JP2011506422A5 - - Google Patents

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Publication number
JP2011506422A5
JP2011506422A5 JP2010537542A JP2010537542A JP2011506422A5 JP 2011506422 A5 JP2011506422 A5 JP 2011506422A5 JP 2010537542 A JP2010537542 A JP 2010537542A JP 2010537542 A JP2010537542 A JP 2010537542A JP 2011506422 A5 JP2011506422 A5 JP 2011506422A5
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JP
Japan
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seq
antibody
variable region
chain variable
autoimmune
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JP2010537542A
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English (en)
Japanese (ja)
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JP5745274B2 (ja
JP2011506422A (ja
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Priority claimed from PCT/IB2008/005011 external-priority patent/WO2010055366A2/en
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Publication of JP2011506422A5 publication Critical patent/JP2011506422A5/ja
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JP2010537542A 2007-12-07 2008-12-08 抗ヒトil−21モノクローナル抗体 Active JP5745274B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1232907P 2007-12-07 2007-12-07
US61/012,329 2007-12-07
PCT/IB2008/005011 WO2010055366A2 (en) 2007-12-07 2008-12-08 Anti-human il-21 monoclonal antibodies

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014036592A Division JP5848384B2 (ja) 2007-12-07 2014-02-27 抗ヒトil−21モノクローナル抗体

Publications (3)

Publication Number Publication Date
JP2011506422A JP2011506422A (ja) 2011-03-03
JP2011506422A5 true JP2011506422A5 (https=) 2011-12-01
JP5745274B2 JP5745274B2 (ja) 2015-07-08

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ID=40899470

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2010537542A Active JP5745274B2 (ja) 2007-12-07 2008-12-08 抗ヒトil−21モノクローナル抗体
JP2014036592A Active JP5848384B2 (ja) 2007-12-07 2014-02-27 抗ヒトil−21モノクローナル抗体
JP2015230496A Active JP6027668B2 (ja) 2007-12-07 2015-11-26 抗ヒトil−21モノクローナル抗体

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014036592A Active JP5848384B2 (ja) 2007-12-07 2014-02-27 抗ヒトil−21モノクローナル抗体
JP2015230496A Active JP6027668B2 (ja) 2007-12-07 2015-11-26 抗ヒトil−21モノクローナル抗体

Country Status (18)

