TWI413531B - 用於治療外科手術疼痛之麻醉乳液調配物 - Google Patents
用於治療外科手術疼痛之麻醉乳液調配物 Download PDFInfo
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- TWI413531B TWI413531B TW098115948A TW98115948A TWI413531B TW I413531 B TWI413531 B TW I413531B TW 098115948 A TW098115948 A TW 098115948A TW 98115948 A TW98115948 A TW 98115948A TW I413531 B TWI413531 B TW I413531B
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- emulsion
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- pain
- fentanyl
- fentanest
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5357108P | 2008-05-15 | 2008-05-15 | |
| US12/424,382 US20090286832A1 (en) | 2008-05-15 | 2009-04-15 | Narcotic emulsion formulations for treatment of surgical pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201006508A TW201006508A (en) | 2010-02-16 |
| TWI413531B true TWI413531B (zh) | 2013-11-01 |
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| TW098115948A TWI413531B (zh) | 2008-05-15 | 2009-05-14 | 用於治療外科手術疼痛之麻醉乳液調配物 |
| TW102123473A TW201406403A (zh) | 2008-05-15 | 2009-05-14 | 用於治療外科手術疼痛之麻醉乳液調配物 |
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| TW102123473A TW201406403A (zh) | 2008-05-15 | 2009-05-14 | 用於治療外科手術疼痛之麻醉乳液調配物 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090286832A1 (enExample) |
| EP (1) | EP2276440A4 (enExample) |
| JP (2) | JP5689053B2 (enExample) |
| KR (1) | KR101361479B1 (enExample) |
| CN (1) | CN101938963A (enExample) |
| AR (1) | AR071779A1 (enExample) |
| AU (1) | AU2009246713B2 (enExample) |
| BR (1) | BRPI0907224A2 (enExample) |
| CA (1) | CA2710546A1 (enExample) |
| EA (1) | EA201000991A1 (enExample) |
| IL (1) | IL209145A0 (enExample) |
| MX (1) | MX2010007698A (enExample) |
| NZ (1) | NZ586461A (enExample) |
| TW (2) | TWI413531B (enExample) |
| WO (1) | WO2009140059A2 (enExample) |
| ZA (1) | ZA201004392B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| KR101564058B1 (ko) * | 2009-02-26 | 2015-10-29 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 암 통증 치료용 마취 유상액 제제 |
| JP6081240B2 (ja) * | 2013-03-13 | 2017-02-15 | テルモ株式会社 | レミフェンタニル注射液剤 |
| EP3192509B1 (en) | 2014-09-12 | 2021-03-31 | Terumo Kabushiki Kaisha | Remifentanil injection |
| WO2021252449A1 (en) * | 2020-06-08 | 2021-12-16 | Harm Reduction Therapeutics, Inc. | Sterilized formulations |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018967A1 (en) * | 1997-10-15 | 1999-04-22 | Panos Therapeutics Limited | Analgesic compositions |
| US20050054523A9 (en) * | 2003-03-14 | 2005-03-10 | Shigeru Nojima | Flue gas denitration catalyst and preparation process thereof |
| US20060111382A1 (en) * | 2004-05-17 | 2006-05-25 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | ４−ビフエニリル酢酸系化合物含有脂肪乳剤 |
| US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
| ATE183092T1 (de) * | 1995-10-28 | 1999-08-15 | Braun Melsungen Ag | Lokalanästhetika und/oder zentralanalgetika enthaltende pharmazeutische zusammensetzungen |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6455525B1 (en) * | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| CA2446837C (en) * | 2001-05-11 | 2012-01-03 | Mitsubishi Pharma Corporation | Stable high-concentration injection containing pyrazolone derivative |
| RU2315037C2 (ru) * | 2002-01-25 | 2008-01-20 | Тереванс, Инк. | Замещенные эфиры фенилуксусной кислоты в качестве короткодействующих седативных снотворных агентов для кратковременной анестезии и создания седативного эффекта, промежуточное соединение, фармацевтическая композиция и применение |
| JP2004043479A (ja) * | 2002-07-11 | 2004-02-12 | Taiho Yakuhin Kogyo Kk | 経鼻吸収用組成物 |
| UA80447C2 (en) * | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| JP4584713B2 (ja) * | 2002-10-08 | 2010-11-24 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって術後疼痛を処置するための方法および神経成長因子アンタゴニストを含有する組成物 |
