JP2011507542A5 - - Google Patents
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- Publication number
- JP2011507542A5 JP2011507542A5 JP2010540181A JP2010540181A JP2011507542A5 JP 2011507542 A5 JP2011507542 A5 JP 2011507542A5 JP 2010540181 A JP2010540181 A JP 2010540181A JP 2010540181 A JP2010540181 A JP 2010540181A JP 2011507542 A5 JP2011507542 A5 JP 2011507542A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- nucleic acid
- assay
- oligocation
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 19
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 238000003556 assay Methods 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 4
- 108091034117 Oligonucleotide Proteins 0.000 claims 4
- 125000005647 linker group Chemical group 0.000 claims 4
- 238000001668 nucleic acid synthesis Methods 0.000 claims 4
- 230000003321 amplification Effects 0.000 claims 3
- 238000003199 nucleic acid amplification method Methods 0.000 claims 3
- 229960002685 biotin Drugs 0.000 claims 2
- 235000020958 biotin Nutrition 0.000 claims 2
- 239000011616 biotin Substances 0.000 claims 2
- 150000001841 cholesterols Chemical class 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical group NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical group NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical group NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- WSNMPAVSZJSIMT-UHFFFAOYSA-N COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 Chemical compound COc1c(C)c2COC(=O)c2c(O)c1CC(O)C1(C)CCC(=O)O1 WSNMPAVSZJSIMT-UHFFFAOYSA-N 0.000 claims 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 claims 1
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 claims 1
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 238000002944 PCR assay Methods 0.000 claims 1
- 239000005700 Putrescine Substances 0.000 claims 1
- 108091028664 Ribonucleotide Proteins 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 238000007385 chemical modification Methods 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000007837 multiplex assay Methods 0.000 claims 1
- 238000003753 real-time PCR Methods 0.000 claims 1
- 239000002336 ribonucleotide Substances 0.000 claims 1
- 125000002652 ribonucleotide group Chemical group 0.000 claims 1
- 229940063673 spermidine Drugs 0.000 claims 1
- 229940063675 spermine Drugs 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US914507P | 2007-12-27 | 2007-12-27 | |
| EP07025148A EP2075342A1 (en) | 2007-12-27 | 2007-12-27 | Method for hybridizing nucleic acids |
| PCT/IB2008/002789 WO2009083763A1 (en) | 2007-12-27 | 2008-09-12 | Method for hybridizing nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507542A JP2011507542A (ja) | 2011-03-10 |
| JP2011507542A5 true JP2011507542A5 (enExample) | 2011-09-15 |
Family
ID=39339663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010540181A Pending JP2011507542A (ja) | 2007-12-27 | 2008-09-12 | 核酸のハイブリダイズ法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8465920B2 (enExample) |
| EP (2) | EP2075342A1 (enExample) |
| JP (1) | JP2011507542A (enExample) |
| KR (1) | KR20100124705A (enExample) |
| CN (1) | CN101978071A (enExample) |
| AU (1) | AU2008345460A1 (enExample) |
| BR (1) | BRPI0821698A2 (enExample) |
| CA (1) | CA2709183A1 (enExample) |
| DK (1) | DK2225393T3 (enExample) |
| ES (1) | ES2537625T3 (enExample) |
| IL (1) | IL206542A0 (enExample) |
| NZ (1) | NZ586373A (enExample) |
| RU (1) | RU2010131166A (enExample) |
| WO (1) | WO2009083763A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3214174B1 (en) | 2010-03-04 | 2019-10-16 | InteRNA Technologies B.V. | A mirna molecule defined by its source and its diagnostic and therapeutic uses in diseases or conditions associated with emt |
| EP2591106A1 (en) | 2010-07-06 | 2013-05-15 | InteRNA Technologies B.V. | Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway |
| JP5795317B2 (ja) * | 2010-09-10 | 2015-10-14 | 株式会社Ｌｓｉメディエンス | 光を用いた核酸の増幅抑制方法および高感度な選択的核酸増幅方法 |
| EP2474617A1 (en) | 2011-01-11 | 2012-07-11 | InteRNA Technologies BV | Mir for treating neo-angiogenesis |
| EP3369818B1 (en) | 2011-12-22 | 2021-06-09 | InteRNA Technologies B.V. | Mirna for treating head and neck cancer |
| KR102146523B1 (ko) * | 2012-01-06 | 2020-08-20 | 조원창 | 표적 핵산의 향상된 증폭 |
| US10201556B2 (en) | 2012-11-06 | 2019-02-12 | Interna Technologies B.V. | Combination for use in treating diseases or conditions associated with melanoma, or treating diseases or conditions associated with activated B-raf pathway |
| US9410172B2 (en) * | 2013-09-16 | 2016-08-09 | General Electric Company | Isothermal amplification using oligocation-conjugated primer sequences |
| DE102017123919A1 (de) | 2017-10-13 | 2019-04-18 | Gna Biosolutions Gmbh | Verfahren und Vorrichtung zur Lyse von Mikroorganismen |
| AU2018358016A1 (en) | 2017-11-03 | 2020-05-07 | Interna Technologies B.V. | MiRNA molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation |
| WO2019155094A1 (en) | 2018-02-12 | 2019-08-15 | Interna Technologies B.V. | Anticancer microrna and lipid formulations thereof |
| KR20200045212A (ko) | 2018-10-22 | 2020-05-04 | (주)바이오니아 | 옥타민 또는 옥타민 유도체가 결합된 프로브 및 이의 용도 |
| CN113444778A (zh) | 2020-03-27 | 2021-09-28 | 广州达安基因股份有限公司 | 具有高杂交性能的寡核苷酸缀合物及其应用 |
| IT202200026595A1 (it) | 2022-12-22 | 2024-06-22 | Fond Telethon Ets | Nuovi inibitori di regolatori epigenetici |
| WO2026133078A1 (en) | 2024-12-17 | 2026-06-25 | Fondazione Telethon Ets | Therapeutic strategy for treating copper-mediated pathologies |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1013770A1 (en) * | 1998-12-23 | 2000-06-28 | Université Louis Pasteur de Strasbourg | Non-viral transfection vector |
| JP2008519053A (ja) * | 2004-11-04 | 2008-06-05 | アンディーノ，ラウル | 小さい干渉ＲＮＡ（ｓｉＲＮＡ）のポリアミン共役体の合成及びそれによって形成された共役体 |
| KR101388320B1 (ko) | 2005-12-15 | 2014-04-22 | 뽈리쁠뤼스-트랑스펙씨옹 | 양이온성 올리고뉴클레오티드, 이를 제조하기 위한 자동화방법 및 이의 용도 |
-
2007
- 2007-12-27 EP EP07025148A patent/EP2075342A1/en not_active Withdrawn
-
2008
- 2008-09-12 US US12/735,261 patent/US8465920B2/en active Active
- 2008-09-12 BR BRPI0821698-3A patent/BRPI0821698A2/pt not_active IP Right Cessation
- 2008-09-12 ES ES08868164.8T patent/ES2537625T3/es active Active
- 2008-09-12 KR KR1020107015189A patent/KR20100124705A/ko not_active Withdrawn
- 2008-09-12 AU AU2008345460A patent/AU2008345460A1/en not_active Abandoned
- 2008-09-12 CN CN2008801227617A patent/CN101978071A/zh active Pending
- 2008-09-12 JP JP2010540181A patent/JP2011507542A/ja active Pending
- 2008-09-12 CA CA2709183A patent/CA2709183A1/en not_active Abandoned
- 2008-09-12 EP EP08868164.8A patent/EP2225393B1/en active Active
- 2008-09-12 NZ NZ586373A patent/NZ586373A/xx not_active IP Right Cessation
- 2008-09-12 RU RU2010131166/10A patent/RU2010131166A/ru not_active Application Discontinuation
- 2008-09-12 WO PCT/IB2008/002789 patent/WO2009083763A1/en not_active Ceased
- 2008-09-12 DK DK08868164.8T patent/DK2225393T3/en active
-
2010
- 2010-06-22 IL IL206542A patent/IL206542A0/en unknown
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