JP2011516064A5 - - Google Patents

Download PDF

Info

Publication number
JP2011516064A5
JP2011516064A5 JP2011502993A JP2011502993A JP2011516064A5 JP 2011516064 A5 JP2011516064 A5 JP 2011516064A5 JP 2011502993 A JP2011502993 A JP 2011502993A JP 2011502993 A JP2011502993 A JP 2011502993A JP 2011516064 A5 JP2011516064 A5 JP 2011516064A5
Authority
JP
Japan
Prior art keywords
nucleic acid
protein
well
cells
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011502993A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011516064A (ja
JP5749156B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/002122 external-priority patent/WO2009123762A2/en
Publication of JP2011516064A publication Critical patent/JP2011516064A/ja
Publication of JP2011516064A5 publication Critical patent/JP2011516064A5/ja
Application granted granted Critical
Publication of JP5749156B2 publication Critical patent/JP5749156B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011502993A 2008-04-05 2009-04-03 生理活性物質の生産のための単一細胞を選抜する方法 Active JP5749156B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US7298508P 2008-04-05 2008-04-05
US61/072,985 2008-04-05
US14157908P 2008-12-30 2008-12-30
US61/141,579 2008-12-30
PCT/US2009/002122 WO2009123762A2 (en) 2008-04-05 2009-04-03 Method of screening single cells for the production of biologically active agents

Publications (3)

Publication Number Publication Date
JP2011516064A JP2011516064A (ja) 2011-05-26
JP2011516064A5 true JP2011516064A5 (https=) 2012-05-24
JP5749156B2 JP5749156B2 (ja) 2015-07-15

Family

ID=41135895

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011502993A Active JP5749156B2 (ja) 2008-04-05 2009-04-03 生理活性物質の生産のための単一細胞を選抜する方法

Country Status (9)

Country Link
US (4) US8309035B2 (https=)
EP (1) EP2260112A4 (https=)
JP (1) JP5749156B2 (https=)
KR (1) KR101679869B1 (https=)
CN (1) CN102046809A (https=)
AU (1) AU2009232353B2 (https=)
BR (1) BRPI0906544A2 (https=)
CA (1) CA2720472C (https=)
WO (3) WO2009123762A2 (https=)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
CA3138078C (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US8309035B2 (en) * 2008-04-05 2012-11-13 Single Cell Technology, Inc. Multi-well system
WO2010040831A1 (en) * 2008-10-10 2010-04-15 Picovitro Ab Genetic analysis in microwells
US8569046B2 (en) * 2009-02-20 2013-10-29 Massachusetts Institute Of Technology Microarray with microchannels
SG174617A1 (en) 2009-04-02 2011-10-28 Fluidigm Corp Multi-primer amplification method for barcoding of target nucleic acids
GB2497912B (en) * 2010-10-08 2014-06-04 Harvard College High-throughput single cell barcoding
EP3582224B1 (en) 2010-12-30 2026-04-29 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
MX349288B (es) 2011-01-21 2017-07-21 Theranos Inc Sistemas y metodos para maximizacion de uso de muestras.
GB201106254D0 (en) * 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103732738A (zh) * 2011-04-28 2014-04-16 小利兰斯坦福大学托管委员会 与样品相关的多核苷酸的鉴定
SG10201605049QA (en) 2011-05-20 2016-07-28 Fluidigm Corp Nucleic acid encoding reactions
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
WO2013090404A2 (en) * 2011-12-13 2013-06-20 Single Cell Technology, Inc. Method of screening a plurality of single secreting cells for functional activity
US9701959B2 (en) 2012-02-02 2017-07-11 Invenra Inc. High throughput screen for biologically active polypeptides
US9646132B2 (en) 2012-05-11 2017-05-09 Life Technologies Corporation Models for analyzing data from sequencing-by-synthesis operations
UA118441C2 (uk) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Антитіло, що розпізнає альфа-синуклеїн
US9850302B2 (en) 2013-07-12 2017-12-26 Prothena Biosciences Limited Antibodies that recognize IAPP
WO2015004633A1 (en) 2013-07-12 2015-01-15 Neotope Biosciences Limited Antibodies that recognize islet-amyloid polypeptide (iapp)
TWI503172B (zh) * 2013-09-03 2015-10-11 Nat Univ Tsing Hua 量測組件
JP6303347B2 (ja) * 2013-09-11 2018-04-04 大日本印刷株式会社 検体画像管理システム及び検体画像管理プログラム
JP5583830B1 (ja) 2013-09-27 2014-09-03 日本瓦斯株式会社 Ｌｐガスメータの指針値入力チェックシステムおよび方法
CA2944402A1 (en) 2014-04-08 2015-10-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
JP2017527288A (ja) 2014-09-04 2017-09-21 セラノス， インコーポレイテッドＴｈｅｒａｎｏｓ， Ｉｎｃ． 病原体及び抗菌薬耐性試験
CN104561231B (zh) * 2015-01-23 2017-01-25 中国科学院重庆绿色智能技术研究院 一种测定浮游藻类细胞比增殖速率的方法
BR112017019906A2 (pt) * 2015-03-31 2018-06-12 Toray Industries, Inc. pedaço de análise
CN107810277B (zh) 2015-04-21 2021-11-02 通用自动化实验技术公司 用于高通量微生物学应用的高分辨率系统、试剂盒、设备和方法
CN108603224B (zh) 2015-12-16 2022-06-28 富鲁达公司 高水平多路复用扩增
EP4414484A3 (en) 2016-02-04 2025-01-15 Trianni, Inc. Enhanced production of immunoglobulins
EP3281701B1 (en) * 2016-08-10 2021-07-14 Roche Diagnostics GmbH Plate with wells for chemical or biological reactions, and method for multiple imaging of such a plate by means of an imaging system
EP3532600A4 (en) * 2016-10-19 2020-09-16 General Automation LAB Technologies Inc. HIGH RESOLUTION SYSTEMS, KITS, DEVICES AND METHODS FOR SCREENING MICRO-ORGANISMS AND OTHER HIGH-PERFORMANCE MICROBIOLOGICAL APPLICATIONS
US11473081B2 (en) 2016-12-12 2022-10-18 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
JP7208902B2 (ja) 2016-12-30 2023-01-19 エクセラ・バイオサイエンシーズ・インコーポレイテッド マルチステージサンプル回収システム
CN107219351A (zh) * 2017-06-08 2017-09-29 广东省生物资源应用研究所 一种基于单细胞芯片技术的抗体筛选方法
JP2019100940A (ja) * 2017-12-06 2019-06-24 東ソー株式会社 未分化細胞を高感度に検出および回収する方法
WO2019213254A1 (en) 2018-05-02 2019-11-07 The General Hospital Corporation High-resolution spatial macromolecule abundance assessment
US12116415B2 (en) 2018-10-09 2024-10-15 Single Cell Technology, Inc. Anti-BCMA antibodies
EP3890876B1 (en) 2018-12-06 2024-05-01 Xcella Biosciences, Inc. Lateral loading of microcapillary arrays
EP4157992A4 (en) * 2020-05-26 2024-07-31 Bio-Rad Laboratories, Inc. APPARATUS AND METHOD FOR RAPID DIGITAL DETECTION
EP4305190A4 (en) 2021-03-11 2025-03-26 Iggenix, Inc. METHODS AND SYSTEMS FOR PREDICTING AN ALLERGIC REACTION
CN113066539A (zh) * 2021-03-22 2021-07-02 上海商汤智能科技有限公司 预测方法及相关装置、设备

