JP5382952B2 - 糖尿病の治療のためのオキサジアゾアントラセン化合物 - Google Patents
糖尿病の治療のためのオキサジアゾアントラセン化合物 Download PDFInfo
- Publication number
- JP5382952B2 JP5382952B2 JP2010549910A JP2010549910A JP5382952B2 JP 5382952 B2 JP5382952 B2 JP 5382952B2 JP 2010549910 A JP2010549910 A JP 2010549910A JP 2010549910 A JP2010549910 A JP 2010549910A JP 5382952 B2 JP5382952 B2 JP 5382952B2
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- JP
- Japan
- Prior art keywords
- phenyl
- oxo
- diaza
- hexahydro
- oxa
- Prior art date
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- 0 *C(*)N(*)C(C(Cc1c2)N(*)Cc1cc(OC1*)c2N(*)C1=O)=O Chemical compound *C(*)N(*)C(C(Cc1c2)N(*)Cc1cc(OC1*)c2N(*)C1=O)=O 0.000 description 5
- VQFUQWSLCGKJHB-LLNQOWJMSA-N CC(C)(C)OC(N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2NC3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O)=O Chemical compound CC(C)(C)OC(N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2NC3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O)=O VQFUQWSLCGKJHB-LLNQOWJMSA-N 0.000 description 1
- WPZBDQDSVIYYQE-PXWFVKLRSA-N CC(C)C(CC[C@@H](C)C1)[C@@H]1OC(C(Cc1c2)NCc1cc(O[C@@H]1c(cc3)ccc3OCc(cc3Cl)ccc3Cl)c2N(C)C1=O)=O Chemical compound CC(C)C(CC[C@@H](C)C1)[C@@H]1OC(C(Cc1c2)NCc1cc(O[C@@H]1c(cc3)ccc3OCc(cc3Cl)ccc3Cl)c2N(C)C1=O)=O WPZBDQDSVIYYQE-PXWFVKLRSA-N 0.000 description 1
- DXDOGYTXQVLEDW-FZIDKRJVSA-N CC(C)c1c(CN(Cc(c(C2)c3)cc(OC4c(cc5)ccc5OCc(cc5Cl)ccc5Cl)c3N(C)C4=O)C2C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)cccc1 Chemical compound CC(C)c1c(CN(Cc(c(C2)c3)cc(OC4c(cc5)ccc5OCc(cc5Cl)ccc5Cl)c3N(C)C4=O)C2C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)cccc1 DXDOGYTXQVLEDW-FZIDKRJVSA-N 0.000 description 1
- UQYVUBICGBEPLT-OOICUZEHSA-N CCC(c1ccccc1)N(Cc(c(C1)c2)cc(O[C@@H]3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2N(C)C3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(OC)=O)=O Chemical compound CCC(c1ccccc1)N(Cc(c(C1)c2)cc(O[C@@H]3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2N(C)C3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(OC)=O)=O UQYVUBICGBEPLT-OOICUZEHSA-N 0.000 description 1
- QQDMVOWSULYZTD-HFGJLVPKSA-N CC[C@@H](c1ccccc1)N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2N(C)C3=O)[C@@H]1C(N[C@@](C)(Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O Chemical compound CC[C@@H](c1ccccc1)N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2N(C)C3=O)[C@@H]1C(N[C@@](C)(Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O QQDMVOWSULYZTD-HFGJLVPKSA-N 0.000 description 1
- ZXJQFMYVTDGFTB-WWAORTSFSA-N CC[C@@H](c1ccccc1)N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4Cl)ccc4Cl)c2N(C)C3=O)[C@@H]1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O Chemical compound CC[C@@H](c1ccccc1)N(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4Cl)ccc4Cl)c2N(C)C3=O)[C@@H]1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O ZXJQFMYVTDGFTB-WWAORTSFSA-N 0.000 description 1
- AGPUINSRNKXTIU-JWLVZHBKSA-N CN1c(cc(CC(C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)N(CC2(CCCC2)c2ccccc2)C2)c2c2)c2OC(c(cc2)ccc2OCc(cc2Cl)ccc2Cl)C1=O Chemical compound CN1c(cc(CC(C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)N(CC2(CCCC2)c2ccccc2)C2)c2c2)c2OC(c(cc2)ccc2OCc(cc2Cl)ccc2Cl)C1=O AGPUINSRNKXTIU-JWLVZHBKSA-N 0.000 description 1
- YKJKZJCVIAUGMO-VOOFDKNSSA-N Cc1ccccc1CN(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2NC3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O Chemical compound Cc1ccccc1CN(Cc(c(C1)c2)cc(OC3c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c2NC3=O)C1C(N[C@@H](Cc(cc1)ccc1-c(cc1)ccc1C#N)C(O)=O)=O YKJKZJCVIAUGMO-VOOFDKNSSA-N 0.000 description 1
