|
US3885035A
(en)
|
1972-04-05 |
1975-05-20 |
Sandoz Ag |
Method for treating arrhythmia by using 1,4-bis(4 quinazolinyl) piperazines
|
|
US3956495A
(en)
|
1973-10-30 |
1976-05-11 |
Eli Lilly And Company |
2,4-Diaminoquinazolines as antithrombotic agents
|
|
US3966936A
(en)
|
1974-02-21 |
1976-06-29 |
Pfizer Inc. |
Piperazino quinazoline bronchodilators
|
|
US4060615A
(en)
|
1976-02-18 |
1977-11-29 |
Mead Johnson & Company |
2-Piperazinyl-6,7-dimethoxyquinazolines
|
|
JPS562968A
(en)
|
1979-06-21 |
1981-01-13 |
Mitsubishi Yuka Yakuhin Kk |
Novel pyrimidine derivative
|
|
JPS6270A
(ja)
|
1985-03-07 |
1987-01-06 |
Sankyo Co Ltd |
シクロペンタ〔ｄ〕ピリミジン誘導体
|
|
MX19185A
(es)
|
1989-01-20 |
1993-12-01 |
Pfizer |
Procedimiento para preparar 3-(1,2,5,6-tretrahidropiridil)-pirrolopiridinas.
|
|
KR100262254B1
(ko)
|
1992-10-05 |
2000-07-15 |
나카히로 마오미 |
피리미딘 화합물
|
|
US5750545A
(en)
|
1993-07-23 |
1998-05-12 |
The Green Cross Corporation |
Triazole derivative and pharmaceutical use thereof
|
|
GB9416189D0
(en)
|
1994-08-10 |
1994-09-28 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
JP2896532B2
(ja)
|
1994-08-13 |
1999-05-31 |
ユーハン コーポレーション |
新規なピリミジン誘導体およびその製造方法
|
|
US5525625A
(en)
|
1995-01-24 |
1996-06-11 |
Warner-Lambert Company |
2-(2-Amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran for treating proliferative disorders
|
|
US7067664B1
(en)
|
1995-06-06 |
2006-06-27 |
Pfizer Inc. |
Corticotropin releasing factor antagonists
|
|
ZA979961B
(en)
|
1996-11-15 |
1999-05-05 |
Lilly Co Eli |
5-HT1F agonists
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
US6506798B1
(en)
|
1997-07-01 |
2003-01-14 |
Warner-Lambert Company |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
|
|
US6310060B1
(en)
|
1998-06-24 |
2001-10-30 |
Warner-Lambert Company |
2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors
|
|
BR9810385A
(pt)
|
1997-07-01 |
2000-09-05 |
Warner Lambert Co |
Derivados de ácido benzóico 2-(4-bromo ou 4-iodo fenilamino) e sua utilização como inibidores de mek
|
|
US6821963B2
(en)
|
1997-07-01 |
2004-11-23 |
Warner-Lambert Company |
4-Bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors
|
|
NZ501276A
(en)
|
1997-07-01 |
2000-10-27 |
Warner Lambert Co |
4-bromo or 4-iodo phenylamino benzhydroxamic acid derivatives and their use as MEK inhibitors in treating proliferative disorders
|
|
EP1067123B1
(en)
|
1998-03-31 |
2011-01-19 |
Kyowa Hakko Kirin Co., Ltd. |
Nitrogenous heterocyclic compounds
|
|
DE19853278A1
(de)
|
1998-11-19 |
2000-05-25 |
Aventis Pharma Gmbh |
Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
|
|
EP1140062B1
(en)
|
1999-01-07 |
2005-04-06 |
Warner-Lambert Company LLC |
Treatment of asthma with mek inhibitors
|
|
WO2000040237A1
(en)
|
1999-01-07 |
2000-07-13 |
Warner-Lambert Company |
Antiviral method using mek inhibitors
|
|
ATE311363T1
(de)
|
1999-01-13 |
2005-12-15 |
Warner Lambert Co |
Sulfohydroxamsäure and sulfohydroxamate und ihre verwendung als mek-inhibitoren
|
|
CA2349180A1
(en)
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
Anthranilic acid derivatives
|
|
CA2348236A1
(en)
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
|
CA2349832A1
(en)
|
1999-01-13 |
2000-07-20 |
Warner-Lambert Company |
Benzenesulfonamide derivatives and their use as mek inhibitors
|
|
DE69926914T2
(de)
|
1999-01-13 |
2006-06-29 |
Warner-Lambert Co. Llc |
1-heterozyklus-substituierte diarylaminen
|
|
IL144214A0
(en)
|
1999-01-13 |
2002-05-23 |
Warner Lambert Co |
Benzoheterocycles and their use as mek inhibitors
|
|
GB9910577D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
PL352835A1
(en)
|
1999-07-16 |
2003-09-08 |
Warner-Lambert Company |
Method for treating chronic pain using mek inhibitors
|
|
HUP0202381A3
(en)
|
1999-07-16 |
2004-12-28 |
Warner Lambert Co |
Method for treating chronic pain using mek inhibitors
|
|
KR20020012315A
(ko)
|
1999-07-16 |
2002-02-15 |
로즈 암스트롱, 크리스틴 에이. 트러트웨인 |
Ｍｅｋ 저해제를 사용한 만성 통증의 치료 방법
|
|
ES2208364T3
(es)
|
1999-07-16 |
2004-06-16 |
Warner-Lambert Company Llc |
Procedimiento para tratar dolor cronico usando inhibidores de mek.
