JP2011520898A5 - - Google Patents
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- JP2011520898A5 JP2011520898A5 JP2011509636A JP2011509636A JP2011520898A5 JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5 JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5
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- amino acid
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12740308P | 2008-05-13 | 2008-05-13 | |
| US61/127,403 | 2008-05-13 | ||
| US19415608P | 2008-09-25 | 2008-09-25 | |
| US61/194,156 | 2008-09-25 | ||
| PCT/US2009/043734 WO2009140348A2 (en) | 2008-05-13 | 2009-05-13 | Anti-il-6/il-6r antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Division JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520898A JP2011520898A (ja) | 2011-07-21 |
| JP2011520898A5 true JP2011520898A5 (https=) | 2013-03-14 |
Family
ID=41319307
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509636A Pending JP2011520898A (ja) | 2008-05-13 | 2009-05-13 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8034344B2 (https=) |
| EP (1) | EP2297202B1 (https=) |
| JP (5) | JP2011520898A (https=) |
| CN (1) | CN102089326B (https=) |
| AU (1) | AU2009246430B2 (https=) |
| CA (1) | CA2724279C (https=) |
| DK (1) | DK2297202T3 (https=) |
| ES (1) | ES2564635T3 (https=) |
| IL (1) | IL209277A (https=) |
| MX (1) | MX2010012031A (https=) |
| WO (1) | WO2009140348A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006035617A1 (de) * | 2006-07-31 | 2008-02-21 | Siemens Ag | Automatische Bestimmung von Tumorlast |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| EP2174667B1 (en) * | 2007-07-26 | 2017-01-04 | Osaka University | Agent for treatment of ophthalmia containing interleukin-6 receptor inhibitor as active ingredient |
| MX2010012031A (es) | 2008-05-13 | 2011-01-20 | Novimmune Sa | Anticuerpos anti-il-6/il-6r y metodos de uso de los mismos. |
| CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
| WO2012098238A1 (en) | 2011-01-21 | 2012-07-26 | Novimmune S.A. | Combination therapies and methods using anti-cd3 modulating agents and anti-il-6 antagonists |
| MX342810B (es) * | 2011-03-03 | 2016-10-13 | Apexigen Inc | Anticuerpos del receptor anti-interleucina-6 (anti-il-6) y sus metodos de uso. |
| WO2013075027A2 (en) * | 2011-11-17 | 2013-05-23 | Emergent Product Development Seattle, Llc | Anti-sil6xr complex binding domains and methods of use |
| KR101510302B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
| US10504132B2 (en) | 2012-11-27 | 2019-12-10 | American Express Travel Related Services Company, Inc. | Dynamic rewards program |
| CA2942546C (en) | 2014-03-17 | 2022-11-22 | Mitsubishi Tanabe Pharma Corporation | Antibody-fynomer conjugates |
| CA2991637C (en) | 2015-07-31 | 2022-07-05 | Medimmune Limited | Methods for treating hepcidin-mediated disorders |
| WO2017079443A1 (en) * | 2015-11-03 | 2017-05-11 | Sanofi Biotechnology | Compositions comprising il6r antibodies for the treatment of uveitis and macular edema and methods of using same |
| KR20250011241A (ko) * | 2016-05-05 | 2025-01-21 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Il-6 및 cd126을 표적으로하는 dna 단일 클론 항체 |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| CN117045784A (zh) | 2016-12-14 | 2023-11-14 | 比奥拉治疗股份有限公司 | 使用利用可摄入装置释放的il-12/il-23抑制剂治疗胃肠道疾病 |
