JP2011501962A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011501962A5 JP2011501962A5 JP2010532219A JP2010532219A JP2011501962A5 JP 2011501962 A5 JP2011501962 A5 JP 2011501962A5 JP 2010532219 A JP2010532219 A JP 2010532219A JP 2010532219 A JP2010532219 A JP 2010532219A JP 2011501962 A5 JP2011501962 A5 JP 2011501962A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- nucleobase
- modified
- compound
- liver cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- 201000007270 liver cancer Diseases 0.000 claims 6
- 210000002966 Serum Anatomy 0.000 claims 4
- 239000002777 nucleoside Substances 0.000 claims 4
- 229920000272 Oligonucleotide Polymers 0.000 claims 3
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108010063628 acarboxyprothrombin Proteins 0.000 claims 2
- 102000013529 alpha-Fetoproteins Human genes 0.000 claims 2
- 108010026331 alpha-Fetoproteins Proteins 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 230000004048 modification Effects 0.000 claims 2
- 238000006011 modification reaction Methods 0.000 claims 2
- 230000004083 survival Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- ZROHGHOFXNOHSO-BNTLRKBRSA-L (1R,2R)-cyclohexane-1,2-diamine;oxalate;platinum(2+) Chemical compound [H][N]([C@@H]1CCCC[C@H]1[N]1([H])[H])([H])[Pt]11OC(=O)C(=O)O1 ZROHGHOFXNOHSO-BNTLRKBRSA-L 0.000 claims 1
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-Methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N 5-flurouricil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 1
- 229960004562 Carboplatin Drugs 0.000 claims 1
- OLESAACUTLOWQZ-UHFFFAOYSA-L Carboplatin Chemical compound O=C1O[Pt]([N]([H])([H])[H])([N]([H])([H])[H])OC(=O)C11CCC1 OLESAACUTLOWQZ-UHFFFAOYSA-L 0.000 claims 1
- 229960004679 Doxorubicin Drugs 0.000 claims 1
- 229960001904 EPIRUBICIN Drugs 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N EPIRUBICIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N Etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 1
- 229960005420 Etoposide Drugs 0.000 claims 1
- 229960002949 Fluorouracil Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N Gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N Irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 1
- 229960004857 Mitomycin Drugs 0.000 claims 1
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- 125000003835 nucleoside group Chemical group 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- KVGZZAHHUNAVKZ-UHFFFAOYSA-N p-dioxin Chemical group O1C=COC=C1 KVGZZAHHUNAVKZ-UHFFFAOYSA-N 0.000 claims 1
- 229960003787 sorafenib Drugs 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98323107P | 2007-10-29 | 2007-10-29 | |
| US60/983,231 | 2007-10-29 | ||
| PCT/US2008/081645 WO2009058907A2 (en) | 2007-10-29 | 2008-10-29 | Targeting micrornas for the treatment of liver cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011501962A JP2011501962A (ja) | 2011-01-20 |
| JP2011501962A5 true JP2011501962A5 (pt) | 2012-05-10 |
| JP5535076B2 JP5535076B2 (ja) | 2014-07-02 |
Family
ID=40524369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532219A Active JP5535076B2 (ja) | 2007-10-29 | 2008-10-29 | 肝臓癌を治療するための標的化ミクロｒｎａ |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US8211867B2 (pt) |
