CN101980723A - 艰难梭菌芽孢的抗体及其用途 - Google Patents

艰难梭菌芽孢的抗体及其用途 Download PDF

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Publication number
CN101980723A
CN101980723A CN2009801113555A CN200980111355A CN101980723A CN 101980723 A CN101980723 A CN 101980723A CN 2009801113555 A CN2009801113555 A CN 2009801113555A CN 200980111355 A CN200980111355 A CN 200980111355A CN 101980723 A CN101980723 A CN 101980723A
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China
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seq
antibody
isolated antibody
clostridium difficile
fragment
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Chinese (zh)
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拉伊·拉贾戈帕尔
魏爱平
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3M Innovative Properties Co
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3M Innovative Properties Co
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/33Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/10Detection of antigens from microorganism in sample from host
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/067Pancreatitis or colitis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2009801113555A 2008-02-28 2009-02-25 艰难梭菌芽孢的抗体及其用途 Pending CN101980723A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3227008P 2008-02-28 2008-02-28
US61/032,270 2008-02-28
PCT/US2009/035050 WO2009108652A1 (en) 2008-02-28 2009-02-25 Antibodies to clostridium difficile spores and uses thereof

Publications (1)

Publication Number Publication Date
CN101980723A true CN101980723A (zh) 2011-02-23

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CN2009801113555A Pending CN101980723A (zh) 2008-02-28 2009-02-25 艰难梭菌芽孢的抗体及其用途

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US (2) US8697374B2 (enExample)
EP (1) EP2271366A4 (enExample)
JP (1) JP2011512817A (enExample)
KR (1) KR20100126760A (enExample)
CN (1) CN101980723A (enExample)
AU (1) AU2009219358A1 (enExample)
BR (1) BRPI0906060A2 (enExample)
CA (1) CA2714720A1 (enExample)
WO (1) WO2009108652A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
CN105555309A (zh) * 2013-04-19 2016-05-04 英穆伦有限公司 治疗和/或预防艰难梭菌相关疾病的方法和组合物
CN108424449A (zh) * 2011-09-16 2018-08-21 Ucb医药有限公司 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体
CN111948388A (zh) * 2020-08-18 2020-11-17 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用
CN114585740A (zh) * 2019-06-05 2022-06-03 利夫加工有限公司 针对艰难梭菌的适配体

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AU2010241947B2 (en) * 2009-03-27 2014-01-16 Gojo Industries, Inc. Compositions and methods for screening and using compounds antagonizing spore-surface interactions
US20120276059A1 (en) 2011-04-29 2012-11-01 Techlab, Inc. Fecal lactoferrin as a biomarker for determining disease severity and for monitoring infection in patients with clostridium difficile disease
US10295535B2 (en) 2011-04-29 2019-05-21 Techlab, Inc. Clostridium difficile dehydrogenase and toxin as a biomarker for monitoring infection in patients with clostridium difficile disease and differentiating carrier state from active disease
CA2848765A1 (en) * 2011-09-15 2013-03-21 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Immunotherapy and diagnosis of mucormycosis using coth
US10364298B2 (en) 2011-11-18 2019-07-30 National Research Council Of Canada Clostridium difficile lipoteichoic acid and uses thereof
CN102590515B (zh) * 2012-01-13 2014-07-30 张春华 艰难梭菌外毒素a检测试剂盒及组成该试剂盒的单克隆抗体
CN104203976A (zh) 2012-03-02 2014-12-10 瑞泽恩制药公司 艰难梭状芽孢杆菌毒素的人源抗体
US9133527B2 (en) * 2012-05-11 2015-09-15 Techlab, Inc. Cell wall protein CwpV (CD0514) as a diagnostic marker for Clostridium difficile ribotype 027
US9079935B2 (en) 2012-08-13 2015-07-14 The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas Reducing risk of contracting Clostridium-difficile associated disease
BR112015004629A2 (pt) * 2012-09-19 2017-11-21 Novartis Ag polipeptídeos de clostridium difficile como vacinas
EP2925362A4 (en) * 2012-11-28 2016-07-20 Cnj Holdings Inc ANTIBODIES DIRECTED AGAINST CLOSTRIDIUM DIFFICILE
WO2015150493A1 (en) * 2014-04-01 2015-10-08 Institut Pasteur Predictive value of clostridium difficile-specific immune response for recurrence and disease outcome
WO2015191419A2 (en) 2014-06-09 2015-12-17 3M Innovative Properties Company Assay devices and method of detecting a target analyte
US20180000793A1 (en) 2015-02-06 2018-01-04 Ernesto Abel-Santos Inhibiting Germination of Clostridium Perfringens Spores to Reduce Necrotic Enteritis
WO2017051413A1 (en) * 2015-09-21 2017-03-30 4C Diagnostics Ltd. Stool specimen collecting, sampling and diagnosing means and methods thereof
WO2023039159A2 (en) 2021-09-09 2023-03-16 Abel Santos Ernesto Inhibitors of c. difficile spore germination
CN119751687B (zh) * 2024-12-26 2025-09-26 杭州医学院 识别艰难梭菌谷氨酸脱氢酶中线性b细胞抗原表位的驼源单域抗体ga4及应用

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US20040033546A1 (en) * 2002-04-10 2004-02-19 The Trustees Of Columbia University In The City Of New York Novel microarrays and methods of use thereof
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102533867A (zh) * 2010-12-10 2012-07-04 西北民族大学 一种艰难梭菌a毒素的类毒素的制备方法
CN108424449A (zh) * 2011-09-16 2018-08-21 Ucb医药有限公司 针对艰难梭菌的主要外毒素TcdA和TcdB的中和抗体
CN105555309A (zh) * 2013-04-19 2016-05-04 英穆伦有限公司 治疗和/或预防艰难梭菌相关疾病的方法和组合物
CN114585740A (zh) * 2019-06-05 2022-06-03 利夫加工有限公司 针对艰难梭菌的适配体
CN111948388A (zh) * 2020-08-18 2020-11-17 山东农业大学 一种检测腐败梭菌的胶体金试纸条及其制备方法和应用

Also Published As

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US20110183360A1 (en) 2011-07-28
EP2271366A4 (en) 2012-06-20
KR20100126760A (ko) 2010-12-02
US20140335543A1 (en) 2014-11-13
WO2009108652A1 (en) 2009-09-03
US8697374B2 (en) 2014-04-15
EP2271366A1 (en) 2011-01-12
JP2011512817A (ja) 2011-04-28
BRPI0906060A2 (pt) 2015-12-01
AU2009219358A1 (en) 2009-09-03
CA2714720A1 (en) 2009-09-03

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Application publication date: 20110223