JP2011520108A5 - - Google Patents

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Publication number
JP2011520108A5
JP2011520108A5 JP2011507627A JP2011507627A JP2011520108A5 JP 2011520108 A5 JP2011520108 A5 JP 2011520108A5 JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011520108 A5 JP2011520108 A5 JP 2011520108A5
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JP
Japan
Prior art keywords
prion
pathogenic conformer
conformer
pathogenic
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011507627A
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English (en)
Japanese (ja)
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JP2011520108A (ja
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Publication date
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Priority claimed from PCT/US2009/042185 external-priority patent/WO2009134942A1/en
Publication of JP2011520108A publication Critical patent/JP2011520108A/ja
Publication of JP2011520108A5 publication Critical patent/JP2011520108A5/ja
Withdrawn legal-status Critical Current

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JP2011507627A 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ Withdrawn JP2011520108A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4939608P 2008-04-30 2008-04-30
US61/049,396 2008-04-30
PCT/US2009/042185 WO2009134942A1 (en) 2008-04-30 2009-04-29 Assay for pathogenic conformers

Publications (2)

Publication Number Publication Date
JP2011520108A JP2011520108A (ja) 2011-07-14
JP2011520108A5 true JP2011520108A5 (enExample) 2013-04-25

Family

ID=40863365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011507627A Withdrawn JP2011520108A (ja) 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ

Country Status (8)

Country Link
US (1) US20110189692A1 (enExample)
EP (1) EP2282753A1 (enExample)
JP (1) JP2011520108A (enExample)
CN (1) CN102083450A (enExample)
AU (1) AU2009243060A1 (enExample)
BR (1) BRPI0910550A2 (enExample)
CA (1) CA2721982A1 (enExample)
WO (1) WO2009134942A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2012127250A (ru) * 2009-11-30 2014-01-20 Новартис Аг Бета-амилоидные агрегаты в спиномозговой жидкости в качестве биомаркеров болезни альцгеймера
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
GB201513444D0 (en) * 2015-07-30 2015-09-16 Univ Durham Peptoid
GB201518675D0 (en) 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
KR20180088874A (ko) * 2015-12-15 2018-08-07 사렙타 쎄러퓨틱스 인코퍼레이티드 펩타이드 올리고뉴클레오타이드 컨쥬게이트
EP3426672B1 (en) 2016-03-09 2021-09-01 Mike-Ann, LLC Peptoid affinity ligands
US20220187323A1 (en) * 2019-03-29 2022-06-16 Sekisui Medical Co., Ltd. Immunoassay reagent and immunoassay method