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4642284A (en) 1983-06-13 1987-02-10 Scripps Clinic And Research Foundation Method and system for detection of complement pathway activation
US4876194A (en) * 1986-07-22 1989-10-24 Hightech Receptor Ab Protein L and subfragments thereof, with immunoglobulin binding activity, a process for preparing thereof, reagent kit, pharmaceutical composition and a peptococcus magnus strain
US5110556A (en) 1986-10-28 1992-05-05 Costar Corporation Multi-well test plate
US5897475A (en) 1994-10-05 1999-04-27 Antex Biologics, Inc. Vaccines comprising enhanced antigenic helicobacter spp.
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5866330A (en) 1995-09-12 1999-02-02 The Johns Hopkins University School Of Medicine Method for serial analysis of gene expression
US7062219B2 (en) * 1997-01-31 2006-06-13 Odyssey Thera Inc. Protein fragment complementation assays for high-throughput and high-content screening
US6548263B1 (en) 1997-05-29 2003-04-15 Cellomics, Inc. Miniaturized cell array methods and apparatus for cell-based screening
JP4313861B2 (ja) * 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US6177282B1 (en) 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
EP1060022A1 (en) * 1998-02-04 2000-12-20 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
US6087103A (en) 1998-03-04 2000-07-11 Lifespan Biosciences, Inc. Tagged ligand arrays for identifying target-ligand interactions
US20030027214A1 (en) * 1999-02-17 2003-02-06 Kamb Carl Alexander Methods for substrate-ligand interaction screening
IL150291A0 (en) * 2000-01-11 2002-12-01 Maxygen Inc Integrated systems and methods for diversity generation and screening
US6818758B2 (en) * 2000-02-22 2004-11-16 Applera Corporation Estrogen receptor beta variants and methods of detection thereof
US6794141B2 (en) * 2000-12-22 2004-09-21 Arcturus Bioscience, Inc. Nucleic acid amplification
US6800453B2 (en) 2001-01-23 2004-10-05 President And Fellows Of Harvard College Nucleic-acid programmable protein arrays
US7299134B2 (en) 2001-02-16 2007-11-20 Bio-Rad Laboratories, Inc. Method for correlating gene expression profiles with protein expression profiles
CN1527720A (zh) 2001-05-11 2004-09-08 Ү³��ѧ 利用蛋白组芯片全面分析蛋白活性
WO2003016574A1 (en) 2001-08-16 2003-02-27 Zhifeng Shao Analysis of gene expression profiles using sequential hybridization
JP4754746B2 (ja) * 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
US20050142539A1 (en) 2002-01-14 2005-06-30 William Herman Targeted ligands
CN1617938A (zh) * 2002-01-16 2005-05-18 戴诺生物技术有限公司 从单个样品中分离核酸和蛋白质的方法
WO2004020973A2 (en) 2002-08-28 2004-03-11 Bionexus Ventures L.L.C. Screening for cell-targeting ligands attached to metal nanoshells for use in target-cell killing
JP3723882B2 (ja) * 2002-11-14 2005-12-07 篤 村口 抗原特異的リンパ球検出用マイクロウェルアレイチップ、抗原特異的リンパ球の検出法及び製造方法
AU2003266712A1 (en) * 2002-11-14 2004-06-23 Hiroyuki Kishi Microwell array chip for detecting antigen-specific lymphocyte, method of detecting antigen-specific lymphocyte and method of cloning antigen-specific lymphocyte antigen receptor gene
JP3738308B2 (ja) * 2002-11-29 2006-01-25 篤 村口 抗原特異的リンパ球抗原受容体遺伝子のクローニング方法
US8574590B2 (en) 2003-07-30 2013-11-05 Integral Molecular, Inc. Lipoparticles comprising proteins, methods of making, and using the same
US20060223194A1 (en) * 2005-04-01 2006-10-05 Viorica Lopez-Avila Methods of screening for post-translationally modified proteins
EP1891240A4 (en) * 2005-06-03 2010-04-21 David E Kohne METHOD FOR GENERATING IMPROVED GENE EXPRESSION ANALYSIS AND GENE EXPRESSION ANALYSIS COMPARISON TEST RESULTS
WO2007035633A2 (en) 2005-09-16 2007-03-29 President & Fellows Of Harvard College Screening assays and methods
US20090306342A1 (en) * 2005-12-30 2009-12-10 Bio-Layer Pty Limited Binding of molecules
US8021877B2 (en) * 2006-04-10 2011-09-20 Massachusetts Institute Of Technology Particle patterning chip
US20080004185A1 (en) * 2006-06-12 2008-01-03 Antara Biosciences Inc. Three dimensional array
WO2007147079A2 (en) * 2006-06-14 2007-12-21 Living Microsystems, Inc. Rare cell analysis using sample splitting and dna tags
US20080090239A1 (en) 2006-06-14 2008-04-17 Daniel Shoemaker Rare cell analysis using sample splitting and dna tags
WO2008093098A2 (en) * 2007-02-02 2008-08-07 Illumina Cambridge Limited Methods for indexing samples and sequencing multiple nucleotide templates
CA3138078C (en) * 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US8304245B2 (en) 2007-11-02 2012-11-06 Children's Hospital And Research Center At Oakland Microfluidic flow lysometer device, system and method
US8309035B2 (en) * 2008-04-05 2012-11-13 Single Cell Technology, Inc. Multi-well system
AR082785A1 (es) * 2010-08-30 2013-01-09 Agrigenetics Inc Plataforma de activacion por marcado para genes de maiz y poblaciones y plantas marcadas resultantes

