JP2013509158A5 - - Google Patents
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- Publication number
- JP2013509158A5 JP2013509158A5 JP2012520621A JP2012520621A JP2013509158A5 JP 2013509158 A5 JP2013509158 A5 JP 2013509158A5 JP 2012520621 A JP2012520621 A JP 2012520621A JP 2012520621 A JP2012520621 A JP 2012520621A JP 2013509158 A5 JP2013509158 A5 JP 2013509158A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fractalkine
- binding fragment
- seq
- host cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 35
- 108010078239 Chemokine CX3CL1 Proteins 0.000 claims 34
- 102000013818 Fractalkine Human genes 0.000 claims 34
- 210000004027 cell Anatomy 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 8
- 208000027866 inflammatory disease Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 206010009900 Colitis ulcerative Diseases 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 108090000835 CX3C Chemokine Receptor 1 Proteins 0.000 claims 1
- 102100039196 CX3C chemokine receptor 1 Human genes 0.000 claims 1
- 102100020997 Fractalkine Human genes 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000024203 complement activation Effects 0.000 claims 1
- 230000007423 decrease Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25652109P | 2009-10-30 | 2009-10-30 | |
| US61/256,521 | 2009-10-30 | ||
| PCT/JP2010/069653 WO2011052799A1 (en) | 2009-10-30 | 2010-10-28 | Compositions and methods for treating inflammatory disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014189668A Division JP2015027304A (ja) | 2009-10-30 | 2014-09-18 | 炎症性疾患を処置するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013509158A JP2013509158A (ja) | 2013-03-14 |
| JP2013509158A5 true JP2013509158A5 (https=) | 2014-09-25 |
| JP5631991B2 JP5631991B2 (ja) | 2014-11-26 |
Family
ID=43922220
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012520621A Active JP5631991B2 (ja) | 2009-10-30 | 2010-10-28 | 炎症性疾患を処置するための組成物および方法 |
| JP2014189668A Abandoned JP2015027304A (ja) | 2009-10-30 | 2014-09-18 | 炎症性疾患を処置するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014189668A Abandoned JP2015027304A (ja) | 2009-10-30 | 2014-09-18 | 炎症性疾患を処置するための組成物および方法 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8932592B2 (https=) |
| EP (1) | EP2493930B1 (https=) |
| JP (2) | JP5631991B2 (https=) |
| KR (2) | KR102099596B1 (https=) |
| CN (1) | CN102597003B (https=) |
| AR (2) | AR078796A1 (https=) |
| AU (1) | AU2010312408B2 (https=) |
| BR (1) | BR112012010266A2 (https=) |
| CA (1) | CA2778895C (https=) |
| CL (2) | CL2012001143A1 (https=) |
| CY (1) | CY1121167T1 (https=) |
| DK (1) | DK2493930T3 (https=) |
| ES (1) | ES2698389T3 (https=) |
| HR (1) | HRP20181973T1 (https=) |
| HU (1) | HUE041952T2 (https=) |
| IL (1) | IL219470A (https=) |
| JO (1) | JO3437B1 (https=) |
| LT (1) | LT2493930T (https=) |
| MX (1) | MX2012005052A (https=) |
| MY (1) | MY158481A (https=) |
| NZ (1) | NZ599779A (https=) |
| PE (1) | PE20121645A1 (https=) |
| PH (1) | PH12012500828A1 (https=) |
| PL (1) | PL2493930T3 (https=) |
| PT (1) | PT2493930T (https=) |
| RS (1) | RS58142B1 (https=) |
| RU (1) | RU2569109C2 (https=) |
| SI (1) | SI2493930T1 (https=) |
| SM (1) | SMT201800637T1 (https=) |
| TW (1) | TWI414308B (https=) |
| UA (1) | UA105073C2 (https=) |
| WO (1) | WO2011052799A1 (https=) |
| ZA (1) | ZA201203002B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9415118B2 (en) * | 2013-03-13 | 2016-08-16 | Novartis Ag | Antibody drug conjugates |
| MY189836A (en) | 2014-11-21 | 2022-03-11 | Bristol Myers Squibb Co | Antibodies against cd73 and uses thereof |
| JP6668345B2 (ja) | 2014-11-21 | 2020-03-18 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 修飾された重鎖定常領域を含む抗体 |
