JP2011506422A5 - - Google Patents
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- JP2011506422A5 JP2011506422A5 JP2010537542A JP2010537542A JP2011506422A5 JP 2011506422 A5 JP2011506422 A5 JP 2011506422A5 JP 2010537542 A JP2010537542 A JP 2010537542A JP 2010537542 A JP2010537542 A JP 2010537542A JP 2011506422 A5 JP2011506422 A5 JP 2011506422A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- variable region
- chain variable
- autoimmune
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1232907P | 2007-12-07 | 2007-12-07 | |
| US61/012,329 | 2007-12-07 | ||
| PCT/IB2008/005011 WO2010055366A2 (en) | 2007-12-07 | 2008-12-08 | Anti-human il-21 monoclonal antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014036592A Division JP5848384B2 (ja) | 2007-12-07 | 2014-02-27 | 抗ヒトil−21モノクローナル抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506422A JP2011506422A (ja) | 2011-03-03 |
| JP2011506422A5 true JP2011506422A5 (https=) | 2011-12-01 |
| JP5745274B2 JP5745274B2 (ja) | 2015-07-08 |
Family
ID=40899470
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537542A Active JP5745274B2 (ja) | 2007-12-07 | 2008-12-08 | 抗ヒトil−21モノクローナル抗体 |
| JP2014036592A Active JP5848384B2 (ja) | 2007-12-07 | 2014-02-27 | 抗ヒトil−21モノクローナル抗体 |
| JP2015230496A Active JP6027668B2 (ja) | 2007-12-07 | 2015-11-26 | 抗ヒトil−21モノクローナル抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014036592A Active JP5848384B2 (ja) | 2007-12-07 | 2014-02-27 | 抗ヒトil−21モノクローナル抗体 |
| JP2015230496A Active JP6027668B2 (ja) | 2007-12-07 | 2015-11-26 | 抗ヒトil−21モノクローナル抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US7883700B2 (https=) |
| EP (3) | EP2217268B1 (https=) |
| JP (3) | JP5745274B2 (https=) |
| KR (2) | KR101615215B1 (https=) |
| CN (2) | CN102027011B (https=) |
| AU (1) | AU2008364115B2 (https=) |
| BR (1) | BRPI0821168B8 (https=) |
| CA (2) | CA2707026C (https=) |
| DK (1) | DK2217268T3 (https=) |
| ES (2) | ES2584237T3 (https=) |
| HU (1) | HUE027828T2 (https=) |
| IL (2) | IL205976A (https=) |
| MX (1) | MX2010006181A (https=) |
| PL (1) | PL2217268T3 (https=) |
| PT (1) | PT2217268T (https=) |
| RU (1) | RU2504552C2 (https=) |
| WO (1) | WO2010055366A2 (https=) |
| ZA (1) | ZA201004046B (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007111714A2 (en) | 2005-11-28 | 2007-10-04 | Zymogenetics, Inc. | Il-21 antagonists |
| US7883700B2 (en) | 2007-12-07 | 2011-02-08 | Zymogenetics, Inc. | Anti-human IL-21 monoclonal antibodies |
| WO2012012531A2 (en) * | 2010-07-20 | 2012-01-26 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods featuring il-6 and il-21 antagonists |
| WO2012098113A1 (en) | 2011-01-17 | 2012-07-26 | Novo Nordisk A/S | Il-21 ligands |
| CN103702721A (zh) * | 2011-05-31 | 2014-04-02 | 诺沃—诺迪斯克有限公司 | Il-21表位和il-21配体 |
| ME03073B (me) * | 2011-10-19 | 2019-01-20 | Galapagos Nv | Ant agonisti il17с za lečenje zapaljenskih poremećaja |
| US20140178396A1 (en) | 2012-12-21 | 2014-06-26 | Novo Nordisk A/S | Treatment of cardiovascular diseases |
| EP2746292A1 (en) | 2012-12-21 | 2014-06-25 | Novo Nordisk A/S | Anti-IL21 antibodies for use in the treatment of nephropathies |
| US10077301B2 (en) * | 2013-06-27 | 2018-09-18 | Monash University | IL-21 binding proteins |
| CN103487572B (zh) * | 2013-10-08 | 2017-03-29 | 北京大学人民医院 | 滤泡辅助性T淋巴细胞(Tfh)在自身免疫性疾病病情预警中的应用 |
| CN104721820A (zh) * | 2013-12-24 | 2015-06-24 | 信达生物制药(苏州)有限公司 | 双特异性单克隆抗体在治疗葡萄膜炎中的用途 |
| WO2015132241A1 (en) * | 2014-03-03 | 2015-09-11 | Novo Nordisk A/S | Treatment of inflammatory diseases |
| AR099625A1 (es) * | 2014-03-21 | 2016-08-03 | Lilly Co Eli | Anticuerpos de il-21 |
| AU2015244025B2 (en) * | 2014-04-08 | 2019-03-21 | Boston Pharmaceuticals Inc. | Binding molecules specific for IL-21 and uses thereof |
| WO2015169789A1 (en) * | 2014-05-07 | 2015-11-12 | Novo Nordisk A/S | Treatment of diabetes type 1 using glp-1 and anti-il-21 |
| DK3139948T3 (da) * | 2014-05-07 | 2020-05-25 | Novo Nordisk As | Behandling af type 1 diabetes under anvendelse af glp-1 og anti-il-21 |