| GB2558223B (en) | 2016-12-22 | 2021-03-31 | Heraeus Electro Nite Int | Method for measuring a temperature of a molten metal bath |
| KR20200012823A (ko) | 2017-02-01 | 2020-02-05 | 예일 유니버시티 | 이뇨제 내성의 치료 |
| WO2018183929A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| CN111051343B (zh) | 2017-09-13 | 2022-11-22 | 江苏恒瑞医药股份有限公司 | Il-6r抗体、其抗原结合片段及医药用途 |
| EP3735421A4 (en) | 2018-01-05 | 2021-09-22 | Corvidia Therapeutics, Inc. | METHOD OF TREATMENT OF IL-6 MEDIATED INFLAMMATION WITHOUT IMMUNSUPPRESSION |
| CN112423773A (zh) * | 2018-05-15 | 2021-02-26 | 鹿特丹伊拉斯谟大学医疗中心 | 用于寨卡病毒感染预后的治疗和生物标志物 |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| US20210363233A1 (en) | 2018-06-20 | 2021-11-25 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| SG11202111742QA (en) | 2019-04-24 | 2021-11-29 | Sanofi Biotechnology | Methods of diagnosis and treatment of rheumatoid arthritis |
| CA3142710A1 (en) | 2019-06-04 | 2020-12-10 | Sanofi Biotechnology | Compositions and methods for treating pain in subjects with rheumatoid arthritis |
| CN114375205A (zh) | 2019-06-20 | 2022-04-19 | 武田药品工业株式会社 | 用基于病毒的基因疗法进行治疗的方法 |
| US20230390391A1 (en) | 2020-01-22 | 2023-12-07 | Regents Of The University Of Minnesota | Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor |
| IL296276A (en) | 2020-03-10 | 2022-11-01 | Tiziana Life Sciences Plc | Compositions of il-6/il-6r antibodies and methods of use thereof |
| WO2021207697A1 (en) | 2020-04-10 | 2021-10-14 | Cantex Pharmaceuticals, Inc. | Treatment of acute lung injury |
| IL297697A (en) * | 2020-06-17 | 2022-12-01 | Tiziana Life Sciences Plc | Preparations and methods for improving chimeric antigen receptor t cell therapies |
| US20240316008A1 (en) | 2020-06-22 | 2024-09-26 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| WO2022040604A1 (en) | 2020-08-21 | 2022-02-24 | BioAge Labs, Inc. | Use of dp1 receptor antagonists for the treatment of viral respiratory tract infections and dysregulated immune response in aged and aging patients |
| AU2021338354A1 (en) | 2020-09-02 | 2023-04-20 | Serhat GUMRUKCU | Expanded memory subsets of gamma delta T cells for immunotherapy |
| US20220332822A1 (en) * | 2021-04-16 | 2022-10-20 | Tiziana Life Sciences Plc | Subcutaneous administration of antibodies for the treatment of disease |
| JP2024530943A (ja) | 2021-08-06 | 2024-08-27 | アンスティテュ・レジオナル・デュ・カンセール・ドゥ・モンペリエ | がんの処置のための方法 |
| WO2024126805A1 (en) | 2022-12-15 | 2024-06-20 | Aarhus Universitet | Synthetic activation of multimeric transmembrane receptors |
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| US6428979B1 (en) | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| CA1341152C (en) | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
| US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| IL88375A (en) | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| ES2093017T3 (es) | 1989-07-20 | 1996-12-16 | Tadamitsu Kishimoto | Anticuerpo contra el receptor de la interleuquina-6 humana. |
| WO1991007986A1 (en) | 1989-12-04 | 1991-06-13 | Schering Corporation | Method of treating septic shock |
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JPH04325095A (ja) | 1991-04-26 | 1992-11-13 | Tosoh Corp | 抗ヒトｉｌ−６モノクロ−ナル抗体及び該抗体を使用するｉｌ−６の測定方法 |
