JP2015535820A5 - - Google Patents

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Publication number
JP2015535820A5
JP2015535820A5 JP2015532387A JP2015532387A JP2015535820A5 JP 2015535820 A5 JP2015535820 A5 JP 2015535820A5 JP 2015532387 A JP2015532387 A JP 2015532387A JP 2015532387 A JP2015532387 A JP 2015532387A JP 2015535820 A5 JP2015535820 A5 JP 2015535820A5
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JP
Japan
Prior art keywords
seq
antibody
hcdr1
hcdr3
hcdr2
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JP2015532387A
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English (en)
Japanese (ja)
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JP2015535820A (ja
JP6507097B2 (ja
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Priority claimed from PCT/EP2013/069302 external-priority patent/WO2014044686A1/en
Publication of JP2015535820A publication Critical patent/JP2015535820A/ja
Publication of JP2015535820A5 publication Critical patent/JP2015535820A5/ja
Application granted granted Critical
Publication of JP6507097B2 publication Critical patent/JP6507097B2/ja
Active legal-status Critical Current
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JP2015532387A 2012-09-19 2013-09-17 Kir3dl2結合剤 Active JP6507097B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261702834P 2012-09-19 2012-09-19
US61/702,834 2012-09-19
PCT/EP2013/069302 WO2014044686A1 (en) 2012-09-19 2013-09-17 Kir3dl2 binding agents

Publications (3)

Publication Number Publication Date
JP2015535820A JP2015535820A (ja) 2015-12-17
JP2015535820A5 true JP2015535820A5 (https=) 2016-10-27
JP6507097B2 JP6507097B2 (ja) 2019-04-24

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ID=49226157

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015532387A Active JP6507097B2 (ja) 2012-09-19 2013-09-17 Kir3dl2結合剤

Country Status (13)

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US (3) US10577419B2 (https=)
EP (1) EP2897980B1 (https=)
JP (1) JP6507097B2 (https=)
CN (1) CN104640880B (https=)
AU (1) AU2013320360B2 (https=)
BR (1) BR112015006060B1 (https=)
CA (1) CA2881765C (https=)
DK (1) DK2897980T3 (https=)
ES (1) ES2770399T3 (https=)
IL (1) IL237220B (https=)
MX (1) MX369148B (https=)
RU (1) RU2682449C2 (https=)
WO (1) WO2014044686A1 (https=)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2539045T3 (es) * 2009-01-19 2015-06-25 Innate Pharma Anticuerpos anti-KIR3D
MX369148B (es) 2012-09-19 2019-10-30 Innate Pharma Agentes de unión kir3dl2.
ES2878749T3 (es) 2013-02-20 2021-11-19 Innate Pharma Un compuesto que se une específicamente a KIR3DL2 para el uso en el tratamiento de linfoma de células T periférico
KR102345173B1 (ko) 2014-03-14 2021-12-29 이나뜨 파르마 에스.에이. 증가된 안정성을 가진 인간화 항체
JP6822849B2 (ja) 2014-06-27 2021-01-27 イナート・ファルマ・ソシエテ・アノニムInnate Pharma Pharma S.A. 多重特異的NKp46結合タンパク質
WO2015197598A2 (en) 2014-06-27 2015-12-30 Innate Pharma Multispecific antigen binding proteins
WO2016030488A1 (en) * 2014-08-27 2016-03-03 Innate Pharma Treatment of celiac disease
EP4019552A1 (en) 2015-06-10 2022-06-29 National Research Council of Canada Carbonic anhydrase ix-specific antibodies and uses thereof
AU2016284871B2 (en) 2015-06-23 2022-09-29 Innate Pharma Multispecific NK engager proteins
DK3313876T3 (da) 2015-06-23 2025-04-22 Innate Pharma Multispecifikke antigenbindende proteiner
WO2017156423A2 (en) * 2016-03-11 2017-09-14 Integrated Biotherapeutics, Inc. Broadly protective antibody cocktails for treatment of filovirus hemorrhagic fever
US10858431B2 (en) * 2016-06-30 2020-12-08 Trellis Bioscience, Llc Monoclonal antibodies targeting killer immunoglobulin-like receptor (KIR) family signaling
EP3529277A1 (en) * 2016-10-21 2019-08-28 Innate Pharma Treatment with anti-kir3dl2 agents
US20190322767A1 (en) 2016-12-23 2019-10-24 Innate Pharma Heterodimeric antigen binding proteins
CA3052291A1 (en) * 2017-02-09 2018-08-16 Memorial Sloan Kettering Cancer Center Anti-kir3dl1 antibodies
CN111032083B (zh) * 2017-05-24 2024-01-12 财团法人生物技术开发中心 抗globo h的人源化抗体及其在癌症治疗中的用途
US10947316B2 (en) * 2017-06-15 2021-03-16 Development Center For Biotechnology Antibody-drug conjugates containing anti-Globo H antibodies and uses thereof
WO2018237364A1 (en) * 2017-06-22 2018-12-27 Development Center For Biotechnology Asymmetric heterodimeric fc-scfv fusion anti-globo h and anti-cd3 bispecifc antibody and uses thereof in caner therapy
EP3713959A1 (en) 2017-11-21 2020-09-30 Innate Pharma Multispecific antigen binding proteins
WO2019156223A1 (ja) * 2018-02-09 2019-08-15 国立大学法人大阪大学 チクングニアウイルスに対する抗体またはその抗原結合断片、およびその用途
WO2020035345A1 (en) 2018-08-14 2020-02-20 Innate Pharma Treatment of colorectal cancer by a combination of an anti-mica antibody and an anti-nkg2a antibody
JP7611834B2 (ja) 2019-01-22 2025-01-10 イナート・ファルマ・ソシエテ・アノニム T細胞リンパ腫の処置
IL291897A (en) 2019-10-04 2022-06-01 Albert Einstein College Medicine Kir3dl3 inhibitory receptor of the immune system and its uses
CN110950960B (zh) * 2019-11-26 2021-05-14 中国农业大学 基于高通量测序和杂合杂交瘤技术的小分子化合物抗体的制备方法
CN113817052A (zh) * 2020-06-19 2021-12-21 南京金斯瑞生物科技有限公司 抗SARS-CoV-2核衣壳蛋白单克隆抗体及其制备方法和用途
EP4288455A1 (en) 2021-02-03 2023-12-13 Mozart Therapeutics, Inc. Binding agents and methods of using the same
WO2022200525A1 (en) 2021-03-26 2022-09-29 Innate Pharma Multispecific proteins comprising an nkp46-binding site, a cancer antgienge binding site fused to a cytokine for nk cell engaging
KR20230165913A (ko) 2021-04-05 2023-12-05 이나뜨 파르마 에스.에이. 면역조직화학 방법 및 kir3dl2-특이적 시약
WO2022258678A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkp30, a cytokine receptor, a tumour antigen and cd16a
BR112023025331A2 (pt) 2021-06-09 2024-02-27 Innate Pharma Proteína multiespecífica, composição farmacêutica, célula recombinante, ácido nucleico ou conjunto de ácidos nucleicos, uso de uma proteína ou composição, métodos ou uso
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a
KR20240019786A (ko) 2021-06-09 2024-02-14 이나뜨 파르마 에스.에이. Cd20, nkp46, cd16에 결합하고 il-2에 접합된 다중특이적 항체
CN113248609B (zh) * 2021-07-14 2021-09-10 深圳市盛波尔生命科学技术有限责任公司 针对再生胰岛衍生蛋白1α的抗体组合以及包含其的检测试剂盒
US20250121090A1 (en) * 2021-07-30 2025-04-17 R.P. Scherer Technologies, Llc Antibody-Drug Conjugates and Methods of Use Thereof
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
IL319568A (en) 2022-09-15 2025-05-01 Avidicure Ip B V Multispecific antigen-binding proteins for NK cell stimulation and their uses
WO2024251884A1 (en) 2023-06-09 2024-12-12 Innate Pharma Nk cell engager proteins comprising anti-cd20 and ant-nkp46 antibody, linked to il-2 in treatment of r/r b-nhl
CN117801108B (zh) * 2023-12-06 2024-06-07 无锡傲锐东源生物科技有限公司 抗人mdm2蛋白单克隆抗体及其杂交瘤细胞株和应用
WO2025191133A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Il-21 muteins, fusion proteins comprising the same and uses thereof
WO2025191139A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Conjugates of her2-specific antigen binding proteins and cytokines
WO2025191136A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025245386A1 (en) * 2024-05-23 2025-11-27 La Jolla Institute For Immunology Kir3dl2 as an anti-cancer target

