JP2011504489A5 - - Google Patents

Info

Publication number

JP2011504489A5

JP2011504489A5 JP2010534597A JP2010534597A JP2011504489A5 JP 2011504489 A5 JP2011504489 A5 JP 2011504489A5 JP 2010534597 A JP2010534597 A JP 2010534597A JP 2010534597 A JP2010534597 A JP 2010534597A JP 2011504489 A5 JP2011504489 A5 JP 2011504489A5

Authority

JP

Japan

Prior art keywords

compound

hydrocarbyl

ccl

halogen

independently

Prior art date

2008-11-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 150000001875 compounds Chemical class 0.000 claims 23
• 229910052760 oxygen Inorganic materials 0.000 claims 17
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 12
• GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 11
• 125000001183 hydrocarbyl group Chemical group 0.000 claims 11
• 229910052736 halogen Inorganic materials 0.000 claims 9
• 150000002367 halogens Chemical class 0.000 claims 9
• 229910052757 nitrogen Inorganic materials 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 8
• 229910052717 sulfur Chemical group 0.000 claims 7
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 125000005842 heteroatom Chemical group 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 229910052727 yttrium Inorganic materials 0.000 claims 6
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
• 125000000623 heterocyclic group Chemical group 0.000 claims 4
• 239000000203 mixture Substances 0.000 claims 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• 229920006395 saturated elastomer Polymers 0.000 claims 4
• 239000011593 sulfur Chemical group 0.000 claims 4
• VKIGAWAEXPTIOL-UHFFFAOYSA-N 2-hydroxyhexanenitrile Chemical compound CCCCC(O)C#N VKIGAWAEXPTIOL-UHFFFAOYSA-N 0.000 claims 3
• -1 2′-deoxyadenosine-5′-fluoromethane-diphosphonate Chemical compound 0.000 claims 3
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
• 102000002298 Purinergic P2Y Receptors Human genes 0.000 claims 3
• 108010000818 Purinergic P2Y Receptors Proteins 0.000 claims 3
• 239000007983 Tris buffer Substances 0.000 claims 3
• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 3
• 239000003085 diluting agent Substances 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 208000035475 disorder Diseases 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 238000010829 isocratic elution Methods 0.000 claims 3
• 230000014759 maintenance of location Effects 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 3
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 150000003863 ammonium salts Chemical class 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 150000001768 cations Chemical class 0.000 claims 2
• 238000000502 dialysis Methods 0.000 claims 2
• MWEQTWJABOLLOS-UHFFFAOYSA-L disodium;[[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;trihydrate Chemical compound O.O.O.[Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)C(O)C1O MWEQTWJABOLLOS-UHFFFAOYSA-L 0.000 claims 2
• 125000001072 heteroaryl group Chemical group 0.000 claims 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
• IWZSHWBGHQBIML-ZGGLMWTQSA-N (3S,8S,10R,13S,14S,17S)-17-isoquinolin-7-yl-N,N,10,13-tetramethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-amine Chemical compound CN(C)[C@H]1CC[C@]2(C)C3CC[C@@]4(C)[C@@H](CC[C@@H]4c4ccc5ccncc5c4)[C@@H]3CC=C2C1 IWZSHWBGHQBIML-ZGGLMWTQSA-N 0.000 claims 1
• OPFJDXRVMFKJJO-ZHHKINOHSA-N N-{[3-(2-benzamido-4-methyl-1,3-thiazol-5-yl)-pyrazol-5-yl]carbonyl}-G-dR-G-dD-dD-dD-NH2 Chemical compound S1C(C=2NN=C(C=2)C(=O)NCC(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(O)=O)C(N)=O)=C(C)N=C1NC(=O)C1=CC=CC=C1 OPFJDXRVMFKJJO-ZHHKINOHSA-N 0.000 claims 1
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 1
• 229910052783 alkali metal Inorganic materials 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000002091 cationic group Chemical group 0.000 claims 1
• 229940125782 compound 2 Drugs 0.000 claims 1
• 229940126086 compound 21 Drugs 0.000 claims 1
• 229940126214 compound 3 Drugs 0.000 claims 1
• 150000002892 organic cations Chemical class 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• ZMANZCXQSJIPKH-UHFFFAOYSA-O triethylammonium ion Chemical compound CC[NH+](CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-O 0.000 claims 1