- KKOKPMHWXQRCPJ-SYVAAPJHSA-N Cc1nc(CN(Cc(c(C2)c3)cc(OC4c(cc5)ccc5OCc(cc5Cl)ccc5Cl)c3NC4=O)C2C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)ccc1 Chemical compound Cc1nc(CN(Cc(c(C2)c3)cc(OC4c(cc5)ccc5OCc(cc5Cl)ccc5Cl)c3NC4=O)C2C(N[C@@H](Cc(cc2)ccc2-c(cc2)ccc2C#N)C(O)=O)=O)ccc1 KKOKPMHWXQRCPJ-SYVAAPJHSA-N 0.000 description 1
- WDTULTZQNLWSEA-PMFORLRSSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc(cc3)Cl)c3Cl)C4=O)N2C(c2ccccc2)=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc(cc3)Cl)c3Cl)C4=O)N2C(c2ccccc2)=O)=O)cc1 WDTULTZQNLWSEA-PMFORLRSSA-N 0.000 description 1
- GCDDSNQSDDTDTE-CWYXMSDZSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3)cc(Cl)c3Cl)C4=O)N2C(OC2CCOCC2)=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3)cc(Cl)c3Cl)C4=O)N2C(OC2CCOCC2)=O)=O)cc1 GCDDSNQSDDTDTE-CWYXMSDZSA-N 0.000 description 1
- OCWQIIPVLBQVEG-BGLVMXALSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3)cc(Cl)c3Cl)C4=O)N2C(OCC2CC2)=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3)cc(Cl)c3Cl)C4=O)N2C(OCC2CC2)=O)=O)cc1 OCWQIIPVLBQVEG-BGLVMXALSA-N 0.000 description 1
- LMKQATDQANPVME-BJLGZMSWSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3Cl)ccc3Cl)C4=O)N2S(c(cccc2)c2[N+]([O-])=O)(=O)=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc(c(C2)c3)cc(N4)c3OC(c(cc3)ccc3OCc(cc3Cl)ccc3Cl)C4=O)N2S(c(cccc2)c2[N+]([O-])=O)(=O)=O)=O)cc1 LMKQATDQANPVME-BJLGZMSWSA-N 0.000 description 1
- SIOLMVPINQYTKK-VOOFDKNSSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc2c3)N(Cc4ccccc4C#N)Cc2cc(OC2c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c3NC2=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc2c3)N(Cc4ccccc4C#N)Cc2cc(OC2c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c3NC2=O)=O)cc1 SIOLMVPINQYTKK-VOOFDKNSSA-N 0.000 description 1
- WWEDIOLJVSBYRU-PMFORLRSSA-N N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc2c3)N(Cc4ccccn4)Cc2cc(OC2c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c3NC2=O)=O)cc1 Chemical compound N#Cc(cc1)ccc1-c1ccc(C[C@@H](C(O)=O)NC(C(Cc2c3)N(Cc4ccccn4)Cc2cc(OC2c(cc4)ccc4OCc(cc4)cc(Cl)c4Cl)c3NC2=O)=O)cc1 WWEDIOLJVSBYRU-PMFORLRSSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3459908P | 2008-03-07 | 2008-03-07 | |
| US61/034,599 | 2008-03-07 | ||
| PCT/US2009/036333 WO2009111700A2 (en) | 2008-03-07 | 2009-03-06 | Oxadiazoanthracene compounds for the treatment of diabetes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011513431A JP2011513431A (ja) | 2011-04-28 |
| JP2011513431A5 JP2011513431A5 (https=) | 2013-02-14 |
| JP5382952B2 true JP5382952B2 (ja) | 2014-01-08 |
Family
ID=41056666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010549910A Active JP5382952B2 (ja) | 2008-03-07 | 2009-03-06 | 糖尿病の治療のためのオキサジアゾアントラセン化合物 |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US7727983B2 (https=) |
| EP (1) | EP2262364B1 (https=) |
| JP (1) | JP5382952B2 (https=) |
| KR (1) | KR101616737B1 (https=) |
| CN (1) | CN101959405B (https=) |
| AU (1) | AU2009221722B2 (https=) |
| BR (1) | BRPI0910282A2 (https=) |
| CA (1) | CA2716664C (https=) |
| DK (1) | DK2262364T3 (https=) |
| EA (1) | EA018225B1 (https=) |
| ES (1) | ES2567451T3 (https=) |
| IL (1) | IL207570A (https=) |
| MA (1) | MA32175B1 (https=) |
| MX (1) | MX2010009752A (https=) |
| NZ (1) | NZ587343A (https=) |
| WO (1) | WO2009111700A2 (https=) |
| ZA (1) | ZA201006367B (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7727983B2 (en) | 2008-03-07 | 2010-06-01 | Transtech Pharma, Inc. | Oxadiazoanthracene compounds for the treatment of diabetes |
| JP5755217B2 (ja) * | 2009-03-30 | 2015-07-29 | トランステック・ファーマ，エルエルシー | 置換アゾアントラセン誘導体、その医薬組成物とその使用の方法 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| DE102010015123A1 (de) | 2010-04-16 | 2011-10-20 | Sanofi-Aventis Deutschland Gmbh | Benzylamidische Diphenylazetidinone, diese Verbindungen enthaltende Arzneimittel und deren Verwendung |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| MX2013006768A (es) | 2010-12-23 | 2013-07-22 | Pfizer | Moduladores de receptor de glucagon. |
