JP2011519863A5 - - Google Patents
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- Publication number
- JP2011519863A5 JP2011519863A5 JP2011507632A JP2011507632A JP2011519863A5 JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5 JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011507632 A JP2011507632 A JP 2011507632A JP 2011519863 A5 JP2011519863 A5 JP 2011519863A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- fluoro
- phenyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- GYZKKKIFYYBYSB-UHFFFAOYSA-N CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O Chemical compound CC(Cc1c2)C=Cc1ncc2-c(cc1)nc2c1C=CCC2NC(c1ccccc1)=O GYZKKKIFYYBYSB-UHFFFAOYSA-N 0.000 description 1
- KMZSRRANCBLSIZ-UHFFFAOYSA-N COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 Chemical compound COCC1C=CC(CNC(c(cccc2cc3)c2nc3-c2ccccc2)=O)=CC1 KMZSRRANCBLSIZ-UHFFFAOYSA-N 0.000 description 1
- PUJQPIUTUFMOES-UHFFFAOYSA-N COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O Chemical compound COc(cc1)ccc1S(Nc1cccc(nc2)c1nc2-c1ccncc1)(=O)=O PUJQPIUTUFMOES-UHFFFAOYSA-N 0.000 description 1
- UOBCRIAKAHFLDZ-UHFFFAOYSA-N COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 Chemical compound COc1ccc(CNC(C(CCC=C2C=C3)=C2N=C3c(cc2)ccc2OC)=O)cc1 UOBCRIAKAHFLDZ-UHFFFAOYSA-N 0.000 description 1
- FBNHXCOGKZBJCL-UHFFFAOYSA-N O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 Chemical compound O=C(c1ccccc1)Nc1cccc2ccc(-c3nc(cccc4)c4cc3)nc12 FBNHXCOGKZBJCL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12611208P | 2008-05-01 | 2008-05-01 | |
| US61/126,112 | 2008-05-01 | ||
| PCT/US2009/042255 WO2009134973A1 (en) | 2008-05-01 | 2009-04-30 | Quenolines and related analogs as sirtuin modulators |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519863A JP2011519863A (ja) | 2011-07-14 |
| JP2011519863A5 true JP2011519863A5 (cg-RX-API-DMAC7.html) | 2012-06-21 |
| JP5425891B2 JP5425891B2 (ja) | 2014-02-26 |
Family
ID=41255415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507632A Expired - Fee Related JP5425891B2 (ja) | 2008-05-01 | 2009-04-30 | サーチュイン調節薬としてのキノリンおよび関連する類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8685970B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2273992B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5425891B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20110007235A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102083438B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009243006B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0912356A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2723135A1 (cg-RX-API-DMAC7.html) |
| EA (1) | EA021938B1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2586459T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL208997A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010012010A (cg-RX-API-DMAC7.html) |
| SG (1) | SG190603A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009134973A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201007677B (cg-RX-API-DMAC7.html) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2011000079A (es) | 2008-07-03 | 2011-03-02 | Sirtris Pharmaceuticals Inc | Bencimidazoles y analogos relacionados como moduladores de sirtuin. |
| MX2011003373A (es) | 2008-09-29 | 2011-06-09 | Sirtris Pharmaceuticals Inc | Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina. |
| CA2752150A1 (en) * | 2009-02-11 | 2010-08-19 | Reaction Biology Corp. | Selective kinase inhibitors |
