JP2011511804A5 - - Google Patents
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- Publication number
- JP2011511804A5 JP2011511804A5 JP2010546054A JP2010546054A JP2011511804A5 JP 2011511804 A5 JP2011511804 A5 JP 2011511804A5 JP 2010546054 A JP2010546054 A JP 2010546054A JP 2010546054 A JP2010546054 A JP 2010546054A JP 2011511804 A5 JP2011511804 A5 JP 2011511804A5
- Authority
- JP
- Japan
- Prior art keywords
- ifnα
- inducible
- expression profile
- marker expression
- therapeutic agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000014509 gene expression Effects 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 239000003550 marker Substances 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 7
- 229940124597 therapeutic agent Drugs 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 6
- 101000959664 Homo sapiens Interferon-induced protein 44-like Proteins 0.000 claims 4
- 101000657037 Homo sapiens Radical S-adenosyl methionine domain-containing protein 2 Proteins 0.000 claims 4
- 102100033749 Radical S-adenosyl methionine domain-containing protein 2 Human genes 0.000 claims 4
- 101000840275 Homo sapiens Interferon alpha-inducible protein 27, mitochondrial Proteins 0.000 claims 3
- 101000840293 Homo sapiens Interferon-induced protein 44 Proteins 0.000 claims 3
- 102100029607 Interferon-induced protein 44 Human genes 0.000 claims 3
- 239000003124 biologic agent Substances 0.000 claims 3
- 102100027769 2'-5'-oligoadenylate synthase 1 Human genes 0.000 claims 2
- 102100035389 2'-5'-oligoadenylate synthase 3 Human genes 0.000 claims 2
- YMZPQKXPKZZSFV-CPWYAANMSA-N 2-[3-[(1r)-1-[(2s)-1-[(2s)-2-[(1r)-cyclohex-2-en-1-yl]-2-(3,4,5-trimethoxyphenyl)acetyl]piperidine-2-carbonyl]oxy-3-(3,4-dimethoxyphenyl)propyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H]([C@H]2C=CCCC2)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 YMZPQKXPKZZSFV-CPWYAANMSA-N 0.000 claims 2
- GTVAUHXUMYENSK-RWSKJCERSA-N 2-[3-[(1r)-3-(3,4-dimethoxyphenyl)-1-[(2s)-1-[(2s)-2-(3,4,5-trimethoxyphenyl)pent-4-enoyl]piperidine-2-carbonyl]oxypropyl]phenoxy]acetic acid Chemical compound C1=C(OC)C(OC)=CC=C1CC[C@H](C=1C=C(OCC(O)=O)C=CC=1)OC(=O)[C@H]1N(C(=O)[C@@H](CC=C)C=2C=C(OC)C(OC)=C(OC)C=2)CCCC1 GTVAUHXUMYENSK-RWSKJCERSA-N 0.000 claims 2
- 102100039922 E3 ISG15-protein ligase HERC5 Human genes 0.000 claims 2
- 101001008907 Homo sapiens 2'-5'-oligoadenylate synthase 1 Proteins 0.000 claims 2
- 101000597332 Homo sapiens 2'-5'-oligoadenylate synthase 3 Proteins 0.000 claims 2
- 101001035145 Homo sapiens E3 ISG15-protein ligase HERC5 Proteins 0.000 claims 2
- 101000814134 Homo sapiens Epithelial-stromal interaction protein 1 Proteins 0.000 claims 2
- 101001082070 Homo sapiens Interferon alpha-inducible protein 6 Proteins 0.000 claims 2
- 101001128393 Homo sapiens Interferon-induced GTP-binding protein Mx1 Proteins 0.000 claims 2
- 101001082065 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 1 Proteins 0.000 claims 2
- 101001082060 Homo sapiens Interferon-induced protein with tetratricopeptide repeats 3 Proteins 0.000 claims 2
- 101001057508 Homo sapiens Ubiquitin-like protein ISG15 Proteins 0.000 claims 2
- 102100029604 Interferon alpha-inducible protein 27, mitochondrial Human genes 0.000 claims 2
- 102100027354 Interferon alpha-inducible protein 6 Human genes 0.000 claims 2
- 102100031802 Interferon-induced GTP-binding protein Mx1 Human genes 0.000 claims 2
- 102100039953 Interferon-induced protein 44-like Human genes 0.000 claims 2
- 102100027355 Interferon-induced protein with tetratricopeptide repeats 1 Human genes 0.000 claims 2
- 102100027302 Interferon-induced protein with tetratricopeptide repeats 3 Human genes 0.000 claims 2
- 102100027266 Ubiquitin-like protein ISG15 Human genes 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 102100027621 2'-5'-oligoadenylate synthase 2 Human genes 0.000 claims 1
