JP2011520108A - 病原性配座異性体についてのアッセイ - Google Patents

病原性配座異性体についてのアッセイ Download PDF

Info

Publication number
JP2011520108A
JP2011520108A JP2011507627A JP2011507627A JP2011520108A JP 2011520108 A JP2011520108 A JP 2011520108A JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011507627 A JP2011507627 A JP 2011507627A JP 2011520108 A JP2011520108 A JP 2011520108A
Authority
JP
Japan
Prior art keywords
prion
pathogenic
reagent
conformer
pathogenic conformer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011507627A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011520108A5 (enExample
Inventor
デイビッド ペレッツ，
シューメイ ワン，
マン（キャロル） ガオ，
アリス ヤム，
アンソニー ラウ，
ピン ウー，
Original Assignee
ノバルティス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2011520108A publication Critical patent/JP2011520108A/ja
Publication of JP2011520108A5 publication Critical patent/JP2011520108A5/ja
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2011507627A 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ Withdrawn JP2011520108A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4939608P 2008-04-30 2008-04-30
US61/049,396 2008-04-30
PCT/US2009/042185 WO2009134942A1 (en) 2008-04-30 2009-04-29 Assay for pathogenic conformers

Publications (2)

Publication Number Publication Date
JP2011520108A true JP2011520108A (ja) 2011-07-14
JP2011520108A5 JP2011520108A5 (enExample) 2013-04-25

Family

ID=40863365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011507627A Withdrawn JP2011520108A (ja) 2008-04-30 2009-04-29 病原性配座異性体についてのアッセイ

Country Status (8)

Country Link
US (1) US20110189692A1 (enExample)
EP (1) EP2282753A1 (enExample)
JP (1) JP2011520108A (enExample)
CN (1) CN102083450A (enExample)
AU (1) AU2009243060A1 (enExample)
BR (1) BRPI0910550A2 (enExample)
CA (1) CA2721982A1 (enExample)
WO (1) WO2009134942A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
JP2018538302A (ja) * 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120116416A (ko) * 2009-11-30 2012-10-22 노파르티스 아게 뇌척수액에서 알츠하이머 병에 대한 생체 마커로서의 아밀로이드 베타 응집체
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法
GB201513444D0 (en) * 2015-07-30 2015-09-16 Univ Durham Peptoid
GB201518675D0 (en) 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
EP3426672B1 (en) 2016-03-09 2021-09-01 Mike-Ann, LLC Peptoid affinity ligands
EP3951389A4 (en) * 2019-03-29 2022-12-14 Sekisui Medical Co., Ltd. IMMUNOLOGICAL ASSAY REAGENT AND IMMUNOLOGICAL ASSAY METHOD