| EP (1) | EP2217248B1 (pt) |
| JP (1) | JP5535076B2 (pt) |
| CN (1) | CN101980712B (pt) |
| AU (1) | AU2008318778B2 (pt) |
| CA (1) | CA2704043C (pt) |
| IL (1) | IL205307A (pt) |
| WO (1) | WO2009058907A2 (pt) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2534300T3 (es) * | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| US8252756B2 (en) | 2005-06-14 | 2012-08-28 | Northwestern University | Nucleic acid functionalized nanoparticles for therapeutic applications |
| ES2527592T3 (es) | 2006-01-05 | 2015-01-27 | The Ohio State University Research Foundation | Métodos basados en microARN para el diagnóstico del cáncer de colon |
| AU2007227423B2 (en) | 2006-03-20 | 2013-11-07 | The Ohio State University Research Foundation | MicroRNA fingerprints during human megakaryocytopoiesis |
| JP5512285B2 (ja) | 2007-02-09 | 2014-06-04 | ノースウェスタン ユニバーシティ | 細胞内標的を検出するための粒子 |
| US8465918B2 (en) | 2007-08-03 | 2013-06-18 | The Ohio State University Research Foundation | Ultraconserved regions encoding ncRNAs |
| AU2008318778B2 (en) | 2007-10-29 | 2014-10-02 | Regulus Therapeutics Inc. | Targeting microRNAs for the treatment of liver cancer |
| EP3064584A3 (en) * | 2008-02-28 | 2016-12-07 | The Ohio State University Research Foundation | Micro rna-based methods and compositions for the diagnosis, prognosis and treatmentof gastric cancer |
| WO2009137807A2 (en) | 2008-05-08 | 2009-11-12 | Asuragen, Inc. | Compositions and methods related to mirna modulation of neovascularization or angiogenesis |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2011017456A2 (en) * | 2009-08-04 | 2011-02-10 | Northwestern University | Localized delivery of nanoparticles for therapeutic and diagnostic applications |
| CN102803511A (zh) | 2009-11-23 | 2012-11-28 | 俄亥俄州立大学 | 用于影响肿瘤细胞生长、迁移和侵袭的材料和方法 |
| AU2010324860A1 (en) * | 2009-11-25 | 2012-06-14 | Dharmacon, Inc. | Minor groove binder (MGB)-oligonucleotide miRNAs antagonists |
| WO2011076141A1 (en) * | 2009-12-24 | 2011-06-30 | Fudan University | Diagnostic kits comprising microrna biomarkers and methods for diagnosis of hepatocellular cancer |
| CN101831427B (zh) * | 2010-04-01 | 2012-07-18 | 清华大学深圳研究生院 | 一种预防肿瘤复发和抑制肿瘤生长的寡聚核酸及其应用 |
| CA2801342A1 (en) * | 2010-06-04 | 2011-12-08 | Eric N. Olson | Regulation of metabolism by mir-378 |
| JP5099571B2 (ja) * | 2010-07-12 | 2012-12-19 | 国立大学法人鳥取大学 | ｍｉＲＮＡ導入による新規ｈｉＰＳＣ作製法 |
| WO2012065049A1 (en) | 2010-11-12 | 2012-05-18 | The Ohio State University Research Foundation | Materials and methods related to microrna-21, mismatch repair, and colorectal cancer |
| CA2817982C (en) | 2010-11-15 | 2020-06-30 | The Regents Of The University Of Michigan | Controlled release mucoadhesive systems |
| CN102140471B (zh) * | 2011-01-10 | 2013-11-20 | 清华大学深圳研究生院 | 一种抑制肿瘤生长的寡聚核酸及其应用 |
| CN102125696B (zh) * | 2011-01-11 | 2013-06-12 | 清华大学深圳研究生院 | 抑制肿瘤生长及血管生成的寡聚核酸组合物及其应用 |
| CN103459598B (zh) | 2011-02-03 | 2016-08-10 | 米尔纳医疗股份有限公司 | Mir-124的合成模拟物 |
| AU2012212023B9 (en) | 2011-02-03 | 2017-01-12 | Mirna Therapeutics, Inc. | Synthetic mimics of miR-34 |
| US8420617B2 (en) | 2011-03-11 | 2013-04-16 | Biocell Laboratories | Multiantivirus compound, composition and method for treatment of virus diseases |