Country Link
US (5) US7883700B2 (https=)
EP (3) EP2217268B1 (https=)
JP (3) JP5745274B2 (https=)
KR (2) KR101615215B1 (https=)
CN (2) CN102027011B (https=)
AU (1) AU2008364115B2 (https=)
BR (1) BRPI0821168B8 (https=)
CA (2) CA2707026C (https=)
DK (1) DK2217268T3 (https=)
ES (2) ES2584237T3 (https=)
HU (1) HUE027828T2 (https=)
IL (2) IL205976A (https=)
MX (1) MX2010006181A (https=)
PL (1) PL2217268T3 (https=)
PT (1) PT2217268T (https=)
RU (1) RU2504552C2 (https=)
WO (1) WO2010055366A2 (https=)
ZA (1) ZA201004046B (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007111714A2 (en) 2005-11-28 2007-10-04 Zymogenetics, Inc. Il-21 antagonists
US7883700B2 (en) 2007-12-07 2011-02-08 Zymogenetics, Inc. Anti-human IL-21 monoclonal antibodies
WO2012012531A2 (en) * 2010-07-20 2012-01-26 Beth Israel Deaconess Medical Center, Inc. Compositions and methods featuring il-6 and il-21 antagonists
WO2012098113A1 (en) 2011-01-17 2012-07-26 Novo Nordisk A/S Il-21 ligands
CN103702721A (zh) * 2011-05-31 2014-04-02 诺沃—诺迪斯克有限公司 Il-21表位和il-21配体
ME03073B (me) * 2011-10-19 2019-01-20 Galapagos Nv Ant agonisti il17с za lečenje zapaljenskih poremećaja
US20140178396A1 (en) 2012-12-21 2014-06-26 Novo Nordisk A/S Treatment of cardiovascular diseases
EP2746292A1 (en) 2012-12-21 2014-06-25 Novo Nordisk A/S Anti-IL21 antibodies for use in the treatment of nephropathies
US10077301B2 (en) * 2013-06-27 2018-09-18 Monash University IL-21 binding proteins
CN103487572B (zh) * 2013-10-08 2017-03-29 北京大学人民医院 滤泡辅助性T淋巴细胞(Tfh)在自身免疫性疾病病情预警中的应用
CN104721820A (zh) * 2013-12-24 2015-06-24 信达生物制药(苏州)有限公司 双特异性单克隆抗体在治疗葡萄膜炎中的用途
WO2015132241A1 (en) * 2014-03-03 2015-09-11 Novo Nordisk A/S Treatment of inflammatory diseases
AR099625A1 (es) * 2014-03-21 2016-08-03 Lilly Co Eli Anticuerpos de il-21
AU2015244025B2 (en) * 2014-04-08 2019-03-21 Boston Pharmaceuticals Inc. Binding molecules specific for IL-21 and uses thereof
WO2015169789A1 (en) * 2014-05-07 2015-11-12 Novo Nordisk A/S Treatment of diabetes type 1 using glp-1 and anti-il-21
DK3139948T3 (da) * 2014-05-07 2020-05-25 Novo Nordisk As Behandling af type 1 diabetes under anvendelse af glp-1 og anti-il-21
RU2609627C2 (ru) * 2014-09-26 2017-02-02 Закрытое Акционерное Общество "Биокад" Высокоаффинные и агрегационно стабильные антитела на основе вариабельных доменов vl и производного vhh
WO2016094962A1 (en) 2014-12-19 2016-06-23 Monash University Il-21 antibodies
US10662240B2 (en) 2014-12-19 2020-05-26 Mabtech Ab Composition, kit and method for inhibition of IL-21 mediated activation of human cells
CA3018792C (en) 2016-03-31 2023-03-28 Eli Lilly And Company Il-21 antibodies and uses thereof
US20190185559A1 (en) * 2016-09-02 2019-06-20 The Brigham And Women's Hospital, Inc. Compositions and methods for treating neoplasias
JP6952295B2 (ja) * 2016-09-09 2021-10-20 国立大学法人金沢大学 ヒト抗hlaモノクローナル抗体の作製方法
EP4029877B1 (en) 2017-08-03 2024-01-17 Amgen Inc. Interleukin-21 muteins and methods of treatment
TW201930344A (zh) 2018-01-12 2019-08-01 美商安進公司 抗pd-1抗體及治療方法
CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
CN116322740A (zh) * 2020-07-13 2023-06-23 特兰斯吉恩股份有限公司 免疫抑制的治疗
CN118370816A (zh) * 2024-03-22 2024-07-23 中日友好医院(中日友好临床医学研究所) Il-2/抗il-2抗体免疫复合物的应用
WO2025257327A1 (en) 2024-06-13 2025-12-18 Almirall, S.A. Therapeutic approaches for the management of hidradenitis suppurativa

