JP2011519863A5 - - Google Patents
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- Publication number
- JP2011519863A5 JP2011519863A5 JP2011507632A JP2011507632A JP2011519863A5 JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5 JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- fluoro
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GYZKKKIFYYBYSB-UHFFFAOYSA-N CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O Chemical compound CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O GYZKKKIFYYBYSB-UHFFFAOYSA-N 0.000 description 1
- KMZSRRANCBLSIZ-UHFFFAOYSA-N COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 Chemical compound COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 KMZSRRANCBLSIZ-UHFFFAOYSA-N 0.000 description 1
- PUJQPIUTUFMOES-UHFFFAOYSA-N COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O Chemical compound COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O PUJQPIUTUFMOES-UHFFFAOYSA-N 0.000 description 1
- UOBCRIAKAHFLDZ-UHFFFAOYSA-N COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 Chemical compound COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 UOBCRIAKAHFLDZ-UHFFFAOYSA-N 0.000 description 1
- FBNHXCOGKZBJCL-UHFFFAOYSA-N O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 Chemical compound O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 FBNHXCOGKZBJCL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12611208P | 2008-05-01 | 2008-05-01 | |
| US61/126,112 | 2008-05-01 | ||
| PCT/US2009/042255 WO2009134973A1 (en) | 2008-05-01 | 2009-04-30 | Quenolines and related analogs as sirtuin modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519863A JP2011519863A (ja) | 2011-07-14 |
| JP2011519863A5 true JP2011519863A5 (https=) | 2012-06-21 |
| JP5425891B2 JP5425891B2 (ja) | 2014-02-26 |
Family
ID=41255415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507632A Expired - Fee Related JP5425891B2 (ja) | 2008-05-01 | 2009-04-30 | サーチュイン調節薬としてのキノリンおよび関連する類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8685970B2 (https=) |
| EP (1) | EP2273992B1 (https=) |
| JP (1) | JP5425891B2 (https=) |
| KR (1) | KR20110007235A (https=) |
| CN (1) | CN102083438B (https=) |
| AU (1) | AU2009243006B2 (https=) |
| BR (1) | BRPI0912356A2 (https=) |
| CA (1) | CA2723135A1 (https=) |
| EA (1) | EA021938B1 (https=) |
| ES (1) | ES2586459T3 (https=) |
| IL (1) | IL208997A0 (https=) |
| MX (1) | MX2010012010A (https=) |
| SG (1) | SG190603A1 (https=) |
| WO (1) | WO2009134973A1 (https=) |
| ZA (1) | ZA201007677B (https=) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2729128C (en) | 2008-07-03 | 2016-05-31 | Sirtris Pharmaceuticals, Inc. | Benzimidazoles and related analogs as sirtuin modulators |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| WO2010093808A1 (en) * | 2009-02-11 | 2010-08-19 | Reaction Biology Corp. | Selective kinase inhibitors |
| AU2010221417A1 (en) * | 2009-03-02 | 2011-09-22 | Sirtris Pharmaceuticals, Inc. | 8-substituted quinolines and related analogs as sirtuin modulators |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| CN101723894B (zh) * | 2009-12-03 | 2011-12-28 | 南京大学 | N-喹啉酰胺类衍生物及其制法与用途 |
| US20120214803A1 (en) | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| WO2012122534A2 (en) | 2011-03-10 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| JP6231085B2 (ja) * | 2012-05-31 | 2017-11-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | アミノキナゾリン誘導体及びピリドピリミジン誘導体 |
| JP6374384B2 (ja) | 2012-08-07 | 2018-08-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
| CN105392788B (zh) | 2013-05-13 | 2018-10-23 | 葛兰素史密斯克莱有限责任公司 | 用作沉默调节蛋白调节剂的取代的桥连脲类似物 |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| WO2014201327A1 (en) | 2013-06-13 | 2014-12-18 | Monsanto Technology Llc | Acetyl-coa carboxylase modulators |
| WO2014201326A1 (en) | 2013-06-13 | 2014-12-18 | Monsanto Technology Llc | Acetyl-coa carboxylase modulators |
| KR20170012449A (ko) | 2014-06-02 | 2017-02-02 | 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 | 결정질 베타-d-니코틴아미드 리보시드의 제조 및 용도 |
| CA2951287A1 (en) | 2014-06-06 | 2015-12-10 | Glaxosmithkline Intellectual Property (No. 2) Limited | Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof |
| US20170281611A1 (en) * | 2014-08-29 | 2017-10-05 | Eiger Biopharmaceuticals, Inc. | Quinolines and their use for treating endoplasmic reticulum stress-caused diseases |
| US20200347038A1 (en) | 2014-08-29 | 2020-11-05 | Russell Dahl | Quinolines that modulate serca and their use for treating disease |