| MX2011009213A (es) * | 2009-03-02 | 2011-12-14 | Sirtris Pharmaceuticals Inc | Quinolinas 8-sustituidas y analogos relacionados como moduladores de sirtuina. |
| MX2012004995A (es) | 2009-10-29 | 2012-10-03 | Sirtris Pharmaceuticals Inc | Piridinas biciclicas y analogos como moduladores de sirtuina. |
| CN101723894B (zh) * | 2009-12-03 | 2011-12-28 | 南京大学 | N-喹啉酰胺类衍生物及其制法与用途 |
| US20120214803A1 (en) * | 2011-02-18 | 2012-08-23 | Vifor (International) Ag | Novel Sulfonaminoquinoline Hepcidin Antagonists |
| WO2012122534A2 (en) | 2011-03-10 | 2012-09-13 | The Trustees Of Columbia University In The City Of New York | N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CA2870407A1 (en) * | 2012-05-31 | 2013-12-05 | F. Hoffmann-La Roche Ag | Aminoquinazoline and pyridopyrimidine derivatives |
| CA2881279C (en) | 2012-08-07 | 2020-07-07 | Merck Patent Gmbh | Pyridopyrimidine derivatives as protein kinase inhibitors |
| WO2016081692A2 (en) * | 2014-11-19 | 2016-05-26 | Glaxosmithkline Llc | Substituted bridged urea analogs as sirtuin modulators |
| KR20160006215A (ko) | 2013-05-13 | 2016-01-18 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 가교 우레아 유사체 |
| AR096614A1 (es) | 2013-06-13 | 2016-01-20 | Monsanto Technology Llc | Moduladores de la acetil-coa carboxilasa |
| US10207995B2 (en) * | 2013-06-13 | 2019-02-19 | Monsanto Technology Llc | Acetyl CoA carboxylase modulators |
| US10316054B2 (en) | 2014-06-02 | 2019-06-11 | Glaxosmithkline Intellectual Property (No. 2) Limited | Preparation and use of crystalline beta-D-nicotinamide riboside |
| JP6559713B2 (ja) | 2014-06-06 | 2019-08-14 | グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ | ニコチンアミドリボシド類似体ならびにその医薬組成物および使用 |
| US20200347038A1 (en) | 2014-08-29 | 2020-11-05 | Russell Dahl | Quinolines that modulate serca and their use for treating disease |
| US20170281611A1 (en) * | 2014-08-29 | 2017-10-05 | Eiger Biopharmaceuticals, Inc. | Quinolines and their use for treating endoplasmic reticulum stress-caused diseases |
| WO2016073891A1 (en) | 2014-11-06 | 2016-05-12 | Lysosomal Therapeutics Inc. | Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders |
| DK3215511T3 (da) | 2014-11-06 | 2024-05-13 | Bial R&D Invest S A | Substituerede pyrazolo(1,5-a)pyrimidiner og deres anvendelse i behandlingen af medicinske lidelser |
| US20170333435A1 (en) | 2014-11-06 | 2017-11-23 | Lysosomal Therapeutics Inc. | Substituted imidazo[1,5-a]pyrimidines and their use in the treatment of medical disorders |
| US10045981B2 (en) | 2015-11-24 | 2018-08-14 | Jakpharm, Llc | Selective kinase inhibitors |
| US10383868B2 (en) * | 2015-11-28 | 2019-08-20 | Russell Dahl | Quinoline containing compounds and their use for treating endoplasmic reticulum stress-related diseases |
| EP4219507A3 (en) | 2015-12-09 | 2023-08-16 | Novartis AG | Thienopyrimidinone nmda receptor modulators and uses thereof |
| HUE051395T2 (hu) | 2015-12-09 | 2021-03-01 | Cadent Therapeutics Inc | Heteroaromás NMDA receptor modulátorok és alkalmazásaik |
| EP3440081A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | PYRROLO [1,2-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| JP7038063B2 (ja) | 2016-04-06 | 2022-03-17 | リソソーマル・セラピューティクス・インコーポレイテッド | ピラゾロ［１，５－ａ］ピリミジニルカルボキサミド化合物および医学的障害の処置におけるその使用 |
| EP3440083A4 (en) | 2016-04-06 | 2019-09-18 | Lysosomal Therapeutics Inc. | IMIDAZO [1,5-A] PYRIMIDINYL-CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDER |
| AU2017261291C1 (en) | 2016-05-05 | 2022-05-26 | Bial - R&D Investments, S.A. | Substituted imidazo[1,2-b]pyridazines, substituted imidazo[1,5-b]pyridazines, related compounds, and their use in the treatment of medical disorders |
| US20190389865A1 (en) * | 2016-05-05 | 2019-12-26 | Lysosomal Therapeutics Inc. | SUBSTITUTED PYRROLO[1,2-a]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS |
| US11345698B2 (en) | 2016-05-05 | 2022-05-31 | Bial—R&D Investments, S.A. | Substituted imidazo[1,2-a]pyridines, substituted imidazo[1,2-a]pyrazines, related compounds, and their use in the treatment of medical disorders |
| JP7058256B2 (ja) | 2016-07-14 | 2022-04-21 | ブリストル－マイヤーズ スクイブ カンパニー | 二環式ヘテロアリール置換化合物 |
| EP3484894B1 (en) | 2016-07-14 | 2020-08-19 | Bristol-Myers Squibb Company | Tricyclic heteroaryl-substituted quinoline and azaquinoline compounds as par4 inhibitors |
| ES2800313T3 (es) | 2016-07-14 | 2020-12-29 | Bristol Myers Squibb Co | Compuestos de heteroarilo bicíclico sustituidos |
| US11274107B2 (en) | 2016-12-22 | 2022-03-15 | Cadent Therapeutics, Inc. | NMDA receptor modulators and uses thereof |
| JP7269917B2 (ja) * | 2017-08-17 | 2023-05-09 | イケナ オンコロジー， インコーポレイテッド | Ａｈｒ阻害剤およびその使用 |
| WO2019057053A1 (zh) * | 2017-09-20 | 2019-03-28 | 北京加科思益新药研发有限公司 | 用作fgfr4抑制剂的稠环衍生物 |
| DK3749669T6 (da) | 2018-02-06 | 2024-11-18 | Ideaya Biosciences Inc | Ahr-modulatorer |
| ES2951872T3 (es) | 2018-08-03 | 2023-10-25 | Novartis Ag | Moduladores del receptor NMDA heteroaromáticos y usos de los mismos |
| CN113101295A (zh) * | 2020-03-20 | 2021-07-13 | 上海疆云医疗健康科技有限公司 | 二苯乙烯类似物在治疗糖尿病肾脏疾病中的用途 |
| US11730729B2 (en) | 2020-07-20 | 2023-08-22 | Neurodon Corporation | Quinolines that modulate SERCA and their use for treating disease |
| KR20230146012A (ko) * | 2021-02-09 | 2023-10-18 | 셀진 코포레이션 | 연충 감염 및 질병의 치료를 위한 설폰아미드 및 이들의용도 |
| CN112939955B (zh) * | 2021-03-05 | 2022-10-21 | 朗捷睿(苏州)生物科技有限公司 | 一种8-(吡啶酰胺)取代香豆素类化合物及其制备方法和应用 |
| TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Ｐｐａｒｇ反向激動劑及其用途 |
| WO2024026423A1 (en) * | 2022-07-27 | 2024-02-01 | Black Diamond Therapeutics, Inc. | Substituted quinoline derivatives as pi3k inhibitors |
Family Cites Families (50)
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| JPS5838449B2 (ja) * | 1979-04-17 | 1983-08-23 | カネボウ株式会社 | 微粉末状絹フィプロインの製造法 |
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-
2009
- 2009-04-30 SG SG2013032677A patent/SG190603A1/en unknown
- 2009-04-30 ES ES09739775.6T patent/ES2586459T3/es active Active
- 2009-04-30 CN CN200980125767.4A patent/CN102083438B/zh not_active Expired - Fee Related
- 2009-04-30 AU AU2009243006A patent/AU2009243006B2/en not_active Ceased
- 2009-04-30 KR KR1020107026866A patent/KR20110007235A/ko not_active Ceased
- 2009-04-30 BR BRPI0912356A patent/BRPI0912356A2/pt not_active IP Right Cessation
- 2009-04-30 MX MX2010012010A patent/MX2010012010A/es not_active Application Discontinuation
- 2009-04-30 CA CA2723135A patent/CA2723135A1/en not_active Abandoned
- 2009-04-30 WO PCT/US2009/042255 patent/WO2009134973A1/en not_active Ceased
- 2009-04-30 US US12/990,339 patent/US8685970B2/en not_active Expired - Fee Related
- 2009-04-30 EA EA201071263A patent/EA021938B1/ru not_active IP Right Cessation
- 2009-04-30 JP JP2011507632A patent/JP5425891B2/ja not_active Expired - Fee Related
- 2009-04-30 EP EP09739775.6A patent/EP2273992B1/en active Active
-
2010
- 2010-10-27 ZA ZA2010/07677A patent/ZA201007677B/en unknown
- 2010-10-28 IL IL208997A patent/IL208997A0/en unknown