JP2011508773A - 不飽和脂肪酸及び酸化窒素放出化合物を含む組成物、並びに認知機能及び関連の機能を高めるためのそれらの使用 - Google Patents
不飽和脂肪酸及び酸化窒素放出化合物を含む組成物、並びに認知機能及び関連の機能を高めるためのそれらの使用 Download PDFInfo
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Abstract
【選択図】なし
Description
[0013]本明細書では以下の略語を使用し得る:AA、アラキドン酸;ALA、αリノレン酸;ANOVA、分散分析;DHA,ドコサへキサエン酸;DPA、ドコサペンタエン酸;EPA、エイコサペンタエン酸;LA、リノール酸;UFA、不飽和脂肪酸(本明細書で使用する場合、UFAは、1つ以上のこのような脂肪酸を称する);NO、酸化窒素;NORC、酸化窒素放出化合物(複数可);及びL−Arg、L−アルギニン。
発明
動物及び試験群
[00123]認知的経験のあるビーグル犬(7.5〜11.6歳までの雄及び雌)を試験した。犬の平均年齢は9.38歳であった。適正にするために、犬は、位置遅延非位置合わせ課題(DNMP)及び特異性課題で訓練されたことを含め、少なくとも6カ月の事前の認知試験の経験を有していなければならなかった。
[00125]犬には、壁掛け式自動給水システム及び/又は水入れから自由に水を摂取させた。動物には、タンパク質32%、脂肪20%、及び繊維3%程度を有する5種類の成犬用メンテナンスフードの内、1種類を1日1回与えた。最初の個々の食物量は、次式「kcal所要量=110kcal/日×(BW×0.75)」(式中、BWは体重である)を用いて計算した。該式は、適切な身体状態で一定の体重を維持することが意図されていた。
認知試験バッテリー
[00127]ランドマーク弁別学習(7〜99日)。自己中心的学習及び逆転(100〜163日)
[00128]この課題では、犬は、外部ランドマークと彼らの近さに基づき、2つの目的物の1つに接近するように訓練された。該課題は、空間内で目的物の場所を特定するために外部ランドマークの利用を伴う、他者中心的空間能力を評価することが意図されていた。犬を、より難しいタイプの同じ一般問題で引き続き試験した。
[00134]一般試験法:施行の開始時、犬に刺激トレーを差し出すために開き戸を開き、犬は、2つの同一の刺激物の内、1つを動かすことによって反応を示すために最大30秒が与えられた。犬が食物報酬を覆う刺激物を動かしたとき、正解反応としてカウントされた。犬が報酬なしの刺激物を動かしたとき、不正解としてカウントされた。動物は、63セッションにわたって、セッション毎に12回の試行を受けた。
ランドマーク試験結果
[00144]手術前に、雄のCharles River系スプラーグドーリーラット(250g、Wilmington、MA)を12時間の明暗周期で動物施設に3日間順応させた。給餌開始の2週間前に、両側の卵巣摘出を実施した。給餌開始の4週間後、ケタミン(60mg/kg)及びキシラジン(10mg/kg)の腹腔内注射後に、麻酔下での一過性中大脳動脈(tMCA)閉塞を実施した。1群当たり15匹のラットを無作為に4つの治療群の1つに割り当てた:
群1−去勢済+対照食事
群2−去勢済+食事II
群3−無処置+対照食事
群4−無処置+食事II
Claims (195)
- 動物の認知機能及び関連する機能を高めるのに有効な量で、1つ以上の不飽和脂肪酸(UFA)及び1つ以上の酸化窒素放出化合物(NORC)を含む、動物の認知機能及び関連する機能を高めるのに適した組成物。
- 前記動物がヒト又はコンパニオンアニマルである、請求項1に記載の組成物。
- 前記コンパニオンアニマルがイヌ又はネコである、請求項2に記載の組成物。
- 前記動物が加齢動物である、請求項1に記載の組成物。
- 前記UFAが天然魚油、ALA、EPA、DPA、DHA、又は任意の源由来の別のn−3脂肪酸の1種又は複数を含む、請求項1に記載の組成物。
- 前記UFAが魚油である、請求項1に記載の組成物。
- 約0.1%〜約50%のUFAを含む、請求項1に記載の組成物。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項1に記載の組成物。
- 前記NORCがシトルリンである、請求項1に記載の組成物。
- 前記NORCがオルニチンである、請求項1に記載の組成物。
- 約0.1%〜約20%のNORCを含む請求項1に記載の組成物。
- 認知機能を高めるのに有効な量で、1つ以上のビタミンB群を更に含む、請求項1に記載の組成物。
- 推奨1日所要量の約0.1〜40倍のビタミンB群を含む、請求項12に記載の組成物。
- 認知機能を高めるのに有効な量で、1つ以上の抗酸化剤を更に含む、請求項1に記載の組成物。
- 約0.0001%〜25%の抗酸化剤を含む、請求項14に記載の組成物。
- 認知機能を高めるのに有効な量で、1つ以上のビタミンB群及び1つ以上の抗酸化剤を更に含む、請求項1に記載の組成物。
- 推奨1日所要量の約0.1〜40倍のビタミンB群及び約0.0001%〜約25%の抗酸化剤を含む、請求項16に記載の組成物。
- ヒト食品組成物、ペットフード組成物又は栄養補助食品として処方された、請求項1に記載の組成物。
- 前記組成物が、約15%〜約50%のタンパク質、約5%〜約40%の脂肪、約5%〜約10%の灰分を更に含み、約5%〜約20%の含水率を有する食品組成物である、請求項18に記載の組成物。
- 認知機能を高めるのに有効な量で、1つ以上の認知薬を更に含む、請求項1に記載の組成物。
- 前記認知薬が、認知に影響を与えるのに有効な量のセレギリン、ニセルゴリン、ホスファチジルセリン、プロペントフィリン、ガランタミン、ビンポセチン、ドネペジル、Ginkgo biloba抽出物、ビスホソホネート、ラロキシフェン、エストロゲン、植物エストロゲン、カルシトニン、リゼドロネート、又はアレンドロネートの1種又は複数である、請求項20に記載の組成物。
- 1つ以上のプレバイオティクス、プロバイオティクス、又はそれらの組合せを更に含む、請求項1に記載の組成物。
- 約0.1%〜約50%の魚油及び約0.1%〜約20%のアルギニンを含む組成物。
- 推奨1日所要量の約0.1〜40倍のビタミンB群及び約0.0001%〜約25%の抗酸化剤を更に含む、請求項23に記載の組成物。
- 請求項1に記載の組成物、及び1つ以上の医薬として又は機能性食品として許容できる担体、希釈剤、又は賦形剤を含む、医薬組成物又は機能性食品(nutraceutical)組成物。
- 動物の認知機能を高める方法であって、前記動物の認知機能を高めるのに有効な量で、1つ以上の不飽和脂肪酸(UFA)及び1つ以上の酸化窒素放出化合物(NORC)を含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項26に記載の方法。
- 前記動物がイヌ又はネコである、請求項26に記載の方法。
- 前記動物が加齢動物である、請求項26に記載の方法。
- 前記UFAが天然魚油、ALA、EPA、DPA、DHA、又は任意の源由来の別のn−3脂肪酸の1種又は複数を含む、請求項26に記載の方法。
- 前記UFAが魚油である、請求項26に記載の方法。
- 前記組成物が約0.1%〜約50%のUFAを含む、請求項26に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項26に記載の方法。
- 前記NORCがシトルリンである、請求項26に記載の方法。