| RU2609627C2 (ru) * | 2014-09-26 | 2017-02-02 | Закрытое Акционерное Общество "Биокад" | Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh |
| WO2016094962A1 (en) | 2014-12-19 | 2016-06-23 | Monash University | Il-21 antibodies |
| US10662240B2 (en) | 2014-12-19 | 2020-05-26 | Mabtech Ab | Composition, kit and method for inhibition of IL-21 mediated activation of human cells |
| CA3018792C (en) | 2016-03-31 | 2023-03-28 | Eli Lilly And Company | Il-21 antibodies and uses thereof |
| US20190185559A1 (en) * | 2016-09-02 | 2019-06-20 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating neoplasias |
| JP6952295B2 (ja) * | 2016-09-09 | 2021-10-20 | 国立大学法人金沢大学 | ヒト抗hlaモノクローナル抗体の作製方法 |
| EP4029877B1 (en) | 2017-08-03 | 2024-01-17 | Amgen Inc. | Interleukin-21 muteins and methods of treatment |
| TW201930344A (zh) | 2018-01-12 | 2019-08-01 | 美商安進公司 | 抗pd-1抗體及治療方法 |
| CN115666704B (zh) | 2019-12-13 | 2025-09-26 | 比特比德科有限责任公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
| CN116322740A (zh) * | 2020-07-13 | 2023-06-23 | 特兰斯吉恩股份有限公司 | 免疫抑制的治疗 |
| CN118370816A (zh) * | 2024-03-22 | 2024-07-23 | 中日友好医院(中日友好临床医学研究所) | Il-2/抗il-2抗体免疫复合物的应用 |
| WO2025257327A1 (en) | 2024-06-13 | 2025-12-18 | Almirall, S.A. | Therapeutic approaches for the management of hidradenitis suppurativa |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331647A (en) | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| EP0216846B2 (en) | 1985-04-01 | 1995-04-26 | Celltech Limited | Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7198789B2 (en) | 1998-03-17 | 2007-04-03 | Genetics Institute, Llc | Methods and compositions for modulating interleukin-21 receptor activity |
| US6057128A (en) | 1998-03-17 | 2000-05-02 | Genetics Institute, Inc. | MU-1, member of the cytokine receptor family |
| US20010023070A1 (en) * | 1998-05-29 | 2001-09-20 | Reinhard Ebner | Interleukins-21 and 22 |
| US6682736B1 (en) * | 1998-12-23 | 2004-01-27 | Abgenix, Inc. | Human monoclonal antibodies to CTLA-4 |
| KR100743640B1 (ko) | 1999-03-09 | 2007-07-27 | 지모제넥틱스, 인코포레이티드 | 신규한 사이토킨 zalpha 11 리간드 |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| ES2279809T3 (es) | 2000-04-05 | 2007-09-01 | Zymogenetics, Inc. | Receptores de citoquina zalfa11 solubles. |
| DE60135393D1 (de) | 2000-06-30 | 2008-09-25 | Zymogenetics Inc | Allelische Variante des Interferon-ähnlichen Proteins Zcyto21 |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| US7083784B2 (en) | 2000-12-12 | 2006-08-01 | Medimmune, Inc. | Molecules with extended half-lives, compositions and uses thereof |
| BRPI0209933B8 (pt) | 2001-05-24 | 2021-05-25 | Zymogenetics Inc | proteína de fusão, e, molécula de ácido nucleico |
| ES2334338T3 (es) | 2001-11-05 | 2010-03-09 | Zymogenetics, Inc. | Antagonistas de il-21. |
| US20040028665A1 (en) | 2002-01-08 | 2004-02-12 | Garner Bryan E. | Compositions and methods for inhibiting pathogenic growth |
| WO2003087320A2 (en) | 2002-04-09 | 2003-10-23 | Beth Israel Deaconess Medical Center, Inc. | Antagonists of il-21 and modulation of il-21-mediated t cell responses |
| US20040016010A1 (en) | 2002-04-17 | 2004-01-22 | Marion Kasaian | IL-21 receptor knockout animal and methods of use thereof |
| DK1531850T3 (da) | 2002-06-07 | 2012-06-04 | Zymogenetics Inc | Anvendelse af 1L-21 og monoklonalt antistof til behandling af solide cancere |
| US7314623B2 (en) | 2002-07-15 | 2008-01-01 | Wyeth | Methods and compositions for modulating T helper (Th) cell development and function |
| CN101972478B (zh) | 2002-10-08 | 2012-10-31 | 免疫医疗公司 | 抗体治疗 |
| US20070092485A1 (en) * | 2002-11-15 | 2007-04-26 | Zymogenetics, Inc. | Cytokine zalpha11 ligand |
| EP1573006B1 (en) | 2002-12-13 | 2009-11-11 | ZymoGenetics, Inc. | Il-21 production in prokaryotic hosts |
| EP1575615A1 (en) | 2002-12-23 | 2005-09-21 | Innate Pharma | Pharmaceutical compositions having an effect on the proliferation of nk cells and a method using the same |