Similar Documents

Publication Publication Date Title
JP2011516064A5 (https=)
CA2720472C (en) Method of screening single cells for the production of biologically active agents
Zykovich et al. Bind-n-Seq: high-throughput analysis of in vitro protein–DNA interactions using massively parallel sequencing
Acevedo et al. Genome-scale ChIP-chip analysis using 10,000 human cells
US8666670B1 (en) Computational methods for transcription factor binding site analysis
JP2020504709A (ja) 制御された化学量論を有するポリヌクレオチドライブラリおよびその合成
CN107750361A (zh) 关系dna操作
Knapp et al. Generating barcoded libraries for multiplex high-throughput sequencing
CN109923216A (zh) 将生物分子的检测组合到使用荧光原位测序的单个试验的方法
JP2013509878A5 (https=)
CN113308562A (zh) 棉花全基因组40k单核苷酸位点及其在棉花基因分型中的应用
Chen et al. Single-cell and spatially resolved omics: advances and limitations
JP2014521316A5 (https=)
RU2014102617A (ru) Выявление аффинно-зрелых человеческих антител
Henikoff et al. In situ tools for chromatin structural epigenomics
Tickle et al. High-throughput screening for high affinity antibodies
Chuang et al. Single-cell sequencing of full-length transcripts and T-cell receptors with automated high-throughput Smart-seq3
US20250154570A1 (en) Materials and methods for large-scale spatial transcriptomics
WO2023081863A1 (en) Methods and compositions for molecular interaction mapping using transposase
Kim et al. ChIP‐chip for genome‐wide analysis of protein binding in mammalian cells
Tur et al. Cell fate decision in erythropoiesis: Insights from multiomics studies
Patil et al. A developmentally regulated deletion element with long terminal repeats has cis-acting sequences in the flanking DNA
Horns et al. Cloning antibodies from single cells in pooled sequence libraries by selective PCR
Odom Identification of transcription factor–DNA interactions in vivo
Russo et al. A scalable, low-cost, sample hashing workflow for multiomic single-cell analysis using the Seq-Well S3 platform