- 前記NORCがオルニチンである、請求項26に記載の方法。
- 前記組成物が約0.1%〜約20%のNORCを含む、請求項26に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上のビタミンB群を更に含む、請求項26に記載の方法。
- 前記組成物が推奨1日所要量の約0.1〜40倍のビタミンB群を含む、請求項37に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上の抗酸化剤を更に含む、請求項26に記載の方法。
- 前記組成物が約0.0001%〜約25%の抗酸化剤を含む、請求項39に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上のビタミンB群及び1つ以上の抗酸化剤を含む、請求項26に記載の方法。
- 前記組成物が推奨1日所要量の約0.1〜40倍のビタミンB群及び約0.0001%〜約25%の抗酸化剤を含む、請求項41に記載の方法。
- 前記組成物が、ヒト食品組成物、ペットフード組成物、又は栄養補助食品として処方されている、請求項26に記載の方法。
- 前記組成物が、約15%〜約50%のタンパク質、約5%〜約40%の脂肪、約5%〜約10%の灰分を更に含み、約5%〜約20%の含水率を有する食品組成物である、請求項43に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上の認知薬と組み合わせて前記動物に投与される、請求項26に記載の方法。
- 前記認知薬が、セレギリン、ニセルゴリン、ホスファチジルセリン、プロペントフィリン、ガランタミン、ビンポセチン、ドネペジル、Ginkgo biloba抽出物、ビスホソホネート、ラロキシフェン、エストロゲン、植物エストロゲン、カルシトニン、リゼドロネート、又はアレンドロネートの1種又は複数である、請求項45に記載の方法。
- 投与される前記組成物が、1つ以上の認知薬を場合により含む医薬組成物又は機能性食品組成物である、請求項26に記載の方法。
- 前記組成物が長期間定期的に投与される、請求項26に記載の方法。
- 前記組成物が前記動物に毎日投与される、請求項48に記載の方法。
- 前記動物が加齢動物である、請求項26に記載の方法。
- 前記動物が加齢に伴う認知障害と関連する表現型を有する、請求項50に記載の方法。
- 前記表現型が、前記表現型を有さない対照動物と比較したとき、想起力の低下、短期記憶喪失、学習速度の低下、学習能力の低下、問題解決力の低下、注意持続期間の低下、運動能力の低下、意識障害の増加、又は痴呆の1つ又は複数を含む、請求項51に記載の方法。
- 前記動物が健康な加齢動物である、請求項26に記載の方法。
- キットの成分に応じて適切に、単一のパッケージの個別の容器で、又は実質的なパッケージの個別の容器で、(a)1つ以上のUFA、(b)1つ以上のNORC、並びに(1)動物による摂取に適した1つ以上の他の成分;(2)1つ以上のビタミンB群;(3)1つ以上の抗酸化剤;(4)1つ以上の認知薬;(5)1つ以上のプレバイオティクス;(6)1つ以上のプロバイオティクス;(7)動物が、認知機能及び関連する機能を高める組成物及び方法から恩恵を受けることができるかを決定するのに適した1つ以上の診断装置;(8)動物への投与用のキットで提供されるUFA、NORC、及び任意の他の成分を組み合わせるか、又は調製する方法に関する説明書;(9)動物の利益のための、複合キット成分、調製キット成分、又は他のキット成分の使用方法に関する説明書;並びに(10)複合又は調製キット成分を動物に投与するための装置の1種又は複数を含む、1つ以上のUFA及びNORCを含む組成物を動物に投与するのに適したキット。
- 情報又は指示を含有する物理的若しくは電子的文書、デジタル記憶媒体、光学記憶媒体、オーディオプレゼンテーション、オーディオビジュアル表示、又はビジュアル表示の1つ又は複数を含む、(1)認知機能を高めるために本発明の組成物を使用すること;(2)本発明のUFA、NORC、ビタミンB群、抗酸化剤、又は他の成分を混合して、認知機能を高めるのに適した組成物を製造すること;(3)認知機能を高めるための本発明のキットを使用すること;及び(4)前記組成物を動物に投与することの1つ又は複数についての情報又は指示を伝達する手段。
- 表示されたウェブサイト、ビジュアル表示キオスク、パンフレット、製品ラベル、添付文書、広告、印刷物、公示、オーディオテープ、ビデオテープ、DVD、CD−ROM、コンピューター可読チップ、コンピューター可読カード、コンピューター可読ディスク、USB装置、ファイヤワイヤー装置、コンピューターメモリー、及びそれらの任意の組合せからなる群から選択される、請求項55に記載の手段。
- UFA、NORC、及び動物による摂取に適した1つ以上の成分を含む食品組成物の製造方法であって、動物による摂取に適した1つ以上の成分と、UFA及びNORCとを混合すること、又はUFA及びNORCを前記食品組成物上に別々に、又は任意の組合せで施すことを含む方法。
- 動物による摂取に適した前記成分が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方である、請求項57に記載の方法。
- 動物の社会的相互作用の低下を低減又は防止する方法であって、社会的相互作用の低下を低減又は防止するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項59に記載の方法。
- 前記動物が加齢動物である、請求項59に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項59に記載の方法。
- 動物の加齢に伴う行動変化を低減又は防止する方法であって、前記動物の加齢に伴う行動変化を低減又は防止するのに有効な量で、UFA及びNORCを前記動物に投与することを含む方法。
- 前記加齢に伴う行動変化が、健忘、失見当、社会的相互作用の低下、睡眠及び覚醒の習慣の変化、「しつけ」の喪失、意識障害、欲求不満、又は気性の変化の1つ又は複数である、請求項63に記載の方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項63に記載の方法。
- 前記動物が加齢動物である、請求項63に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項63に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項63に記載の方法。
- 前記NORCがシトルリンである、請求項63に記載の方法。
- 前記NORCがオルニチンである、請求項63に記載の方法。
- 動物の訓練可能性を高める方法であって、訓練可能性を高めるのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項71に記載の方法。
- 前記動物が若齢動物又は成熟動物である、請求項71に記載の方法。
- 前記動物が加齢動物である、請求項71に記載の方法。
- 前記動物が野生動物である、請求項71に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項71に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項71に記載の方法。
- 前記NORCがシトルリンである、請求項71に記載の方法。
- 前記NORCがオルニチンである、請求項71に記載の方法。