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6498017B2 (en) * 1907-11-28 2002-12-24 Evotec Biosystems Ag Method for measuring the association of substructures of pathological protein depositions
US4006117A (en) * 1973-01-24 1977-02-01 Hooker Chemicals & Plastics Corporation Amine phosphite antioxidants
US3843443A (en) * 1973-03-30 1974-10-22 J Fishman Polypeptide materials bound to fluorocarbon polymers
US4244721A (en) * 1979-01-31 1981-01-13 Pedro Buarque De Macedo Method of making composite borosilicate glass articles
US4507230A (en) * 1982-05-12 1985-03-26 Research Corporation Peptide synthesis reagents and method of use
US4952496A (en) * 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
DE3500180A1 (de) * 1985-01-04 1986-07-10 Ernst Prof. Dr. 7400 Tübingen Bayer Pfropfcopolymerisate aus vernetzten polymeren und polyoxyethylen, verfahren zu ihrer herstellung und ihre verwendung
US5292814A (en) * 1987-04-29 1994-03-08 Ernst Bayer Process for the preparation of monodispersed polymer beads
DE69023900T4 (de) * 1989-02-24 1996-10-02 The Regents Of The University Of California, Berkeley, Calif. Gentechnologisch veränderte immunglobuline.
US5306812A (en) * 1989-09-08 1994-04-26 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5231167A (en) * 1989-09-08 1993-07-27 The Regents Of The University Of California Immunoglobulin-binding polypeptides
US5811387A (en) * 1990-05-15 1998-09-22 Chiron Corporation Peptoid mixtures
DE69132470D1 (de) * 1990-08-06 2000-12-21 Chiron Corp Verfahren zum nachweis von cytokinkonvertasehemmern
EP0620761A1 (en) * 1991-01-04 1994-10-26 Perseptive Biosystems, Inc. Sulfonamide bonded hydrophilic coatings
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5846717A (en) * 1996-01-24 1998-12-08 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US5773572A (en) * 1991-12-03 1998-06-30 Proteus Molecular Design Limited Fragments of prion proteins
US5424413A (en) * 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
TW327194B (en) * 1992-05-01 1998-02-21 American Cyanamid Co Novel amyloid precursor proteins and methods of using same
US5831005A (en) * 1992-09-24 1998-11-03 Chiron Corporation Synthesis of N-substituted oligomers
US5877278A (en) * 1992-09-24 1999-03-02 Chiron Corporation Synthesis of N-substituted oligomers
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5792901A (en) * 1994-05-13 1998-08-11 The Regents Of The University Of California Detecting prions in a sample and prion preparation and transgenic animal used for same
US5565186A (en) * 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US5908969A (en) * 1994-05-13 1999-06-01 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
US6168776B1 (en) * 1994-07-19 2001-01-02 University Of Pittsburgh Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6376170B1 (en) * 1994-10-03 2002-04-23 The Scripps Research Institute Ligand capture-directed selection of antibody
US5639581A (en) * 1994-10-24 1997-06-17 Fuji Xerox Co., Ltd. Charge transporting polymer, process for producing the same, and organic electronic device containing the same
US5854215A (en) * 1995-03-14 1998-12-29 Praecis Pharmaceuticals Incorporated Modulators of β-amyloid peptide aggregation
US5948763A (en) * 1995-06-07 1999-09-07 New York University Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits
AU707484B2 (en) * 1995-09-14 1999-07-08 Regents Of The University Of California, The Antibodies specific for native PrPsc
US5750361A (en) * 1995-11-02 1998-05-12 The Regents Of The University Of California Formation and use of prion protein (PRP) complexes
US6090606A (en) * 1996-01-24 2000-07-18 Third Wave Technologies, Inc. Cleavage agents
US5985557A (en) * 1996-01-24 1999-11-16 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
JP4320054B2 (ja) * 1996-08-13 2009-08-26 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド ポリヌクレオチド送達のための組成物および方法
EP1015013A4 (en) * 1997-01-10 2002-07-24 Massachusetts Inst Technology TREATMENTS RELATING TO NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY beta-AMYLOID PEPTIDES
EP0861900A1 (en) * 1997-02-21 1998-09-02 Erziehungsdirektion Of The Canton Zurich Immunological detection of prions
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US20010001061A1 (en) * 1997-02-21 2001-05-10 Prusiner Stanley B. Assay for disease related conformation of a protein
US6787319B2 (en) * 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
US7005295B1 (en) * 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
DE69841014D1 (de) * 1997-04-28 2009-09-10 Novartis Vaccines & Diagnostic Vorrichtung zur herstellung von oligomeren, insbesondere peptoiden, mit rückführung der reagenzien
US5962669A (en) * 1997-06-02 1999-10-05 The Regents Of The University Of California Nucleic acid encoding prion protein variant
US6214565B1 (en) * 1998-10-09 2001-04-10 The Regents Of The University Of California Assay for disease related conformation of a protein and isolating same
EP1073723B1 (en) * 1998-04-14 2005-08-17 Sugen, Inc. Ste20-related protein kinases
US6211149B1 (en) * 1998-08-03 2001-04-03 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors of formation of protease resistant prion protein
GB2348203B (en) * 1998-11-04 2002-06-19 Imp College Innovations Ltd Solube beta-forms of prion proteins, methods of preparation and use
US6551843B1 (en) * 1999-01-29 2003-04-22 Immunivest Corporation Methods for enhancing binding interactions between members of specific binding pairs
FR2801106B1 (fr) * 1999-11-12 2007-10-05 Commissariat Energie Atomique Procede de diagnostic d'une esst provoquee par une souche d'atnc dans un echantillon biologique et son utilisation dans le diagnostic differentiel des differentes souches d'atnc
US6235483B1 (en) * 2000-01-31 2001-05-22 Agilent Technologies, Inc. Methods and kits for indirect labeling of nucleic acids
KR20020081330A (ko) * 2000-02-16 2002-10-26 노오쓰웨스턴 유니버시티 폴리펩토이드 폐 계면활성제
EP1272509A2 (en) * 2000-04-05 2003-01-08 V.I. Technologies, Inc. Prion-binding peptidic ligands and methods of using same
US6511809B2 (en) * 2000-06-13 2003-01-28 E. I. Du Pont De Nemours And Company Method for the detection of an analyte by means of a nucleic acid reporter
WO2001097785A2 (en) * 2000-06-20 2001-12-27 Caprion Pharmaceuticals Inc. Basic copolymers for the treatment of prion-related-disease
US6505025B2 (en) * 2000-06-22 2003-01-07 Kyocera Corporation Color image forming apparatus and process
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
US6721761B2 (en) * 2000-12-20 2004-04-13 American Management Systems, Inc. System for assigning digital identifiers to telephone numbers and IP numbers
JP4235544B2 (ja) * 2001-05-31 2009-03-11 アドライフ インコーポレーティッド 欠陥折畳み蛋白質センサー方法
US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
CA2466841A1 (en) * 2001-11-21 2003-06-05 New York University Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid .beta., prion protein, amylin, .alpha.-synuclein, or polyglutamine repeats for induction of an immune response thereto
US20040052928A1 (en) * 2002-09-06 2004-03-18 Ehud Gazit Peptides and methods using same for diagnosing and treating amyloid-associated diseases
BRPI0307976B8 (pt) * 2002-02-28 2021-07-27 Microsens Biophage Ltd processo para a ligação seletiva de uma forma anormal agregativa de uma proteína, e, processo ou ensaio quanto à presença de uma forma agregativa anormal de uma proteína de uma amostra
ES2380925T3 (es) * 2002-04-09 2012-05-21 The Scripps Research Institute Polipéptidos híbridos con motivos injertados y usos de los mismos
US20040208919A1 (en) * 2002-06-13 2004-10-21 Nicolau Yves C. Vaccination against prion diseases
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1382971A1 (en) * 2002-07-17 2004-01-21 Pepscan Systems B.V. Detection of prion disease
US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
NZ572892A (en) * 2002-12-03 2010-03-26 Univ North Carolina State Prion protein ligands with the sequence YVHEA
US7393658B2 (en) * 2003-04-04 2008-07-01 Pathogen Removal And Diagnostic Technologies, Inc. Prion protein binding materials and methods of use
WO2004092197A2 (en) * 2003-04-07 2004-10-28 The Regents Of The University Of California Amyloid-specific peptides and uses thereof
US7439041B2 (en) * 2003-08-13 2008-10-21 Novartis Vaccines And Diagnostics, Inc. Prion-specific peptide reagents
US20060035242A1 (en) * 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
JP3910569B2 (ja) * 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
US7482172B2 (en) * 2005-09-19 2009-01-27 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
WO2006076497A2 (en) * 2005-01-13 2006-07-20 Novartis Vaccines And Diagnostics Inc. Osplation of pathogenic prions
EP1848831A4 (en) * 2005-01-13 2008-11-05 Novartis Vaccines & Diagnostic ELISA TESTS USING PRION-SPECIFIC PEPTIDE REAGENT
WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents
EP2152744A4 (en) * 2007-04-26 2012-02-15 Univ Yale PRION PROTEIN AS RECEPTOR FOR AMYLOID-BETA OLIGOMERS

