JP2011503071A5 - ヨードニトロベンズアミド化合物と抗腫瘍剤の組み合わせによる卵巣がんの治療 - Google Patents
ヨードニトロベンズアミド化合物と抗腫瘍剤の組み合わせによる卵巣がんの治療 Download PDFInfo
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- JP2011503071A5 JP2011503071A5 JP2010533126A JP2010533126A JP2011503071A5 JP 2011503071 A5 JP2011503071 A5 JP 2011503071A5 JP 2010533126 A JP2010533126 A JP 2010533126A JP 2010533126 A JP2010533126 A JP 2010533126A JP 2011503071 A5 JP2011503071 A5 JP 2011503071A5
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- topoisomerase inhibitor
- ovarian cancer
- nitrobenzamide
- iodo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 206010061535 Ovarian neoplasm Diseases 0.000 title claims 10
- 206010033128 Ovarian cancer Diseases 0.000 title claims 9
- JWMYQGBWTXDELZ-UHFFFAOYSA-N 3-iodo-2-nitrobenzamide Chemical class NC(=O)C1=CC=CC(I)=C1[N+]([O-])=O JWMYQGBWTXDELZ-UHFFFAOYSA-N 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 claims 12
- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 12
- MDOJTZQKHMAPBK-UHFFFAOYSA-N 4-iodo-3-nitrobenzamide Chemical compound NC(=O)C1=CC=C(I)C([N+]([O-])=O)=C1 MDOJTZQKHMAPBK-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000002207 metabolite Substances 0.000 claims 5
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 4
- 230000007812 deficiency Effects 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- 229960000303 topotecan Drugs 0.000 claims 4
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical group C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 4
- 108700020463 BRCA1 Proteins 0.000 claims 3
- 102000036365 BRCA1 Human genes 0.000 claims 3
- 101150072950 BRCA1 gene Proteins 0.000 claims 3
- 102000052609 BRCA2 Human genes 0.000 claims 3
- 108700020462 BRCA2 Proteins 0.000 claims 3
- 101150008921 Brca2 gene Proteins 0.000 claims 3
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 3
- 229960004768 irinotecan Drugs 0.000 claims 3
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 3
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 229940127093 camptothecin Drugs 0.000 claims 2
- 230000002950 deficient Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 claims 1
- FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 claims 1
- HAWSQZCWOQZXHI-UHFFFAOYSA-N CPT-OH Natural products C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-UHFFFAOYSA-N 0.000 claims 1
- 230000033616 DNA repair Effects 0.000 claims 1
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 claims 1
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 claims 1
- 208000021309 Germ cell tumor Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 claims 1
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 1
- 229950009429 exatecan Drugs 0.000 claims 1
- ZVYVPGLRVWUPMP-FYSMJZIKSA-N exatecan Chemical compound C1C[C@H](N)C2=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC3=CC(F)=C(C)C1=C32 ZVYVPGLRVWUPMP-FYSMJZIKSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 238000005549 size reduction Methods 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Description
Claims (19)
- ４−ヨード−３−ニトロベンズアミド、又はその代謝物もしくは薬学的に許容しうる塩、及び少なくとも１つのトポイソメラーゼ阻害剤の、卵巣がんに罹患しているヒト患者における進行性卵巣がんの治療用の、医薬品の製造のための使用。
- ４−ヨード−３−ニトロベンズアミド、又はその代謝物、又はその薬学的に許容しうる塩、及び少なくとも１つのトポイソメラーゼ阻害剤が、別々の剤形で提供され、そして順次投与される、請求項１に記載の使用。
- ４−ヨード−３−ニトロベンズアミド、又はその代謝物、又はその薬学的に許容しうる塩、及び少なくとも１つのトポイソメラーゼ阻害剤が、別々の剤形で提供され、そして同時に投与される、請求項１に記載の使用。
- 卵巣がんは転移性である、請求項１〜３のいずれかに記載の使用。
- トポイソメラーゼ阻害剤はトポイソメラーゼＩ阻害剤である、請求項１〜３のいずれかに記載の使用。
- トポイソメラーゼ阻害剤はトポイソメラーゼII阻害剤である、請求項１〜３のいずれかに記載の使用。
- トポイソメラーゼ阻害剤は、トポテカン、イリノテカン、ルートテカン、エキサテカン
及びカンプトセシンからなる群より選ばれる、請求項１〜３のいずれかに記載の使用。 - トポイソメラーゼ阻害剤は、トポテカン、イリノテカン及びカンプトセシンからなる群より選ばれる、請求項１〜３のいずれかに記載の使用。
- トポイソメラーゼ阻害剤はカンプトセシン誘導体である、請求項１〜３のいずれかに記載の使用。