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002219229B2 (en) 2000-12-18 2007-12-20 Institut National De La Sante Et De La Recherche Medicale (I.N.S.E.R.M.) Means for the diagnosis and therapy of CTCL
HRP20120845T1 (hr) * 2003-07-02 2012-11-30 Innate Pharma Protutijela za pan-kir2dl nk-receptor i njihova uporaba u dijagnostici i lijeäśenju
ES2539045T3 (es) 2009-01-19 2015-06-25 Innate Pharma Anticuerpos anti-KIR3D
WO2011027310A1 (en) * 2009-09-03 2011-03-10 Koninklijke Philips Electronics N.V. Novel tumor markers
US20130315933A1 (en) * 2010-10-06 2013-11-28 Christoph Renner Antibodies Directed Against HLA-B27 Homodimers and Methods and Uses Thereof in Diagnosis and Therapy
MX369148B (es) 2012-09-19 2019-10-30 Innate Pharma Agentes de unión kir3dl2.
WO2014044681A1 (en) * 2012-09-19 2014-03-27 Innate Pharma Kir3dl2 binding agents
ES2878749T3 (es) 2013-02-20 2021-11-19 Innate Pharma Un compuesto que se une específicamente a KIR3DL2 para el uso en el tratamiento de linfoma de células T periférico
US20160130346A1 (en) * 2013-05-29 2016-05-12 Institut National De La Sante Et De La Recherche Medicale Kir3dl2 is a biomarker and a therapeutic target useful for respectively preventing and treating a subset of cutaneous and non-cutaneous peripheral t-cell lymphomas
KR102345173B1 (ko) 2014-03-14 2021-12-29 이나뜨 파르마 에스.에이. 증가된 안정성을 가진 인간화 항체
EP3529277A1 (en) 2016-10-21 2019-08-28 Innate Pharma Treatment with anti-kir3dl2 agents

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