- 動物の最適な脳機能を維持する方法であって、脳機能の低下を防止又は遅延させるのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項80に記載の方法。
- 前記動物が若齢動物又は成熟動物である、請求項80に記載の方法。
- 前記動物が加齢動物である、請求項80に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項80に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体、請求項80に記載の方法。
- 前記NORCがシトルリンである、請求項80に記載の方法。
- 前記NORCがオルニチンである、請求項80に記載の方法。
- 動物の学習及び記憶を促進する方法であって、学習及び記憶を促進するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項88に記載の方法。
- 前記動物が若齢動物又は成熟動物である、請求項88に記載の方法。
- 前記動物が加齢動物である、請求項88に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項88に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項88に記載の方法。
- 前記NORCがシトルリンである、請求項88に記載の方法。
- 前記NORCがオルニチンである、請求項88に記載の方法。
- 動物の記憶喪失を低減する方法であって、経時的に記憶喪失を低減するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項96に記載の方法。
- 前記動物が加齢動物である、請求項96に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項96に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項96に記載の方法。
- 前記NORCがシトルリンである、請求項96に記載の方法。
- 前記NORCがオルニチンである、請求項96に記載の方法。
- 動物の脳老化を遅延させる方法であって、脳老化を遅延させるのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項103に記載の方法。
- 前記動物が加齢動物である、請求項103に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項103に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項103に記載の方法。
- 前記NORCがシトルリンである、請求項103に記載の方法。
- 前記NORCがオルニチンである、請求項103に記載の方法。
- 動物の発作を予防又は治療する方法であって、発作を予防又は治療するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項110に記載の方法。
- 前記動物が加齢動物である、請求項110に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項110に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項110に記載の方法。
- 前記NORCがシトルリンである、請求項110に記載の方法。
- 前記NORCがオルニチンである、請求項110に記載の方法。
- 動物の痴呆を予防又は治療する方法であって、痴呆を予防又は治療するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項117に記載の方法。
- 前記動物が加齢動物である、請求項117に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項117に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項117に記載の方法。
- 前記NORCがシトルリンである、請求項117に記載の方法。
- 前記NORCがオルニチンである、請求項117に記載の方法。
- アルツハイマー病を患っているか、又はそれにかかりやすい動物のアルツハイマー病を予防又は治療する方法であって、アルツハイマー病を予防又は治療するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒトである、請求項124に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項124に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項124に記載の方法。
- 前記NORCがシトルリンである、請求項124に記載の方法。
- 前記NORCがオルニチンである、請求項124に記載の方法。
- アルツハイマー病を患っているか、又はそれにかかりやすい動物の認知機能を高める方法であって、認知機能を高めるのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒトである、請求項130に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項130に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項130に記載の方法。
- 前記NORCがシトルリンである、請求項130に記載の方法。
- 前記NORCがオルニチンである、請求項130に記載の方法。
- 動物の精神的明晰性及び精神的敏捷性を維持する方法であって、精神的明晰性及び精神的敏捷性を維持するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒトである、請求項136に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項136に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項136に記載の方法。
- 前記NORCがシトルリンである、請求項136に記載の方法。
- 前記NORCがオルニチンである、請求項136に記載の方法。
- 本発明の組成物を含むパッケージ、及び前記パッケージの内容が、動物の、認知機能を高め、認知、運動、又は行動機能を変化させ、社会的相互作用の低下を低減又は防止し、加齢に伴う行動変化を低減又は防止し、訓練可能性を高め、最適な脳機能を維持し、学習及び記憶を促進し、及び/又は記憶喪失を低減するのに適した組成物を含有することを示す、用語(複数可)、ピクチャー、デザイン、頭字語、スローガン、語句若しくは他の標語、又はそれらの組合せを含有する前記パッケージに添付されたラベル。
- 動物の、認知機能を高め、認知、運動、又は行動機能を変化させ、社会的相互作用の低下を低減又は防止し、加齢に伴う行動変化を低減又は防止し、訓練可能性を高め、最適な脳機能を維持し、学習及び記憶を促進し、及び/又は記憶喪失を低減するための薬剤を調製するためのUFA及びNORCの使用。
- アルツハイマー病を患っているか、又はそれにかかりやすい動物のアルツハイマー病を予防又は治療するための、請求項143に記載の薬剤の使用。
- 前記動物がヒトである、請求項144に記載の薬剤の使用。