- カンプトセシン誘導体は、１０−ヒドロキシカンプトセシン、トポテカン、イリノテカン及び９−アミノカンプトセシンからなる群より選ばれる、請求項９に記載の使用。
- トポイソメラーゼ阻害剤はトポテカンである、請求項１〜３のいずれかに記載の使用。
- 卵巣腫瘍のサイズ縮小、転移の減少、完全寛解、部分寛解、安定、及び病理学的完全奏効からなる群より選ばれる少なくとも１つの治療効果をもたらす、請求項１〜３のいずれかに記載の使用。
- 卵巣がんは相同組換えＤＮＡ修復における欠損である、請求項１〜３のいずれかに記載の使用。
- 卵巣がんはＢＲＣＡ欠損である、請求項１〜３のいずれかに記載の使用。
- ＢＲＣＡ欠損は、ＢＲＣＡ１欠損、ＢＲＣＡ２欠損、又はＢＲＣＡ１及びＢＲＣＡ２両方の欠損である、請求項１４に記載の使用。
- トポイソメラーゼ阻害剤を、４−ヨード−３−ニトロベンズアミド又はその薬学的に許容しうる塩を、投与する前に、投与と同時に、又は投与後に投与する、請求項１に記載の使用。
- 卵巣がんは、上皮性腫瘍、胚細胞腫瘍又は間質細胞腫瘍である、請求項１〜３のいずれかに記載の使用。
- ４−ヨード−３−ニトロベンズアミド、又はその代謝物若しくは薬学的に許容しうる塩、及び少なくとも１つのトポイソメラーゼ阻害剤の、ＢＲＣＡ１又はＢＲＣＡ２に関連した進行性卵巣がんの治療用の、医薬品の製造のための使用。
- バイアルの組合せを含む剤形であって、第一バイアルは４−ヨード−３−ニトロベンズアミド、又はその代謝物若しくは薬学的に許容しうる塩を含み、そして第二バイアルは少なくとも１つのトポイソメラーゼ阻害剤を含む、進行性卵巣がんの治療のための、上記剤形。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98733507P | 2007-11-12 | 2007-11-12 | |
| US1236407P | 2007-12-07 | 2007-12-07 | |
| US5852808P | 2008-06-03 | 2008-06-03 | |
| PCT/US2008/012757 WO2009064444A2 (en) | 2007-11-12 | 2008-11-12 | Treatment of uterine cancer and ovarian cancer with a parp inhibitor alone or in combination with anti-tumor agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011503071A JP2011503071A (ja) | 2011-01-27 |
| JP2011503071A5 true JP2011503071A5 (ja) | 2011-12-22 |
Family
ID=40623903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010533126A Abandoned JP2011503071A (ja) | 2007-11-12 | 2008-11-12 | Ｐａｒｐ阻害剤単独又は抗腫瘍剤との組み合わせによる子宮がん及び卵巣がんの治療 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20090123419A1 (ja) |
| EP (1) | EP2217244A4 (ja) |
| JP (1) | JP2011503071A (ja) |
| KR (1) | KR20100102607A (ja) |
| CN (1) | CN101918003A (ja) |
| AU (1) | AU2008321382A1 (ja) |
| CA (1) | CA2705417A1 (ja) |
| CO (1) | CO6290649A2 (ja) |
| CR (1) | CR11486A (ja) |
| DO (2) | DOP2010000142A (ja) |
| EC (1) | ECSP10010235A (ja) |
| GT (1) | GT201000137A (ja) |
| IL (1) | IL205633A0 (ja) |
| MA (1) | MA32748B1 (ja) |
| MX (1) | MX2010005221A (ja) |
| NI (1) | NI201000084A (ja) |
| NZ (1) | NZ586123A (ja) |
| SG (1) | SG185954A1 (ja) |
| TN (1) | TN2010000209A1 (ja) |
| WO (1) | WO2009064444A2 (ja) |
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-
2008
- 2008-11-12 US US12/269,833 patent/US20090123419A1/en not_active Abandoned
- 2008-11-12 WO PCT/US2008/012757 patent/WO2009064444A2/en active Application Filing
- 2008-11-12 SG SG2012081592A patent/SG185954A1/en unknown
- 2008-11-12 NZ NZ586123A patent/NZ586123A/xx not_active IP Right Cessation
- 2008-11-12 EP EP08848605A patent/EP2217244A4/en not_active Withdrawn
- 2008-11-12 CA CA2705417A patent/CA2705417A1/en not_active Withdrawn
- 2008-11-12 CN CN2008801245418A patent/CN101918003A/zh not_active Withdrawn
- 2008-11-12 MX MX2010005221A patent/MX2010005221A/es unknown
- 2008-11-12 JP JP2010533126A patent/JP2011503071A/ja not_active Abandoned
- 2008-11-12 AU AU2008321382A patent/AU2008321382A1/en not_active Withdrawn
- 2008-11-12 KR KR1020107012840A patent/KR20100102607A/ko not_active Application Discontinuation
-
2009
- 2009-07-14 US US12/502,943 patent/US20100009930A1/en not_active Abandoned
-
2010
- 2010-05-09 IL IL205633A patent/IL205633A0/en unknown
- 2010-05-11 GT GT201000137A patent/GT201000137A/es unknown
- 2010-05-11 NI NI201000084A patent/NI201000084A/es unknown
- 2010-05-11 TN TN2010000209A patent/TN2010000209A1/fr unknown
- 2010-05-12 DO DO2010000142A patent/DOP2010000142A/es unknown
- 2010-06-07 EC EC2010010235A patent/ECSP10010235A/es unknown
- 2010-06-10 CR CR11486A patent/CR11486A/es unknown
- 2010-06-11 CO CO10070932A patent/CO6290649A2/es not_active Application Discontinuation
- 2010-06-11 MA MA32905A patent/MA32748B1/fr unknown
-
2012
- 2012-11-16 DO DO2012000290A patent/DOP2012000290A/es unknown
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