JP2011511806A5 - - Google Patents
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- JP2011511806A5 JP2011511806A5 JP2010546093A JP2010546093A JP2011511806A5 JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5 JP 2010546093 A JP2010546093 A JP 2010546093A JP 2010546093 A JP2010546093 A JP 2010546093A JP 2011511806 A5 JP2011511806 A5 JP 2011511806A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- moiety
- atoms
- haloalkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* Chemical compound *c1nc(c(*=C)c(*)c(*)c2*)c2[n]1* 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2703208P | 2008-02-07 | 2008-02-07 | |
| PCT/US2009/033569 WO2009100438A2 (en) | 2008-02-07 | 2009-02-09 | Compounds that enhance atoh-1 expression |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Division JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Atoh1発現を増強する化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511806A JP2011511806A (ja) | 2011-04-14 |
| JP2011511806A5 true JP2011511806A5 (enExample) | 2012-03-29 |
Family
ID=40408118
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546093A Ceased JP2011511806A (ja) | 2008-02-07 | 2009-02-09 | Atoh1発現を増強する化合物 |
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Atoh1発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Atoh1発現を増強する化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014087579A Expired - Fee Related JP5749829B2 (ja) | 2008-02-07 | 2014-04-21 | Atoh1発現を増強する化合物 |
| JP2015099316A Expired - Fee Related JP6199340B2 (ja) | 2008-02-07 | 2015-05-14 | Atoh1発現を増強する化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US8188131B2 (enExample) |
| EP (2) | EP2254572B1 (enExample) |
| JP (3) | JP2011511806A (enExample) |
| CN (1) | CN101990433B (enExample) |
| AU (1) | AU2009212135B2 (enExample) |
| CA (1) | CA2714370C (enExample) |
| WO (1) | WO2009100438A2 (enExample) |
Families Citing this family (68)
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| EP2094836B1 (en) | 2006-11-15 | 2016-06-08 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| EP2786993B1 (en) | 2007-08-13 | 2017-11-15 | Monsanto Technology LLC | Compositions and methods for controlling nematodes |
| AU2009212135B2 (en) | 2008-02-07 | 2014-08-21 | Massachusetts Eye & Ear Infirmary | Compounds that enhance Atoh-1 expression |
| CN110194765A (zh) | 2009-02-10 | 2019-09-03 | 孟山都技术有限公司 | 用于控制线虫的组合物和方法 |
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| ES2574253T3 (es) | 2009-12-18 | 2016-06-16 | Mitsubishi Tanabe Pharma Corporation | Nuevo agente antiplaquetario |
| EP2560966B1 (en) * | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
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| EP2678050B1 (en) * | 2011-02-24 | 2020-10-14 | Emory University | Noggin blocking compositions for ossification and methods related thereto |
| WO2013120107A1 (en) * | 2012-02-09 | 2013-08-15 | University Of Rochester | Methods and compositions for treating a subject to inhibit hearing loss |
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| HK1211875A1 (en) | 2012-09-07 | 2016-06-03 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| RU2641916C2 (ru) | 2012-10-02 | 2018-01-23 | Байер Кропсайенс Аг | Гетероциклические соединения в качестве пестицидов |
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| ES2853483T3 (es) | 2013-03-15 | 2021-09-16 | Verseon Int Corporation | Compuestos aromáticos multisustituidos como inhibidores de la serina proteasa |
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| EP2970141B1 (en) | 2013-03-15 | 2020-02-26 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
| EP2991644B1 (en) | 2013-04-04 | 2020-03-25 | University of Maryland, Baltimore | Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity |
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| SG11201510327TA (en) | 2013-06-17 | 2016-01-28 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| EP3653229A1 (en) | 2013-12-12 | 2020-05-20 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for genome editing |
| JP2017501149A (ja) | 2013-12-12 | 2017-01-12 | ザ・ブロード・インスティテュート・インコーポレイテッド | 粒子送達構成成分を用いた障害及び疾患の標的化のためのcrispr−cas系及び組成物の送達、使用及び治療適用 |
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| CN104072425B (zh) * | 2014-07-09 | 2016-12-07 | 大连理工大学 | 苯并咪唑类化合物及其应用 |
| WO2016022776A2 (en) | 2014-08-06 | 2016-02-11 | Massachusetts Eye And Ear Infirmary | Increasing atoh1 life to drive sensorineural hair cell differentiantion |
| BR112017004704A2 (pt) | 2014-09-17 | 2018-01-23 | Verseon Corp | composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio em um indivíduo |
| EP3212773B1 (en) | 2014-10-29 | 2021-09-15 | Massachusetts Eye and Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
| WO2016094874A1 (en) | 2014-12-12 | 2016-06-16 | The Broad Institute Inc. | Escorted and functionalized guides for crispr-cas systems |
| EP3230452B1 (en) | 2014-12-12 | 2025-06-11 | The Broad Institute, Inc. | Dead guides for crispr transcription factors |
| EP3889260A1 (en) | 2014-12-12 | 2021-10-06 | The Broad Institute, Inc. | Protected guide rnas (pgrnas) |