- アルツハイマー病を患っているか、又はそれにかかりやすい動物の認知機能を高めるための、請求項143に記載の薬剤の使用。
- 前記動物がヒトである、請求項146に記載の薬剤の使用。
- 前記薬剤が1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項143に記載の薬剤の使用。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項143に記載の薬剤の使用。
- 前記NORCがシトルリンである、請求項143に記載の薬剤の使用。
- 前記NORCがオルニチンである、請求項143に記載の薬剤の使用。
- 動物の認知機能を高める方法であって、前記動物の認知機能を高めるのに有効な量で、1つ以上の不飽和脂肪酸(UFA)、及び代謝して酸化窒素放出化合物(NORC)を生成することができる1つ以上の補助食品を含む組成物を前記動物に投与することを含む方法。
- 前記補助食品がシトルリンである、請求項152に記載の方法。
- 前記補助食品がオルニチンである、請求項152に記載の方法。
- 前記動物がヒトである、請求項152に記載の方法。
- 前記動物がイヌ又はネコである、請求項152に記載の方法。
- 前記動物が加齢動物である、請求項152に記載の方法。
- 前記UFAが天然魚油、ALA、EPA、DPA、DHA、又は任意の源由来の別のn−3脂肪酸の1種又は複数を含む、請求項152に記載の方法。
- 前記UFAが魚油である、請求項152に記載の方法。
- 前記組成物が約0.1%〜約50%のUFAを含む、請求項152に記載の方法。
- 前記組成物が約0.1%〜約20%の補助食品を含む、請求項152に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上のビタミンB群を更に含む、請求項152に記載の方法。
- 前記組成物が推奨1日所要量の約0.1〜40倍のビタミンB群を含む、請求項162に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上の抗酸化剤を更に含む、請求項152に記載の方法。
- 前記組成物が約0.0001%〜約25%の抗酸化剤を含む、請求項164に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上のビタミンB群及び1つ以上の抗酸化剤を含む、請求項152に記載の方法。
- 前記組成物が推奨1日所要量の約0.1〜40倍のビタミンB群及び約0.0001%〜約25%の抗酸化剤を含む、請求項166に記載の方法。
- 前記組成物が、ヒト食品組成物、ペットフード組成物、又は栄養補助食品として処方された、請求項152に記載の方法。
- 前記組成物が、約15%〜約50%のタンパク質、約5%〜約40%の脂肪、約5%〜約10%の灰分を更に含み、約5%〜約20%の含水率を有する食品組成物である、請求項168に記載の方法。
- 前記組成物が、認知機能を高めるのに有効な量で、1つ以上の認知薬と組み合わせて前記動物に投与される、請求項152に記載の方法。
- 前記認知薬が、セレギリン、ニセルゴリン、ホスファチジルセリン、プロペントフィリン、ガランタミン、ビンポセチン、ドネペジル、Ginkgo biloba抽出物、ビスホソホネート、ラロキシフェン、エストロゲン、植物エストロゲン、カルシトニン、リゼドロネート、又はアレンドロネートの1種又は複数である、請求項170に記載の方法。
- 投与される前記組成物が1つ以上の認知薬を場合により含む医薬又は機能性食品成物である、請求項152に記載の方法。
- 前記組成物が長期間定期的に投与される、請求項152に記載の方法。
- 前記組成物が前記動物に毎日投与される、請求項173に記載の方法。
- 前記動物が加齢動物である、請求項152に記載の方法。
- 前記動物が加齢に伴う認知障害と関連する表現型を有する、請求項175に記載の方法。
- 前記表現型が、前記表現型を有さない対照動物と比較したとき、想起力の低下、短期記憶喪失、学習速度の低下、学習能力の低下、問題解決力の低下、注意持続期間の低下、運動能力の低下、意識障害の増加、又は痴呆の1つ又は複数を含む、請求項176に記載の方法。
- 前記動物が健康な加齢動物である、請求項152に記載の方法。
- 前記動物がコンパニオンアニマルである、請求項152に記載の方法。
- 動物の健康を促進する方法であって、動物の健康を促進するのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項180に記載の方法。
- 前記動物が若齢動物又は成熟動物である、請求項180に記載の方法。
- 前記動物が加齢動物である、請求項180に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項180に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項180に記載の方法。
- 前記NORCがシトルリンである、請求項180に記載の方法。
- 前記NORCがオルニチンである、請求項180に記載の方法。
- 動物の壮年期を延ばす方法であって、動物の壮年期を延ばすのに有効な量で、UFA及びNORCを含む組成物を前記動物に投与することを含む方法。
- 前記動物がヒト又はコンパニオンアニマルである、請求項188に記載の方法。
- 前記動物が若齢動物又は成熟動物である、請求項188に記載の方法。
- 前記動物が加齢動物である、請求項188に記載の方法。
- 前記組成物が、1つ以上のビタミンB群、1つ以上の抗酸化剤、又はその両方を更に含む、請求項188に記載の方法。
- 前記NORCがアルギニン又はその酸化窒素放出誘導体である、請求項188に記載の方法。
- 前記NORCがシトルリンである、請求項188に記載の方法。
- 前記NORCがオルニチンである、請求項188に記載の方法。
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014515011A (ja) * | 2011-03-18 | 2014-06-26 | ネステク ソシエテ アノニム | 加齢に伴う疾病を改善するのに有用な組成物及び方法 |
US20160367509A1 (en) * | 2015-06-22 | 2016-12-22 | Nestec Sa | Compositions and methods for enhancing neurogenesis in animals |
JP2017502283A (ja) * | 2013-12-19 | 2017-01-19 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高タンパク質食品の腐敗を決定するための方法 |
JP2018502571A (ja) * | 2014-12-29 | 2018-02-01 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 食品組成物および使用方法 |
JP2019530665A (ja) * | 2016-09-29 | 2019-10-24 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 認知症ではない患者における神経保護薬としての、ω3脂肪酸及びコリン |
JP2020513805A (ja) * | 2017-03-18 | 2020-05-21 | マクガラー,スティーブン,エム. | カンナビジオール酸を含むペットフード |
