JP2018510636A5 - - Google Patents
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- Publication number
- JP2018510636A5 JP2018510636A5 JP2017549507A JP2017549507A JP2018510636A5 JP 2018510636 A5 JP2018510636 A5 JP 2018510636A5 JP 2017549507 A JP2017549507 A JP 2017549507A JP 2017549507 A JP2017549507 A JP 2017549507A JP 2018510636 A5 JP2018510636 A5 JP 2018510636A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- cdr3
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 100
- 102000036639 antigens Human genes 0.000 claims description 100
- 108091007433 antigens Proteins 0.000 claims description 100
- 239000012634 fragment Substances 0.000 claims description 56
- 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 claims description 30
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 claims description 16
- 102000046810 human CEACAM6 Human genes 0.000 claims description 14
- 241000282567 Macaca fascicularis Species 0.000 claims description 10
- 229940125644 antibody drug Drugs 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 150000007523 nucleic acids Chemical group 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 108010062802 CD66 antigens Proteins 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 4
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 230000035772 mutation Effects 0.000 claims description 4
- 230000003053 immunization Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 claims description 2
- 102220470708 Carcinoembryonic antigen-related cell adhesion molecule 6_I63F_mutation Human genes 0.000 claims description 2
- 108090000695 Cytokines Proteins 0.000 claims description 2
- 102000004127 Cytokines Human genes 0.000 claims description 2
- 101000914337 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 3 Proteins 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 102100037850 Interferon gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims description 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 229940039227 diagnostic agent Drugs 0.000 claims description 2
- 239000000032 diagnostic agent Substances 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 2
- 102000055639 human CEACAM3 Human genes 0.000 claims description 2
- 102000047627 human CEACAM5 Human genes 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 102220193249 rs1057516144 Human genes 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 229940127557 pharmaceutical product Drugs 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15160292.7 | 2015-03-23 | ||
| EP15160292 | 2015-03-23 | ||
| PCT/EP2016/056104 WO2016150899A2 (en) | 2015-03-23 | 2016-03-21 | Anti-ceacam6 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212437A Division JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510636A JP2018510636A (ja) | 2018-04-19 |
| JP2018510636A5 true JP2018510636A5 (https=) | 2019-02-21 |
| JP6815329B2 JP6815329B2 (ja) | 2021-01-20 |
Family
ID=52692556
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549507A Active JP6815329B2 (ja) | 2015-03-23 | 2016-03-21 | 抗ｃｅａｃａｍ６抗体およびその使用 |
| JP2020212437A Active JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020212437A Active JP7185379B2 (ja) | 2015-03-23 | 2020-12-22 | 抗ｃｅａｃａｍ６抗体およびその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US10584167B2 (https=) |
| EP (2) | EP3274370B1 (https=) |
| JP (2) | JP6815329B2 (https=) |
| KR (1) | KR102749339B1 (https=) |
| CN (1) | CN107743495B (https=) |
| AR (1) | AR104047A1 (https=) |
