CA2723648A1 - Methods for identification and use of agents targeting cancer stem cells - Google Patents

Methods for identification and use of agents targeting cancer stem cells Download PDF

Info

Publication number
CA2723648A1
CA2723648A1 CA2723648A CA2723648A CA2723648A1 CA 2723648 A1 CA2723648 A1 CA 2723648A1 CA 2723648 A CA2723648 A CA 2723648A CA 2723648 A CA2723648 A CA 2723648A CA 2723648 A1 CA2723648 A1 CA 2723648A1
Authority
CA
Canada
Prior art keywords
cells
cancer
compound
cell
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2723648A
Other languages
English (en)
French (fr)
Inventor
Piyush Gupta
Tamer T. Onder
Eric S. Lander
Robert Weinberg
Sendurai Mani
Mai-Jing Liao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Harvard University
Whitehead Institute for Biomedical Research
Original Assignee
Massachusetts Institute of Technology
Harvard University
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Institute of Technology, Harvard University, Whitehead Institute for Biomedical Research filed Critical Massachusetts Institute of Technology
Publication of CA2723648A1 publication Critical patent/CA2723648A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5073—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
CA2723648A 2008-04-10 2009-04-10 Methods for identification and use of agents targeting cancer stem cells Abandoned CA2723648A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US4394808P 2008-04-10 2008-04-10
US61/043,948 2008-04-10
US5356308P 2008-05-15 2008-05-15
US61/053,563 2008-05-15
PCT/US2009/002254 WO2009126310A2 (en) 2008-04-10 2009-04-10 Methods for identification and use of agents targeting cancer stem cells

Publications (1)

Publication Number Publication Date
CA2723648A1 true CA2723648A1 (en) 2009-10-15

Family

ID=41162467

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2723648A Abandoned CA2723648A1 (en) 2008-04-10 2009-04-10 Methods for identification and use of agents targeting cancer stem cells

Country Status (6)