| EP3159007A1 (en) | 2015-10-19 | 2017-04-26 | Eisai R&D Management Co., Ltd. | Pharmaceutical composition for treating rheumatoid arthritis |
| JP2017154975A (ja) * | 2016-02-29 | 2017-09-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | クローン病を治療するための医薬組成物 |
| JP2018070473A (ja) * | 2016-10-26 | 2018-05-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 関節リウマチを治療するための医薬組成物 |
| JP2018177701A (ja) * | 2017-04-14 | 2018-11-15 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | クローン病を治療するための医薬組成物 |
| US20220196674A1 (en) * | 2019-04-17 | 2022-06-23 | Abdolamir Landi | Treatment of autoimmune liver disease |
| US20220205980A1 (en) * | 2019-04-23 | 2022-06-30 | Eisai R&D Management Co., Ltd. | Biomarker for rheumatoid arthritis treatment |
| KR20220110827A (ko) * | 2019-12-09 | 2022-08-09 | 알렉시온 파마슈티칼스, 인코포레이티드 | 시신경척수염 스펙트럼 장애의 치료를 위한 항-c5 항체 |
| CN113087795B (zh) * | 2019-12-23 | 2025-06-10 | 上海普铭生物科技有限公司 | 针对趋化因子cx3cl1的抗体及其应用 |
| WO2022092183A1 (ja) | 2020-10-30 | 2022-05-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
| CN121537534B (zh) * | 2026-01-22 | 2026-04-07 | 华中科技大学同济医学院附属协和医院 | 靶向cx3cl1的嵌合抗原受体-巨噬细胞及在gjb2突变相关遗传性耳聋治疗中的应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
| US6180377B1 (en) | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
| AU691811B2 (en) * | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
| US6114507A (en) | 1995-06-30 | 2000-09-05 | Mochida Pharmaceutical Co., Ltd. | Anti-Fas ligand antibody and assay method using the anti-Fas ligand antibody |
| US6096312A (en) | 1995-06-30 | 2000-08-01 | Mochida Pharmaceutical Co., Ltd. | Agent for suppressing a reduction of CD4+ lymphocytes |
| CA2225852C (en) * | 1995-06-30 | 2009-04-14 | Mochida Pharmaceutical Co., Ltd. | Anti-fas ligand antibody and assay method using the anti-fas ligand antibody |
| US6566503B2 (en) | 1996-01-24 | 2003-05-20 | Schering Corporation | Mammalian CX3C chemokine |
| EP0876487B1 (en) | 1996-01-24 | 2008-03-12 | Schering Corporation | Mammalian cx3c chemokine genes |
| US6548654B1 (en) | 1996-01-24 | 2003-04-15 | Schering Corporation | DNA encoding mammalian CX3C chemokine genes |
| US7115379B1 (en) | 1996-01-24 | 2006-10-03 | Schering Corporation | Anti-mammalian CX3C cytokine antibodies |
| US6043086A (en) * | 1996-05-07 | 2000-03-28 | Millenium Biotherapeutics, Inc. | Neurotactin and uses therefor |
| EP0966484A4 (en) | 1996-05-07 | 2002-04-17 | Millennium Pharm Inc | NEUROTACTIN AND APPLICATIONS THEREOF |
| SE9802729D0 (sv) | 1998-08-13 | 1998-08-13 | Astra Pharma Prod | Novel Compounds |
| WO2000011950A1 (en) | 1998-08-31 | 2000-03-09 | Oregon Health Science University | Prevention of cell migration initiation with cmv us28 receptor antagonists |
| JP2001218581A (ja) | 1999-11-30 | 2001-08-14 | Eisai Co Ltd | モノクローナル抗体の作製法 |
| US6677321B1 (en) | 1999-12-09 | 2004-01-13 | Bruce Levin | Methods and compositions for treatment of inflammatory disease |
| WO2001060406A1 (en) * | 2000-02-18 | 2001-08-23 | Millennium Pharmaceuticals, Inc. | Therapeutic methods that target fractalkine or cx3cr1 |
| US8647612B2 (en) | 2008-03-05 | 2014-02-11 | Encore Health, Llc | Dithiol compounds, derivatives, and treatment of presbyopia |
| JP4263391B2 (ja) * | 2001-03-19 | 2009-05-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 抗ｃｘ３ｃｒ１抗体、抗フラクタルカイン抗体及びフラクタルカインの利用 |
| US20020192212A1 (en) * | 2001-03-19 | 2002-12-19 | Toshio Imai | Uses of anti-CX3CR1 antibody, anti-fractalkine antibody and fractalkine |
| SE0101082D0 (sv) | 2001-03-27 | 2001-03-27 | Astrazeneca Ab | Novel use |
| WO2003018549A2 (en) | 2001-08-30 | 2003-03-06 | Chemocentryx, Inc. | Bicyclic compounds as inhibitors of chemokine binding to us28 |
| JP2006512313A (ja) | 2002-10-31 | 2006-04-13 | アムジェン インコーポレイテッド | 抗炎症剤 |
