JP2011522835A5 - - Google Patents
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- Publication number
- JP2011522835A5 JP2011522835A5 JP2011512705A JP2011512705A JP2011522835A5 JP 2011522835 A5 JP2011522835 A5 JP 2011522835A5 JP 2011512705 A JP2011512705 A JP 2011512705A JP 2011512705 A JP2011512705 A JP 2011512705A JP 2011522835 A5 JP2011522835 A5 JP 2011522835A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- suppressor
- antibody
- isolated
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001744 T-lymphocyte Anatomy 0.000 claims 13
- 210000001821 langerhans cell Anatomy 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102000001398 Granzyme Human genes 0.000 claims 2
- 108060005986 Granzyme Proteins 0.000 claims 2
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 2
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 2
- 206010052779 Transplant rejections Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229930192851 perforin Natural products 0.000 claims 1
- 210000005259 peripheral blood Anatomy 0.000 claims 1
- 239000011886 peripheral blood Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5964708P | 2008-06-06 | 2008-06-06 | |
| US61/059,647 | 2008-06-06 | ||
| PCT/US2009/046464 WO2009149382A2 (en) | 2008-06-06 | 2009-06-05 | Anti-cd8 antibodies block priming of cytotoxic effectors and lead to generation of regulatory cd8+t cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011522835A JP2011522835A (ja) | 2011-08-04 |
| JP2011522835A5 true JP2011522835A5 (OSRAM) | 2012-07-19 |
Family
ID=41398905
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512705A Pending JP2011522835A (ja) | 2008-06-06 | 2009-06-05 | 抗ｃｄ８抗体は、細胞傷害性エフェクターのプライミングを遮断し、制御性ｃｄ８＋ｔ細胞の生成を導く |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090304659A1 (OSRAM) |
| EP (1) | EP2297204A4 (OSRAM) |
| JP (1) | JP2011522835A (OSRAM) |
| KR (1) | KR20110025812A (OSRAM) |
| CN (1) | CN102112491A (OSRAM) |
| AU (1) | AU2009255999A1 (OSRAM) |
| BR (1) | BRPI0915582A2 (OSRAM) |
| CA (1) | CA2728772A1 (OSRAM) |
| IL (1) | IL209798A0 (OSRAM) |
| MX (1) | MX2010013265A (OSRAM) |
| NZ (1) | NZ590197A (OSRAM) |
| TW (1) | TW201000130A (OSRAM) |
| WO (1) | WO2009149382A2 (OSRAM) |
| ZA (1) | ZA201100061B (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5825966B2 (ja) * | 2011-10-11 | 2015-12-02 | 株式会社日本バイオセラピー研究所 | Ｃｄ５６陽性ｔ細胞増強方法 |
| US10092597B2 (en) | 2014-01-14 | 2018-10-09 | The University Of Hong Kong | Human CD8+ regulatory T cells inhibit GVHD and preserve general immunity in humanized mice |
| WO2018085897A1 (en) * | 2016-11-14 | 2018-05-17 | Murdoch Childrens Research Institute | Transplant rejection assay |
| BR112020001360A2 (pt) * | 2017-07-24 | 2020-08-11 | Regeneron Pharmaceuticals, Inc. | anticorpo monoclonal isolado ou fragmento de ligação a antígeno deste que se liga a cd8, composição farmacêutica, molécula de ácido nucleico, vetor de expressão, célula hospedeira, conjugado de anticorpo, métodos para gerar imagens de um tecido que expressa cd8, para tratar um sujeito tendo um tumor sólido, para prever uma resposta positiva a uma terapia antitumoral, para monitorar uma resposta de um tumor em um sujeito a uma terapia antitumoral, para prever ou monitorar a eficácia da terapia antitumoral e para monitorar a presença de células t em um tumor ao longo do tempo, e, composto. |
| WO2020250940A1 (ja) | 2019-06-11 | 2020-12-17 | 小野薬品工業株式会社 | 免疫抑制剤 |
| JP7688941B2 (ja) * | 2020-07-21 | 2025-06-05 | スーチョウ スマートヌクライド バイオファーマシューティカル カンパニー リミテッド | Ｃｄ８結合ポリペプチドおよびその使用 |
| CN112156110B (zh) * | 2020-09-15 | 2022-10-14 | 上海交通大学医学院 | Cd8+抑制性t细胞在免疫调节中的应用及诱导方法 |
| WO2022245500A1 (en) | 2021-05-19 | 2022-11-24 | Asher Biotherapeutics, Inc. | Il-21 polypeptides and targeted constructs |