| AU (1) | AU2016236270B2 (https=) |
| BR (1) | BR112017020373A2 (https=) |
| CA (1) | CA2980390A1 (https=) |
| CY (1) | CY1122627T1 (https=) |
| DK (1) | DK3274370T3 (https=) |
| ES (1) | ES2768784T3 (https=) |
| HR (1) | HRP20192280T1 (https=) |
| HU (1) | HUE048111T2 (https=) |
| IL (1) | IL254534B (https=) |
| LT (1) | LT3274370T (https=) |
| MX (1) | MX376973B (https=) |
| PE (1) | PE20171790A1 (https=) |
| PL (1) | PL3274370T3 (https=) |
| PT (1) | PT3274370T (https=) |
| RS (1) | RS59878B1 (https=) |
| RU (1) | RU2739163C2 (https=) |
| SG (1) | SG11201707800QA (https=) |
| SI (1) | SI3274370T1 (https=) |
| TW (1) | TWI719969B (https=) |
| WO (1) | WO2016150899A2 (https=) |
| ZA (1) | ZA201707138B (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20171790A1 (es) | 2015-03-23 | 2017-12-28 | Bayer Pharma AG | Anticuerpos anti-ceacam6 y sus usos |
| CN109843327B (zh) | 2016-07-07 | 2022-05-13 | 小利兰·斯坦福大学托管委员会 | 抗体佐剂缀合物 |
| ES2968264T3 (es) | 2016-10-10 | 2024-05-08 | Singapore Health Serv Pte Ltd | Anticuerpos anti-CEACAM6 y métodos de utilización |
| EP3560957A4 (en) * | 2016-11-14 | 2020-10-21 | Dinona | ANTIBODIES BINDING SPECIFICALLY TO CD66C AND ASSOCIATED USE |
| WO2018128486A1 (ko) * | 2017-01-05 | 2018-07-12 | 한국생명공학연구원 | Ceacam6에 특이적으로 결합하는 항-ceacam6 키메릭 항원 수용체 |
| JP7325045B2 (ja) * | 2017-02-27 | 2023-08-14 | カイロス セラピューティクス， インコーポレイテッド | 癌を処置する抗体コンストラクトおよび方法 |
| EA201992546A1 (ru) | 2017-04-24 | 2020-03-06 | Мемориал Слоан Кеттеринг Кэнсер Сентер | Средства на основе антител к cd33 |
| WO2018217459A2 (en) * | 2017-05-23 | 2018-11-29 | Academia Sinica | Conditional internalization of pegylated agents by pretargeting bi-specific peg-binding antibodies for diagnosis and therapy |
| HUE065510T2 (hu) * | 2017-08-10 | 2024-05-28 | Grifols Diagnostic Solutions Inc | Immunglobulin Fc-régiót és poli-His domént tartalmazó oligomerizációs címke |
| KR102134954B1 (ko) | 2018-01-08 | 2020-07-16 | 충북대학교 산학협력단 | CEACAM6 발현 억제를 위한 siRNA 및 이를 포함하는 선암 치료제 |
| AU2019221544B2 (en) * | 2018-02-13 | 2025-07-10 | Precision Biologics, Inc. | Methods and compositions for targeting Treg cells |
| US10752691B2 (en) * | 2018-03-13 | 2020-08-25 | Tusk Therapeutics Ltd. | Anti-CD25 antibody agents |
| KR102373502B1 (ko) * | 2018-05-14 | 2022-03-11 | 주식회사 금호에이치티 | 골수유래억제세포 관련 질환의 예방 및 치료 용도 |
| BR112020023746A2 (pt) | 2018-05-23 | 2021-02-17 | Beigene, Ltd. | anticorpo, composição farmacêutica, método para tratar câncer, ácido nucleico isolado, vetor, célula hospedeira, processo para a produção de um anticorpo e reagente de diagnóstico |
| EP3802599B1 (en) * | 2018-06-03 | 2023-12-20 | LamKap Bio beta AG | Bispecific antibodies against ceacam5 and cd47 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN112996814B (zh) * | 2018-11-14 | 2025-01-03 | 拜耳公司 | 用于治疗癌症的抗ceacam6和抗pd-1或抗pd-l1抗体的药物组合 |
| EP3897844B1 (en) * | 2018-12-19 | 2023-11-15 | Deutsches Krebsforschungszentrum | Pharmaceutical combination of anti ceacam6 and tim3 antibodies |
| WO2020190725A1 (en) | 2019-03-15 | 2020-09-24 | Bolt Biotherapeutics, Inc. | Immunoconjugates targeting her2 |
| AU2020289301B2 (en) * | 2019-06-04 | 2025-07-24 | Biotheus Inc. | CEACAM5-resistant monoclonal antibody and preparation method thereof and use thereof |
| WO2021050799A1 (en) * | 2019-09-13 | 2021-03-18 | Purdue Research Foundation | Compositions and methods for cancer treatment by enhancing antitumor immunity using tannic acid-based nanocapsules |