Country Link
US (2) US20110191868A1 (enExample)
EP (2) EP2274617A4 (enExample)
JP (2) JP2011522515A (enExample)
CN (1) CN102144163A (enExample)
CA (1) CA2723648A1 (enExample)
WO (1) WO2009126310A2 (enExample)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2393917B1 (en) 2009-02-03 2016-04-06 Koninklijke Nederlandse Akademie van Wetenschappen Culture medium for epithelial stem cells and organoids comprising said stem cells.
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US20120295346A1 (en) * 2009-07-22 2012-11-22 Tufts University Methods and compositions for modulating membrane potential to influence cell behavior
EP2322927A1 (en) * 2009-11-16 2011-05-18 Deutsches Krebsforschungszentrum Compounds inhibiting CD95 signaling for the treatment of pancreatic cancer
WO2011096728A2 (en) * 2010-02-03 2011-08-11 Samsung Life Public Welfare Foundation Method for proliferating stem cells by activating c-met/hgf signaling and notch signaling
RU2012148398A (ru) 2010-04-18 2014-05-27 Иеда Рисеч Энд Девелопмент Ко. Лтд. МОЛЕКУЛЫ И СПОСОБЫ ПРИМЕНЕНИЯ МОЛЕКУЛ ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНЕЙ, АССОЦИИРОВАННЫХ С ErbB/ErbB ЛИГАНДАМИ
US10095842B2 (en) * 2010-05-28 2018-10-09 Salgomed, Inc. Methods for artificial combinatorial control of biological systems
US20110293525A1 (en) * 2010-05-29 2011-12-01 Board Of Trustees Of The University Of Illinois Tumor stem cells
JP2013532489A (ja) * 2010-08-02 2013-08-19 ザ ブロード インスティテュート， インコーポレイテッド 遺伝子発現プロファイリングに基づくがん治療への応答の予測ならびにモニタリング
WO2012030854A2 (en) 2010-09-01 2012-03-08 Whitehead Institute For Biomedical Research Compositions and methods for modulating emt and uses thereof
US9778264B2 (en) 2010-09-03 2017-10-03 Abbvie Stemcentrx Llc Identification and enrichment of cell subpopulations
EP2689787A1 (en) 2010-09-03 2014-01-29 Stem Centrx, Inc. Identification and enrichment of cell subpopulations
GB201100180D0 (en) * 2011-01-06 2011-02-23 Capsant Neurotechnologies Ltd Tumour cell and tissue culture
FR2970179B1 (fr) * 2011-01-11 2013-01-18 Centre Nat Rech Scient Moyens pour reduire ou eradiquer le pouvoir tumoral de cellules souches cancereuses et/ou metastasiques
US9216177B2 (en) 2011-02-28 2015-12-22 Drexel University Small molecular inhibitors of RAD51 recombinase and methods thereof
JP2014509323A (ja) 2011-02-28 2014-04-17 マックマスター ユニヴァーシティ ドーパミン受容体遮断薬による癌の処置
JP6002748B2 (ja) * 2011-03-24 2016-10-05 ザ・ロゴシン・インスティテュート・インコーポレイテッド 癌幹細胞の数を選択的に減少させる化合物をスクリーニングするためのアッセイ
WO2012131564A1 (en) * 2011-03-27 2012-10-04 Oncostem Diagnostics Pvt. Ltd. Markers for identifying tumor cells, methods and kit thereof
US9351988B2 (en) 2011-05-02 2016-05-31 Universite De Geneve Macrocyclic lactones and use thereof
US9791449B2 (en) * 2011-06-03 2017-10-17 The General Hospital Corporation Ovarian cancer stem cells and methods of isolation and uses thereof
EA201490230A1 (ru) 2011-07-08 2014-06-30 Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч Применение меченых ингибиторов hsp90
WO2013032907A1 (en) * 2011-08-26 2013-03-07 The Broad Institute, Inc. Compounds and methods for the treatment of cancer stem cells
US9327023B2 (en) 2011-10-25 2016-05-03 The Regents Of The University Of Michigan HER2 targeting agent treatment in non-HER2-amplified cancers having HER2 expressing cancer stem cells
WO2013071247A1 (en) 2011-11-10 2013-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic Gene expression signatures of neoplasm responsiveness to theraphy
WO2013071066A1 (en) * 2011-11-11 2013-05-16 The Broad Institute, Inc. Signatures associated with the response to cancer therapy
CN103127052A (zh) * 2011-12-05 2013-06-05 维瑞斯特姆有限公司 治疗组合物和相关使用方法
CN103193841A (zh) 2012-01-06 2013-07-10 维瑞斯特姆有限公司 治疗性化合物及相关使用方法
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
CN103243074B (zh) * 2012-02-14 2014-10-01 中国科学院动物研究所 一种人结直肠癌肿瘤细胞系及其制备方法和应用
US20150017134A1 (en) * 2012-03-01 2015-01-15 Whitehead Institute For Biomedical Research Emt-inducing transcription factors cooperate with sox9
CA2866358C (en) * 2012-03-06 2020-06-23 Cellect Biotechnology Ltd. Devices and methods for selecting apoptosis-signaling resistant cells, and uses thereof
US9080154B1 (en) * 2012-04-02 2015-07-14 Bowling Green State University Cancer stem cell survivor lines
KR101463183B1 (ko) 2012-06-05 2014-11-21 연세대학교 산학협력단 암 줄기세포 특성에 기초한 암의 신규한 치료용 타겟 및 바이오마커
ES2660969T5 (es) 2012-06-22 2021-09-03 Gentium S R L Método basado en euglobulina para determinar la actividad biológica de defibrotida
WO2014009245A2 (en) * 2012-07-09 2014-01-16 Qithera Gmbh Novel drug target indentification methods
US20150038511A1 (en) 2012-08-09 2015-02-05 Celgene Corporation Treatment of immune-related and inflammatory diseases
LT2882441T (lt) * 2012-08-09 2020-07-27 Celgene Corporation Su imunitetu susijusių ir uždegiminių ligų gydymas