WO2022191184A1 (ja) * | 2021-03-08 | 2022-09-15 | 国立大学法人九州大学 | グレリン受容体感受性増強剤、グレリン受容体感受性増強用組成物及びグレリン受容体の活性化方法 |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8252742B2 (en) * | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
CA2912259C (en) | 2005-05-27 | 2020-04-28 | Mark H. Schoenfisch | Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications |
MX2010003568A (es) * | 2007-10-04 | 2010-04-21 | Nestec Sa | Composiciones y metodos para mejorar la funcion cognitiva. |
CA2731088C (en) * | 2008-07-18 | 2015-09-22 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
AU2013200758B2 (en) * | 2008-07-18 | 2014-06-12 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
EP4249001A3 (en) | 2009-08-21 | 2023-11-29 | Novan, Inc. | Topical gels |
AU2010293065B2 (en) * | 2009-09-11 | 2016-05-05 | Nestec S.A. | Compositions and methods for enhancing cognitive and related functions in animals |
MX346594B (es) * | 2009-12-29 | 2017-03-24 | Nestec Sa | Composiciones nutricionales que comprenden hojuelas de frutas que incluyen acido docosahexaenoico. |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
CN102552457A (zh) * | 2010-12-24 | 2012-07-11 | 漆又毛 | 一种氨基酸和提取物组合物的药物用途 |
JP2014504605A (ja) * | 2011-01-25 | 2014-02-24 | ネステク ソシエテ アノニム | 動物の視覚系の劣化を治療、緩和又は予防するための方法及び組成物 |
WO2012112340A2 (en) * | 2011-02-18 | 2012-08-23 | Nestec S.A. | Methods and compositions for treating, reducing, or preventing damage to the nervous system of animals |
EP2681286B1 (en) | 2011-02-28 | 2018-08-15 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
AT511776B1 (de) * | 2011-07-26 | 2014-03-15 | Gonadosan Gmbh | Verwendung von citrullin und ein kombinationspräparat zur verbesserung der männlichen fertilität |
US20130059028A1 (en) * | 2011-09-01 | 2013-03-07 | Julie Marie Foy | Compositions and Methods for Providing a Life-Stage-Appropriate Animal Diet |
CN102600124B (zh) * | 2012-02-06 | 2014-03-26 | 单宝华 | Omega-3增强组合物及其应用 |
AU2013339057B2 (en) * | 2012-10-30 | 2018-08-30 | Kyowa Hakko Bio Co., Ltd. | Agent for preventing or improving decline in brain function |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
CN103609752B (zh) * | 2013-12-02 | 2016-05-25 | 内蒙古伊利实业集团股份有限公司 | 一种改善脑部认知功能的组合物及其制备方法与应用 |
WO2015160234A1 (en) * | 2014-04-17 | 2015-10-22 | N.V. Nutricia | Composition for brain improvement |
MX2017004662A (es) * | 2014-10-10 | 2017-07-26 | Nestec Sa | Composiciones y metodos para mejorar la movilidad o actividad o tratar la fragilidad. |
MA40847A (fr) * | 2014-10-22 | 2017-09-13 | Raffaele Migliaccio | Association comprenant de la spiruline et du palmitoyléthanolamide et/ou des sels ou des dérivés pharmaceutiquement acceptables de ceux-ci et leurs formulations, pour une utilisation dans la prévention et/ou le traitement d'états d'hyperactivité des tissus |
CN105602998A (zh) * | 2016-01-18 | 2016-05-25 | 青岛哈拿生物科技有限公司 | 一种水溶性天然一氧化氮的制作方法及应用 |
CA3024365A1 (en) * | 2016-05-27 | 2017-11-30 | Nestec S.A. | Nutritional composition for treating or preventing impaired mobility |
JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
US20210128587A1 (en) * | 2017-04-11 | 2021-05-06 | Societe Des Produits Nestle S.A. | Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals |
SG11202001142VA (en) | 2017-08-14 | 2020-03-30 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2018A (en) * | 1841-03-26 | Joseph francis | ||