| CA2970370A1 (en) | 2014-12-24 | 2016-06-30 | Massachusetts Institute Of Technology | Crispr having or associated with destabilization domains |
| US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
| CN108137595B (zh) | 2015-06-18 | 2021-04-20 | 听治疗有限责任公司 | 预防和治疗听力损失的方法和组合物 |
| WO2016205749A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| JO3491B1 (ar) | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| JP2017073472A (ja) * | 2015-10-07 | 2017-04-13 | 株式会社ディスコ | 半導体装置の製造方法 |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) * | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
| JP7033789B2 (ja) | 2016-06-29 | 2022-03-11 | オトノミー,インク. | トリグリセリド耳用製剤とその使用 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| EP3562487B1 (en) | 2016-12-29 | 2023-11-29 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| CN110461835A (zh) * | 2017-03-24 | 2019-11-15 | 诺华股份有限公司 | 异噁唑甲酰胺化合物及其用途 |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| US11590152B2 (en) | 2018-01-26 | 2023-02-28 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss |
| CN119410637A (zh) | 2018-04-27 | 2025-02-11 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| US11911416B2 (en) | 2018-08-01 | 2024-02-27 | University Of Iowa Research Foundation | Compositions and methods to restore hearing loss and balance through embryonic ear transplant |
| US20220062281A1 (en) * | 2018-08-13 | 2022-03-03 | National Centre For Biological Sciences-Tifr | Inhibitors to target hiv-1 nef-cd80/cd86 interactions for therapeutic intervention |
| WO2020041380A1 (en) | 2018-08-20 | 2020-02-27 | The Broad Institute, Inc. | Methods and compositions for optochemical control of crispr-cas9 |
| EP3860562A1 (en) | 2018-10-02 | 2021-08-11 | Frequency Therapeutics, Inc. | Pharmaceutical compositions comprising otic therapeutic agents and related methods |
| CN113544266A (zh) | 2018-12-17 | 2021-10-22 | 博德研究所 | Crispr相关转座酶系统和其使用方法 |
| US12358893B2 (en) | 2019-01-08 | 2025-07-15 | Corxel Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| CN119320772A (zh) * | 2019-02-08 | 2025-01-17 | 分贝治疗公司 | 肌球蛋白15启动子及其用途 |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR TREATMENT OF SENSORINEURAL HEARING LOSS USING OTOFERLIN DOUBLE VECTOR SYSTEMS |
| SG11202111191YA (en) | 2019-04-08 | 2021-11-29 | Frequency Therapeutics Inc | Combination of chir99021 and valproic acid for treating hearing loss |
| WO2020236967A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Random crispr-cas deletion mutant |
| WO2021000928A1 (zh) * | 2019-07-04 | 2021-01-07 | 中美瑞康核酸技术(南通)研究院有限公司 | 激活atoh1基因的寡聚核酸分子及其应用 |
| US20220298501A1 (en) | 2019-08-30 | 2022-09-22 | The Broad Institute, Inc. | Crispr-associated mu transposase systems |
| CA3153197A1 (en) | 2019-10-03 | 2021-04-08 | Ryan T. Gill | Crispr systems with engineered dual guide nucleic acids |
| US20230340537A1 (en) | 2020-01-17 | 2023-10-26 | The Broad Institute, Inc. | Small type ii-d cas proteins and methods of use thereof |
| EP4419672A2 (en) | 2021-06-01 | 2024-08-28 | Artisan Development Labs, Inc. | Compositions and methods for targeting, editing, or modifying genes |
| CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| WO2023149548A1 (ja) * | 2022-02-03 | 2023-08-10 | 国立大学法人富山大学 | 新規医薬組成物 |
| US20250388896A1 (en) | 2022-03-01 | 2025-12-25 | Celyntra Therapeutics Sa | Composition and methods for transgene insertion |
| WO2025059533A1 (en) | 2023-09-13 | 2025-03-20 | The Broad Institute, Inc. | Crispr enzymes and systems |
| WO2025081042A1 (en) | 2023-10-12 | 2025-04-17 | Renagade Therapeutics Management Inc. | Nickase-retron template-based precision editing system and methods of use |
| WO2025117544A1 (en) | 2023-11-29 | 2025-06-05 | The Broad Institute, Inc. | Engineered omega guide molecule and iscb compositions, systems, and methods of use thereof |
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-
2009
- 2009-02-09 AU AU2009212135A patent/AU2009212135B2/en not_active Ceased
- 2009-02-09 CA CA2714370A patent/CA2714370C/en active Active
- 2009-02-09 EP EP09708566.6A patent/EP2254572B1/en not_active Not-in-force
- 2009-02-09 CN CN200980112358.0A patent/CN101990433B/zh not_active Expired - Fee Related
- 2009-02-09 EP EP13182379.1A patent/EP2732819B1/en active Active
- 2009-02-09 JP JP2010546093A patent/JP2011511806A/ja not_active Ceased
- 2009-02-09 US US12/368,173 patent/US8188131B2/en not_active Expired - Fee Related
- 2009-02-09 WO PCT/US2009/033569 patent/WO2009100438A2/en not_active Ceased
-
2012
- 2012-04-24 US US13/454,702 patent/US8859597B2/en active Active
-
2014
- 2014-04-21 JP JP2014087579A patent/JP5749829B2/ja not_active Expired - Fee Related
- 2014-10-10 US US14/511,911 patent/US9433610B2/en not_active Expired - Fee Related
-
2015
- 2015-05-14 JP JP2015099316A patent/JP6199340B2/ja not_active Expired - Fee Related
-
2016
- 2016-08-18 US US15/240,303 patent/US10406163B2/en active Active
-
2019
- 2019-07-22 US US16/518,788 patent/US11160808B2/en not_active Expired - Fee Related
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