| WO2021178951A1 (en) * | 2020-03-06 | 2021-09-10 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Tumor targeted fluorescence guidance for intraoperative margin assessment |
| CN111533808B (zh) * | 2020-03-10 | 2021-02-09 | 南京医科大学 | 一种可自分泌TLR4 scFv且靶向cMet的嵌合抗原受体修饰的T细胞及其应用 |
| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| CN112457402B (zh) * | 2020-10-21 | 2022-08-30 | 北京纽安博生物技术有限公司 | 抗ceacam6单域抗体、人源化单域抗体及其融合蛋白和应用 |
| WO2022116079A1 (zh) * | 2020-12-03 | 2022-06-09 | 上海吉倍生物技术有限公司 | 一种抗ceacam5的人源化抗体及其制备方法和用途 |
| US20240024317A1 (en) * | 2020-12-11 | 2024-01-25 | Materia Therapeutics Inc. | Cancer treatment using bosentan in combination with a checkpoint inhibitor |
| WO2022133089A1 (en) * | 2020-12-18 | 2022-06-23 | Bioardis, Llc | Cea6 binding molecules and uses thereof |
| CN112521509B (zh) * | 2020-12-23 | 2022-07-08 | 姚雪英 | 一种抗ceacam5人源化抗体、其缀合物及其用途 |
| CN118043352A (zh) | 2021-09-02 | 2024-05-14 | 德国癌症研究中心公共法律基金会 | 副作用减少的抗cecam6抗体 |
| KR20250024741A (ko) | 2022-03-23 | 2025-02-19 | 시나픽스 비.브이. | 암배아성 항원을 발현하는 종양을 표적화하기 위한 항체-컨쥬게이트 |
| CN116196415B (zh) * | 2022-12-07 | 2023-08-01 | 浙江省肿瘤医院 | 用于增敏pd-1抗体的混合制剂及其使用方法 |
| WO2024243217A1 (en) * | 2023-05-25 | 2024-11-28 | BioLegend, Inc. | Ceacam6 binding antibodies and antigen-binding fragments thereof |
| WO2025237329A1 (en) * | 2024-05-15 | 2025-11-20 | Nona Biosciences (Suzhou) Co., Ltd. | Ceacam6-binding protein |
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-
2016
- 2016-03-21 PE PE2017001579A patent/PE20171790A1/es unknown
- 2016-03-21 MX MX2017012278A patent/MX376973B/es active IP Right Grant
- 2016-03-21 SI SI201630585T patent/SI3274370T1/sl unknown
- 2016-03-21 ES ES16713784T patent/ES2768784T3/es active Active
- 2016-03-21 WO PCT/EP2016/056104 patent/WO2016150899A2/en not_active Ceased
- 2016-03-21 SG SG11201707800QA patent/SG11201707800QA/en unknown
- 2016-03-21 BR BR112017020373-1A patent/BR112017020373A2/pt not_active IP Right Cessation
- 2016-03-21 PT PT167137843T patent/PT3274370T/pt unknown
- 2016-03-21 PL PL16713784T patent/PL3274370T3/pl unknown
- 2016-03-21 HR HRP20192280TT patent/HRP20192280T1/hr unknown
- 2016-03-21 TW TW105108621A patent/TWI719969B/zh active
- 2016-03-21 DK DK16713784.3T patent/DK3274370T3/da active
- 2016-03-21 EP EP16713784.3A patent/EP3274370B1/en active Active
- 2016-03-21 EP EP19202632.6A patent/EP3628688A1/en active Pending
- 2016-03-21 US US15/561,013 patent/US10584167B2/en active Active
- 2016-03-21 AU AU2016236270A patent/AU2016236270B2/en active Active
- 2016-03-21 CA CA2980390A patent/CA2980390A1/en active Pending
- 2016-03-21 RU RU2017137010A patent/RU2739163C2/ru active
- 2016-03-21 CN CN201680024895.XA patent/CN107743495B/zh active Active
- 2016-03-21 KR KR1020177029946A patent/KR102749339B1/ko active Active
- 2016-03-21 HU HUE16713784A patent/HUE048111T2/hu unknown
- 2016-03-21 JP JP2017549507A patent/JP6815329B2/ja active Active
- 2016-03-21 RS RS20200132A patent/RS59878B1/sr unknown
- 2016-03-21 LT LTEP16713784.3T patent/LT3274370T/lt unknown
- 2016-03-22 AR ARP160100772A patent/AR104047A1/es not_active Application Discontinuation
-
2017
- 2017-09-17 IL IL254534A patent/IL254534B/en unknown
- 2017-10-20 ZA ZA2017/07138A patent/ZA201707138B/en unknown
-
2020
- 2020-01-29 US US16/776,326 patent/US11773164B2/en active Active
- 2020-01-29 US US16/776,329 patent/US11866495B2/en active Active
- 2020-02-13 CY CY20201100133T patent/CY1122627T1/el unknown
- 2020-12-22 JP JP2020212437A patent/JP7185379B2/ja active Active
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