| WO2012096824A1 (en) | 2011-01-12 | 2012-07-19 | Transtech Pharma, Inc. | Phenylglyoxylic acid derivatives and their preparation and use |
| HRP20161177T1 (hr) | 2011-02-08 | 2016-11-04 | Pfizer Inc. | Modulator glukagonskog receptora |
| AU2012288493B2 (en) | 2011-07-22 | 2015-08-06 | Pfizer Inc. | Quinolinyl glucagon receptor modulators |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EA201491749A1 (ru) * | 2012-03-22 | 2015-01-30 | ТРАНСТЕК ФАРМА, ЭлЭлСи | Трис-(гидроксиметил)аминометановые соли низкомолекулярного агониста glp1r, их фармацевтические композиции и применение |
| WO2014064215A1 (en) | 2012-10-24 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | TPL2 KINASE INHIBITORS FOR PREVENTING OR TREATING DIABETES AND FOR PROMOTING β-CELL SURVIVAL |
| SG10201704716XA (en) * | 2013-01-17 | 2017-07-28 | Vtv Therapeutics Llc | Combinations Of A GLP1R Agonist And Metformin And Use Thereof For The Treatment Of Type 2 Diabetes And Other Disorders |
| EP3172199B1 (en) * | 2014-07-25 | 2020-07-01 | Celgene International II Sarl | Pyrimidine derivatives as glp-1 receptor modulators |
| US10426818B2 (en) | 2015-03-24 | 2019-10-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Method and pharmaceutical composition for use in the treatment of diabetes |
| JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
| WO2019103060A1 (ja) * | 2017-11-22 | 2019-05-31 | 第一三共株式会社 | 縮合三環化合物 |
| EP3790549A1 (en) | 2018-05-08 | 2021-03-17 | vTv Therapeutics LLC | Therapeutic uses of glp1r agonists |
| CR20210341A (es) | 2018-11-22 | 2021-11-25 | Qilu Regor Therapeutics Inc | Agonistas de glp-ir y usos de los mismos |
| AU2020256647B2 (en) * | 2019-04-12 | 2025-07-31 | Qilu Regor Therapeutics Inc. | GLP-1R agonists and uses thereof |
| CA3157525A1 (en) | 2019-10-25 | 2021-04-29 | Gilead Sciences, Inc. | Glp-1r modulating compounds |
| US12459954B2 (en) | 2020-04-01 | 2025-11-04 | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Crystalline form a of GLP-1 receptor agonist and preparation method therefor |
| WO2021196951A1 (zh) | 2020-04-01 | 2021-10-07 | 杭州中美华东制药有限公司 | Glp-1受体激动剂游离碱的药学上可接受的酸式盐及其制备方法 |
| TW202144340A (zh) | 2020-04-03 | 2021-12-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用 |
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| JPS6345270A (ja) * | 1986-02-11 | 1988-02-26 | Takeda Chem Ind Ltd | １，４−ベンゾオキサジン誘導体，その製造法およびそれを含有する医薬用組成物 |
| EP0233728A1 (en) * | 1986-02-11 | 1987-08-26 | Takeda Chemical Industries, Ltd. | 1,4-Benzoxazine derivatives their production and use |
| CA2233888A1 (en) * | 1995-10-06 | 1997-04-10 | Ligand Pharmaceuticals Incorporated | Dimer-selective rxr modulators and methods for their use |
| JP2002534512A (ja) * | 1999-01-15 | 2002-10-15 | ノボ ノルディスク アクティーゼルスカブ | 非ペプチドｇｌｐ−１アゴニスト |
| EP1236719A4 (en) * | 1999-12-03 | 2003-06-25 | Kyoto Pharma Ind | NOVEL HETEROCYCLIC COMPOUNDS AND SALTS THEREOF, USE OF THESE COMPOUNDS IN MEDICINE |
| EP1125925A1 (en) | 2000-02-15 | 2001-08-22 | Applied Research Systems ARS Holding N.V. | Amine derivatives for the treatment of apoptosis |
| US20050222036A1 (en) | 2000-08-24 | 2005-10-06 | Thomas Jefferson University | Peptide compositions with effects on blood glucose |
| MXPA05010137A (es) * | 2003-03-26 | 2005-11-16 | Actelion Pharmaceuticals Ltd | Derivados de tetrahidroisoquinolil acetamida para usarse como antagonistas del receptor de orexina. |
| US7727983B2 (en) * | 2008-03-07 | 2010-06-01 | Transtech Pharma, Inc. | Oxadiazoanthracene compounds for the treatment of diabetes |
| US8501982B2 (en) | 2010-06-09 | 2013-08-06 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
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