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
EP0216846B2 (en) 1985-04-01 1995-04-26 Celltech Limited Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US20010023070A1 (en) * 1998-05-29 2001-09-20 Reinhard Ebner Interleukins-21 and 22
US6682736B1 (en) * 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
KR100743640B1 (ko) 1999-03-09 2007-07-27 지모제넥틱스, 인코포레이티드 신규한 사이토킨 zalpha 11 리간드
US6307024B1 (en) * 1999-03-09 2001-10-23 Zymogenetics, Inc. Cytokine zalpha11 Ligand
ES2279809T3 (es) 2000-04-05 2007-09-01 Zymogenetics, Inc. Receptores de citoquina zalfa11 solubles.
DE60135393D1 (de) 2000-06-30 2008-09-25 Zymogenetics Inc Allelische Variante des Interferon-ähnlichen Proteins Zcyto21
EP1332209B1 (en) 2000-09-08 2009-11-11 Universität Zürich Collections of repeat proteins comprising repeat modules
US7083784B2 (en) 2000-12-12 2006-08-01 Medimmune, Inc. Molecules with extended half-lives, compositions and uses thereof
BRPI0209933B8 (pt) 2001-05-24 2021-05-25 Zymogenetics Inc proteína de fusão, e, molécula de ácido nucleico
ES2334338T3 (es) 2001-11-05 2010-03-09 Zymogenetics, Inc. Antagonistas de il-21.
US20040028665A1 (en) 2002-01-08 2004-02-12 Garner Bryan E. Compositions and methods for inhibiting pathogenic growth
WO2003087320A2 (en) 2002-04-09 2003-10-23 Beth Israel Deaconess Medical Center, Inc. Antagonists of il-21 and modulation of il-21-mediated t cell responses
US20040016010A1 (en) 2002-04-17 2004-01-22 Marion Kasaian IL-21 receptor knockout animal and methods of use thereof
DK1531850T3 (da) 2002-06-07 2012-06-04 Zymogenetics Inc Anvendelse af 1L-21 og monoklonalt antistof til behandling af solide cancere
US7314623B2 (en) 2002-07-15 2008-01-01 Wyeth Methods and compositions for modulating T helper (Th) cell development and function
CN101972478B (zh) 2002-10-08 2012-10-31 免疫医疗公司 抗体治疗
US20070092485A1 (en) * 2002-11-15 2007-04-26 Zymogenetics, Inc. Cytokine zalpha11 ligand
EP1573006B1 (en) 2002-12-13 2009-11-11 ZymoGenetics, Inc. Il-21 production in prokaryotic hosts
EP1575615A1 (en) 2002-12-23 2005-09-21 Innate Pharma Pharmaceutical compositions having an effect on the proliferation of nk cells and a method using the same
NZ542306A (en) * 2003-03-14 2008-04-30 Wyeth Corp Antibodies against human IL-21 receptor and uses therefor
CA2518854A1 (en) * 2003-03-21 2004-10-07 Wyeth Treating immunological disorder using agonists of interleukin-21/interleukin-21 receptor
JP2007508332A (ja) 2003-10-17 2007-04-05 ノボ ノルディスク アクティーゼルスカブ 併用療法
JP4471721B2 (ja) 2004-04-20 2010-06-02 独立行政法人産業技術総合研究所 抗インターロイキン21受容体(il−21r)抗体および本抗体を産生するハイブリドーマ
EP1753458A4 (en) 2004-05-19 2009-07-22 Wyeth Corp MODULATION OF IMMUNOGLOBULIN PRODUCTION AND ATOPIC DISORDERS
US20060008844A1 (en) 2004-06-17 2006-01-12 Avidia Research Institute c-Met kinase binding proteins
RU2007102287A (ru) 2004-08-05 2008-09-10 Вайет (Us) Антагонисты активности рецептора интерлейкина-21
KR100654124B1 (ko) 2004-11-18 2006-12-08 주식회사 하이닉스반도체 벙커 디펙트를 억제할 수 있는 반도체 소자 제조 방법
ITRM20040586A1 (it) * 2004-11-29 2005-02-28 Giuliani Spa Epitopi antigenici dell'interleuchina-21, anticorpi relativi e loro uso in campo medico.
WO2006105538A2 (en) * 2005-03-31 2006-10-05 Centocor, Inc. Methods and compositions for treating il-21 related pathologies
DK200501310A (da) * 2005-09-21 2005-10-01 Novo Nordisk As The invention relates to the treatment or prevention of autoimmune diseases and latent autoimmune diabetes in the adults
WO2007114861A2 (en) * 2005-11-28 2007-10-11 Zymogenetics, Inc. Il-21 receptor antagonists
WO2007111714A2 (en) * 2005-11-28 2007-10-04 Zymogenetics, Inc. Il-21 antagonists
US7883700B2 (en) 2007-12-07 2011-02-08 Zymogenetics, Inc. Anti-human IL-21 monoclonal antibodies

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