CA2716664C - Oxadiazoanthracene compounds - Google Patents

Oxadiazoanthracene compounds Download PDF

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Publication number
CA2716664C
CA2716664C CA2716664A CA2716664A CA2716664C CA 2716664 C CA2716664 C CA 2716664C CA 2716664 A CA2716664 A CA 2716664A CA 2716664 A CA2716664 A CA 2716664A CA 2716664 C CA2716664 C CA 2716664C
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CA
Canada
Prior art keywords
oxo
diaza
oxa
anthracene
hexahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2716664A
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English (en)
French (fr)
Other versions
CA2716664A1 (en
Inventor
Adnan M.M. Mjalli
Dharma Rao Polisetti
Thomas Scott Yokum
Kalpathy Santhosh
Mustafa Guzel
Christopher Behme
Stephen Thomas Davis
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vTv Therapeutics LLC
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vTv Therapeutics LLC
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Publication date
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Publication of CA2716664A1 publication Critical patent/CA2716664A1/en
Application granted granted Critical
Publication of CA2716664C publication Critical patent/CA2716664C/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA2716664A 2008-03-07 2009-03-06 Oxadiazoanthracene compounds Active CA2716664C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3459908P 2008-03-07 2008-03-07
US61/034,599 2008-03-07
PCT/US2009/036333 WO2009111700A2 (en) 2008-03-07 2009-03-06 Oxadiazoanthracene compounds for the treatment of diabetes

Publications (2)

Publication Number Publication Date
CA2716664A1 CA2716664A1 (en) 2009-09-11
CA2716664C true CA2716664C (en) 2016-10-11

Family

ID=41056666

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2716664A Active CA2716664C (en) 2008-03-07 2009-03-06 Oxadiazoanthracene compounds

Country Status (17)

Country Link
US (7) US7727983B2 (https=)
EP (1) EP2262364B1 (https=)
JP (1) JP5382952B2 (https=)
KR (1) KR101616737B1 (https=)
CN (1) CN101959405B (https=)
AU (1) AU2009221722B2 (https=)
BR (1) BRPI0910282A2 (https=)
CA (1) CA2716664C (https=)
DK (1) DK2262364T3 (https=)
EA (1) EA018225B1 (https=)
ES (1) ES2567451T3 (https=)
IL (1) IL207570A (https=)
MA (1) MA32175B1 (https=)
MX (1) MX2010009752A (https=)
NZ (1) NZ587343A (https=)
WO (1) WO2009111700A2 (https=)
ZA (1) ZA201006367B (https=)

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WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
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US10426818B2 (en) 2015-03-24 2019-10-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Method and pharmaceutical composition for use in the treatment of diabetes
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JP2023528726A (ja) 2020-04-01 2023-07-06 ハンジョウ ジョンメイ フアドン ファーマシューティカル シーオー．，エルティーディー． Ｇｌｐ１ｒアゴニスト遊離塩基の薬学的に許容される酸塩類およびその調製法
TW202144340A (zh) 2020-04-03 2021-12-01 大陸商江蘇恆瑞醫藥股份有限公司 稠合咪唑類衍生物、其製備方法及其在醫藥上的應用
TW202210461A (zh) * 2020-05-28 2022-03-16 中國大陸商杭州中美華東製藥有限公司 一種（ｓ）—２—胺基—３—（４—（２，３—二甲基吡啶—４—基）苯基）丙酸甲酯二酸鹽的製備方法
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Also Published As

Publication number Publication date
MX2010009752A (es) 2010-09-30
EP2262364A4 (en) 2012-04-04
US9120813B2 (en) 2015-09-01
AU2009221722A1 (en) 2009-09-11
EP2262364B1 (en) 2016-03-02
EP2262364A2 (en) 2010-12-22
BRPI0910282A2 (pt) 2015-09-01
JP5382952B2 (ja) 2014-01-08
CN101959405B (zh) 2014-07-02
HK1148435A1 (en) 2011-09-09
US7906507B2 (en) 2011-03-15
NZ587343A (en) 2012-05-25
US8703766B2 (en) 2014-04-22
US20140187769A1 (en) 2014-07-03
WO2009111700A2 (en) 2009-09-11
MA32175B1 (fr) 2011-03-01
US20110039837A1 (en) 2011-02-17
US20100197677A1 (en) 2010-08-05
AU2009221722B2 (en) 2014-12-18
CA2716664A1 (en) 2009-09-11
IL207570A (en) 2014-03-31
US20090306063A1 (en) 2009-12-10
KR101616737B1 (ko) 2016-05-02
CN101959405A (zh) 2011-01-26
KR20100131455A (ko) 2010-12-15
US7727983B2 (en) 2010-06-01
US20100324033A1 (en) 2010-12-23
WO2009111700A3 (en) 2010-03-04
IL207570A0 (en) 2010-12-30
US20150087640A1 (en) 2015-03-26
DK2262364T3 (en) 2016-03-21
ZA201006367B (en) 2011-05-25
US7790714B2 (en) 2010-09-07
US8933222B2 (en) 2015-01-13
EA201071045A1 (ru) 2011-02-28
ES2567451T3 (es) 2016-04-22
JP2011513431A (ja) 2011-04-28
US8524708B2 (en) 2013-09-03
US20130317015A1 (en) 2013-11-28
EA018225B1 (ru) 2013-06-28

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