JP2011508773A5 - - Google Patents
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- JP2011508773A5 JP2011508773A5 JP2010541427A JP2010541427A JP2011508773A5 JP 2011508773 A5 JP2011508773 A5 JP 2011508773A5 JP 2010541427 A JP2010541427 A JP 2010541427A JP 2010541427 A JP2010541427 A JP 2010541427A JP 2011508773 A5 JP2011508773 A5 JP 2011508773A5
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- 241001465754 Metazoa Species 0.000 claims 12
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims 8
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims 8
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- 230000003920 cognitive function Effects 0.000 claims 6
- 230000007423 decrease Effects 0.000 claims 4
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 2
- 229930003270 Vitamin B Natural products 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 230000001149 cognitive effect Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 230000006870 function Effects 0.000 claims 2
- ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims 2
- 235000019156 vitamin B Nutrition 0.000 claims 2
- 239000011720 vitamin B Substances 0.000 claims 2
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 1
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 239000004475 Arginine Substances 0.000 claims 1
- 102000055006 Calcitonin Human genes 0.000 claims 1
- 108060001064 Calcitonin Proteins 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- 208000022540 Consciousness disease Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 241000218628 Ginkgo Species 0.000 claims 1
- 235000011201 Ginkgo Nutrition 0.000 claims 1
- 244000194101 Ginkgo biloba Species 0.000 claims 1
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- YSEXMKHXIOCEJA-FVFQAYNVSA-N Nicergoline Chemical compound C([C@@H]1C[C@]2([C@H](N(C)C1)CC=1C3=C2C=CC=C3N(C)C=1)OC)OC(=O)C1=CN=CC(Br)=C1 YSEXMKHXIOCEJA-FVFQAYNVSA-N 0.000 claims 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims 1
- RBQOQRRFDPXAGN-UHFFFAOYSA-N Propentofylline Chemical compound CN1C(=O)N(CCCCC(C)=O)C(=O)C2=C1N=CN2CCC RBQOQRRFDPXAGN-UHFFFAOYSA-N 0.000 claims 1
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 1
- DDNCQMVWWZOMLN-IRLDBZIGSA-N Vinpocetine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OCC)N5C2=C1 DDNCQMVWWZOMLN-IRLDBZIGSA-N 0.000 claims 1
- 229940062527 alendronate Drugs 0.000 claims 1
- 230000003078 antioxidant effect Effects 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 229960003121 arginine Drugs 0.000 claims 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 1
- 230000037147 athletic performance Effects 0.000 claims 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 1
- 229960004015 calcitonin Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 208000010877 cognitive disease Diseases 0.000 claims 1
- 229960003530 donepezil Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000262 estrogen Substances 0.000 claims 1
- 229940011871 estrogen Drugs 0.000 claims 1
- 235000021323 fish oil Nutrition 0.000 claims 1
- 229960003980 galantamine Drugs 0.000 claims 1
- ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims 1
- 229960003642 nicergoline Drugs 0.000 claims 1
- 239000002840 nitric oxide donor Substances 0.000 claims 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 1
- 229960003104 ornithine Drugs 0.000 claims 1
- 239000003075 phytoestrogen Substances 0.000 claims 1
- 229960002934 propentofylline Drugs 0.000 claims 1
- GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 claims 1
- 229960004622 raloxifene Drugs 0.000 claims 1
- 229940089617 risedronate Drugs 0.000 claims 1
- MEZLKOACVSPNER-GFCCVEGCSA-N selegiline Chemical compound C#CCN(C)[C@H](C)CC1=CC=CC=C1 MEZLKOACVSPNER-GFCCVEGCSA-N 0.000 claims 1
- 229960003946 selegiline Drugs 0.000 claims 1
- 229960000744 vinpocetine Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1009708P | 2008-01-04 | 2008-01-04 | |
| US61/010,097 | 2008-01-04 | ||
| US13738208P | 2008-07-30 | 2008-07-30 | |
| US61/137,382 | 2008-07-30 | ||
| PCT/US2008/013870 WO2009088433A1 (en) | 2008-01-04 | 2008-12-19 | Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing congnitive and related functions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508773A JP2011508773A (ja) | 2011-03-17 |
| JP2011508773A5 true JP2011508773A5 (enExample) | 2012-02-09 |
| JP5979816B2 JP5979816B2 (ja) | 2016-08-31 |
Family
ID=40853324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541427A Active JP5979816B2 (ja) | 2008-01-04 | 2008-12-19 | 不飽和脂肪酸及び酸化窒素放出化合物を含む組成物、並びに認知機能及び関連の機能を高めるためのそれらの使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20100233304A1 (enExample) |
| EP (2) | EP2224930B1 (enExample) |
| JP (1) | JP5979816B2 (enExample) |
| CN (2) | CN101909632A (enExample) |
| AU (1) | AU2008347177B2 (enExample) |
