JP2011520108A - 病原性配座異性体についてのアッセイ - Google Patents

病原性配座異性体についてのアッセイ Download PDF

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JP2011520108A
JP2011520108A JP2011507627A JP2011507627A JP2011520108A JP 2011520108 A JP2011520108 A JP 2011520108A JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011520108 A JP2011520108 A JP 2011520108A
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Prior art keywords
prion
pathogenic
reagent
conformer
pathogenic conformer
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Japanese (ja)
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JP2011520108A5 (enExample
Inventor
デイビッド ペレッツ，
シューメイ ワン，
マン（キャロル） ガオ，
アリス ヤム，
アンソニー ラウ，
ピン ウー，
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ノバルティス アーゲー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2011507627A 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ Withdrawn JP2011520108A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4939608P 2008-04-30 2008-04-30
US61/049,396 2008-04-30
PCT/US2009/042185 WO2009134942A1 (en) 2008-04-30 2009-04-29 Assay for pathogenic conformers

Publications (2)

Publication Number Publication Date
JP2011520108A true JP2011520108A (ja) 2011-07-14
JP2011520108A5 JP2011520108A5 (enExample) 2013-04-25

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JP2011507627A Withdrawn JP2011520108A (ja) 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ

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US (1) US20110189692A1 (enExample)
EP (1) EP2282753A1 (enExample)
JP (1) JP2011520108A (enExample)
CN (1) CN102083450A (enExample)
AU (1) AU2009243060A1 (enExample)
BR (1) BRPI0910550A2 (enExample)
CA (1) CA2721982A1 (enExample)
WO (1) WO2009134942A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
JP2018538302A (ja) * 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2507637A1 (en) * 2009-11-30 2012-10-10 Novartis AG Amyloid beta aggregates in cerebro spinal fluid as biomarkers for alzheimer's disease
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法
GB201513444D0 (en) * 2015-07-30 2015-09-16 Univ Durham Peptoid
GB201518675D0 (en) 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
US11053282B2 (en) 2016-03-09 2021-07-06 Mike-Ann, Llc Peptoid affinity ligands
CN113677993A (zh) * 2019-03-29 2021-11-19 积水医疗株式会社 免疫测定试剂和免疫测定方法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
JP2018538302A (ja) * 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体

Also Published As

Publication number Publication date
WO2009134942A1 (en) 2009-11-05
AU2009243060A1 (en) 2009-11-05
EP2282753A1 (en) 2011-02-16
BRPI0910550A2 (pt) 2015-09-29
CN102083450A (zh) 2011-06-01
CA2721982A1 (en) 2009-11-05
US20110189692A1 (en) 2011-08-04

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