| PE20050627A1 (es) * | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
| EP1520586A1 (en) | 2003-09-30 | 2005-04-06 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Inhibition of fractalkine or of its receptor for the treatment of atopic allergic diseases |
| WO2005032589A1 (ja) * | 2003-10-02 | 2005-04-14 | Japan Science And Technology Agency | Ｇｖｈｄの予防及び治療 |
| CA2541533A1 (en) | 2003-10-07 | 2005-04-14 | Astrazeneca Ab | New 2-substituted, 4-amino-thiazolo[4,5-d] pyrimidines, useful as chemokine receptor antagonists, esp. cx3cr1 |
| US8911726B2 (en) | 2004-09-22 | 2014-12-16 | Kyowa Hakko Kirin Co., Ltd | Stabilized human Igg4 antibodies |
| ES2641815T3 (es) | 2004-10-29 | 2017-11-14 | Eisai R&D Management Co., Ltd. | Tratamiento para enfermedades inflamatorias |
| UA90707C2 (en) | 2005-04-06 | 2010-05-25 | Астразенека Аб | Novel 5-substituted 7-amino-[1,3]thiazolo[4,5-d]pyrimidine derivatives |
| AR053347A1 (es) | 2005-04-06 | 2007-05-02 | Astrazeneca Ab | Derivados de [1,3]tiazolo[4,5-d]pirimidin-2(3h)-ona 5,7-sustituidos |
| PT2094728E (pt) * | 2006-10-26 | 2013-05-27 | Janssen Biotech Inc | Métodos de adaptação de anticorpos monoclonais ao ser humano |
| MX2010002683A (es) * | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
-
2010
- 2010-10-27 JO JOP/2010/0374A patent/JO3437B1/ar active
- 2010-10-28 EP EP10826929.1A patent/EP2493930B1/en active Active
- 2010-10-28 CA CA2778895A patent/CA2778895C/en active Active
- 2010-10-28 AR ARP100103947A patent/AR078796A1/es active IP Right Grant
- 2010-10-28 ES ES10826929T patent/ES2698389T3/es active Active
- 2010-10-28 MX MX2012005052A patent/MX2012005052A/es active IP Right Grant
- 2010-10-28 US US13/504,742 patent/US8932592B2/en active Active
- 2010-10-28 WO PCT/JP2010/069653 patent/WO2011052799A1/en not_active Ceased
- 2010-10-28 SM SM20180637T patent/SMT201800637T1/it unknown
- 2010-10-28 HR HRP20181973TT patent/HRP20181973T1/hr unknown
- 2010-10-28 KR KR1020167014386A patent/KR102099596B1/ko active Active
- 2010-10-28 KR KR1020127014048A patent/KR101627605B1/ko active Active
- 2010-10-28 PE PE2012000580A patent/PE20121645A1/es active IP Right Grant
- 2010-10-28 DK DK10826929.1T patent/DK2493930T3/en active
- 2010-10-28 MY MYPI2012001924A patent/MY158481A/en unknown
- 2010-10-28 SI SI201031803T patent/SI2493930T1/sl unknown
- 2010-10-28 RU RU2012122203/10A patent/RU2569109C2/ru active
- 2010-10-28 LT LTEP10826929.1T patent/LT2493930T/lt unknown
- 2010-10-28 UA UAA201206559A patent/UA105073C2/uk unknown
- 2010-10-28 BR BR112012010266A patent/BR112012010266A2/pt not_active Application Discontinuation
- 2010-10-28 HU HUE10826929A patent/HUE041952T2/hu unknown
- 2010-10-28 NZ NZ599779A patent/NZ599779A/en not_active IP Right Cessation
- 2010-10-28 TW TW099137131A patent/TWI414308B/zh active
- 2010-10-28 PT PT10826929T patent/PT2493930T/pt unknown
- 2010-10-28 PL PL10826929T patent/PL2493930T3/pl unknown
- 2010-10-28 RS RS20181424A patent/RS58142B1/sr unknown
- 2010-10-28 AU AU2010312408A patent/AU2010312408B2/en active Active
- 2010-10-28 JP JP2012520621A patent/JP5631991B2/ja active Active
- 2010-10-28 CN CN201080049138.0A patent/CN102597003B/zh active Active
- 2010-10-28 PH PH1/2012/500828A patent/PH12012500828A1/en unknown
-
2012
- 2012-04-24 ZA ZA2012/03002A patent/ZA201203002B/en unknown
- 2012-04-29 IL IL219470A patent/IL219470A/en active IP Right Grant
- 2012-04-30 CL CL2012001143A patent/CL2012001143A1/es unknown
-
2014
- 2014-09-18 JP JP2014189668A patent/JP2015027304A/ja not_active Abandoned
-
2015
- 2015-01-15 CL CL2015000114A patent/CL2015000114A1/es unknown
-
2017
- 2017-09-15 AR ARP170102555A patent/AR109533A2/es unknown
-
2018
- 2018-11-29 CY CY20181101274T patent/CY1121167T1/el unknown
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