JP2003532622A (ja) * | 1999-06-14 | 2003-11-05 | ヘンリー フォード ヘルス システム | 神経発生を誘導する一酸化窒素ドナー |
JP2006503105A (ja) * | 2002-09-20 | 2006-01-26 | ノバルティス アクチエンゲゼルシャフト | ロイシンに富んだ栄養的組成物 |
CN1810257A (zh) * | 2005-05-26 | 2006-08-02 | 钟健琳 | 活脑素口服液 |
WO2007022991A1 (en) * | 2005-08-26 | 2007-03-01 | Nestec S.A. | Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis in ischemia or after ischemic episode in the brain |
WO2007041418A2 (en) * | 2005-09-30 | 2007-04-12 | Nestec S.A. | Methods and compositions for improving cognitive function |
WO2007115282A2 (en) * | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294520B1 (en) | 1989-03-27 | 2001-09-25 | Albert T. Naito | Material for passage through the blood-brain barrier |
GB2268871A (en) * | 1992-07-04 | 1994-01-26 | Bio Nutritional Health Service | Composition for use as a food or food supplement |
IT1264987B1 (it) * | 1993-12-14 | 1996-10-17 | Prospa Bv | Sali di un acido grasso poliinsaturo e formulazioni farmaceutiche che li contengono |
HUP9800049A3 (en) | 1995-02-23 | 1999-01-28 | Novartis Nutrition Ag | Amino acid compositions and use thereof in clinical nutrition, and use of the said amino acids for preparing pharmaceutical compns. for the diminution of tnf |
CA2185983C (en) | 1996-09-19 | 2004-04-13 | Wie-Jong Kwak | Process of extracting and purifying biologically effective ingredients from combined medicinal plants and their extract composition |
US5874471A (en) * | 1997-02-27 | 1999-02-23 | Waugh; William Howard | Orthomolecular medical use of L-citrulline for vasoprotection, relaxative smooth muscle tone and cell protection |
US7135498B1 (en) * | 1999-06-14 | 2006-11-14 | Henry Ford Health System | Nitric oxide donors for inducing neurogenesis |
JP4669095B2 (ja) | 1999-07-19 | 2011-04-13 | 太陽化学株式会社 | ペットの問題行動抑制組成物 |
US20040043013A1 (en) * | 2000-12-28 | 2004-03-04 | Mccleary Edward Larry | Metabolic uncoupling therapy |
US20050002992A1 (en) | 2003-06-17 | 2005-01-06 | Mccleary Edward Larry | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
EP1378236B1 (en) | 2001-03-23 | 2007-06-27 | Ajinomoto Co., Inc. | Agents against stress-induced diseases |
US20060014773A1 (en) * | 2001-04-19 | 2006-01-19 | Mccleary Edward L | Mental agility lozenge, edible strip, food or drink |
US6964969B2 (en) * | 2001-04-19 | 2005-11-15 | Mccleary Edward Larry | Composition and method for treating impaired or deteriorating neurological function |
DE10131516B4 (de) | 2001-07-02 | 2004-05-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Steuereinheit zur Flussregulierung |
AU2002336638A1 (en) * | 2001-10-12 | 2003-04-28 | Cornell Research Foundation, Inc. | Reversing or preventing premature vascular senescence |
NL1019368C2 (nl) | 2001-11-14 | 2003-05-20 | Nutricia Nv | Preparaat voor het verbeteren van receptorwerking. |
US7514107B2 (en) * | 2002-03-21 | 2009-04-07 | Mars, Incorporated | Treatment of diseases involving defective gap junctional communication |
US20040001817A1 (en) | 2002-05-14 | 2004-01-01 | Giampapa Vincent C. | Anti-aging nutritional supplement |
JP2006520335A (ja) | 2003-03-18 | 2006-09-07 | ノバルティス アクチエンゲゼルシャフト | 脂肪酸とアミノ酸を含有する組成物 |
WO2005006877A1 (en) | 2003-07-03 | 2005-01-27 | Hill's Pet Nutrition, Inc. | Compositions and methods for decreasing age-related deterioration in metal activities in companion animals |