| WO2024112867A1 (en) | 2022-11-23 | 2024-05-30 | University Of Georgia Research Foundation, Inc. | Compositions and methods of use thereof for increasing immune responses |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5178858A (en) * | 1987-12-02 | 1993-01-12 | Reichert Thomas A | Method for prevention of graft versus host disease |
| CA1339840C (en) * | 1988-12-16 | 1998-04-28 | Kenneth Kortright | Method and apparatus for screening cells or formed bodies with populations expressing selected characteristics |
| US5601828A (en) * | 1989-03-15 | 1997-02-11 | Tkb Associates Limited Partnership | CD8 derivatives and methods of use for cellular modulation and enhancement of cellular engraftment |
| GB8912497D0 (en) * | 1989-05-31 | 1989-07-19 | Cobbold Stephen P | Monoclonal antibodies |
| US5690933A (en) * | 1989-05-31 | 1997-11-25 | Glaxo Wellcome Inc. | Monoclonal antibodies for inducing tolerance |
| BR9107024A (pt) * | 1990-11-23 | 1993-08-31 | Coulter Corp | Processo e aparelho para analisar calculos de pelo menos um grupo de celulas de interesse e processo e aparelho para analisar pelo menos uma populacao de celulas sanguineas brancas ou um subconjunto desta pupolacao a partir de uma amostra sanguinea completa |
| US6911220B1 (en) * | 1992-02-19 | 2005-06-28 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| US5876708A (en) * | 1992-02-19 | 1999-03-02 | The General Hospital Corporation | Allogeneic and xenogeneic transplantation |
| EP0939796B1 (en) * | 1996-04-05 | 2009-05-27 | South Alabama Medical Science Foundation | Uses of oncofetal antigen specific cd4, cd8 cytotoxic and suppressor t cells and interleukin-10 |
| IL126714A (en) * | 1997-02-28 | 2010-12-30 | Enzo Therapeutics Inc | Use of cells, organs or components thereof for the preparation of a pharmaceutical composition for establishing selective immune downregulation |
| US6803036B1 (en) * | 1998-03-03 | 2004-10-12 | University Of Southern California | Use of cytokines, cells and mitogens to inhibit graft versus host disease |
| US20040022761A1 (en) * | 2001-05-11 | 2004-02-05 | Banchereau Jacques F | Compositions and methods for producing antigen-presenting cells |
| CA2499826C (en) * | 2002-09-27 | 2015-03-24 | Bioe, Inc. | Cell separation compositions and methods |
| WO2004083404A2 (en) * | 2003-03-19 | 2004-09-30 | Isogenis, Inc. | Gene therapy vectors having reduced immunogenicity based on cd8 alpha-chain |
| GB0314461D0 (en) * | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| EP1674479A1 (en) * | 2004-12-22 | 2006-06-28 | Memorial Sloan-Kettering Cancer Center | Modulation of Fc Gamma receptors for optimizing immunotherapy |
| JP2009542714A (ja) * | 2006-06-30 | 2009-12-03 | ベイラー リサーチ インスティテュート | ＧＭ−ＣＳＦ及びインターフェロンαを用いて生成され、且つ熱処理され死滅したがん細胞を取り込んだ樹状細胞 |
-
2009
- 2009-06-05 US US12/479,349 patent/US20090304659A1/en not_active Abandoned
- 2009-06-05 CA CA2728772A patent/CA2728772A1/en not_active Abandoned
- 2009-06-05 MX MX2010013265A patent/MX2010013265A/es active IP Right Grant
- 2009-06-05 EP EP09759540.9A patent/EP2297204A4/en not_active Withdrawn
- 2009-06-05 AU AU2009255999A patent/AU2009255999A1/en not_active Abandoned
- 2009-06-05 WO PCT/US2009/046464 patent/WO2009149382A2/en not_active Ceased
- 2009-06-05 KR KR1020117000123A patent/KR20110025812A/ko not_active Withdrawn
- 2009-06-05 JP JP2011512705A patent/JP2011522835A/ja active Pending
- 2009-06-05 NZ NZ590197A patent/NZ590197A/xx not_active IP Right Cessation
- 2009-06-05 BR BRPI0915582A patent/BRPI0915582A2/pt not_active IP Right Cessation
- 2009-06-05 CN CN2009801301198A patent/CN102112491A/zh active Pending
- 2009-06-06 TW TW098118952A patent/TW201000130A/zh unknown
-
2010
- 2010-12-06 IL IL209798A patent/IL209798A0/en unknown
-
2011
- 2011-01-03 ZA ZA2011/00061A patent/ZA201100061B/en unknown
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