JP2011521949A5 - - Google Patents
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- Publication number
- JP2011521949A5 JP2011521949A5 JP2011511661A JP2011511661A JP2011521949A5 JP 2011521949 A5 JP2011521949 A5 JP 2011521949A5 JP 2011511661 A JP2011511661 A JP 2011511661A JP 2011511661 A JP2011511661 A JP 2011511661A JP 2011521949 A5 JP2011521949 A5 JP 2011521949A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- ser
- pharmaceutically acceptable
- ala
- trp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims description 46
- 150000001875 compounds Chemical class 0.000 claims description 37
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 32
- 150000003839 salts Chemical class 0.000 claims description 25
- AGPKZVBTJJNPAG-RFZPGFLSSA-N D-Isoleucine Chemical compound CC[C@@H](C)[C@@H](N)C(O)=O AGPKZVBTJJNPAG-RFZPGFLSSA-N 0.000 claims description 24
- ODKSFYDXXFIFQN-SCSAIBSYSA-N D-arginine Chemical compound OC(=O)[C@H](N)CCCNC(N)=N ODKSFYDXXFIFQN-SCSAIBSYSA-N 0.000 claims description 18
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 claims description 18
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 claims description 18
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims description 18
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 claims description 16
- -1 D-Nle Chemical compound 0.000 claims description 12
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims description 12
- KZSNJWFQEVHDMF-SCSAIBSYSA-N D-valine Chemical compound CC(C)[C@@H](N)C(O)=O KZSNJWFQEVHDMF-SCSAIBSYSA-N 0.000 claims description 12
- 102000008314 Type 1 Melanocortin Receptor Human genes 0.000 claims description 12
- 108010021428 Type 1 Melanocortin Receptor Proteins 0.000 claims description 12
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 12
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 claims description 8
- FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 claims description 8
- OUYCCCASQSFEME-MRVPVSSYSA-N D-tyrosine Chemical compound OC(=O)[C@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-MRVPVSSYSA-N 0.000 claims description 8
- 201000001441 melanoma Diseases 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 claims description 6
- 150000008575 L-amino acids Chemical class 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 5
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims description 4
- CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 claims description 4
- RHGKLRLOHDJJDR-SCSAIBSYSA-N D-citrulline Chemical compound OC(=O)[C@H](N)CCCNC(N)=O RHGKLRLOHDJJDR-SCSAIBSYSA-N 0.000 claims description 4
- 206010061218 Inflammation Diseases 0.000 claims description 4
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 4
- 230000000259 anti-tumor effect Effects 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 206010052779 Transplant rejections Diseases 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 208000032467 Aplastic anaemia Diseases 0.000 claims description 2
- QADCERNTBWTXFV-JSGCOSHPSA-N Arg-Trp Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCNC(N)=N)N)C(O)=O)=CNC2=C1 QADCERNTBWTXFV-JSGCOSHPSA-N 0.000 claims description 2
- UGJLILSJKSBVIR-ZFWWWQNUSA-N Arg-Trp-Gly Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(O)=O)=CNC2=C1 UGJLILSJKSBVIR-ZFWWWQNUSA-N 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 208000023328 Basedow disease Diseases 0.000 claims description 2
- 208000015943 Coeliac disease Diseases 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000007882 Gastritis Diseases 0.000 claims description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 2
- 208000015023 Graves' disease Diseases 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- YSPZCHGIWAQVKQ-AVGNSLFASA-N Lys-Pro-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCCN YSPZCHGIWAQVKQ-AVGNSLFASA-N 0.000 claims description 2