US6951658B1 (en) | 2003-07-08 | 2005-10-04 | Pearson Research & Development Limited | Emu-based compositions for mental well-being and method of use |
EP1665940A4 (en) | 2003-09-02 | 2011-01-19 | Bbk Bio Corp | DIETETIC FOODSTUFF |
CA2549429A1 (en) | 2003-12-22 | 2005-07-07 | Wakunaga Pharmaceutical Co., Ltd. | Fat composition |
US20060002985A1 (en) | 2004-07-02 | 2006-01-05 | Zicker Steven C | Compositions and methods for decreasing age-related deterioration in mental activities in companion animals |
EP1634599A1 (en) | 2004-08-20 | 2006-03-15 | N.V. Nutricia | Iimmune stimulatory infant nutrition |
DK1830883T3 (da) | 2004-12-29 | 2013-11-25 | Hills Pet Nutrition Inc | Fremgangsmåde til at hæmme en nedgang i indlæring og/eller hukommelse hos dyr |
BRPI0519610A2 (pt) | 2004-12-30 | 2009-02-25 | Hills Pet Nutrition Inc | mÉtodos para melhorar a qualidade de vida de um animal idoso ou muito idoso, de um canino de raÇa regular ou pequena, idoso ou muito idoso, de um cço de raÇa grande idoso ou muito idoso, e de um gato idoso ou muito idoso |
JP2008526214A (ja) | 2004-12-30 | 2008-07-24 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 発育期の動物の生活の質を高めるための方法 |
US8324276B2 (en) * | 2005-01-24 | 2012-12-04 | Pronova Biopharma Norge As | Fatty acid composition for treatment of alzheimer's disease and cognitive dysfunction |
US20100049583A1 (en) | 2005-06-30 | 2010-02-25 | Koninklijke Philips Electronics, N.V. | Method and system for selection of information |
RU2444356C2 (ru) | 2005-07-08 | 2012-03-10 | Мартек Байосайенсиз Корпорейшн | Полиненасыщенные жирные кислоты для лечения деменции и состояний, связанных с преддеменцией |
CA2631343C (en) | 2005-12-02 | 2014-02-11 | Mochida Pharmaceutical Co., Ltd. | The combination of omega-3 fatty acids and thyroid hormone for treating alzheimer's dementia |
ES2366034T3 (es) | 2005-12-23 | 2011-10-14 | N.V. Nutricia | Composición que comprende ácidos grasos poliinsaturados, proteínas, manganeso y/o molibdeno y nucleósidos/nucleótidos para el tratamiento de la demencia. |
MX2010003568A (es) | 2007-10-04 | 2010-04-21 | Nestec Sa | Composiciones y metodos para mejorar la funcion cognitiva. |
WO2014100896A1 (en) | 2012-12-31 | 2014-07-03 | Aastra Technologies Limited | Interface adapter |
-
2008
- 2008-12-19 JP JP2010541427A patent/JP5979816B2/ja active Active
- 2008-12-19 CN CN200880123505XA patent/CN101909632A/zh active Pending
- 2008-12-19 EP EP16163261.7A patent/EP3058942B2/en active Active
- 2008-12-19 BR BRPI0822238A patent/BRPI0822238B8/pt active IP Right Grant
- 2008-12-19 EP EP08869735.4A patent/EP2224930B1/en active Active
- 2008-12-19 CA CA2709660A patent/CA2709660C/en active Active
- 2008-12-19 RU RU2010132637/15A patent/RU2500402C2/ru active
- 2008-12-19 US US12/734,013 patent/US20100233304A1/en not_active Abandoned
- 2008-12-19 ES ES08869735.4T patent/ES2586757T3/es active Active
- 2008-12-19 CA CA2994586A patent/CA2994586C/en active Active
- 2008-12-19 WO PCT/US2008/013870 patent/WO2009088433A1/en active Application Filing
- 2008-12-19 MX MX2010007438A patent/MX337760B/es active IP Right Grant
- 2008-12-19 AU AU2008347177A patent/AU2008347177B2/en active Active
- 2008-12-19 ES ES16163261T patent/ES2773928T5/es active Active
- 2008-12-19 CN CN201510779748.0A patent/CN105267969A/zh active Pending
-