|
|
MXPA02008103A
(es)
|
2000-03-15 |
2002-11-29 |
Warner Lambert Co |
Diarilaminas sustituidas con 5-amida como inhibidores mek.
|
|
JP3811775B2
(ja)
|
2000-07-19 |
2006-08-23 |
ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー |
４−ヨードフェニルアミノベンズヒドロキサム酸の酸素化エステル
|
|
SK2072003A3
(en)
|
2000-08-25 |
2004-01-08 |
Warner Lambert Co |
Process for making N-aryl-anthranilic acids and their derivatives
|
|
US7067532B2
(en)
|
2000-11-02 |
2006-06-27 |
Astrazeneca |
Substituted quinolines as antitumor agents
|
|
WO2002083139A1
(en)
|
2001-04-10 |
2002-10-24 |
Merck & Co., Inc. |
Inhibitors of akt activity
|
|
DE60225127T2
(de)
|
2001-04-30 |
2009-02-19 |
Glaxo Group Ltd., Greenford |
Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf)
|
|
WO2003022214A2
(en)
|
2001-09-06 |
2003-03-20 |
Millennium Pharmaceuticals, Inc. |
Piperazine and homopiperazine compounds
|
|
US20030187026A1
(en)
|
2001-12-13 |
2003-10-02 |
Qun Li |
Kinase inhibitors
|
|
TW200306819A
(en)
|
2002-01-25 |
2003-12-01 |
Vertex Pharma |
Indazole compounds useful as protein kinase inhibitors
|
|
KR100984595B1
(ko)
|
2002-03-13 |
2010-09-30 |
어레이 바이오파마 인크. |
Ｍｅｋ 억제제로서의 ｎ3 알킬화 벤즈이미다졸 유도체
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
EP1482944A4
(en)
|
2002-03-13 |
2006-04-19 |
Array Biopharma Inc |
NZ ALKYL BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
|
|
US7273869B2
(en)
|
2002-04-08 |
2007-09-25 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
EP1496906A4
(en)
|
2002-04-08 |
2006-05-03 |
Merck & Co Inc |
HEMMER OF ACT ACTIVITY
|
|
US7223738B2
(en)
|
2002-04-08 |
2007-05-29 |
Merck & Co., Inc. |
Inhibitors of Akt activity
|
|
JP4394959B2
(ja)
|
2002-04-08 |
2010-01-06 |
メルク エンド カムパニー インコーポレーテッド |
Ａｋｔ活性の阻害剤
|
|
AU2003230367A1
(en)
|
2002-05-10 |
2003-11-11 |
Neurocrine Biosciences, Inc. |
Substituted piperazine as melanocortin receptors ligands
|
|
JP2006507299A
(ja)
|
2002-10-30 |
2006-03-02 |
メルク エンド カムパニー インコーポレーテッド |
Ａｋｔ活性の阻害薬
|
|
US20040102360A1
(en)
|
2002-10-30 |
2004-05-27 |
Barnett Stanley F. |
Combination therapy
|
|
US20040099681A1
(en)
*
|
2002-11-21 |
2004-05-27 |
Nice-Pak Products, Inc. |
Non-planar dispenser for articles
|
|
GB0308208D0
(en)
|
2003-04-09 |
2003-05-14 |
Glaxo Group Ltd |
Chemical compounds
|
|
EP1620095A4
(en)
|
2003-04-24 |
2009-04-01 |
Merck & Co Inc |
HEMMER OF ACT ACTIVITY
|
|
EP1646615B1
(en)
|
2003-06-06 |
2009-08-26 |
Vertex Pharmaceuticals Incorporated |
Pyrimidine derivatives as modulators of atp-binding cassette transporters
|
|
CN1894222A
(zh)
|
2003-08-05 |
2007-01-10 |
沃泰克斯药物股份有限公司 |
作为电压门控离子通道抑制剂的稠合嘧啶化合物
|
|
ES2293317T3
(es)
|
2003-08-12 |
2008-03-16 |
F. Hoffmann-La Roche Ag |
Derivados de tetrahidroquinazolina com antagonistas de cfr.