| CN102178959B (zh) * | 2011-03-15 | 2013-10-23 | 清华大学深圳研究生院 | 抑制肺转移肿瘤生长的siRNA及其寡聚核酸组合与应用 |
| WO2012145374A1 (en) * | 2011-04-19 | 2012-10-26 | Regulus Therapeutics Inc. | TARGETING miR-378 FAMILY MEMBERS FOR THE TREATMENT OF METABOLIC DISORDERS |
| PL3211082T3 (pl) | 2011-04-25 | 2021-08-02 | Sanofi | Związki mikroRNA i sposoby modulowania aktywności miR-21 |
| US8697408B2 (en) * | 2011-05-06 | 2014-04-15 | New England Biolabs, Inc. | Ligation enhancement |
| WO2013040499A1 (en) | 2011-09-14 | 2013-03-21 | Northwestern University | Nanoconjugates able to cross the blood-brain barrier |
| JP2014530612A (ja) | 2011-10-14 | 2014-11-20 | ジ・オハイオ・ステート・ユニバーシティ | 卵巣がんに関する方法および材料 |
| CN104619353A (zh) * | 2011-12-13 | 2015-05-13 | 俄亥俄州国家创新基金会 | 与miR-21和miR-29a相关的方法和组合物、外切体抑制和癌症转移 |
| WO2013110053A1 (en) | 2012-01-20 | 2013-07-25 | The Ohio State University | Breast cancer biomarker signatures for invasiveness and prognosis |
| EA030211B1 (ru) | 2012-04-25 | 2018-07-31 | Регьюлэс Терапьютикс Инк. | Соединения на основе микрорнк и способы модулирования активности mir-21 |
| JP2014027898A (ja) * | 2012-07-31 | 2014-02-13 | Yamaguchi Univ | 肝細胞がん発症リスクの判定方法 |
| UA116639C2 (uk) | 2012-10-09 | 2018-04-25 | Рег'Юлес Терап'Ютікс Інк. | Способи лікування синдрому альпорта |
| US9994846B2 (en) | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| CA2932122C (en) | 2013-12-03 | 2022-04-19 | Northwestern University | Liposomal particles, methods of making same and uses thereof |
| PL3164113T3 (pl) | 2014-06-04 | 2019-09-30 | Exicure, Inc. | Wielowartościowe dostarczanie modulatorów immunologicznych w liposomowych kolistych kwasach nukleinowych do zastosowań profilaktycznych lub terapeutycznych |
| CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| CN108026528A (zh) * | 2015-08-20 | 2018-05-11 | 比奥基内生物科学协会合作研究中心 | 治疗肝疾病和病症的方法和组合物 |
| JP2019517182A (ja) | 2016-04-20 | 2019-06-20 | コンヴィーダ ワイヤレス， エルエルシー | ダウンリンク同期 |
| EP3446425B1 (en) * | 2016-04-20 | 2024-02-21 | InterDigital Patent Holdings, Inc. | Physical channels in new radio |
| EP3446515B1 (en) | 2016-04-20 | 2020-12-02 | Convida Wireless, LLC | System information provisioning |
| WO2017184865A1 (en) | 2016-04-20 | 2017-10-26 | Convida Wireless, Llc | Configurable reference signals |
| KR20220141916A (ko) | 2016-05-11 | 2022-10-20 | 콘비다 와이어리스, 엘엘씨 | 새로운 라디오 다운링크 제어 채널 |
| WO2017218785A1 (en) | 2016-06-15 | 2017-12-21 | Convida Wireless, Llc | Grant-less uplink transmission for new radio |
| WO2017218794A1 (en) | 2016-06-15 | 2017-12-21 | Convida Wireless, Llc | Upload control signaling for new radio |
| US10306671B2 (en) | 2016-06-15 | 2019-05-28 | Convida Wireless, Llc | Grant-less operations |
| WO2018031875A1 (en) | 2016-08-11 | 2018-02-15 | Convida Wireless, Llc | Beamforming sweeping and training in a flexible frame structure for new radio |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| CN110290794A (zh) | 2016-11-01 | 2019-09-27 | 纽约州州立大学研究基金会 | 5-卤代尿嘧啶修饰的微rna及其在癌症治疗中的用途 |
| US11236337B2 (en) | 2016-11-01 | 2022-02-01 | The Research Foundation For The State University Of New York | 5-halouracil-modified microRNAs and their use in the treatment of cancer |
| CN109891772B (zh) | 2016-11-03 | 2022-10-04 | 康维达无线有限责任公司 | Nr中的帧结构 |