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
JP2018538302A (ja) * 2015-12-15 2018-12-27 サレプタ セラピューティクス， インコーポレイテッド ペプチドオリゴヌクレオチド複合体

Also Published As

Publication number Publication date
CN102083450A (zh) 2011-06-01
CA2721982A1 (en) 2009-11-05
AU2009243060A1 (en) 2009-11-05
WO2009134942A1 (en) 2009-11-05
US20110189692A1 (en) 2011-08-04
EP2282753A1 (en) 2011-02-16
BRPI0910550A2 (pt) 2015-09-29

Similar Documents

Publication Publication Date Title
AU2010315133B2 (en) Positively charged species as binding reagents in the separation of protein aggregates from monomers
JP2011520108A (ja) 病原性配座異性体についてのアッセイ
JP5209477B2 (ja) プリオンに特異的なペプトイド試薬
JP2012181210A (ja) プリオン特異的ペプチド試薬を使用するｅｌｉｓａアッセイ
EP1575989B1 (en) PrP sp sc /sp -INTERACTING MOLECULES AND USES THEREOF
AU2015314783A1 (en) Detection of misfolded proteins
JP2008527382A5 (enExample)
US20090191571A1 (en) Isolation and Detection of Pathogenic Prions
US20210102961A1 (en) Detection of misfolded proteins
AU2012244255A1 (en) Prion-specific peptoid reagents
HK1118336B (en) Elisa assays using prion-specific peptide reagents
Porat Aggregation of Amylin in type II diabetes: Molecular recognition elements in islet amyloid assembly and functional inhibition
WO2017179647A1 (ja) アミロスフェロイド（ａｓｐｄ）結合阻害ペプチド、並びに評価及びスクリーニング方法
HK1163124A (en) Prion-specific peptoid reagents
MX2008003147A (en) Prion-specific peptoid reagents

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120327

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130228

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20130909

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20130925