US10106778B2 (en) 2012-11-08 2018-10-23 Whitehead Institute For Biomedical Research Selective targeting of cancer stem cells
US9551036B2 (en) 2013-02-25 2017-01-24 Whitehead Institute For Biomedical Research Metabolic gene mesenchymal signatures and uses thereof
GB2513299A (en) 2013-03-12 2014-10-29 Cellact Pharma Gmbh Biomedizinzentrum Compounds for targeting cancer stem cells
EP2972381A2 (en) * 2013-03-14 2016-01-20 Galapagos NV Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition
CN104840961B (zh) * 2014-02-14 2016-03-23 马立伟 癌症干细胞敏感剂在制备抗癌症干细胞试剂盒中的应用
JP6491671B2 (ja) * 2014-03-17 2019-03-27 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ 核因子−κＢの移行に基づいて化合物の毒性を予測するための方法
EP2921855A1 (en) * 2014-03-20 2015-09-23 Centre National de la Recherche Scientifique (CNRS) Use of compounds inhibiting apelin / apj / gp130 signaling for treating cancer
AU2015233370A1 (en) * 2014-03-20 2016-09-22 Centre National De La Recherche Scientifique (Cnrs) Use of compounds inhibiting Apelin / APJ / GP130 signaling for treating cancer
WO2015168255A1 (en) 2014-04-29 2015-11-05 Whitehead Institute For Biomedical Research Methods and compositions for targeting cancer stem cells
WO2015171339A1 (en) * 2014-05-06 2015-11-12 The Board Of Regents Of The University Of Texas System Identification and isolation of neural stem cells and neurosphere initiating cells
CA2949171A1 (en) 2014-05-16 2015-11-19 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
US10245266B2 (en) 2014-05-19 2019-04-02 Celgene Corporation 3-(4-((4-morpholinomethyl-benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione for the treatment of systemic lupus erythematosus
JP6277894B2 (ja) * 2014-07-08 2018-02-14 株式会社島津製作所 上皮間葉転換の有無を判別する方法
WO2016047688A1 (ja) * 2014-09-24 2016-03-31 国立研究開発法人国立がん研究センター 扁平上皮がんに対する化学放射線療法の有効性を評価するための方法
US20170304251A1 (en) * 2014-10-09 2017-10-26 Paul Anthony Spagnuolo Avocado-derived lipids for use in treating leukemia
GB201421092D0 (en) * 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
GB201421094D0 (en) * 2014-11-27 2015-01-14 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
WO2016098041A1 (en) * 2014-12-18 2016-06-23 Saarum Sciences Private Ltd Establishment and use of an in vitro platform for emt
CN104725511B (zh) * 2015-02-16 2018-01-12 华南农业大学 一种猪肠道干细胞的分离培养方法
SMT201800303T1 (it) * 2015-05-14 2018-07-17 NuCana plc Trattamenti per il cancro
US11931347B2 (en) * 2015-09-23 2024-03-19 Minerva Biotechnologies Corporation Method of screening for agents for differentiating stem cells
GB201603569D0 (en) 2016-03-01 2016-04-13 Koninklijke Nederlandse Akademie Van Wetenschappen Improved differentiation method
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
CN106701886B (zh) * 2016-12-16 2021-06-22 管晓翔 一种三阴性乳腺癌细胞上皮间质转换过程中对内皮细胞分泌功能影响的检测方法
CN111278443A (zh) * 2017-11-08 2020-06-12 丹娜法伯癌症研究院 使用rhoa显性负型治疗癌症的组合物和方法
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
EP3502700A1 (en) * 2017-12-21 2019-06-26 Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron Methods based on the detection of rad51 foci in tumor cells
CN108410986B (zh) * 2018-02-26 2021-06-22 中国人民解放军总医院 Cdh6促进骨肉瘤生长和转移
US10146914B1 (en) 2018-03-01 2018-12-04 Recursion Pharmaceuticals, Inc. Systems and methods for evaluating whether perturbations discriminate an on target effect
GB201819224D0 (en) 2018-11-26 2019-01-09 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatocyte expansion methods
CN109512833B (zh) * 2018-12-04 2020-10-30 天津医科大学总医院 E2f6抑制剂的功能与用途
CN110082536B (zh) * 2019-04-17 2022-06-10 广州医科大学附属肿瘤医院 一种乳腺癌细胞标志物细胞因子群及其应用
EP4121111A4 (en) * 2020-03-20 2024-05-15 University of Houston System METHODS AND COMPOSITIONS FOR THE TREATMENT OF INFLAMMATORY AND FIBROTIC LUNG DISEASES
WO2022020359A1 (en) * 2020-07-24 2022-01-27 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
CN116783487A (zh) * 2020-08-05 2023-09-19 乔斯林糖尿病中心公司 终末期肾病生物标记物组
WO2022059026A1 (en) * 2020-09-21 2022-03-24 Mestastop Solutions Private Limited Systems and methods for predicting cancer metastasis and screening of drugs
CN112730840B (zh) * 2021-01-29 2023-10-17 章毅 鉴别cd44和cd24分子表型的方法
CN113125689B (zh) * 2021-03-29 2022-02-22 创芯国际生物科技(广州)有限公司 一种新型mtt细胞活力检测试剂盒及其应用
CN114181102B (zh) * 2021-11-10 2023-06-23 深圳市检验检疫科学研究院 己雷琐辛半抗原、人工抗原、抗体及其合成方法和应用
CN116286658A (zh) * 2022-09-26 2023-06-23 南通大学 Traf5抑制剂在制备人恶性黑色素瘤治疗药物中的应用
CN115992240A (zh) * 2022-10-28 2023-04-21 中山大学附属第三医院 E2f转录因子2作为治疗靶点在制备预防和/或治疗多发性骨髓瘤的药物中的应用
CN115948558B (zh) * 2023-01-19 2025-04-11 重庆医科大学 乳腺癌肺特异性转移的标志物及其药物组合物与应用
CN117347621B (zh) * 2023-08-25 2024-03-12 广东省农业科学院农业生物基因研究中心 一种用蛋白模拟抗原-纳米抗体检测黄曲霉毒素b1的方法
WO2025170878A1 (en) * 2024-02-05 2025-08-14 Exvivo Labs Inc Methods for high-throughput drug screens at clonal resolution

