JP2011513431A5 - - Google Patents

Info

Publication number

JP2011513431A5

JP2011513431A5 JP2010549910A JP2010549910A JP2011513431A5 JP 2011513431 A5 JP2011513431 A5 JP 2011513431A5 JP 2010549910 A JP2010549910 A JP 2010549910A JP 2010549910 A JP2010549910 A JP 2010549910A JP 2011513431 A5 JP2011513431 A5 JP 2011513431A5

Authority

JP

Japan

Prior art keywords

phenyl

compound

cyano

acceptable salt

group

Prior art date

2009-03-06

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• -1 2 -n- hexyl Chemical group 0.000 claims 14
• 150000001875 compounds Chemical class 0.000 claims 13
• 150000003839 salts Chemical class 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 2
• 125000001424 substituent group Chemical group 0.000 claims 2
• DLIDOWKXQKFZIN-IKABJYOBSA-N (2s)-2-[[(3s)-7-benzoyl-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-oxo-1,6,8,9-tetrahydropyrido[4,3-g][1,4]benzoxazine-8-carbonyl]amino]-3-[4-(4-cyanophenyl)phenyl]propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)C1N(CC2=CC=3O[C@H](C(=O)NC=3C=C2C1)C=1C=CC(OCC=2C=C(Cl)C(Cl)=CC=2)=CC=1)C(=O)C=1C=CC=CC=1)C(C=C1)=CC=C1C1=CC=C(C#N)C=C1 DLIDOWKXQKFZIN-IKABJYOBSA-N 0.000 claims 1
• WWEDIOLJVSBYRU-IKABJYOBSA-N (2s)-3-[4-(4-cyanophenyl)phenyl]-2-[[(3s)-3-[4-[(3,4-dichlorophenyl)methoxy]phenyl]-2-oxo-7-(pyridin-2-ylmethyl)-1,6,8,9-tetrahydropyrido[4,3-g][1,4]benzoxazine-8-carbonyl]amino]propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)C1N(CC2=CC=3O[C@H](C(=O)NC=3C=C2C1)C=1C=CC(OCC=2C=C(Cl)C(Cl)=CC=2)=CC=1)CC=1N=CC=CC=1)C(C=C1)=CC=C1C1=CC=C(C#N)C=C1 WWEDIOLJVSBYRU-IKABJYOBSA-N 0.000 claims 1
• 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
• 125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 125000004093 cyano group Chemical group *C#N 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
• 0 *C(*)N(*)C(C(Cc1c2)N(*)Cc1cc(OC1*)c2N(*)C1=O)=O Chemical compound *C(*)N(*)C(C(Cc1c2)N(*)Cc1cc(OC1*)c2N(*)C1=O)=O 0.000 description 1