|
|
AU2004272437A1
(en)
|
2003-09-09 |
2005-03-24 |
Ono Pharmaceutical Co., Ltd. |
CRF antagonists and heterobicyclic compounds
|
|
WO2005039564A1
(en)
|
2003-10-02 |
2005-05-06 |
Vertex Pharmaceuticals Incorporated |
Phthalimide compounds useful as protein kinase inhibitors
|
|
NZ590160A
(en)
*
|
2003-11-21 |
2012-07-27 |
Array Biopharma Inc |
AKT protein kinase inhibitors
|
|
WO2005117909A2
(en)
|
2004-04-23 |
2005-12-15 |
Exelixis, Inc. |
Kinase modulators and methods of use
|
|
TW200621257A
(en)
|
2004-10-20 |
2006-07-01 |
Astellas Pharma Inc |
Pyrimidine derivative fused with nonaromatic ring
|
|
UY29177A1
(es)
|
2004-10-25 |
2006-05-31 |
Astex Therapeutics Ltd |
Derivados sustituidos de purina, purinona y deazapurina, composiciones que los contienen métodos para su preparación y sus usos
|
|
JP5274842B2
(ja)
|
2004-12-28 |
2013-08-28 |
エグゼリクシス， インコーポレイテッド |
免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
|
|
US20090111805A1
(en)
|
2005-02-24 |
2009-04-30 |
Pfizer Inc. |
Bicyclic heteroaromatic derivatives useful as anticancer agents
|
|
EP2354140A1
(en)
|
2005-05-20 |
2011-08-10 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
UY29610A1
(es)
|
2005-06-21 |
2007-01-31 |
Cancer Rec Tech Ltd |
Aril-alquilaminas y heteroaril-alquilaminas como inhibidores de la quinasa proteínica
|
|
JP2009511528A
(ja)
|
2005-10-13 |
2009-03-19 |
グラクソ グループ リミテッド |
Ｓｙｋ阻害物質としてのピロロピリミジン誘導体群
|
|
CA2635541A1
(en)
|
2005-12-28 |
2007-07-12 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic compounds and their use as mineralocorticoid receptor ligands
|
|
JP2009534454A
(ja)
|
2006-04-25 |
2009-09-24 |
アステックス、セラピューティックス、リミテッド |
医薬化合物
|
|
KR20090024834A
(ko)
|
2006-07-05 |
2009-03-09 |
인터뮨, 인크. |
Ｃ형 간염 바이러스 복제의 신규 억제제
|
|
CA2656566C
(en)
|
2006-07-06 |
2014-06-17 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
|
GB0613518D0
(en)
|
2006-07-06 |
2006-08-16 |
Phytopharm Plc |
Chemical compounds
|
|
ATE523499T1
(de)
|
2006-07-06 |
2011-09-15 |
Array Biopharma Inc |
Cyclopenta [d]-pyrimidine als akt-proteinkinasehemmer
|
|
ATE532789T1
(de)
|
2006-07-06 |
2011-11-15 |
Array Biopharma Inc |
Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren
|
|
UA95641C2
(xx)
|
2006-07-06 |
2011-08-25 |
Эррей Биофарма Инк. |
Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
|
|
MX2009000117A
(es)
|
2006-07-06 |
2009-01-23 |
Glaxo Group Ltd |
N-fenilmetil-5-oxo-prolin-2-amidas sustituidas como antagonistas de receptores p2x7 y sus metodos de uso.
|
|
TW200808325A
(en)
|
2006-07-06 |
2008-02-16 |
Astrazeneca Ab |
Novel compounds
|
|
US7910747B2
(en)
|
2006-07-06 |
2011-03-22 |
Bristol-Myers Squibb Company |
Phosphonate and phosphinate pyrazolylamide glucokinase activators
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
PL2044056T3
(pl)
|
2006-07-14 |
2013-01-31 |
Novartis Ag |
Pochodne pirymidyny jako inhibitory ALK-5
|
|
WO2008012635A2
(en)
|
2006-07-26 |
2008-01-31 |
Pfizer Products Inc. |
Amine derivatives useful as anticancer agents
|
|
CN101918373B
(zh)
|
2007-07-05 |
2013-06-05 |
阵列生物制药公司 |
作为akt蛋白激酶抑制剂的嘧啶基环戊烷
|
|
WO2009006567A2
(en)
|
2007-07-05 |
2009-01-08 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as akt protein kinase inhibitors
|