| US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| AU7967294A (en) | 1993-10-06 | 1995-05-01 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
| DE69534075T2 (de) | 1994-06-07 | 2005-07-21 | Chugai Seiyaku K.K. | Vorbeugungs- und heilmittel für erkrankungen, die durch fibrin- oder thrombusbildung hervorgerufen werden |
| ES2384222T3 (es) * | 1994-10-07 | 2012-07-02 | Chugai Seiyaku Kabushiki Kaisha | Inhibición del crecimiento anómalo de células sinoviales utilizando un antagonista de IL-6 como principio activo |
| CN1306963C (zh) | 1994-10-21 | 2007-03-28 | 岸本忠三 | 用于治疗il－6产生所致疾病的药物组合物 |
| CA2230949C (en) * | 1995-09-28 | 2009-11-17 | Judith Chebath | Synthetic peptides that inhibit il-6 activity |
| JPH1066582A (ja) | 1996-08-27 | 1998-03-10 | Tosoh Corp | Ｉｌ−６のヘリックスｄ領域を認識する抗体の遺伝子断片等 |
| EP2322216A1 (en) | 1997-03-21 | 2011-05-18 | Chugai Seiyaku Kabushiki Kaisha | A preventive or therapeutic agent for sensitized T cell-mediated diseases comprising IL-6 antagonist as an active ingredient |
| US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| CN100374159C (zh) | 1998-03-17 | 2008-03-12 | 中外制药株式会社 | 一种包含il-6拮抗剂活性成分的炎性肠道疾病的预防或治疗剂 |
| US6261250B1 (en) | 1998-08-20 | 2001-07-17 | Rle Corporation | Method and apparatus for enhancing cardiovascular activity and health through rhythmic limb elevation |
| ES2276525T3 (es) | 1998-08-24 | 2007-06-16 | Chugai Seiyaku Kabushiki Kaisha | Preventivos o remedios para la pancreatitis que contienen anticuerpos anti-receptor il-6 como ingrediente activo. |
| US6419944B2 (en) | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| JP4325095B2 (ja) | 2000-09-08 | 2009-09-02 | 株式会社デンソー | ＳｉＣ素子の製造方法 |
| CN1259973C (zh) | 2000-10-25 | 2006-06-21 | 中外制药株式会社 | 含有il－6拮抗剂作为有效成分的牛皮癣的预防或治疗剂 |
| AU2000279624A1 (en) | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| JP4889187B2 (ja) | 2000-10-27 | 2012-03-07 | 中外製薬株式会社 | Ｉｌ−６アンタゴニストを有効成分として含有する血中ｍｍｐ−３濃度低下剤 |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| KR100899357B1 (ko) | 2001-04-27 | 2009-05-26 | 다이셀 가가꾸 고교 가부시끼가이샤 | 다환식구조를 갖는 다당유도체로 이루어지는 분리제 |
| PT2308888T (pt) | 2001-11-14 | 2017-05-03 | Janssen Biotech Inc | Anticorpos anti-il-6, composições, métodos e utilizações |
| US7482436B2 (en) | 2002-08-30 | 2009-01-27 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Human antihuman interleukin-6 antibody and fragment of antibody |
| WO2004073741A1 (ja) | 2003-02-24 | 2004-09-02 | Chugai Seiyaku Kabushiki Kaisha | インターロイキン－６アンタゴニストを含有する脊髄損傷治療剤 |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| AR045056A1 (es) | 2003-07-15 | 2005-10-12 | Amgen Inc | Anticuerpos anti-ngf humanos neutralizantes como inhibidores selectivos de la via de ngf |
| US20050100550A1 (en) | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
| AR048210A1 (es) | 2003-12-19 | 2006-04-12 | Chugai Pharmaceutical Co Ltd | Un agente preventivo para la vasculitis. |
| ATE464908T1 (de) | 2004-02-11 | 2010-05-15 | Warner Lambert Co | Verfahren zur behandlung von osteoarthritis mit anti-il-6 antikörpern |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| US20070036788A1 (en) | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| KR100595113B1 (ko) | 2005-03-07 | 2006-06-30 | 삼성에스디아이 주식회사 | 펌프 진동 및 소음 방지 구조가 구비된 연료 전지 시스템 |