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
EP0336248A1 (de) 1988-03-31 1989-10-11 Hoechst Aktiengesellschaft Am F-Ring substituierte Nigericinderivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und Verwendung derselben als antiviral wirksam und antibakteriell wirksame Substanzen
EP0346760A2 (de) 1988-06-14 1989-12-20 Hoechst Aktiengesellschaft Nigericinderivate, Verfahren zu deren Herstellung, diese enthaltende Mittel und Verwendung derselben
DE3829450A1 (de) 1988-08-31 1990-03-01 Hoechst Ag Nigericinderivate, verfahren zu deren herstellung, diese enthaltende mittel und verwendung derselben
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5211657A (en) 1988-11-07 1993-05-18 The United States Government As Represented By The Secretary Of The Department Of Health And Human Services Laminin a chain deduced amino acid sequence, expression vectors and active synthetic peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5229415A (en) 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
GB9312154D0 (en) 1993-06-12 1993-07-28 Pfizer Ltd Antiparasitic agents
US20020042079A1 (en) * 1994-02-01 2002-04-11 Sanford M. Simon Methods and agents for measuring and controlling multidrug resistance
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
US6190657B1 (en) 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
CZ296326B6 (cs) 1997-07-23 2006-02-15 Pfizer Inc. Zpusob prípravy avermektinové slouceniny
US8334238B2 (en) 1998-04-17 2012-12-18 Rigel, Inc. Multiparameter FACS assays to detect alterations in cellular parameters and to screen small molecule libraries
US20040101936A1 (en) * 2000-02-24 2004-05-27 Hirofumi Endo Process for producing avermectin derivative
US20050209310A1 (en) * 2000-12-22 2005-09-22 Chaplin David J Methods for modulating tumor growth and metastasis
SE0102168D0 (sv) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
EP1438319A1 (en) 2001-10-26 2004-07-21 Centre National De La Recherche Scientifique (Cnrs) Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
TW200300416A (en) 2001-11-27 2003-06-01 Bristol Myers Squibb Co Method of synthesizing a paclitaxel derivative
AU2002358086B2 (en) 2001-12-03 2009-06-04 Universitatsklinikum Charite Der Humboldt-Universitat Zu Berlin Technologie Transferstelle Podophyllotoxins as antiproliferative agents
US6566393B1 (en) 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
US20050026866A1 (en) 2002-08-02 2005-02-03 Pawelek John M. Agents and methods for treatment of disease by oligosaccharide targeting agents
WO2005082875A2 (en) * 2004-02-24 2005-09-09 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
CA2572223C (en) * 2004-06-25 2014-08-12 The Johns Hopkins University Angiogenesis inhibitors
WO2006021008A2 (en) * 2004-08-20 2006-02-23 Lind Stuart E Ionophores as cancer chemotherapeutic agents
CA2601157A1 (en) * 2005-03-16 2006-09-28 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2656548A1 (en) 2005-06-30 2007-01-11 Whitehead Institute Progenitor cells and uses thereof
CA2619889C (en) * 2005-08-22 2020-05-05 The Johns Hopkins University Use of itraconazole and salts thereof for treating cancer
CA2623125A1 (en) * 2005-09-20 2007-03-29 Osi Pharmaceuticals, Inc. Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
DE102007007750A1 (de) 2006-08-17 2008-02-21 Bayer Cropscience Ag Avermectinderivate
FR2906465B1 (fr) 2006-09-28 2008-11-28 Galderma Sa Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques chez l'homme
WO2008095165A2 (en) * 2007-02-01 2008-08-07 Dana-Farber Cancer Institute, Inc. Cell co-culture systems and uses thereof
US20090054312A1 (en) * 2007-08-22 2009-02-26 Wolf Dieter A SMIPs: Small molecule inhibitors of p27 depletion in cancers and other proliferative diseases
WO2010037134A2 (en) * 2008-09-29 2010-04-01 Stemlifeline, Inc. Multi-stage stem cell carcinogenesis