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- 2017-02-23 US US15/440,702 patent/US10111911B2/en active Active
-
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- 2018-10-03 US US16/150,979 patent/US10973859B2/en active Active
-
2021
- 2021-03-19 US US17/206,851 patent/US11951137B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2018A (en) * | 1841-03-26 | Joseph francis | ||
JP2003532622A (ja) * | 1999-06-14 | 2003-11-05 | ヘンリー フォード ヘルス システム | 神経発生を誘導する一酸化窒素ドナー |
JP2006503105A (ja) * | 2002-09-20 | 2006-01-26 | ノバルティス アクチエンゲゼルシャフト | ロイシンに富んだ栄養的組成物 |
CN1810257A (zh) * | 2005-05-26 | 2006-08-02 | 钟健琳 | 活脑素口服液 |
WO2007022991A1 (en) * | 2005-08-26 | 2007-03-01 | Nestec S.A. | Compositions and methods for improving functional vascular integrity, cellular survival and reducing apoptosis in ischemia or after ischemic episode in the brain |
WO2007041418A2 (en) * | 2005-09-30 | 2007-04-12 | Nestec S.A. | Methods and compositions for improving cognitive function |
WO2007115282A2 (en) * | 2006-04-03 | 2007-10-11 | Accera, Inc. | Use of ketogenic compounds for treatment of age-associated memory impairment |
Non-Patent Citations (6)
Title |
---|
JPN6010022079; 山田清文, 他.: '学習記憶における一酸化窒素の役割' 医学のあゆみ Vol.184, No.8, 19980221, p.674-675 * |
JPN6013026918; Neurobiology of Aging vol.25, 2004, P.311-314 * |
JPN6013053965; オレオサイエンス vol.6, no.2, 2006, p.67-76 * |
JPN6013053966; 第46回日本老年医学会学術集会記録 vol.42, 2005, p.174-176 * |
JPN6013053967; 臨床病理 vol.52, no.3, 2004, p.249-253 * |
JPN6013053968; Indian J Physiol Pharmacol vol.49, no.2, 2005, p.179-186 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014515011A (ja) * | 2011-03-18 | 2014-06-26 | ネステク ソシエテ アノニム | 加齢に伴う疾病を改善するのに有用な組成物及び方法 |
JP2017502283A (ja) * | 2013-12-19 | 2017-01-19 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 高タンパク質食品の腐敗を決定するための方法 |
JP2018502571A (ja) * | 2014-12-29 | 2018-02-01 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 食品組成物および使用方法 |
JP2019205461A (ja) * | 2014-12-29 | 2019-12-05 | ヒルズ・ペット・ニュートリシャン・インコーポレーテッド | 食品組成物および使用方法 |
US20160367509A1 (en) * | 2015-06-22 | 2016-12-22 | Nestec Sa | Compositions and methods for enhancing neurogenesis in animals |
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EP2224930A1 (en) | 2010-09-08 |
US20190030088A1 (en) | 2019-01-31 |
JP5979816B2 (ja) | 2016-08-31 |
US20210205373A1 (en) | 2021-07-08 |
AU2008347177A1 (en) | 2009-07-16 |
ES2773928T5 (es) | 2023-06-28 |
MX337760B (es) | 2016-03-17 |
EP3058942B2 (en) | 2023-03-22 |
US10111911B2 (en) | 2018-10-30 |
EP2224930A4 (en) | 2011-06-22 |
AU2008347177B2 (en) | 2014-04-17 |
RU2010132637A (ru) | 2012-02-10 |
CA2709660A1 (en) | 2009-07-16 |
US20170157182A1 (en) | 2017-06-08 |
CN101909632A (zh) | 2010-12-08 |
US11951137B2 (en) | 2024-04-09 |
BRPI0822238B1 (pt) | 2020-03-10 |
CA2994586A1 (en) | 2009-07-16 |
CN105267969A (zh) | 2016-01-27 |
US10973859B2 (en) | 2021-04-13 |
US20100233304A1 (en) | 2010-09-16 |
BRPI0822238B8 (pt) | 2021-05-25 |
CA2709660C (en) | 2018-06-05 |
EP3058942A1 (en) | 2016-08-24 |
CA2994586C (en) | 2020-07-21 |
EP2224930B1 (en) | 2016-06-15 |
ES2586757T3 (es) | 2016-10-18 |
ES2773928T3 (es) | 2020-07-15 |
WO2009088433A1 (en) | 2009-07-16 |
RU2500402C2 (ru) | 2013-12-10 |
BRPI0822238A2 (pt) | 2015-06-30 |
EP3058942B1 (en) | 2019-12-04 |
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