JP2011504489A - 非加水分解性ヌクレオシド二又は三リン酸誘導体及びその使用 - Google Patents
非加水分解性ヌクレオシド二又は三リン酸誘導体及びその使用 Download PDFInfo
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65744—Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
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- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98988807P | 2007-11-23 | 2007-11-23 | |
| PCT/IL2008/001535 WO2009066298A1 (en) | 2007-11-23 | 2008-11-23 | Non-hydrolyzable nucleoside di- or tri-phosphate derivatives and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011504489A true JP2011504489A (ja) | 2011-02-10 |
| JP2011504489A5 JP2011504489A5 (enExample) | 2012-01-12 |
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| JP2010534597A Pending JP2011504489A (ja) | 2007-11-23 | 2008-11-23 | 非加水分解性ヌクレオシド二又は三リン酸誘導体及びその使用 |
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| US (1) | US20100256086A1 (enExample) |
| EP (1) | EP2231688A1 (enExample) |
| JP (1) | JP2011504489A (enExample) |
| CN (1) | CN101925610A (enExample) |
| BR (1) | BRPI0819832A2 (enExample) |
| WO (1) | WO2009066298A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012032513A1 (en) | 2010-09-07 | 2012-03-15 | Bar-Ilan University | Boranophosphate derivatives for the treatment of osteoarthritis |
| WO2012073237A1 (en) * | 2010-12-01 | 2012-06-07 | Bar-Ilan University | Uridine di- or tri-phosphate derivatives and uses thereof |
| KR102445887B1 (ko) | 2016-04-21 | 2022-09-21 | 아스트로사이트 파마슈티컬스, 인코포레이티드 | 신경계 및 심혈관계 병태 치료를 위한 화합물 및 방법 |
| CN111448203B (zh) * | 2017-11-10 | 2023-06-13 | 欧伦股份公司 | 用于制备坎格雷洛的有效方法 |
| EP3749322A4 (en) | 2018-02-09 | 2021-11-17 | Astrocyte Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR THE TREATMENT OF ADDICTION AND RELATED DISORDERS |
| EP3856741A4 (en) | 2018-09-26 | 2022-06-22 | Astrocyte Pharmaceuticals, Inc. | POLYMORPHOUS COMPOUNDS AND USES THEREOF |
| CN111434671B (zh) * | 2019-01-11 | 2023-07-11 | 凯思凯迪（上海）医药科技有限公司 | 肝脏特异性ampk激动剂及其制法和应用 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658890A (en) * | 1993-06-11 | 1997-08-19 | Sloan-Kettering Institute For Cancer Research | C-nucleoside isostere of nicotinamide adenine dinucleotide, analogs thereof and use as anti-cancer agent |
| WO1999003480A1 (en) * | 1997-07-17 | 1999-01-28 | William Harvey Research Limited | Use of adenosine tri- or tetra-phosphates and their analogues for the treatment of cerebral infarction |
| US20040077585A1 (en) * | 1997-02-10 | 2004-04-22 | Peterson Ward M. | Method of treating edematous retinal disorders |
| US20050053612A1 (en) * | 2003-08-20 | 2005-03-10 | Granstein Richard D. | Nucleotide regulation of immune responses |
| JP2005508970A (ja) * | 2001-10-24 | 2005-04-07 | バーイラン ユニバーシティー | 抗糖尿病性の２−置換−５’−ｏ−（１−ボラノトリホスフェート）アデノシン誘導体 |
| US20060287271A1 (en) * | 2005-06-15 | 2006-12-21 | Bar-Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| WO2007020018A1 (en) * | 2005-08-12 | 2007-02-22 | Universite Libre De Bruxelles | Use of purinergic and pyrimidinergic receptor agonists for dendritic cells based immunotherapies |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5859231A (en) * | 1993-09-03 | 1999-01-12 | Duke University | Synthesis of oligonucleotides with boranophosphonate linkages |
| US5620676A (en) * | 1994-03-08 | 1997-04-15 | The United States Of America As Represented By The Department Of Health And Human Services | Biologically active ATP analogs |
-
2008
- 2008-11-23 EP EP08852177A patent/EP2231688A1/en not_active Withdrawn
- 2008-11-23 BR BRPI0819832A patent/BRPI0819832A2/pt not_active IP Right Cessation
- 2008-11-23 US US12/744,473 patent/US20100256086A1/en not_active Abandoned
- 2008-11-23 CN CN2008801255871A patent/CN101925610A/zh active Pending
- 2008-11-23 WO PCT/IL2008/001535 patent/WO2009066298A1/en not_active Ceased
- 2008-11-23 JP JP2010534597A patent/JP2011504489A/ja active Pending
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| US5658890A (en) * | 1993-06-11 | 1997-08-19 | Sloan-Kettering Institute For Cancer Research | C-nucleoside isostere of nicotinamide adenine dinucleotide, analogs thereof and use as anti-cancer agent |
| US20040077585A1 (en) * | 1997-02-10 | 2004-04-22 | Peterson Ward M. | Method of treating edematous retinal disorders |
| WO1999003480A1 (en) * | 1997-07-17 | 1999-01-28 | William Harvey Research Limited | Use of adenosine tri- or tetra-phosphates and their analogues for the treatment of cerebral infarction |
| JP2005508970A (ja) * | 2001-10-24 | 2005-04-07 | バーイラン ユニバーシティー | 抗糖尿病性の２−置換−５’−ｏ−（１−ボラノトリホスフェート）アデノシン誘導体 |
| US20050053612A1 (en) * | 2003-08-20 | 2005-03-10 | Granstein Richard D. | Nucleotide regulation of immune responses |
| US20060287271A1 (en) * | 2005-06-15 | 2006-12-21 | Bar-Ilan University | Dinucleoside poly(borano)phosphate derivatives and uses thereof |
| WO2007020018A1 (en) * | 2005-08-12 | 2007-02-22 | Universite Libre De Bruxelles | Use of purinergic and pyrimidinergic receptor agonists for dendritic cells based immunotherapies |
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| JPN6013038150; Ｔｅｔｒａｈｅｄｒｏｎ Ｌｅｔｔｅｒｓ ３２（４４）, 1991, ６４２５-６４２８ * |
| JPN6013038152; Ｂｒｉｔｉｓｈ Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｌｏｇｙ １４９（４）, 2006, ４１６-４２３ * |
| JPN6013038154; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４７（１８）, 2004, ４４０５-４４１６ * |
| JPN6013038157; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４２（２６）, 1999, ５３３８-５３４７ * |
| JPN6013038158; Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ ４２（２６）, 1999, ５３２５-５３３７ * |
| JPN6013038161; Ｅｘｐｅｒｔ Ｏｐｉｎｉｏｎ ｏｎ Ｔｈｅｒａｐｅｕｔｉｃ Ｐａｔｅｎｔｓ ９（４）, 1999, ３８５-３９９ * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009066298A1 (en) | 2009-05-28 |
| BRPI0819832A2 (pt) | 2015-09-08 |
| CN101925610A (zh) | 2010-12-22 |
| EP2231688A1 (en) | 2010-09-29 |
| US20100256086A1 (en) | 2010-10-07 |
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