JP2011520883A5 - - Google Patents
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- Publication number
- JP2011520883A5 JP2011520883A5 JP2011509539A JP2011509539A JP2011520883A5 JP 2011520883 A5 JP2011520883 A5 JP 2011520883A5 JP 2011509539 A JP2011509539 A JP 2011509539A JP 2011509539 A JP2011509539 A JP 2011509539A JP 2011520883 A5 JP2011520883 A5 JP 2011520883A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- pharmaceutical composition
- fentanyl
- composition according
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000839 emulsion Substances 0.000 claims 25
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229960002428 fentanyl Drugs 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 238000004945 emulsification Methods 0.000 claims 6
- 239000003925 fat Substances 0.000 claims 6
- 229960004207 fentanyl citrate Drugs 0.000 claims 6
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 238000002347 injection Methods 0.000 claims 6
- 239000007924 injection Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 3
- 239000005642 Oleic acid Substances 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 230000001609 comparable effect Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000008344 egg yolk phospholipid Substances 0.000 claims 3
- 229940068998 egg yolk phospholipid Drugs 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 239000003921 oil Substances 0.000 claims 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 3
- 239000008347 soybean phospholipid Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000003533 narcotic effect Effects 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5357108P | 2008-05-15 | 2008-05-15 | |
| US61/053,571 | 2008-05-15 | ||
| US12/424,382 | 2009-04-15 | ||
| US12/424,382 US20090286832A1 (en) | 2008-05-15 | 2009-04-15 | Narcotic emulsion formulations for treatment of surgical pain |
| PCT/US2009/041991 WO2009140059A2 (en) | 2008-05-15 | 2009-04-28 | Narcotic emulsion formulations for treatment of surgical pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107385A Division JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520883A JP2011520883A (ja) | 2011-07-21 |
| JP2011520883A5 true JP2011520883A5 (enExample) | 2011-11-10 |
| JP5689053B2 JP5689053B2 (ja) | 2015-03-25 |
Family
ID=41316744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509539A Expired - Fee Related JP5689053B2 (ja) | 2008-05-15 | 2009-04-28 | 手術痛の治療のための麻薬性乳剤 |
| JP2014107385A Expired - Fee Related JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107385A Expired - Fee Related JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090286832A1 (enExample) |
| EP (1) | EP2276440A4 (enExample) |
| JP (2) | JP5689053B2 (enExample) |
| KR (1) | KR101361479B1 (enExample) |
| CN (1) | CN101938963A (enExample) |
| AR (1) | AR071779A1 (enExample) |
| AU (1) | AU2009246713B2 (enExample) |
| BR (1) | BRPI0907224A2 (enExample) |
| CA (1) | CA2710546A1 (enExample) |
| EA (1) | EA201000991A1 (enExample) |
| IL (1) | IL209145A0 (enExample) |
| MX (1) | MX2010007698A (enExample) |
| NZ (1) | NZ586461A (enExample) |
| TW (2) | TWI413531B (enExample) |
| WO (1) | WO2009140059A2 (enExample) |
| ZA (1) | ZA201004392B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| KR101564058B1 (ko) * | 2009-02-26 | 2015-10-29 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 암 통증 치료용 마취 유상액 제제 |
| JP6081240B2 (ja) * | 2013-03-13 | 2017-02-15 | テルモ株式会社 | レミフェンタニル注射液剤 |
| EP3192509B1 (en) | 2014-09-12 | 2021-03-31 | Terumo Kabushiki Kaisha | Remifentanil injection |
| WO2021252449A1 (en) * | 2020-06-08 | 2021-12-16 | Harm Reduction Therapeutics, Inc. | Sterilized formulations |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | ４−ビフエニリル酢酸系化合物含有脂肪乳剤 |