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4006117A (en) * 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US3843443A (en) * 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
US4244721A (en) * 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
JP3355351B2 (ja) * 1989-02-24 2002-12-09 ユーロジェン・ホールディング・ソシエテ・アノニム 遺伝的に工作されたイムノグロブリン
US5306812A (en) * 1989-09-08 1994-04-26 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5231167A (en) * 1989-09-08 1993-07-27 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5811387A (en) * 1990-05-15 1998-09-22 Chiron Corporation Peptoid mixtures
DE69132470D1 (de) * 1990-08-06 2000-12-21 Chiron Corp Verfahren zum nachweis von cytokinkonvertasehemmern
AU654323B2 (en) * 1991-01-04 1994-11-03 Perseptive Biosystems, Inc. Sulfonamide bonded hydrophilic coating
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
EP0616613B1 (en) * 1991-12-03 1999-03-17 Proteus Molecular Design Limited Fragments of prion proteins
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
TW327194B (en) * 1992-05-01 1998-02-21 American Cyanamid Co Novel amyloid precursor proteins and methods of using same
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5831005A (en) * 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5908969A (en) * 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6376170B1 (en) * 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
US5639581A (en) * 1994-10-24 1997-06-17 Fuji Xerox Co., Ltd. Charge transporting polymer, process for producing the same, and organic electronic device containing the same
US5854215A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
ATE263374T1 (de) * 1995-09-14 2004-04-15 Univ California Für natives prp-sc spezifische antikörper
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6251433B1 (en) * 1996-08-13 2001-06-26 Chiron Corporation Polycationic polymers
CA2277519A1 (en) * 1997-01-10 1998-07-16 Massachusetts Institute Of Technology Treatments for neurotoxicity in alzheimer's disease by .beta.-amyloid peptides
EP0861900A1 (en) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US7005295B1 (en) * 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) * 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
ES2329955T3 (es) * 1997-04-28 2009-12-02 Novartis Vaccines And Diagnostics, Inc. Aparato para la sintesis de oligomeros, especialmente peptoides, con reciclado de reactivos.
US5962669A (en) * 1997-06-02 1999-10-05 The Regents Of The University Of California Nucleic acid encoding prion protein variant
ATE223058T1 (de) * 1997-09-19 2002-09-15 Evotec Ag Verfahren zur messung der assoziation von teilstrukturen pathologischer proteinablagerungen
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
ES2248997T3 (es) * 1998-04-14 2006-03-16 Sugen, Inc. Proteina-quinasas ste20-relacionadas.
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
JP2003523348A (ja) * 2000-02-16 2003-08-05 ノースウェスタン ユニバーシティ ポリペプトイド肺サーファクタント
WO2001077687A2 (en) * 2000-04-05 2001-10-18 V.I Technologies, Inc. Prion-binding peptidic ligands and methods of using same
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
AU6887101A (en) * 2000-06-20 2002-01-02 Caprion Pharmaceuticals, Inc. Copolymers and methods of treating prion-related diseases
US6505025B2 (en) * 2000-06-22 2003-01-07 Kyocera Corporation Color image forming apparatus and process
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
US6721761B2 (en) * 2000-12-20 2004-04-13 American Management Systems, Inc. System for assigning digital identifiers to telephone numbers and IP numbers
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2448981C (en) * 2001-05-31 2014-03-18 Arete Associates Misfolded protein sensor method
AU2002357007A1 (en) * 2001-11-21 2003-06-10 New York University SYNTHETIC IMMUNOGENIC BUT NON-DEPOSIT-FORMING POLYPEPTIDES AND PEPTIDES HOMOLOGOUS TO AMYLOID Beta, PRION PROTEIN, AMYLIN, Alpha-SYNUCLEIN, OR POLYGLUTAMINE REPEATS FOR INDUCTION OF AN IMMUNE RESPONSE THERETO
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
BRPI0307976B8 (pt) * 2002-02-28 2021-07-27 Microsens Biophage Ltd processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra
WO2003085086A2 (en) * 2002-04-09 2003-10-16 The Scripps Research Institute Motif-grafted hybrid polypeptides and uses thereof
US20040208919A1 (en) * 2002-06-13 2004-10-21 Nicolau Yves C. Vaccination against prion diseases
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
NZ540417A (en) * 2002-12-03 2008-04-30 Pathogen Removal And Diagnosti Prion protein ligands and methods of use
DK1615992T3 (da) * 2003-04-04 2013-12-09 Pathogen Removal & Diagnostic Technologies Inc Prionproteinbindende materialer og fremgangsmåder til anvendelse
WO2004092197A2 (en) * 2003-04-07 2004-10-28 The Regents Of The University Of California Amyloid-specific peptides and uses thereof
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) * 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
JP3910569B2 (ja) * 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7482172B2 (en) * 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
EP1848830A4 (en) * 2005-01-13 2009-05-06 Novartis Vaccines & Diagnostic Osplation of pathogenic prions
CN101166976B (zh) * 2005-01-13 2013-06-12 诺华疫苗和诊断公司 利用朊病毒特异性肽试剂的elisa试验
US7834144B2 (en) * 2005-09-09 2010-11-16 Novartis Ag Prion-specific peptoid reagents
EP2152744A4 (en) * 2007-04-26 2012-02-15 Univ Yale PRION PROTEIN AS RECEPTOR FOR AMYLOID-BETA OLIGOMERS

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