| BR (1) | BRPI0822238B8 (enExample) |
| CA (2) | CA2994586C (enExample) |
| ES (2) | ES2773928T5 (enExample) |
| MX (1) | MX337760B (enExample) |
| RU (1) | RU2500402C2 (enExample) |
| WO (1) | WO2009088433A1 (enExample) |
Families Citing this family (38)
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| US8252742B2 (en) * | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
| AU2008307494B2 (en) * | 2007-10-04 | 2013-09-05 | Société des Produits Nestlé S.A. | Compositions and methods for enhancing cognitive function |
| AU2013200758B2 (en) * | 2008-07-18 | 2014-06-12 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| JP2011528556A (ja) * | 2008-07-18 | 2011-11-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高齢の動物の生活の質を向上させるための方法 |
| ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
| DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
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| CN102552457A (zh) * | 2010-12-24 | 2012-07-11 | 漆又毛 | 一种氨基酸和提取物组合物的药物用途 |
| CN103442725A (zh) * | 2011-01-25 | 2013-12-11 | 雀巢产品技术援助有限公司 | 治疗、减轻或预防动物的视觉系统衰退的方法和组合物 |
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| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
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| AT511776B1 (de) * | 2011-07-26 | 2014-03-15 | Gonadosan Gmbh | Verwendung von citrullin und ein kombinationspräparat zur verbesserung der männlichen fertilität |
| US20130059028A1 (en) * | 2011-09-01 | 2013-03-07 | Julie Marie Foy | Compositions and Methods for Providing a Life-Stage-Appropriate Animal Diet |
| CN102600124B (zh) * | 2012-02-06 | 2014-03-26 | 单宝华 | Omega-3增强组合物及其应用 |
| CA2888791C (en) * | 2012-10-30 | 2021-07-27 | Kyowa Hakko Bio Co., Ltd. | Use of a combination of citrulline and glutathione in the treatment of brain damage and cognitive decline |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
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| MA40847A (fr) * | 2014-10-22 | 2017-09-13 | Raffaele Migliaccio | Association comprenant de la spiruline et du palmitoyléthanolamide et/ou des sels ou des dérivés pharmaceutiquement acceptables de ceux-ci et leurs formulations, pour une utilisation dans la prévention et/ou le traitement d'états d'hyperactivité des tissus |
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| JP7270546B2 (ja) * | 2017-04-11 | 2023-05-10 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル |
| MA49906A (fr) | 2017-08-14 | 2020-06-24 | Axcella Health Inc | Acides aminés à chaîne ramifiée pour le traitement d'une maladie du foie |
| EP3810123A1 (en) | 2018-06-20 | 2021-04-28 | Axcella Health Inc. | Compositions and methods for the treatment of fat infiltration in muscle |
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| JP5043677B2 (ja) † | 2005-12-02 | 2012-10-10 | 持田製薬株式会社 | アルツハイマー型認知症予防・治療剤 |
| PL1800675T4 (pl) | 2005-12-23 | 2012-02-29 | Nutricia Nv | Kompozycja zawierająca wielonienasycone kwasy tłuszczowe, białka, mangan, i/lub molibden oraz nukleozydy/nukleotydy do leczenia otępienia |
| KR20090003148A (ko) * | 2006-04-03 | 2009-01-09 | 액세라인크 | 나이와 관련된 기억 손상의 치료를 위한 케톤 생성조성물의 용도 |
| AU2008307494B2 (en) † | 2007-10-04 | 2013-09-05 | Société des Produits Nestlé S.A. | Compositions and methods for enhancing cognitive function |
| EP2939314B1 (en) | 2012-12-31 | 2018-08-29 | Mitel Networks Corporation | Interface adapter |
-
2008
- 2008-12-19 CN CN200880123505XA patent/CN101909632A/zh active Pending
- 2008-12-19 ES ES16163261T patent/ES2773928T5/es active Active
- 2008-12-19 ES ES08869735.4T patent/ES2586757T3/es active Active
- 2008-12-19 WO PCT/US2008/013870 patent/WO2009088433A1/en not_active Ceased
- 2008-12-19 RU RU2010132637/15A patent/RU2500402C2/ru active
- 2008-12-19 AU AU2008347177A patent/AU2008347177B2/en active Active
- 2008-12-19 EP EP08869735.4A patent/EP2224930B1/en active Active
- 2008-12-19 CA CA2994586A patent/CA2994586C/en active Active
- 2008-12-19 CN CN201510779748.0A patent/CN105267969A/zh active Pending
- 2008-12-19 JP JP2010541427A patent/JP5979816B2/ja active Active
- 2008-12-19 MX MX2010007438A patent/MX337760B/es active IP Right Grant
- 2008-12-19 BR BRPI0822238A patent/BRPI0822238B8/pt active IP Right Grant
- 2008-12-19 US US12/734,013 patent/US20100233304A1/en not_active Abandoned
- 2008-12-19 CA CA2709660A patent/CA2709660C/en active Active
- 2008-12-19 EP EP16163261.7A patent/EP3058942B2/en active Active
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2017
- 2017-02-23 US US15/440,702 patent/US10111911B2/en active Active
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2018
- 2018-10-03 US US16/150,979 patent/US10973859B2/en active Active
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2021
- 2021-03-19 US US17/206,851 patent/US11951137B2/en active Active
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