- 102100039621 Epithelial-stromal interaction protein 1 Human genes 0.000 claims 1
- 101001008910 Homo sapiens 2'-5'-oligoadenylate synthase 2 Proteins 0.000 claims 1
- 101001065568 Homo sapiens Lymphocyte antigen 6E Proteins 0.000 claims 1
- 101000604998 Homo sapiens Lysosome-associated membrane glycoprotein 3 Proteins 0.000 claims 1
- 101000635777 Homo sapiens Receptor-transporting protein 4 Proteins 0.000 claims 1
- 101000868472 Homo sapiens Sialoadhesin Proteins 0.000 claims 1
- 101000644847 Homo sapiens Ubl carboxyl-terminal hydrolase 18 Proteins 0.000 claims 1
- 102100032131 Lymphocyte antigen 6E Human genes 0.000 claims 1
- 102100038213 Lysosome-associated membrane glycoprotein 3 Human genes 0.000 claims 1
- 201000002481 Myositis Diseases 0.000 claims 1
- 102100030854 Receptor-transporting protein 4 Human genes 0.000 claims 1
- 102100032855 Sialoadhesin Human genes 0.000 claims 1
- 102100020726 Ubl carboxyl-terminal hydrolase 18 Human genes 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000004547 gene signature Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 150000003384 small molecules Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US696308P | 2008-02-08 | 2008-02-08 | |
| PCT/US2009/033407 WO2009100342A2 (en) | 2008-02-08 | 2009-02-06 | Disease markers and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511804A JP2011511804A (ja) | 2011-04-14 |
| JP2011511804A5 true JP2011511804A5 (https=) | 2012-03-15 |
Family
ID=40952717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010546054A Pending JP2011511804A (ja) | 2008-02-08 | 2009-02-06 | 疾患マーカーおよびその使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110262928A1 (https=) |
| EP (2) | EP2848702A1 (https=) |
| JP (1) | JP2011511804A (https=) |
| KR (1) | KR20110005783A (https=) |
| CN (1) | CN101999001B (https=) |
| AU (1) | AU2009212216B2 (https=) |
| BR (1) | BRPI0908065A2 (https=) |
| CA (1) | CA2714410A1 (https=) |
| ES (1) | ES2529593T3 (https=) |
| MX (1) | MX2010008698A (https=) |
| SG (1) | SG188147A1 (https=) |
| WO (1) | WO2009100342A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2666873B1 (en) * | 2007-07-12 | 2016-03-09 | The Brigham and Women's Hospital, Inc. | Compositions and methods for diagnosing and assessing inflammatory myopathies |
| MX340916B (es) | 2008-01-18 | 2016-07-29 | President And Fellows Of Harvard College * | Metodos para detectar señales de identificacion de enfermedad o condiciones en fluidos corporales. |
| JP2012522508A (ja) * | 2009-03-31 | 2012-09-27 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | シェーグレン症候群の診断および治療のためのバイオマーカーとしての示差的に発現されるマイクロｒｎａ |
| CA2772921A1 (en) * | 2009-09-03 | 2011-03-10 | Medimmune, Llc | Type 1 interferon diagnostic |
| US20130022985A1 (en) * | 2010-04-08 | 2013-01-24 | Hiroyuki Yoshitomi | Examination method to determine contraction or activity of diseases related immune system or joint system |
| AU2011280997A1 (en) | 2010-07-23 | 2013-02-28 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| EP2596132A4 (en) | 2010-07-23 | 2013-12-18 | Harvard College | METHOD FOR DETECTING SIGNS FOR ILLNESS OR SUFFERING IN BODY FLUIDS |
| TW201209171A (en) | 2010-07-23 | 2012-03-01 | Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| WO2013020926A1 (en) * | 2011-08-11 | 2013-02-14 | Febit Holding Gmbh | Complex sets of mirnas as non-invasive biomarkers for psoriasis |
| ITRM20110685A1 (it) | 2011-12-23 | 2013-06-24 | Internat Ct For Genetic En Gineering And | Microrna per la rigenerazione cardiaca attraverso l induzione della proliferazione dei miociti cardiaci |
| EP2653554A1 (en) * | 2012-04-17 | 2013-10-23 | Istituto Nazionale Di Genetica Molecolare-INGM | Immune response biomarkers |
