JP2011522515A - 癌幹細胞を標的とする薬剤を同定する方法およびその使用 - Google Patents

癌幹細胞を標的とする薬剤を同定する方法およびその使用 Download PDF

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JP2011522515A
JP2011522515A JP2011504009A JP2011504009A JP2011522515A JP 2011522515 A JP2011522515 A JP 2011522515A JP 2011504009 A JP2011504009 A JP 2011504009A JP 2011504009 A JP2011504009 A JP 2011504009A JP 2011522515 A JP2011522515 A JP 2011522515A
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cells
cancer
cell
compound
test
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JP2011522515A5 (enExample
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グプタ，ピユシュ
オンデル，タマー，ティー．
ランダー，エリック，エス．
ウェインバーグ，ロバート
マニ，セーナトゥライ
リャオ，マイ−ジン
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Massachusetts Institute of Technology
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

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JP2011504009A 2008-04-10 2009-04-10 癌幹細胞を標的とする薬剤を同定する方法およびその使用 Pending JP2011522515A (ja)

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US4394808P 2008-04-10 2008-04-10
US61/043,948 2008-04-10
US5356308P 2008-05-15 2008-05-15
US61/053,563 2008-05-15
PCT/US2009/002254 WO2009126310A2 (en) 2008-04-10 2009-04-10 Methods for identification and use of agents targeting cancer stem cells

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JP2014515821A (ja) * 2011-03-27 2014-07-03 オンコステム ダイアグノスティックス（モーリシャス）プライベート リミテッド 腫瘍細胞を同定するためのマーカー、その方法およびキット
JP2016017835A (ja) * 2014-07-08 2016-02-01 株式会社島津製作所 上皮間葉転換の有無を判別する方法
JP2016522675A (ja) * 2013-03-14 2016-08-04 ガラパゴス・ナムローゼ・フェンノートシャップＧａｌａｐａｇｏｓ Ｎ．Ｖ． 上皮間葉移行に関連した疾患の治療において有用な分子標的及び前記標的のインヒビター
JPWO2016047688A1 (ja) * 2014-09-24 2017-07-06 国立研究開発法人国立がん研究センター 扁平上皮がんに対する化学放射線療法の有効性を評価するための方法
JP2018070623A (ja) * 2012-08-09 2018-05-10 セルジーン コーポレイション 免疫関連及び炎症性疾患の治療
JP2020058360A (ja) * 2014-11-27 2020-04-16 ゲンチウム エス．アール．エル． デフィブロチドの能力を決定する為の細胞に基づく方法

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