MX2013000877A - Aplicación de dihidroxiclorinas beta-funcionalizadas para tfd. - Google Patents
Aplicación de dihidroxiclorinas beta-funcionalizadas para tfd.Info
- Publication number
- MX2013000877A MX2013000877A MX2013000877A MX2013000877A MX2013000877A MX 2013000877 A MX2013000877 A MX 2013000877A MX 2013000877 A MX2013000877 A MX 2013000877A MX 2013000877 A MX2013000877 A MX 2013000877A MX 2013000877 A MX2013000877 A MX 2013000877A
- Authority
- MX
- Mexico
- Prior art keywords
- pdt
- chlorins
- another embodiment
- precursors
- dihydroxy
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención proporciona métodos para obtener compuestos biológicamente activos que se pueden usar como fotosensibilizadores para aplicaciones de diagnóstico y terapéuticas, particularmente para la TFD del cáncer, infecciones y otras enfermedades hiperproliferativas, diagnósticos de fluorescencia y tratamiento de TFD de una indicación no tumoral tal como artritis, enfermedades inflamatorias, infecciones virales o bacterianas, trastornos dermatológicos, oftalmológicos o urológicos. Una modalidad de la presente invención consiste de un método para sintetizar las diceto-clorinas como precursores. En otra modalidad más, estos precursores se convierten a hidroxi y dihidroxi-clorinas B-funcionalizadas. Otra modalidad es para proporcionar compuestos anfifílicos con una afinidad de membrana más alta y eficacia de TFD mejorada. Otra modalidad consiste en la formulación del isómero deseado en una formulación liposomal para ser inyectada, evitando los efectos indeseables como la precipitación en el sitio de inyección o la farmacocinética demorada de los sistemas de tetrapirrol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36670710P | 2010-07-22 | 2010-07-22 | |
| PCT/US2011/047576 WO2012012809A2 (en) | 2010-07-22 | 2011-08-12 | APPLICATION OF β-FUNCTIONALIZED DIHYDROXY-CHLORINS FOR PDT |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013000877A true MX2013000877A (es) | 2013-07-03 |
| MX353394B MX353394B (es) | 2018-01-11 |
Family
ID=45497505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013000877A MX353394B (es) | 2010-07-22 | 2011-08-12 | Aplicación de dihidroxiclorinas beta-funcionalizadas para tfd. |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP2870159B1 (es) |
| JP (1) | JP2013532664A (es) |
| CN (1) | CN103097390B (es) |
| BR (1) | BR112013001576A2 (es) |
| IL (1) | IL224381B (es) |
| MX (1) | MX353394B (es) |
| PL (1) | PL2870159T3 (es) |
| WO (1) | WO2012012809A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013001577B1 (pt) * | 2010-07-22 | 2021-05-04 | Biolitec Unternehmensbeteiligungs Ii Ag | conjugados de carboidrato e dihidroxiclorina |
| WO2013015774A1 (en) | 2011-07-22 | 2013-01-31 | Biolitec Pharma Marketing Ltd | Glyco-substituted dihydroxy-chlorins and b-functionalized chlorins for anti-microbial photodynamic therapy |
| CN103995045A (zh) * | 2014-05-29 | 2014-08-20 | 武汉矽感科技有限公司 | 离子迁移谱仪用于检测乐果和马拉硫磷残留的用途及方法 |
| US9722103B2 (en) | 2015-06-26 | 2017-08-01 | Sunpower Corporation | Thermal compression bonding approaches for foil-based metallization of solar cells |
| CN104940950B (zh) * | 2015-07-09 | 2017-11-28 | 武汉大学 | 一种肿瘤靶向多肽光敏剂键合物 |
| CN111196819B (zh) * | 2018-11-16 | 2023-03-28 | 中国科学院上海药物研究所 | 一类d-a-d型苯并吡嗪类化合物及制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648485A (en) * | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
| FR2877943B1 (fr) * | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
| EP2350058B1 (en) * | 2008-09-18 | 2018-10-24 | biolitec Unternehmensbeteiligungs II AG | Novel method and application of unsymmetrically meso-substituted porphyrins and chlorins for pdt |
| JP6041360B2 (ja) * | 2011-07-22 | 2016-12-07 | バイオリテック ウンターネーメンスベタイリグンクス ツヴァイ アクツィエンゲゼルシャフト | 抗菌性光線力学療法のための、糖−置換ジヒドロキシ−クロリン及びβ−官能化クロリン |
-
2011
- 2011-08-12 CN CN201180039522.7A patent/CN103097390B/zh active Active
- 2011-08-12 PL PL11810524T patent/PL2870159T3/pl unknown
- 2011-08-12 JP JP2013520904A patent/JP2013532664A/ja active Pending
- 2011-08-12 BR BR112013001576A patent/BR112013001576A2/pt not_active Application Discontinuation
- 2011-08-12 WO PCT/US2011/047576 patent/WO2012012809A2/en active Application Filing
- 2011-08-12 MX MX2013000877A patent/MX353394B/es active IP Right Grant
- 2011-08-12 EP EP11810524.6A patent/EP2870159B1/en active Active
-
2013
- 2013-01-23 IL IL224381A patent/IL224381B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012012809A3 (en) | 2012-05-18 |
| EP2870159A2 (en) | 2015-05-13 |
| MX353394B (es) | 2018-01-11 |
| EP2870159B1 (en) | 2017-06-28 |
| WO2012012809A2 (en) | 2012-01-26 |
| BR112013001576A2 (pt) | 2016-07-19 |
| CN103097390A (zh) | 2013-05-08 |
| JP2013532664A (ja) | 2013-08-19 |
| EP2870159A4 (en) | 2015-08-12 |
| PL2870159T3 (pl) | 2018-01-31 |
| IL224381B (en) | 2018-03-29 |
| CN103097390B (zh) | 2017-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: BIOLITEC UNTERNEHMENSBETEILIGUNGS II AG |
|
| FG | Grant or registration |