| NZ542306A (en) * | 2003-03-14 | 2008-04-30 | Wyeth Corp | Antibodies against human IL-21 receptor and uses therefor |
| CA2518854A1 (en) * | 2003-03-21 | 2004-10-07 | Wyeth | Treating immunological disorder using agonists of interleukin-21/interleukin-21 receptor |
| JP2007508332A (ja) | 2003-10-17 | 2007-04-05 | ノボ ノルディスク アクティーゼルスカブ | 併用療法 |
| JP4471721B2 (ja) | 2004-04-20 | 2010-06-02 | 独立行政法人産業技術総合研究所 | 抗インターロイキン21受容体(il−21r)抗体および本抗体を産生するハイブリドーマ |
| EP1753458A4 (en) | 2004-05-19 | 2009-07-22 | Wyeth Corp | MODULATION OF IMMUNOGLOBULIN PRODUCTION AND ATOPIC DISORDERS |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| RU2007102287A (ru) | 2004-08-05 | 2008-09-10 | Вайет (Us) | Антагонисты активности рецептора интерлейкина-21 |
| KR100654124B1 (ko) | 2004-11-18 | 2006-12-08 | 주식회사 하이닉스반도체 | 벙커 디펙트를 억제할 수 있는 반도체 소자 제조 방법 |
| ITRM20040586A1 (it) * | 2004-11-29 | 2005-02-28 | Giuliani Spa | Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico. |
| WO2006105538A2 (en) * | 2005-03-31 | 2006-10-05 | Centocor, Inc. | Methods and compositions for treating il-21 related pathologies |
| DK200501310A (da) * | 2005-09-21 | 2005-10-01 | Novo Nordisk As | The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults |
| WO2007114861A2 (en) * | 2005-11-28 | 2007-10-11 | Zymogenetics, Inc. | Il-21 receptor antagonists |
| WO2007111714A2 (en) * | 2005-11-28 | 2007-10-04 | Zymogenetics, Inc. | Il-21 antagonists |
| US7883700B2 (en) | 2007-12-07 | 2011-02-08 | Zymogenetics, Inc. | Anti-human IL-21 monoclonal antibodies |
-
2008
- 2008-12-08 US US12/330,334 patent/US7883700B2/en active Active
- 2008-12-08 HU HUE08878088A patent/HUE027828T2/en unknown
- 2008-12-08 JP JP2010537542A patent/JP5745274B2/ja active Active
- 2008-12-08 ES ES08878088.7T patent/ES2584237T3/es active Active
- 2008-12-08 AU AU2008364115A patent/AU2008364115B2/en active Active
- 2008-12-08 PL PL08878088.7T patent/PL2217268T3/pl unknown
- 2008-12-08 CN CN200880126330.8A patent/CN102027011B/zh active Active
- 2008-12-08 EP EP08878088.7A patent/EP2217268B1/en active Active
- 2008-12-08 CA CA2707026A patent/CA2707026C/en active Active
- 2008-12-08 EP EP16161751.9A patent/EP3103813A1/en not_active Withdrawn
- 2008-12-08 DK DK08878088.7T patent/DK2217268T3/en active
- 2008-12-08 EP EP11185989.8A patent/EP2426146B1/en active Active
- 2008-12-08 BR BRPI0821168A patent/BRPI0821168B8/pt active IP Right Grant
- 2008-12-08 ES ES11185989T patent/ES2572231T3/es active Active
- 2008-12-08 MX MX2010006181A patent/MX2010006181A/es active IP Right Grant
- 2008-12-08 PT PT88780887T patent/PT2217268T/pt unknown
- 2008-12-08 KR KR1020167002415A patent/KR101615215B1/ko active Active
- 2008-12-08 CA CA2910933A patent/CA2910933C/en active Active
- 2008-12-08 CN CN201310148259.6A patent/CN103772502B/zh active Active
- 2008-12-08 KR KR1020107014852A patent/KR101591316B1/ko active Active
- 2008-12-08 WO PCT/IB2008/005011 patent/WO2010055366A2/en not_active Ceased
- 2008-12-08 RU RU2010123049/10A patent/RU2504552C2/ru active
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2009
- 2009-06-11 US US12/483,098 patent/US8124089B2/en active Active
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2010
- 2010-05-26 IL IL205976A patent/IL205976A/en active IP Right Grant
- 2010-06-07 ZA ZA2010/04046A patent/ZA201004046B/en unknown
- 2010-12-17 US US12/971,495 patent/US8241629B2/en active Active
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2012
- 2012-01-11 US US13/348,366 patent/US8226948B1/en active Active
- 2012-05-17 US US13/474,001 patent/US8361470B2/en active Active
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2014
- 2014-02-27 JP JP2014036592A patent/JP5848384B2/ja active Active
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2015
- 2015-07-15 IL IL239947A patent/IL239947A/en active IP Right Grant
- 2015-11-26 JP JP2015230496A patent/JP6027668B2/ja active Active
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