US4956302A (en) | 1987-09-11 | 1990-09-11 | Abbott Laboratories | Lateral flow chromatographic binding assay device |
| AU2684488A (en) | 1988-06-27 | 1990-01-04 | Carter-Wallace, Inc. | Test device and method for colored particle immunoassay |
| EP1997891A1 (en) | 1988-09-02 | 2008-12-03 | Dyax Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5231003A (en) | 1990-05-11 | 1993-07-27 | Cambridge Bioscience Corporation | Monoclonal antibodies specific for toxin b of clostridium difficile |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| WO1992009690A2 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| ATE439435T1 (de) | 1991-03-01 | 2009-08-15 | Dyax Corp | Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon |
| DE69233750D1 (de) | 1991-04-10 | 2009-01-02 | Scripps Research Inst | Bibliotheken heterodimerer Rezeptoren mittels Phagemiden |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US5610023A (en) | 1995-03-31 | 1997-03-11 | Lee Laboratories, Inc. | Method of purification of clostridium difficile toxin A and production of mono-specific antibodies |
| US5753517A (en) | 1996-03-29 | 1998-05-19 | University Of British Columbia | Quantitative immunochromatographic assays |
| US7179611B2 (en) | 1997-02-10 | 2007-02-20 | Bd Lee Laboratories | Mono-specific polyclonal antibodies and methods for detecting Clostridium difficile Toxin A |
| US5965375A (en) | 1997-04-04 | 1999-10-12 | Biosite Diagnostics | Diagnostic tests and kits for Clostridium difficile |
| AU8395498A (en) * | 1997-07-11 | 1999-02-08 | Regents of The University of Arizona, The | Hen egg yolk antibodies to (clostridium difficile) antigens and use in therapy for pseudomembranous colitis |
| US5876960A (en) | 1997-08-11 | 1999-03-02 | The United States Of America As Represented By The Secretary Of The Army | Bacterial spore detection and quantification methods |
| US6733760B1 (en) | 1999-04-09 | 2004-05-11 | Techlab, Inc. | Recombinant toxin A/toxin B vaccine against Clostridium difficile |
| US6974573B2 (en) | 1999-11-01 | 2005-12-13 | Mucovax Holdings, B.V. | Antibody production in farm animals |
| US7074454B1 (en) | 1999-11-01 | 2006-07-11 | Mucovax Holding B.V. | Production of mammary secretion antibodies in farm animals |
| ES2258483T3 (es) | 1999-11-01 | 2006-09-01 | Mucovax Holding B.V | Produccion de anticuerpos de secrecion mamaria en animales de granja. |
| US6509196B1 (en) | 2000-01-04 | 2003-01-21 | Response Biomedical Corp. | Compensation for non-specific signals in quantitative immunoassays |
| GB0007263D0 (en) | 2000-03-24 | 2000-05-17 | Imperial College | Peptides |
| US6498041B1 (en) | 2000-08-18 | 2002-12-24 | Echo Technologies, Inc. | Optical sensors for rapid, sensitive detection and quantitation of bacterial spores |
| US6815178B1 (en) | 2001-11-19 | 2004-11-09 | Antony R. Shoaf | Endospore detection method |
| AU2002366448A1 (en) | 2001-11-30 | 2003-09-02 | California Institute Of Technology | An improvement in a method bacterial endospore quantification using lanthanide dipicolinate luminescence |
| US7428045B2 (en) | 2002-01-10 | 2008-09-23 | Chemimage Corporation | Raman spectral analysis of pathogens |
| US20040014154A1 (en) | 2002-02-01 | 2004-01-22 | Adrian Ponce | Methods and apparatus for assays of bacterial spores |
| US20030175318A1 (en) | 2002-03-06 | 2003-09-18 | Schilling Amanda S. | Application of germination solution improved efficacy of biological decontamination |
| US20040033546A1 (en) * | 2002-04-10 | 2004-02-19 | The Trustees Of Columbia University In The City Of New York | Novel microarrays and methods of use thereof |
| US7608419B2 (en) | 2003-11-13 | 2009-10-27 | California Institute Of Technology | Method and apparatus for detecting and quantifying bacterial spores on a surface |
| WO2004069848A2 (en) | 2003-01-28 | 2004-08-19 | Diversa Corporation | Amidases, nucleic acids encoding them and methods for making and using them |
| US7189522B2 (en) | 2005-03-11 | 2007-03-13 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| US20060275920A1 (en) | 2005-06-01 | 2006-12-07 | Petrilla John F | Apparatus and method for discriminating among lateral flow assay test indicators |
-
2009
- 2009-02-25 CA CA2714720A patent/CA2714720A1/en not_active Abandoned
- 2009-02-25 CN CN2009801113555A patent/CN101980723A/zh active Pending
- 2009-02-25 KR KR1020107021314A patent/KR20100126760A/ko not_active Withdrawn
- 2009-02-25 BR BRPI0906060A patent/BRPI0906060A2/pt not_active IP Right Cessation
- 2009-02-25 US US12/919,254 patent/US8697374B2/en not_active Expired - Fee Related
- 2009-02-25 EP EP09715042A patent/EP2271366A4/en not_active Withdrawn
- 2009-02-25 WO PCT/US2009/035050 patent/WO2009108652A1/en not_active Ceased
- 2009-02-25 AU AU2009219358A patent/AU2009219358A1/en not_active Abandoned
- 2009-02-25 JP JP2010548830A patent/JP2011512817A/ja active Pending
-
2014
- 2014-03-12 US US14/205,995 patent/US20140335543A1/en not_active Abandoned
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