| EP4406616A3 (en) | 2014-11-06 | 2024-11-06 | Bial-R&D Investments, S.A. | Substituted pyrazolo(1,5-a)pyrimidines and their use in the treatment of medical disorders |
| US20180185368A1 (en) | 2014-11-06 | 2018-07-05 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| US10045981B2 (en) | 2015-11-24 | 2018-08-14 | Jakpharm, Llc | Selective kinase inhibitors |
| US10383868B2 (en) * | 2015-11-28 | 2019-08-20 | Russell Dahl | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases |
| JP7071917B2 (ja) | 2015-12-09 | 2022-05-19 | カデント セラピューティクス，インコーポレーテッド | ヘテロ芳香族ｎｍｄａ受容体モジュレーターおよびその使用 |
| EP4006038A1 (en) | 2015-12-09 | 2022-06-01 | Cadent Therapeutics, Inc. | Thienopyrimidinone nmda receptor modulators and uses thereof |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| CA3020305A1 (en) | 2016-04-06 | 2017-10-12 | Lysosomal Therapeutics Inc. | Imidazo [1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| AU2017246455B2 (en) | 2016-04-06 | 2021-09-30 | Bial - R&D Investments, S.A. | Pyrazolo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders |
| KR102530515B1 (ko) | 2016-05-05 | 2023-05-09 | 비알 - 알&디 인베스트먼츠, 에스.에이. | 치환된 이미다조[1,2-b]피리다진, 치환된 이미다조[1,5-b]피리다진, 관련 화합물, 및 의학적 장애의 치료에서의 그의 용도 |
| EP3452480A4 (en) * | 2016-05-05 | 2019-11-06 | Lysosomal Therapeutics Inc. | SUBSTITUTED PYRROLO [1,2-] TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| WO2017192931A1 (en) | 2016-05-05 | 2017-11-09 | Lysosomal Therapeutics Inc. | SUBSTITUTED IMDAZO[1,2-α]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-α]PYRAZINES, RELATED COMPOUNDS, AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| KR102494647B1 (ko) | 2016-07-14 | 2023-01-31 | 브리스톨-마이어스 스큅 컴퍼니 | 비시클릭 헤테로아릴 치환된 화합물 |
| CN109689664B (zh) | 2016-07-14 | 2022-04-15 | 百时美施贵宝公司 | 作为par4抑制剂的三环杂芳基取代的喹啉和氮杂喹啉化合物 |
| EP3484878B1 (en) | 2016-07-14 | 2020-08-19 | Bristol-Myers Squibb Company | Bicyclic heteroaryl substituted compounds |
| US11274107B2 (en) | 2016-12-22 | 2022-03-15 | Cadent Therapeutics, Inc. | NMDA receptor modulators and uses thereof |
| BR112020003116A2 (pt) | 2017-08-17 | 2020-08-04 | Ikena Oncology, Inc. | inibidores de ahr e usos dos mesmos |
| CN111164075A (zh) * | 2017-09-20 | 2020-05-15 | 北京加科思新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
| JP7382348B2 (ja) | 2018-02-06 | 2023-11-16 | アイディアヤ バイオサイエンシーズ，インコーポレイティド | ＡｈＲモジュレータ |
| AR115905A1 (es) | 2018-08-03 | 2021-03-10 | Cadent Therapeutics Inc | 5-(3-cloro-4-fluorofenil)-7-ciclopropil-3-(2-(3-fluoro-3-metilazetidin-1-il)-2-oxoetil)-3,7-dihidro-4h-pirrolo[2,3-d]pirimidin-4-ona como modulador de los receptores de nmda |
| CN113101295A (zh) * | 2020-03-20 | 2021-07-13 | 上海疆云医疗健康科技有限公司 | 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途 |
| US11730729B2 (en) | 2020-07-20 | 2023-08-22 | Neurodon Corporation | Quinolines that modulate SERCA and their use for treating disease |
| EP4291555A1 (en) * | 2021-02-09 | 2023-12-20 | Celgene Corporation | Sulfonamides and their use for treatment of helminthic infections and diseases |
| CN112939955B (zh) * | 2021-03-05 | 2022-10-21 | 朗捷睿(苏州)生物科技有限公司 | 一种8-(吡啶酰胺)取代香豆素类化合物及其制备方法和应用 |
| PT4426434T (pt) | 2021-11-02 | 2025-11-24 | Flare Therapeutics Inc | Agonistas inversos de pparg e suas utilizações |
| WO2024026423A1 (en) * | 2022-07-27 | 2024-02-01 | Black Diamond Therapeutics, Inc. | Substituted quinoline derivatives as pi3k inhibitors |
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-
2009
- 2009-04-30 ES ES09739775.6T patent/ES2586459T3/es active Active
- 2009-04-30 CA CA2723135A patent/CA2723135A1/en not_active Abandoned
- 2009-04-30 AU AU2009243006A patent/AU2009243006B2/en not_active Ceased
- 2009-04-30 EA EA201071263A patent/EA021938B1/ru not_active IP Right Cessation
- 2009-04-30 MX MX2010012010A patent/MX2010012010A/es not_active Application Discontinuation
- 2009-04-30 EP EP09739775.6A patent/EP2273992B1/en active Active
- 2009-04-30 BR BRPI0912356A patent/BRPI0912356A2/pt not_active IP Right Cessation
- 2009-04-30 SG SG2013032677A patent/SG190603A1/en unknown
- 2009-04-30 JP JP2011507632A patent/JP5425891B2/ja not_active Expired - Fee Related
- 2009-04-30 US US12/990,339 patent/US8685970B2/en not_active Expired - Fee Related
- 2009-04-30 CN CN200980125767.4A patent/CN102083438B/zh not_active Expired - Fee Related
- 2009-04-30 WO PCT/US2009/042255 patent/WO2009134973A1/en not_active Ceased
- 2009-04-30 KR KR1020107026866A patent/KR20110007235A/ko not_active Ceased
-
2010
- 2010-10-27 ZA ZA2010/07677A patent/ZA201007677B/en unknown
- 2010-10-28 IL IL208997A patent/IL208997A0/en unknown