EA021938B1 - Хинолины и их аналоги в качестве модуляторов сиртуина - Google Patents

Хинолины и их аналоги в качестве модуляторов сиртуина Download PDF

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EA021938B1
EA021938B1 EA201071263A EA201071263A EA021938B1 EA 021938 B1 EA021938 B1 EA 021938B1 EA 201071263 A EA201071263 A EA 201071263A EA 201071263 A EA201071263 A EA 201071263A EA 021938 B1 EA021938 B1 EA 021938B1
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EA
Eurasian Patent Office
Prior art keywords
alkyl
phenyl
carboxamide
quinoline
substituted
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EA201071263A
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English (en)
Russian (ru)
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EA201071263A1 (ru
Inventor
Чи Б. Ву
Джереми С. Диш
Стефани К. Спрингер
Чарльз А. Блум
Роберт Б. Перни
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Сертрис Фармасьютикалз, Инк.
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Publication of EA201071263A1 publication Critical patent/EA201071263A1/ru
Publication of EA021938B1 publication Critical patent/EA021938B1/ru

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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Animal Behavior & Ethology (AREA)
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  • Cardiology (AREA)
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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
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  • Psychiatry (AREA)
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  • Vascular Medicine (AREA)
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EA201071263A 2008-05-01 2009-04-30 Хинолины и их аналоги в качестве модуляторов сиртуина EA021938B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12611208P 2008-05-01 2008-05-01
PCT/US2009/042255 WO2009134973A1 (en) 2008-05-01 2009-04-30 Quenolines and related analogs as sirtuin modulators

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EA201071263A1 EA201071263A1 (ru) 2011-06-30
EA021938B1 true EA021938B1 (ru) 2015-10-30

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US (1) US8685970B2 (cg-RX-API-DMAC7.html)
EP (1) EP2273992B1 (cg-RX-API-DMAC7.html)
JP (1) JP5425891B2 (cg-RX-API-DMAC7.html)
KR (1) KR20110007235A (cg-RX-API-DMAC7.html)
CN (1) CN102083438B (cg-RX-API-DMAC7.html)
AU (1) AU2009243006B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0912356A2 (cg-RX-API-DMAC7.html)
CA (1) CA2723135A1 (cg-RX-API-DMAC7.html)
EA (1) EA021938B1 (cg-RX-API-DMAC7.html)
ES (1) ES2586459T3 (cg-RX-API-DMAC7.html)
IL (1) IL208997A0 (cg-RX-API-DMAC7.html)
MX (1) MX2010012010A (cg-RX-API-DMAC7.html)
SG (1) SG190603A1 (cg-RX-API-DMAC7.html)
WO (1) WO2009134973A1 (cg-RX-API-DMAC7.html)
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US11730729B2 (en) 2020-07-20 2023-08-22 Neurodon Corporation Quinolines that modulate SERCA and their use for treating disease
US11827626B2 (en) 2014-08-29 2023-11-28 Neurodon Corporation Quinolines that modulate SERCA and their use for treating disease

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MX2011000079A (es) 2008-07-03 2011-03-02 Sirtris Pharmaceuticals Inc Bencimidazoles y analogos relacionados como moduladores de sirtuin.
MX2011003373A (es) 2008-09-29 2011-06-09 Sirtris Pharmaceuticals Inc Quinazolinona, quinolona y analogos relacionados como moduladores de sirtuina.
CA2752150A1 (en) * 2009-02-11 2010-08-19 Reaction Biology Corp. Selective kinase inhibitors
MX2011009213A (es) * 2009-03-02 2011-12-14 Sirtris Pharmaceuticals Inc Quinolinas 8-sustituidas y analogos relacionados como moduladores de sirtuina.
MX2012004995A (es) 2009-10-29 2012-10-03 Sirtris Pharmaceuticals Inc Piridinas biciclicas y analogos como moduladores de sirtuina.
CN101723894B (zh) * 2009-12-03 2011-12-28 南京大学 N-喹啉酰胺类衍生物及其制法与用途
US20120214803A1 (en) * 2011-02-18 2012-08-23 Vifor (International) Ag Novel Sulfonaminoquinoline Hepcidin Antagonists
WO2012122534A2 (en) 2011-03-10 2012-09-13 The Trustees Of Columbia University In The City Of New York N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2870407A1 (en) * 2012-05-31 2013-12-05 F. Hoffmann-La Roche Ag Aminoquinazoline and pyridopyrimidine derivatives
CA2881279C (en) 2012-08-07 2020-07-07 Merck Patent Gmbh Pyridopyrimidine derivatives as protein kinase inhibitors
WO2016081692A2 (en) * 2014-11-19 2016-05-26 Glaxosmithkline Llc Substituted bridged urea analogs as sirtuin modulators
KR20160006215A (ko) 2013-05-13 2016-01-18 글락소스미스클라인 엘엘씨 시르투인 조절제로서의 치환된 가교 우레아 유사체
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