Also Published As

Publication number Publication date
US20140294729A1 (en) 2014-10-02
JP2014128294A (ja) 2014-07-10
WO2009126310A3 (en) 2010-02-25
EP2274617A2 (en) 2011-01-19
JP2011522515A (ja) 2011-08-04
EP2385370A1 (en) 2011-11-09
CN102144163A (zh) 2011-08-03
WO2009126310A2 (en) 2009-10-15
EP2274617A4 (en) 2011-11-09
US20110191868A1 (en) 2011-08-04

Similar Documents

Publication Publication Date Title
CA2723648A1 (en) Methods for identification and use of agents targeting cancer stem cells
Wang et al. CCL18 from tumor‐cells promotes epithelial ovarian cancer metastasis via mTOR signaling pathway
Gradilone et al. Circulating tumor cells (CTCs) in metastatic breast cancer (MBC): prognosis, drug resistance and phenotypic characterization
Yoshikawa et al. xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
Andre et al. Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer
Cui et al. Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
Liu et al. TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition
Angeloni et al. Implications of stemness-related signaling pathways in breast cancer response to therapy
Li et al. O-GlcNAcylation modulates Bmi-1 protein stability and potential oncogenic function in prostate cancer
Xu et al. N6-methyladenosine modification regulates imatinib resistance of gastrointestinal stromal tumor by enhancing the expression of multidrug transporter MRP1
Chen et al. H2AK119Ub1 and H3K27Me3 in molecular staging for survival prediction of patients with pancreatic ductal adenocarcinoma
Kwon et al. Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer
O'Toole et al. Molecular markers associated with response to chemotherapy in gastro-entero-pancreatic neuroendocrine tumors
Chen et al. IL‐1RA suppresses esophageal cancer cell growth by blocking IL‐1α
Ge et al. RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8+ T cell infiltration in colorectal cancer
Gunes et al. Thioredoxin interacting protein promotes invasion in hepatocellular carcinoma
Huang et al. Overexpressed ACBD3 has prognostic value in human breast cancer and promotes the self-renewal potential of breast cancer cells by activating the Wnt/beta-catenin signaling pathway
Xu et al. Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p
Chen et al. Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling
Yang et al. Phosphorylase kinase β represents a novel prognostic biomarker and inhibits malignant phenotypes of liver cancer cell
Wang et al. Evaluation of Annexin A7, Galectin-3 and Gelsolin as possible biomarkers of hepatocarcinoma lymphatic metastasis
Lin et al. Pin1 positively affects tumorigenesis of esophageal squamous cell carcinoma and correlates with poor survival of patients
Chebouti et al. Analysis of disseminated tumor cells before and after platinum based chemotherapy in primary ovarian cancer. Do stem cell like cells predict prognosis?
US10881677B2 (en) Composition for modulating IRAK1
Yang et al. Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140409

FZDE Discontinued

Effective date: 20171130