- PQPMMGQTRQFSDA-SRVKXCTJSA-N Met-Glu-His Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O PQPMMGQTRQFSDA-SRVKXCTJSA-N 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 2
- VVKVHAOOUGNDPJ-SRVKXCTJSA-N Ser-Tyr-Ser Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(O)=O VVKVHAOOUGNDPJ-SRVKXCTJSA-N 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 230000007815 allergy Effects 0.000 claims description 2
- 239000002246 antineoplastic agent Substances 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- 201000004982 autoimmune uveitis Diseases 0.000 claims description 2
- 210000004899 c-terminal region Anatomy 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 229940127089 cytotoxic agent Drugs 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 206010025135 lupus erythematosus Diseases 0.000 claims description 2
- 201000006417 multiple sclerosis Diseases 0.000 claims description 2
- 206010028417 myasthenia gravis Diseases 0.000 claims description 2
- 208000031225 myocardial ischemia Diseases 0.000 claims description 2
- 201000008482 osteoarthritis Diseases 0.000 claims description 2
- 239000003504 photosensitizing agent Substances 0.000 claims description 2
- 239000002534 radiation-sensitizing agent Substances 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 108010071207 serylmethionine Proteins 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
- 230000005784 autoimmunity Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5637308P | 2008-05-27 | 2008-05-27 | |
| US61/056,373 | 2008-05-27 | ||
| PCT/US2009/037809 WO2009151708A2 (en) | 2008-05-27 | 2009-03-20 | Peptide analogs of alpha-melanocyte stimulating hormone |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150428A Division JP6170019B2 (ja) | 2008-05-27 | 2014-07-24 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521949A JP2011521949A (ja) | 2011-07-28 |
| JP2011521949A5 true JP2011521949A5 (enExample) | 2013-04-18 |
| JP5624027B2 JP5624027B2 (ja) | 2014-11-12 |
Family
ID=41278142
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011511661A Expired - Fee Related JP5624027B2 (ja) | 2008-05-27 | 2009-03-20 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
| JP2014150428A Expired - Fee Related JP6170019B2 (ja) | 2008-05-27 | 2014-07-24 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
| JP2017000343A Expired - Fee Related JP6585099B2 (ja) | 2008-05-27 | 2017-01-05 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
| JP2019017752A Withdrawn JP2019065053A (ja) | 2008-05-27 | 2019-02-04 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150428A Expired - Fee Related JP6170019B2 (ja) | 2008-05-27 | 2014-07-24 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
| JP2017000343A Expired - Fee Related JP6585099B2 (ja) | 2008-05-27 | 2017-01-05 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
| JP2019017752A Withdrawn JP2019065053A (ja) | 2008-05-27 | 2019-02-04 | α−メラニン形成細胞刺激ホルモンのペプチド類似体 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8440793B2 (enExample) |
| EP (2) | EP2297178B1 (enExample) |
| JP (4) | JP5624027B2 (enExample) |
| KR (4) | KR101810110B1 (enExample) |
| CN (2) | CN107098957A (enExample) |
| AU (1) | AU2009258054B2 (enExample) |
| BR (1) | BRPI0912141A2 (enExample) |
| CA (2) | CA2726076C (enExample) |
| DK (2) | DK2297178T3 (enExample) |
| ES (2) | ES2715329T3 (enExample) |
| IL (3) | IL209369A (enExample) |
| MX (3) | MX2010012990A (enExample) |
| PT (2) | PT2816055T (enExample) |
| RU (1) | RU2496786C2 (enExample) |
| TR (1) | TR201903610T4 (enExample) |
| WO (1) | WO2009151708A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101810110B1 (ko) | 2008-05-27 | 2017-12-18 | 젠자임 코포레이션 | 알파-멜라노사이트 자극 호르몬의 펩티드 유사체 |