| US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
| ATE183092T1 (de) * | 1995-10-28 | 1999-08-15 | Braun Melsungen Ag | Lokalanästhetika und/oder zentralanalgetika enthaltende pharmazeutische zusammensetzungen |
| GB9721746D0 (en) * | 1997-10-15 | 1997-12-10 | Panos Therapeutics Limited | Compositions |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6455525B1 (en) * | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| CA2446837C (en) * | 2001-05-11 | 2012-01-03 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
| RU2315037C2 (ru) * | 2002-01-25 | 2008-01-20 | Тереванс, Инк. | Замещенные эфиры фенилуксусной кислоты в качестве короткодействующих седативных снотворных агентов для кратковременной анестезии и создания седативного эффекта, промежуточное соединение, фармацевтическая композиция и применение |
| JP2004043479A (ja) * | 2002-07-11 | 2004-02-12 | Taiho Yakuhin Kogyo Kk | 経鼻吸収用組成物 |
| UA80447C2 (en) * | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| JP4584713B2 (ja) * | 2002-10-08 | 2010-11-24 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって術後疼痛を処置するための方法および神経成長因子アンタゴニストを含有する組成物 |
| US7648982B2 (en) * | 2003-02-28 | 2010-01-19 | Ym Biosciences Inc. | Opioid delivery system |
| JP2004275852A (ja) * | 2003-03-14 | 2004-10-07 | Mitsubishi Heavy Ind Ltd | 排煙脱硝触媒及びその製造方法 |
| WO2005112926A1 (en) * | 2004-05-17 | 2005-12-01 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
| DE102004025357B4 (de) * | 2004-05-19 | 2007-03-29 | Beiersdorf Ag | Emulsionskonzentrat mit wasserlöslichen und öllöslichen Polymeren und kosmetische Zubereitung enthaltend Emulsionskonzentrat sowie ein Verfahren zu dessen Herstellung und dessen Verwendung |
| US7871632B2 (en) * | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| US20060189682A1 (en) * | 2005-02-02 | 2006-08-24 | Payne Joseph E | Water soluble prodrugs of COX-2 inhibitors |
| CN101137395B (zh) * | 2005-03-14 | 2012-10-31 | 株式会社大塚制药工场 | 含有水难溶性药物的医药组合物 |
| WO2006115690A2 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| MX374396B (es) * | 2006-01-25 | 2025-03-06 | Insys Therapeutics Inc | Rocio de fentanilo sublingual. |
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| KR101564058B1 (ko) * | 2009-02-26 | 2015-10-29 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 암 통증 치료용 마취 유상액 제제 |
-
2009
- 2009-04-15 US US12/424,382 patent/US20090286832A1/en not_active Abandoned
- 2009-04-28 CN CN2009801021888A patent/CN101938963A/zh active Pending
- 2009-04-28 BR BRPI0907224-1A patent/BRPI0907224A2/pt not_active IP Right Cessation
- 2009-04-28 NZ NZ586461A patent/NZ586461A/en not_active IP Right Cessation
- 2009-04-28 EA EA201000991A patent/EA201000991A1/ru unknown
- 2009-04-28 WO PCT/US2009/041991 patent/WO2009140059A2/en not_active Ceased
- 2009-04-28 CA CA2710546A patent/CA2710546A1/en not_active Abandoned
- 2009-04-28 JP JP2011509539A patent/JP5689053B2/ja not_active Expired - Fee Related
- 2009-04-28 AU AU2009246713A patent/AU2009246713B2/en not_active Ceased
- 2009-04-28 KR KR1020107015502A patent/KR101361479B1/ko not_active Expired - Fee Related
- 2009-04-28 MX MX2010007698A patent/MX2010007698A/es not_active Application Discontinuation
- 2009-04-28 EP EP09747145A patent/EP2276440A4/en not_active Withdrawn
- 2009-05-13 AR ARP090101725A patent/AR071779A1/es not_active Application Discontinuation
- 2009-05-14 TW TW098115948A patent/TWI413531B/zh not_active IP Right Cessation
- 2009-05-14 TW TW102123473A patent/TW201406403A/zh unknown
-
2010
- 2010-06-22 ZA ZA2010/04392A patent/ZA201004392B/en unknown
- 2010-11-04 IL IL209145A patent/IL209145A0/en unknown
-
2014
- 2014-05-23 JP JP2014107385A patent/JP5889364B2/ja not_active Expired - Fee Related
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