| WO2018102397A1 (en) | 2016-11-29 | 2018-06-07 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
| WO2020068251A1 (en) | 2018-09-27 | 2020-04-02 | Convida Wireless, Llc | Sub-band operations in unlicensed spectrums of new radio |
| CN109880907A (zh) * | 2019-03-26 | 2019-06-14 | 中国人民解放军第八一医院 | 一种肝癌细胞侵袭转移的分子机制研究方法 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070884A2 (en) * | 2002-02-20 | 2003-08-28 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF MDR P-GLYCOPROTEIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| JP4334165B2 (ja) | 2001-07-13 | 2009-09-30 | コニカミノルタホールディングス株式会社 | 静電潜像現像用トナーと画像形成方法及び画像形成装置 |
| JP4371812B2 (ja) * | 2001-09-28 | 2009-11-25 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | マイクロｒｎａ分子 |
| JP4369691B2 (ja) | 2003-06-26 | 2009-11-25 | 株式会社Ｉｄｘ | マイクロ波化学反応装置 |
| WO2005013901A2 (en) * | 2003-07-31 | 2005-02-17 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and compositions for use in modulation of small non-coding rnas |
| EP1654536A4 (en) * | 2003-08-07 | 2008-07-30 | Ocimum Biosolutions Inc | MODELING OF HEPATOCYTE PRIMARY TOXICITY IN THE RAT |
| JP3959722B2 (ja) | 2003-10-15 | 2007-08-15 | 住友金属工業株式会社 | 線材コイルの冷却装置 |
| CA2554818A1 (en) * | 2004-02-09 | 2005-08-25 | Thomas Jefferson University | Diagnosis and treatment of cancers with microrna located in or near cancer-associated chromosomal features |
| US20050182005A1 (en) * | 2004-02-13 | 2005-08-18 | Tuschl Thomas H. | Anti-microRNA oligonucleotide molecules |
| WO2005118806A2 (en) * | 2004-05-28 | 2005-12-15 | Ambion, Inc. | METHODS AND COMPOSITIONS INVOLVING MicroRNA |
| US7635563B2 (en) * | 2004-06-30 | 2009-12-22 | Massachusetts Institute Of Technology | High throughput methods relating to microRNA expression analysis |
| AU2005272816B2 (en) * | 2004-08-10 | 2011-08-11 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
| ES2534300T3 (es) | 2004-11-12 | 2015-04-21 | Asuragen, Inc. | Procedimientos y composiciones que implican miARN y moléculas inhibidoras de miARN |
| CN1800388A (zh) | 2005-01-07 | 2006-07-12 | 中国人民解放军军事医学科学院放射医学研究所 | 八种人源miRNA |
| US9085774B2 (en) * | 2005-04-19 | 2015-07-21 | Basf Plant Science Gmbh | Methods controlling gene expression |
| US20070065844A1 (en) * | 2005-06-08 | 2007-03-22 | Massachusetts Institute Of Technology | Solution-based methods for RNA expression profiling |
| JP2007073737A (ja) | 2005-09-07 | 2007-03-22 | Toyo Ink Mfg Co Ltd | 複数の導電性回路層を有するプリント配線板並びにその製造方法 |
| DE102005046385B4 (de) | 2005-09-28 | 2012-03-22 | Siemens Ag | Verfahren und Vorrichtung zur Nachbearbeitung eines 3D-Bilddatensatzes, insbesondere für die virtuelle Kolonographie |
| JP4483757B2 (ja) | 2005-09-30 | 2010-06-16 | セイコーエプソン株式会社 | 有機ｅｌ装置及び光学装置 |
| JP2007097429A (ja) * | 2005-09-30 | 2007-04-19 | Mitsubishi Rayon Co Ltd | ｎｏｎ−ｃｏｄｉｎｇＲＮＡの検出データ補正方法 |
| US20070092882A1 (en) * | 2005-10-21 | 2007-04-26 | Hui Wang | Analysis of microRNA |
| US20100286044A1 (en) * | 2005-12-29 | 2010-11-11 | Exiqon A/S | Detection of tissue origin of cancer |
| JP5213723B2 (ja) * | 2006-01-27 | 2013-06-19 | アイシス ファーマシューティカルズ， インコーポレーテッド | マイクロｒｎａの調節に使用するためのオリゴマー化合物及び組成物 |
| WO2007095614A2 (en) * | 2006-02-15 | 2007-08-23 | University Of Louisville Research Foundation, Inc. | Microarray, system, and method for detecting, identifying, and quantitating micro-rnas |
