JP2013509878A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013509878A5 JP2013509878A5 JP2012537966A JP2012537966A JP2013509878A5 JP 2013509878 A5 JP2013509878 A5 JP 2013509878A5 JP 2012537966 A JP2012537966 A JP 2012537966A JP 2012537966 A JP2012537966 A JP 2012537966A JP 2013509878 A5 JP2013509878 A5 JP 2013509878A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- antigen
- acid sequence
- binding substance
- acid sequences
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25845709P | 2009-11-05 | 2009-11-05 | |
| US61/258,457 | 2009-11-05 | ||
| PCT/US2010/055290 WO2011056864A1 (en) | 2009-11-05 | 2010-11-03 | Methods of generating improved antigen-binding agents using chain shuffling and optionally somatic hypermutation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013509878A JP2013509878A (ja) | 2013-03-21 |
| JP2013509878A5 true JP2013509878A5 (https=) | 2013-12-12 |
Family
ID=43970313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012537966A Pending JP2013509878A (ja) | 2009-11-05 | 2010-11-03 | 鎖シャフリングおよび任意に体細胞超変異を用いる、改善された抗原結合物質の生成方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20120251552A1 (https=) |
| EP (1) | EP2496706A4 (https=) |
| JP (1) | JP2013509878A (https=) |
| WO (1) | WO2011056864A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012000536A2 (pt) | 2009-07-08 | 2020-08-11 | Kymab Limited | métodos para produção de anticorpo ou cadeia leve ou pesada de anticorpo específico para um antígeno desejado, para produção de anticorpo ou cadeia de anticorpo e seu uso, composição farmacêutica e derivado de anticorpo quimérico |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| BR112013002831A2 (pt) | 2010-08-05 | 2016-11-01 | Anaptysbio Inc | anticorpos direcionados contra a il-17 |
| BR112014006394A2 (pt) | 2011-09-19 | 2017-03-28 | Kymab Ltd | manipulação de diversidade genética de imunoglobulina e terapêuticos multi-anticorpos |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) * | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| TWI619727B (zh) * | 2013-02-27 | 2018-04-01 | 中央研究院 | 抗體之原位親和力成熟作用 |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| AU2014296253A1 (en) | 2013-07-30 | 2016-02-04 | President And Fellows Of Harvard College | Quantitative DNA-based imaging and super-resolution imaging |
| DE112014004537T5 (de) | 2013-10-01 | 2016-07-21 | Kymab Limited | Tiermodelle und therapeutische Moleküle |
| CN118185874A (zh) * | 2016-04-04 | 2024-06-14 | 苏黎世联邦理工学院 | 一种重组哺乳动物b细胞 |
| CA3214281A1 (en) * | 2021-03-19 | 2022-09-22 | Elpis Biopharmaceuticals | Antibodies specific to sialic acid-binding ig-like lectin 15 and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5855885A (en) * | 1993-01-22 | 1999-01-05 | Smith; Rodger | Isolation and production of catalytic antibodies using phage technology |
| US7094571B2 (en) * | 2000-10-27 | 2006-08-22 | The Board Of Regents Of The University Of Texas System | Combinatorial protein library screening by periplasmic expression |
| US20040156832A1 (en) * | 2002-09-30 | 2004-08-12 | Centec Limited | Immunoglobulin compositions and methods |
| US7604994B2 (en) * | 2003-09-03 | 2009-10-20 | Morphotek, Inc. | Genetically altered antibody-producing cell lines with improved antibody characteristics |
| BRPI0807952A2 (pt) * | 2007-02-20 | 2014-06-10 | Anaptysbio Inc | Sistemas de hipermutação somática |
-
2010
- 2010-11-03 WO PCT/US2010/055290 patent/WO2011056864A1/en not_active Ceased
- 2010-11-03 EP EP10829021.4A patent/EP2496706A4/en not_active Withdrawn
- 2010-11-03 US US13/505,535 patent/US20120251552A1/en not_active Abandoned
- 2010-11-03 JP JP2012537966A patent/JP2013509878A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013509878A5 (https=) | ||
| Saeed et al. | Antibody engineering for pursuing a healthier future | |
| Bowers et al. | Mammalian cell display for the discovery and optimization of antibody therapeutics | |
| US11629434B2 (en) | Antibody screening methods | |
| JP2012518390A5 (https=) | ||
| JP2012143232A5 (https=) | ||
| JP7628153B2 (ja) | ｍＲＮＡディスプレイ抗体ライブラリー及び方法 | |
| US20130288900A1 (en) | Combinatorial libraries of conformationally constrained polypeptide sequences | |
| US20190002558A1 (en) | Compositions and methods for the identification and isolation of cell-membrane protein specific binding moieties | |
| ES2822159T3 (es) | Método para generar una biblioteca de anticuerpos sin exposición previa al antígeno, dicha biblioteca y la(s) aplicación(ones) de la misma | |
| JP2019068837A (ja) | 標的分子に結合するポリペプチドの決定方法及び決定システム | |
| Ferrara et al. | Specific binder for Lightning-Link® biotinylated proteins from an antibody phage library | |
| Horns et al. | Cloning antibodies from single cells in pooled sequence libraries by selective PCR | |
| Schofield et al. | Genetic methods of antibody generation and their use in immunohistochemistry | |
| Mössner et al. | Directed evolution with fast and efficient selection technologies | |
| Umetsu et al. | Protein–protein interactions and selection: generation of molecule‐binding proteins on the basis of tertiary structural information | |
| Clements | Building systems for generating potent, de novo antibodies using autonomous hypermutation and surface display in yeast | |
| Sasso et al. | Research Article One-Step Recovery of scFv Clones from High-Throughput Sequencing-Based Screening of Phage Display Libraries Challenged to Cells Expressing Native Claudin-1 | |
| Tiller | Synthetic Antibodies | |
| HK40047350A (en) | Antibody screening methods | |
| HK40047350B (en) | Antibody screening methods | |
| Benhar | Combinatorial Libraries of Arrayable Single-Chain Antibodies |