| CN101914138A (zh) * | 2010-07-13 | 2010-12-15 | 华东师范大学 | 一种用偶联剂制得的肝癌靶向肽-阿霉素及合成方法 |
| CN102008732B (zh) * | 2010-11-08 | 2012-10-24 | 武汉华耀生物医药有限公司 | 一种叶酸偶联抗体药物及其制备方法与应用 |
| WO2012158960A2 (en) | 2011-05-17 | 2012-11-22 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Melanocortin 1 receptor ligands and methods of use |
| MX366171B (es) | 2012-11-21 | 2019-07-01 | Univ Cincinnati | Composiciones farmaceuticas y metodos terapeuticos de uso que comprenden agonistas selectivos del receptor de melanocortina. |
| WO2015067503A1 (en) * | 2013-11-07 | 2015-05-14 | Clinuvel Ag | Alpha-msh analogues for use in the treatment of psoriasis |
| WO2016066702A1 (en) * | 2014-10-28 | 2016-05-06 | Clinuvel Ag | Inflammatory disease |
| WO2017019664A1 (en) | 2015-07-28 | 2017-02-02 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| SG10201506686WA (en) * | 2015-08-24 | 2017-03-30 | Agency Science Tech & Res | Conjugates |
| CN106905432B (zh) * | 2015-12-18 | 2018-12-21 | 兰州大学 | 一种α促黑素细胞激素的融合蛋白及其制备方法和应用 |
| EP3448872A4 (en) * | 2016-04-27 | 2019-12-11 | The Regents of the University of California | PREPARATION OF FUNCTIONAL HOMOCYSTEINRESTES IN POLYPEPTIDES AND PEPTIDES |
| US20220072092A1 (en) * | 2016-06-24 | 2022-03-10 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| AU2017281940C1 (en) | 2016-06-24 | 2024-11-07 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| US11591367B2 (en) | 2016-10-04 | 2023-02-28 | Dsm Ip Assets B.V. | Melanocortin-1-receptor agonists |
| KR101957014B1 (ko) * | 2017-04-18 | 2019-06-20 | 순천대학교 산학협력단 | 항염증 활성을 나타내는 펩타이드 및 이를 유효성분으로 포함하는 항염증용 조성물 |
| WO2021056106A1 (en) | 2019-09-23 | 2021-04-01 | Dds Research Inc. | Lipid vesicle compositions with penetration enhancing agents |
| US20230058316A1 (en) * | 2020-02-07 | 2023-02-23 | Ewha University - Industry Collaboration Foundation | Pegylated ige-dependent histamine-releasing factor (hrf)-binding peptide and use thereof |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| RU2766340C1 (ru) * | 2021-02-10 | 2022-03-15 | Игорь Закванович Зайцев | Пептидный толерогенный компаунд |
| KR20240035939A (ko) * | 2021-03-24 | 2024-03-19 | 글로 파마, 인크. | 피부 색소침착을 감소시키기 위한 펩타이드 및 방법 |
| WO2023091689A1 (en) | 2021-11-19 | 2023-05-25 | University Of Iowa Research Foundation | Combined use of mcr1-directed radiotherapy and immune checkpoint inhibition in the treatment of melanoma |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894443A (en) * | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| US4542225A (en) * | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4952394A (en) * | 1987-11-23 | 1990-08-28 | Bristol-Myers Company | Drug-monoclonal antibody conjugates |
| US5194425A (en) | 1988-06-23 | 1993-03-16 | Anergen, Inc. | Mhc-mediated toxic conjugates useful in ameliorating autoimmunity |
| US5137877B1 (en) | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
| US5618528A (en) * | 1994-02-28 | 1997-04-08 | Sterling Winthrop Inc. | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units |
| US5612474A (en) * | 1994-06-30 | 1997-03-18 | Eli Lilly And Company | Acid labile immunoconjugate intermediates |
| AU3374795A (en) | 1994-08-29 | 1996-03-22 | Prizm Pharmaceuticals, Inc. | Conjugates of vascular endothelial growth factor with targeted agents |
| US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
| US5858401A (en) * | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| ES2297862T3 (es) * | 1996-07-12 | 2008-05-01 | Immunomedics, Inc. | Analogos de peptidos que se unen a radiometales. |
| US6350430B1 (en) | 1997-10-27 | 2002-02-26 | Lion Bioscience Science Ag | Melanocortin receptor ligands and methods of using same |