| JO3058B1 (ar) | 2005-04-29 | 2017-03-15 | Applied Molecular Evolution Inc | الاجسام المضادة لمضادات -اي ال-6,تركيباتها طرقها واستعمالاتها |
| SI1960430T1 (sl) | 2005-12-09 | 2015-01-30 | Ucb Pharma, S.A. | Molekule protiteles s specifiäśnostjo za äśloveĺ ki il-6 |
| ATE550353T1 (de) * | 2005-12-30 | 2012-04-15 | Merck Patent Gmbh | Die bindung von mit il-6ralpha komplexiertem il-6 an gp130 verhindernde anti-il-6-antikörper |
| JP5307708B2 (ja) | 2006-06-02 | 2013-10-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒトｉｌ−６受容体に対する高親和性抗体 |
| JP4743037B2 (ja) | 2006-07-28 | 2011-08-10 | 株式会社デンソー | 車両検出装置 |
| CN101563365B (zh) | 2006-08-03 | 2012-10-31 | 瓦西尼斯公司 | 抗-il-6单克隆抗体及其用途 |
| HUE048024T2 (hu) | 2006-08-10 | 2020-05-28 | Roy C Levitt | Anakinra bronchiolitis obliterans szindróma kezelésében való alkalmazásra |
| ES2433380T3 (es) | 2006-11-30 | 2013-12-10 | Medimmune Limited | Anticuerpos específicos para el complejo de interleucina 6 y el receptor de interleucina 6 |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| WO2008071685A1 (en) | 2006-12-13 | 2008-06-19 | Ablynx N.V. | Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex |
| TWI363414B (en) | 2007-01-29 | 2012-05-01 | Touch Micro System Tech | Interposer for connecting a plurality of chips and method for manufacturing the same |
| MX2010012031A (es) | 2008-05-13 | 2011-01-20 | Novimmune Sa | Anticuerpos anti-il-6/il-6r y metodos de uso de los mismos. |
-
2009
- 2009-05-13 MX MX2010012031A patent/MX2010012031A/es active IP Right Grant
- 2009-05-13 EP EP09747432.4A patent/EP2297202B1/en active Active
- 2009-05-13 WO PCT/US2009/043734 patent/WO2009140348A2/en not_active Ceased
- 2009-05-13 CA CA2724279A patent/CA2724279C/en active Active
- 2009-05-13 JP JP2011509636A patent/JP2011520898A/ja active Pending
- 2009-05-13 ES ES09747432.4T patent/ES2564635T3/es active Active
- 2009-05-13 CN CN200980127494.7A patent/CN102089326B/zh active Active
- 2009-05-13 AU AU2009246430A patent/AU2009246430B2/en active Active
- 2009-05-13 US US12/465,295 patent/US8034344B2/en active Active
- 2009-05-13 DK DK09747432.4T patent/DK2297202T3/en active
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2010
- 2010-11-11 IL IL209277A patent/IL209277A/en active IP Right Grant
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2011
- 2011-09-07 US US13/227,157 patent/US8337849B2/en active Active
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2012
- 2012-12-21 US US13/723,694 patent/US9234034B2/en active Active
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2015
- 2015-03-25 JP JP2015062036A patent/JP6195586B2/ja active Active
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2016
- 2016-01-12 US US14/993,153 patent/US9828430B2/en active Active
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2017
- 2017-05-01 JP JP2017091252A patent/JP2017128613A/ja not_active Withdrawn
- 2017-11-27 US US15/823,086 patent/US10759862B2/en active Active
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2020
- 2020-06-08 JP JP2020099264A patent/JP6923709B2/ja active Active
- 2020-07-31 US US16/944,828 patent/US11613582B2/en active Active
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2021
- 2021-07-29 JP JP2021124411A patent/JP7297823B2/ja active Active
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