JP2011507860A - 異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用 - Google Patents
異常瘢痕または過剰瘢痕の治療のための抗コネキシンポリヌクレオチドおよび抗コネキシンペプチドの使用 Download PDFInfo
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017140231A (ja) * | 2016-02-10 | 2017-08-17 | 株式会社アルチザンラボ | 止血材およびそれを含有する創傷被覆材 |
| US10195339B2 (en) | 2014-03-20 | 2019-02-05 | Terumo Kabushiki Kaisha | Fluidic pump |
| WO2019026177A1 (ja) * | 2017-08-01 | 2019-02-07 | 株式会社アルチザンラボ | 止血材およびそれを含有する創傷被覆材 |
| JP2021029134A (ja) * | 2019-08-19 | 2021-03-01 | 学校法人順天堂 | ギャップ結合機能制御剤のスクリーニング方法 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101573131B (zh) | 2005-02-03 | 2017-12-01 | 科达治疗有限公司 | 抗‑连接蛋白化合物及其治疗应用 |
| PT2049123E (pt) | 2006-08-03 | 2013-03-06 | Horizon Pharma Ag | Tratamento de doença reumatóide com glucocorticóide de libertação retardada |
| CA2710380A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin 43 poly nucleotide for the treatment of fibrotic conditions |
| US9999702B2 (en) * | 2010-04-09 | 2018-06-19 | Kci Licensing Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| MX351881B (es) | 2012-03-01 | 2017-11-01 | Firststring Res Inc | Geles tópicos que contienen péptidos de alfa-conexina c- terminal (act). |
| WO2015019124A1 (en) * | 2013-08-05 | 2015-02-12 | Societe De Developpement Et De Recherche Industrielle | Molecular targets for the prevention and/or treatment of fibrosis, hypertrophic scars or keloids |
| WO2016029191A2 (en) | 2014-08-22 | 2016-02-25 | Auckland Uniservices Limited | Channel modulators |
| CN107106544B (zh) | 2014-09-19 | 2021-09-24 | 纪念斯隆-凯特琳癌症中心 | 用于治疗脑转移瘤的方法 |
| WO2017192620A2 (en) * | 2016-05-03 | 2017-11-09 | University Of Auckland | Novel peptides and peptidomimetics |
| CN111201247A (zh) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | 治疗方法和新颖构建体 |
| EP3675874B1 (en) * | 2017-09-01 | 2023-11-29 | Excel Med, LLC | Pharmaceuticals composition for treating keloid and uses thereof |
| US12667586B2 (en) | 2023-03-07 | 2026-06-30 | Glaukos Corporation | Treatments for ocular surface disorders |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001522878A (ja) * | 1997-11-17 | 2001-11-20 | ニコラス ブイー ペリコン， | リポ酸を使用する瘢痕組織の治療 |
| JP2002535377A (ja) * | 1999-01-27 | 2002-10-22 | ユニバーシテイ・カレツジ・ロンドン | コネキシンに対するアンチセンスヌクレオチドを含む配合物 |
| JP2006527234A (ja) * | 2003-06-09 | 2006-11-30 | アセンド セラピュティクス インコーポレイテッド | ４−ヒドロキシタモキシフェンによる過剰瘢痕化の治療及び予防 |
| JP2007084446A (ja) * | 2005-09-20 | 2007-04-05 | Pola Chem Ind Inc | 皮膚外用剤 |
| JP2011506447A (ja) * | 2007-12-11 | 2011-03-03 | コーダ セラピューティクス， インコーポレイテッド | 損傷した創傷治癒組成物および治療 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2542471C2 (ru) * | 2006-11-15 | 2015-02-20 | Коуда Терапьютикс, Инк. | Улучшенные способы и композиции для заживления ран |
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2008
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- 2008-12-22 EP EP08868457A patent/EP2252320A2/en not_active Ceased
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- 2008-12-22 US US12/809,986 patent/US20130184220A1/en not_active Abandoned
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2010
- 2010-07-21 ZA ZA2010/05221A patent/ZA201005221B/en unknown
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2014
- 2014-12-08 JP JP2014248303A patent/JP2015057430A/ja active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001522878A (ja) * | 1997-11-17 | 2001-11-20 | ニコラス ブイー ペリコン， | リポ酸を使用する瘢痕組織の治療 |
| JP2002535377A (ja) * | 1999-01-27 | 2002-10-22 | ユニバーシテイ・カレツジ・ロンドン | コネキシンに対するアンチセンスヌクレオチドを含む配合物 |
| JP2006527234A (ja) * | 2003-06-09 | 2006-11-30 | アセンド セラピュティクス インコーポレイテッド | ４−ヒドロキシタモキシフェンによる過剰瘢痕化の治療及び予防 |
| JP2007084446A (ja) * | 2005-09-20 | 2007-04-05 | Pola Chem Ind Inc | 皮膚外用剤 |
| JP2011506447A (ja) * | 2007-12-11 | 2011-03-03 | コーダ セラピューティクス， インコーポレイテッド | 損傷した創傷治癒組成物および治療 |
Non-Patent Citations (3)
| Title |
|---|
| JPN6013028061; Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｐｌａｓｔｉｃ Ｓｕｒｇｅｒｙ Ｖｏｌ．５８, 2005, ｐ．６５８-６６７ * |
| JPN7013002158; Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ Ｖｏｌ．１２８, 200710, ｐ．１０３９-１０４９ * |
| JPN7013002159; Ｃｕｒｒｅｎｔ Ｂｉｏｌｏｇｙ Ｖｏｌ．１３, 2003, ｐ．１６９７-１７０３ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10195339B2 (en) | 2014-03-20 | 2019-02-05 | Terumo Kabushiki Kaisha | Fluidic pump |
| JP2017140231A (ja) * | 2016-02-10 | 2017-08-17 | 株式会社アルチザンラボ | 止血材およびそれを含有する創傷被覆材 |
| WO2019026177A1 (ja) * | 2017-08-01 | 2019-02-07 | 株式会社アルチザンラボ | 止血材およびそれを含有する創傷被覆材 |
| US11938230B2 (en) | 2017-08-01 | 2024-03-26 | Artisan Lab Co., Ltd. | Hemostatic material and wound dressing containing same |
| JP2021029134A (ja) * | 2019-08-19 | 2021-03-01 | 学校法人順天堂 | ギャップ結合機能制御剤のスクリーニング方法 |
| JP7393780B2 (ja) | 2019-08-19 | 2023-12-07 | 学校法人順天堂 | ギャップ結合機能制御剤のスクリーニング方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201005221B (en) | 2011-06-29 |
| CA2710232A1 (en) | 2009-07-09 |
| JP2015057430A (ja) | 2015-03-26 |
| WO2009085274A2 (en) | 2009-07-09 |
| US20130184220A1 (en) | 2013-07-18 |
| WO2009085274A3 (en) | 2009-10-01 |
| EP2252320A2 (en) | 2010-11-24 |
| AU2008343755A1 (en) | 2009-07-09 |
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