| US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| US20020193332A1 (en) * | 2001-02-12 | 2002-12-19 | Hedley Mary Lynne | Methods of treating bladder disorders |
| US6969702B2 (en) * | 2002-11-20 | 2005-11-29 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| WO2005120588A2 (en) * | 2004-05-26 | 2005-12-22 | The Curators Of The University Of Missouri | Peptides delivered to cell nuclei |
| EP2236151B1 (en) * | 2005-07-08 | 2012-05-23 | Ipsen Pharma | Melanocortin receptor ligands |
| MX2008012721A (es) * | 2006-04-05 | 2009-02-20 | Unversity Of California | Composiciones y metodos para el analisis y tratamiento de sindrome de consuncion por sida y disfuncion de celulas inmunes. |
| FR2914646A1 (fr) * | 2007-04-04 | 2008-10-10 | Neorphys Soc Par Actions Simpl | Analogues peptidiques des recepteurs des melanocortines |
| US8069129B2 (en) * | 2007-04-10 | 2011-11-29 | Ab Initio Technology Llc | Editing and compiling business rules |
| CN101302245B (zh) * | 2007-05-09 | 2011-11-16 | 中国人民解放军军事医学科学院毒物药物研究所 | 黑色素皮质激素受体四肽类激动剂及其制备方法和用途 |
| KR101810110B1 (ko) | 2008-05-27 | 2017-12-18 | 젠자임 코포레이션 | 알파-멜라노사이트 자극 호르몬의 펩티드 유사체 |
-
2009
- 2009-03-20 KR KR1020167020183A patent/KR101810110B1/ko not_active Expired - Fee Related
- 2009-03-20 RU RU2010153217/04A patent/RU2496786C2/ru not_active IP Right Cessation
- 2009-03-20 CA CA2726076A patent/CA2726076C/en not_active Expired - Fee Related
- 2009-03-20 JP JP2011511661A patent/JP5624027B2/ja not_active Expired - Fee Related
- 2009-03-20 MX MX2010012990A patent/MX2010012990A/es active IP Right Grant
- 2009-03-20 KR KR1020187030624A patent/KR20180118250A/ko not_active Ceased
- 2009-03-20 US US12/408,560 patent/US8440793B2/en active Active
- 2009-03-20 TR TR2019/03610T patent/TR201903610T4/tr unknown
- 2009-03-20 DK DK09763002.4T patent/DK2297178T3/da active
- 2009-03-20 DK DK14178968.5T patent/DK2816055T3/en active
- 2009-03-20 ES ES14178968T patent/ES2715329T3/es active Active
- 2009-03-20 KR KR1020177023883A patent/KR20170102050A/ko not_active Ceased
- 2009-03-20 EP EP09763002.4A patent/EP2297178B1/en not_active Not-in-force
- 2009-03-20 MX MX2013012525A patent/MX356295B/es unknown
- 2009-03-20 ES ES09763002.4T patent/ES2492670T3/es active Active
- 2009-03-20 KR KR1020107029335A patent/KR101666631B1/ko not_active Expired - Fee Related
- 2009-03-20 PT PT14178968T patent/PT2816055T/pt unknown
- 2009-03-20 BR BRPI0912141A patent/BRPI0912141A2/pt not_active IP Right Cessation
- 2009-03-20 CA CA2998948A patent/CA2998948A1/en not_active Abandoned
- 2009-03-20 CN CN201611160601.4A patent/CN107098957A/zh active Pending
- 2009-03-20 PT PT97630024T patent/PT2297178E/pt unknown
- 2009-03-20 AU AU2009258054A patent/AU2009258054B2/en not_active Ceased
- 2009-03-20 WO PCT/US2009/037809 patent/WO2009151708A2/en not_active Ceased
- 2009-03-20 CN CN200980120892.6A patent/CN102143970B/zh not_active Expired - Fee Related
- 2009-03-20 EP EP14178968.5A patent/EP2816055B1/en not_active Not-in-force
-
2010
- 2010-11-17 IL IL209369A patent/IL209369A/en not_active IP Right Cessation
- 2010-11-26 MX MX2018006299A patent/MX2018006299A/es unknown
-
2013
- 2013-05-08 US US13/890,039 patent/US9115174B2/en active Active
-
2014
- 2014-07-24 JP JP2014150428A patent/JP6170019B2/ja not_active Expired - Fee Related
-
2015
- 2015-08-19 US US14/830,572 patent/US9738698B2/en active Active
-
2016
- 2016-05-29 IL IL245906A patent/IL245906A0/en unknown
-
2017
- 2017-01-05 JP JP2017000343A patent/JP6585099B2/ja not_active Expired - Fee Related
- 2017-05-01 IL IL252058A patent/IL252058A0/en unknown
- 2017-07-10 US US15/645,974 patent/US10385108B2/en active Active
-
2019
- 2019-02-04 JP JP2019017752A patent/JP2019065053A/ja not_active Withdrawn
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