| US20100184209A1 (en) | 2006-02-17 | 2010-07-22 | Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
| CA3042781C (en) * | 2006-04-03 | 2021-10-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| AU2007272947B2 (en) * | 2006-07-13 | 2013-06-06 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Micro-RNA-based methods and compositions for the diagnosis and treatment of colon cancer-related diseases |
| US20080199961A1 (en) | 2006-08-25 | 2008-08-21 | Avi Biopharma, Inc. | ANTISENSE COMPOSITION AND METHOD FOR INHIBITION OF miRNA BIOGENESIS |
| CA2667617A1 (en) * | 2006-11-01 | 2008-05-08 | The Ohio State University Research Foundation | Microrna expression signature for predicting survival and metastases in hepatocellular carcinoma |
| EP2104735A2 (en) * | 2006-12-08 | 2009-09-30 | Asuragen, INC. | Mir-21 regulated genes and pathways as targets for therapeutic intervention |
| JP2009043353A (ja) | 2007-08-09 | 2009-02-26 | Pioneer Electronic Corp | タイトル付与装置、タイトル付与方法、タイトル付与プログラム、および記録媒体 |
| EP2623599B1 (en) * | 2007-10-04 | 2019-01-02 | Roche Innovation Center Copenhagen A/S | Micromirs |
| AU2008318778B2 (en) | 2007-10-29 | 2014-10-02 | Regulus Therapeutics Inc. | Targeting microRNAs for the treatment of liver cancer |
-
2008
- 2008-10-29 AU AU2008318778A patent/AU2008318778B2/en active Active
- 2008-10-29 US US12/740,211 patent/US8211867B2/en active Active
- 2008-10-29 CA CA2704043A patent/CA2704043C/en active Active
- 2008-10-29 WO PCT/US2008/081645 patent/WO2009058907A2/en active Application Filing
- 2008-10-29 JP JP2010532219A patent/JP5535076B2/ja active Active
- 2008-10-29 EP EP08844596.0A patent/EP2217248B1/en active Active
- 2008-10-29 CN CN200880121316.9A patent/CN101980712B/zh active Active
-
2010
- 2010-04-25 IL IL205307A patent/IL205307A/en active IP Right Grant
-
2012
- 2012-05-25 US US13/481,105 patent/US8680067B2/en active Active
-
2014
- 2014-01-30 US US14/168,812 patent/US9150857B2/en active Active
-
2015
- 2015-08-24 US US14/833,889 patent/US9506062B2/en not_active Expired - Fee Related
-
2016
- 2016-10-26 US US15/334,422 patent/US9845470B2/en active Active
-
2017
- 2017-11-15 US US15/813,584 patent/US10301627B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011501962A5 (pt) | ||
| JP2016501513A5 (pt) | ||
| JP2018528781A5 (pt) | ||
| JP2020115865A5 (pt) | ||
| JP2007533742A5 (ja) | 癌治療のためのスルビビンオリゴヌクレオチドおよびゲムシタビンを含む組成物 | |
| IL264288A (en) | Methods and preparations for regulating expression of apolipoprotein(a) | |
| CN103080314B (zh) | 显性突变基因表达抑制剂 | |
| JP2017505623A5 (pt) | ||
| JP2015507625A5 (pt) | ||
| JP2015519891A5 (pt) | ||
| JP2011516410A5 (pt) | ||
| JP2012050438A5 (pt) | ||
| JP2010507579A5 (pt) | ||
| JP2016520312A5 (pt) | ||
| JP2014511686A5 (pt) | ||
| RU2016116849A (ru) | Композиции для модуляции экспрессии c90rf72 | |
| JP2015502365A5 (pt) | ||
| JP2020500929A5 (pt) | ||
| JP2008523157A5 (pt) | ||
| JP2014513954A5 (pt) | ||
| EP3364984B1 (en) | Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof | |
| JP2014530004A5 (pt) | ||
| JP2011250796A5 (pt) | ||
| TWI762732B (zh) | 用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子 | |
| JP2014521310A5 (pt) |