| WO2014164362A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting prostate cancer |
| NZ771629A (en) | 2013-03-09 | 2022-12-23 | Harry Stylli | Methods of detecting cancer |
| EP3013985A4 (en) * | 2013-06-28 | 2017-07-19 | Acumen Research Laboratories Pte. Ltd. | Sepsis biomarkers and uses thereof |
| US10626464B2 (en) | 2014-09-11 | 2020-04-21 | Cell Mdx, Llc | Methods of detecting prostate cancer |
| JP6531306B2 (ja) * | 2015-02-20 | 2019-06-19 | 一三 西野 | 炎症性筋疾患鑑別マーカー及びそれを用いた炎症性筋疾患と非炎症性筋疾患の鑑別方法 |
| CN108379584B (zh) * | 2018-04-12 | 2020-08-11 | 上海交复生物医药科技有限公司 | RSAD2通过wnt通路影响肿瘤细胞替莫唑胺耐药性 |
| WO2019210179A1 (en) * | 2018-04-27 | 2019-10-31 | Stemline Therapeutics, Inc. | Methods of treating an autoimmune disease with a human interleukin-3 (il-3)-diphtheria toxin conjugate (dt-il3) |
| CN110085282A (zh) * | 2019-04-23 | 2019-08-02 | 华中师范大学 | 核酸结构中核苷酸与核苷酸相互作用预测的方法 |
| CN110108880A (zh) * | 2019-05-30 | 2019-08-09 | 四川大学华西医院 | Fez1自身抗体检测试剂在制备肺癌筛查试剂盒中的用途 |
| CN110161235B (zh) * | 2019-06-26 | 2022-04-12 | 江苏省中医院 | 三种血清蛋白联合用于强直性脊柱炎诊断的用途 |
| BR112022006441A2 (pt) * | 2019-10-04 | 2022-07-05 | Univ Michigan Regents | Métodos para determinar a capacidade de resposta à terapia antifator de necrose tumoral no tratamento da psoríase |
| CN111378742A (zh) * | 2020-04-16 | 2020-07-07 | 嘉兴程瑞医药科技有限公司 | microRNA生物标志物及其在制备自身免疫疾病检测试剂盒中的应用 |
| CN113388677A (zh) * | 2021-06-17 | 2021-09-14 | 河北医科大学第二医院 | 包括ifi44的干燥症诊断标志物组合 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8303165D0 (en) | 1983-02-04 | 1983-03-09 | Secher D S | Monoclonal antibody |
| EP0139676B1 (en) | 1983-02-04 | 1992-11-25 | Cytoclonal Pharmaceutics Inc. | Production and characterization of hybridoma antibodies directed specifically against common determinant(s) present among closely related, but distinct proteins |
| DE3306060A1 (de) | 1983-02-22 | 1984-08-23 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Neue immunglobulin-produzierende hybridzellinien, deren verwendung und verfahren zu deren herstellung |
| EP0205404B1 (en) | 1985-06-11 | 1992-07-15 | Ciba-Geigy Ag | Hybrid interferons |
| US7087726B2 (en) | 2001-02-22 | 2006-08-08 | Genentech, Inc. | Anti-interferon-α antibodies |
| US20070166281A1 (en) * | 2004-08-21 | 2007-07-19 | Kosak Kenneth M | Chloroquine coupled antibodies and other proteins with methods for their synthesis |
| US7833795B2 (en) * | 2004-08-24 | 2010-11-16 | The Trustees Of The University Of Pennsylvania | Assessment of cardiovascular risk using isoprostane biomarkers and COX-2 selective inhibitors |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| DK2327792T3 (da) * | 2005-08-05 | 2014-01-13 | Genentech Inc | Fremgangsmåder og sammensætninger til påvisning af autoimmunsygdomme |
| EP2712930A3 (en) | 2006-12-06 | 2014-04-23 | MedImmune, LLC | Interferon alpha-induced pharmacodynamic markers |
-
2009
- 2009-02-06 KR KR1020107019933A patent/KR20110005783A/ko not_active Ceased
- 2009-02-06 MX MX2010008698A patent/MX2010008698A/es active IP Right Grant
- 2009-02-06 CN CN2009801123932A patent/CN101999001B/zh active Active
- 2009-02-06 WO PCT/US2009/033407 patent/WO2009100342A2/en not_active Ceased
- 2009-02-06 JP JP2010546054A patent/JP2011511804A/ja active Pending
- 2009-02-06 CA CA2714410A patent/CA2714410A1/en not_active Abandoned
- 2009-02-06 US US12/866,586 patent/US20110262928A1/en not_active Abandoned
- 2009-02-06 BR BRPI0908065-1A patent/BRPI0908065A2/pt not_active IP Right Cessation
- 2009-02-06 EP EP14191479.6A patent/EP2848702A1/en not_active Withdrawn
- 2009-02-06 AU AU2009212216A patent/AU2009212216B2/en active Active
- 2009-02-06 ES ES09709316.5T patent/ES2529593T3/es active Active
- 2009-02-06 EP EP09709316.5A patent/EP2252703B1/en active Active
- 2009-02-06 SG SG2013010608A patent/SG188147A1/en unknown
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