| US7648982B2 (en) * | 2003-02-28 | 2010-01-19 | Ym Biosciences Inc. | Opioid delivery system |
| DE102004025357B4 (de) * | 2004-05-19 | 2007-03-29 | Beiersdorf Ag | Emulsionskonzentrat mit wasserlöslichen und öllöslichen Polymeren und kosmetische Zubereitung enthaltend Emulsionskonzentrat sowie ein Verfahren zu dessen Herstellung und dessen Verwendung |
| US7871632B2 (en) * | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| US20060189682A1 (en) * | 2005-02-02 | 2006-08-24 | Payne Joseph E | Water soluble prodrugs of COX-2 inhibitors |
| CN101137395B (zh) * | 2005-03-14 | 2012-10-31 | 株式会社大塚制药工场 | 含有水难溶性药物的医药组合物 |
| WO2006115690A2 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| MX374396B (es) * | 2006-01-25 | 2025-03-06 | Insys Therapeutics Inc | Rocio de fentanilo sublingual. |
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| KR101564058B1 (ko) * | 2009-02-26 | 2015-10-29 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 암 통증 치료용 마취 유상액 제제 |
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2009
- 2009-04-15 US US12/424,382 patent/US20090286832A1/en not_active Abandoned
- 2009-04-28 CN CN2009801021888A patent/CN101938963A/zh active Pending
- 2009-04-28 BR BRPI0907224-1A patent/BRPI0907224A2/pt not_active IP Right Cessation
- 2009-04-28 NZ NZ586461A patent/NZ586461A/en not_active IP Right Cessation
- 2009-04-28 EA EA201000991A patent/EA201000991A1/ru unknown
- 2009-04-28 WO PCT/US2009/041991 patent/WO2009140059A2/en not_active Ceased
- 2009-04-28 CA CA2710546A patent/CA2710546A1/en not_active Abandoned
- 2009-04-28 JP JP2011509539A patent/JP5689053B2/ja not_active Expired - Fee Related
- 2009-04-28 AU AU2009246713A patent/AU2009246713B2/en not_active Ceased
- 2009-04-28 KR KR1020107015502A patent/KR101361479B1/ko not_active Expired - Fee Related
- 2009-04-28 MX MX2010007698A patent/MX2010007698A/es not_active Application Discontinuation
- 2009-04-28 EP EP09747145A patent/EP2276440A4/en not_active Withdrawn
- 2009-05-13 AR ARP090101725A patent/AR071779A1/es not_active Application Discontinuation
- 2009-05-14 TW TW098115948A patent/TWI413531B/zh not_active IP Right Cessation
- 2009-05-14 TW TW102123473A patent/TW201406403A/zh unknown
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2010
- 2010-06-22 ZA ZA2010/04392A patent/ZA201004392B/en unknown
- 2010-11-04 IL IL209145A patent/IL209145A0/en unknown
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2014
- 2014-05-23 JP JP2014107385A patent/JP5889364B2/ja not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999018967A1 (en) * | 1997-10-15 | 1999-04-22 | Panos Therapeutics Limited | Analgesic compositions |
| US20050054523A9 (en) * | 2003-03-14 | 2005-03-10 | Shigeru Nojima | Flue gas denitration catalyst and preparation process thereof |
| US20060111382A1 (en) * | 2004-05-17 | 2006-05-25 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
Also Published As
| Publication number | Publication date |
|---|---|
| EA201000991A1 (ru) | 2011-06-30 |
| AR071779A1 (es) | 2010-07-14 |
| CN101938963A (zh) | 2011-01-05 |
| US20090286832A1 (en) | 2009-11-19 |
| TW201406403A (zh) | 2014-02-16 |
| WO2009140059A2 (en) | 2009-11-19 |
| IL209145A0 (en) | 2011-01-31 |
| JP5889364B2 (ja) | 2016-03-22 |
| AU2009246713A1 (en) | 2009-11-19 |
| NZ586461A (en) | 2012-07-27 |
| BRPI0907224A2 (pt) | 2019-02-26 |
| KR101361479B1 (ko) | 2014-02-12 |
| JP2011520883A (ja) | 2011-07-21 |
| JP5689053B2 (ja) | 2015-03-25 |
| WO2009140059A3 (en) | 2010-01-07 |
| JP2014205681A (ja) | 2014-10-30 |
| CA2710546A1 (en) | 2009-11-19 |
| TW201006508A (en) | 2010-02-16 |
| ZA201004392B (en) | 2011-06-29 |
| EP2276440A2 (en) | 2011-01-26 |
| EP2276440A4 (en) | 2011-06-29 |
| AU2009246713B2 (en) | 2012-10-25 |
| MX2010007698A (es) | 2010-11-22 |
| KR20100126270A (ko) | 2010-12-01 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |