JP2011506334A5 - - Google Patents
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- JP2011506334A5 JP2011506334A5 JP2010537045A JP2010537045A JP2011506334A5 JP 2011506334 A5 JP2011506334 A5 JP 2011506334A5 JP 2010537045 A JP2010537045 A JP 2010537045A JP 2010537045 A JP2010537045 A JP 2010537045A JP 2011506334 A5 JP2011506334 A5 JP 2011506334A5
- Authority
- JP
- Japan
- Prior art keywords
- immunogenic composition
- antigen
- microparticles
- composition
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 114
- 230000002163 immunogen Effects 0.000 claims description 97
- 239000000427 antigen Substances 0.000 claims description 72
- 102000036639 antigens Human genes 0.000 claims description 72
- 108091007433 antigens Proteins 0.000 claims description 72
- 239000011859 microparticle Substances 0.000 claims description 58
- 239000002671 adjuvant Substances 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 26
- 229920002988 biodegradable polymer Polymers 0.000 claims description 13
- 239000004621 biodegradable polymer Substances 0.000 claims description 13
- 244000052769 pathogen Species 0.000 claims description 13
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 10
- 239000008346 aqueous phase Substances 0.000 claims description 10
- 201000005702 Pertussis Diseases 0.000 claims description 8
- 241000700605 Viruses Species 0.000 claims description 8
- SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 claims description 7
- 229940124669 imidazoquinoline Drugs 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 241000606768 Haemophilus influenzae Species 0.000 claims description 6
- 241000580858 Simian-Human immunodeficiency virus Species 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000004094 surface-active agent Substances 0.000 claims description 6
- 241000588650 Neisseria meningitidis Species 0.000 claims description 5
- 239000003945 anionic surfactant Substances 0.000 claims description 5
- 230000028993 immune response Effects 0.000 claims description 5
- 241000894006 Bacteria Species 0.000 claims description 4
- 201000006082 Chickenpox Diseases 0.000 claims description 4
- 241000991587 Enterovirus C Species 0.000 claims description 4
- 241000233866 Fungi Species 0.000 claims description 4
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 4
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 4
- 201000005505 Measles Diseases 0.000 claims description 4
- 206010034038 Parotitis Diseases 0.000 claims description 4
- 230000024932 T cell mediated immunity Effects 0.000 claims description 4
- 206010043376 Tetanus Diseases 0.000 claims description 4
- 206010046980 Varicella Diseases 0.000 claims description 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 4
- 206010013023 diphtheria Diseases 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- 229940045808 haemophilus influenzae type b Drugs 0.000 claims description 4
- 208000006454 hepatitis Diseases 0.000 claims description 4
- 231100000283 hepatitis Toxicity 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 244000045947 parasite Species 0.000 claims description 4
- 201000005404 rubella Diseases 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 3
- 239000007764 o/w emulsion Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 3
- 239000007762 w/o emulsion Substances 0.000 claims description 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 2
- 241000711549 Hepacivirus C Species 0.000 claims description 2
- 241000700721 Hepatitis B virus Species 0.000 claims description 2
- 241000712431 Influenza A virus Species 0.000 claims description 2
- 201000009906 Meningitis Diseases 0.000 claims description 2
- 206010028980 Neoplasm Diseases 0.000 claims description 2
- 229920001273 Polyhydroxy acid Polymers 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 2
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 2
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 239000003093 cationic surfactant Substances 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 150000004676 glycans Chemical class 0.000 claims description 2
- 239000007972 injectable composition Substances 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 239000002736 nonionic surfactant Substances 0.000 claims description 2
- 239000012074 organic phase Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 229940065514 poly(lactide) Drugs 0.000 claims description 2
- 102000040430 polynucleotide Human genes 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims description 2
- 239000002157 polynucleotide Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 238000004062 sedimentation Methods 0.000 claims description 2
- 238000000935 solvent evaporation Methods 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 150000003505 terpenes Chemical class 0.000 claims description 2
- 210000004881 tumor cell Anatomy 0.000 claims description 2
- 229960004441 tyrosine Drugs 0.000 claims description 2
- 239000002888 zwitterionic surfactant Substances 0.000 claims description 2
- 230000036039 immunity Effects 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US570407P | 2007-12-07 | 2007-12-07 | |
| PCT/US2008/085506 WO2009076158A1 (en) | 2007-12-07 | 2008-12-04 | Compositions for inducing immune responses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014117206A Division JP6013400B2 (ja) | 2007-12-07 | 2014-06-06 | 免疫応答を誘導するための組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011506334A JP2011506334A (ja) | 2011-03-03 |
| JP2011506334A5 true JP2011506334A5 (enExample) | 2012-02-02 |
Family
ID=40329118
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010537045A Pending JP2011506334A (ja) | 2007-12-07 | 2008-12-04 | 免疫応答を誘導するための組成物 |
| JP2014117206A Expired - Fee Related JP6013400B2 (ja) | 2007-12-07 | 2014-06-06 | 免疫応答を誘導するための組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014117206A Expired - Fee Related JP6013400B2 (ja) | 2007-12-07 | 2014-06-06 | 免疫応答を誘導するための組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8815253B2 (enExample) |
| EP (2) | EP3067048B1 (enExample) |
| JP (2) | JP2011506334A (enExample) |
| AU (1) | AU2008335457B2 (enExample) |
| CA (1) | CA2708145C (enExample) |
| ES (1) | ES2664753T3 (enExample) |
| WO (1) | WO2009076158A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010138193A2 (en) * | 2009-05-27 | 2010-12-02 | Selecta Biosciences, Inc. | Targeted synthetic nanocarriers with ph sensitive release of immunomodulatory agents |
| US20130101609A1 (en) * | 2010-01-24 | 2013-04-25 | Novartis Ag | Irradiated biodegradable polymer microparticles |
| US20110293700A1 (en) * | 2010-05-26 | 2011-12-01 | Selecta Biosciences, Inc. | Nanocarrier compositions with uncoupled adjuvant |
| EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
| EA201391392A1 (ru) * | 2011-03-25 | 2014-04-30 | Селекта Байосайенсиз, Инк. | Синтетические наноносители с осмотически опосредованным высвобождением |
| CN109172819A (zh) | 2011-07-29 | 2019-01-11 | 西莱克塔生物科技公司 | 产生体液和细胞毒性t淋巴细胞（ctl）免疫应答的合成纳米载体 |
| US9358461B2 (en) * | 2012-12-26 | 2016-06-07 | Sony Interactive Entertainment America Llc | Systems and methods for ranking of cloud executed mini-games based on tag content and social network content |
| ES2887367T3 (es) * | 2013-10-09 | 2021-12-22 | Toray Industries | Inmunopotenciador |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
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| BRPI0515316A (pt) * | 2004-09-14 | 2008-07-15 | Chiron Corp | compostos de imidazoquinolina |
| EP1812056B1 (en) | 2004-11-15 | 2013-08-07 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
| WO2007052058A1 (en) * | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics Srl | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| CA2643322C (en) * | 2006-02-24 | 2015-07-21 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| WO2007109810A2 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Methods for the preparation of imidazole-containing compounds |
-
2008
- 2008-12-04 EP EP16164271.5A patent/EP3067048B1/en active Active
- 2008-12-04 WO PCT/US2008/085506 patent/WO2009076158A1/en not_active Ceased
- 2008-12-04 US US12/746,723 patent/US8815253B2/en active Active
- 2008-12-04 JP JP2010537045A patent/JP2011506334A/ja active Pending
- 2008-12-04 AU AU2008335457A patent/AU2008335457B2/en not_active Ceased
- 2008-12-04 EP EP08860518A patent/EP2244695A1/en not_active Withdrawn
- 2008-12-04 ES ES16164271.5T patent/ES2664753T3/es active Active
- 2008-12-07 CA CA2708145A patent/CA2708145C/en not_active Expired - Fee Related
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2014
- 2014-06-06 JP JP2014117206A patent/JP6013400B2/ja not_active Expired - Fee Related
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