JP2011500690A5 - - Google Patents

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Publication number
JP2011500690A5
JP2011500690A5 JP2010530005A JP2010530005A JP2011500690A5 JP 2011500690 A5 JP2011500690 A5 JP 2011500690A5 JP 2010530005 A JP2010530005 A JP 2010530005A JP 2010530005 A JP2010530005 A JP 2010530005A JP 2011500690 A5 JP2011500690 A5 JP 2011500690A5
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JP
Japan
Prior art keywords
composition
subject
blood glucose
glucose level
fasting blood
Prior art date
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JP2010530005A
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English (en)
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JP5558358B2 (ja
JP2011500690A (ja
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Priority claimed from PCT/US2008/075433 external-priority patent/WO2009051908A1/en
Publication of JP2011500690A publication Critical patent/JP2011500690A/ja
Publication of JP2011500690A5 publication Critical patent/JP2011500690A5/ja
Application granted granted Critical
Publication of JP5558358B2 publication Critical patent/JP5558358B2/ja
Expired - Fee Related legal-status Critical Current
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Claims (8)

  1. 対象の空腹時血糖値を低減させるための、ｔｒａｎｓ−クロミフェン又はその塩
    から本質的に成る組成物。
  2. 前記対象が二次性低ゴナドトロピン性性腺機能低下症を有する女性である、請求項１に記載の組成物。
  3. 前記対象が１２５ｍｇ／ｄｌ〜１４０ｍｇ／ｄｌの間の空腹時血糖値を有する、請求項１又は２に記載の組成物。
  4. 前記対象が１１０ｍｇ／ｄｌ〜１２５ｍｇ／ｄｌの間の空腹時血糖値を有する、請求項１又は２に記載の組成物。
  5. 前記対象の空腹時血糖値を１１０ｍｇ／ｄｌ未満に低減する、請求項１〜４のいずれか１項に記載の組成物。
  6. ｔｒａｎｓ−クロミフェンが約１２．５〜約５０ｍｇの用量で存在する、請求項１〜５のいずれか１項に記載の組成物。
  7. ｔｒａｎｓ−クロミフェンが１２．５、２５、又は５０ｍｇの用量で存在する、請求項６に記載の組成物。
  8. 前記対象のテストステロン値が３００ｎｇ／ｄｌ未満である、請求項２〜７のいずれか１項に記載の組成物。
JP2010530005A 2007-10-16 2008-09-05 メタボリック症候群用のｔｒａｎｓ−クロミフェン Expired - Fee Related JP5558358B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98033407P 2007-10-16 2007-10-16
US60/980,334 2007-10-16
PCT/US2008/075433 WO2009051908A1 (en) 2007-10-16 2008-09-05 Trans-clomiphene for metabolic syndrome

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014114963A Division JP5856652B2 (ja) 2007-10-16 2014-06-03 メタボリック症候群用のｔｒａｎｓ−クロミフェン

Publications (3)

Publication Number Publication Date
JP2011500690A JP2011500690A (ja) 2011-01-06
JP2011500690A5 true JP2011500690A5 (ja) 2011-10-13
JP5558358B2 JP5558358B2 (ja) 2014-07-23

Family

ID=40023452

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2010530005A Expired - Fee Related JP5558358B2 (ja) 2007-10-16 2008-09-05 メタボリック症候群用のｔｒａｎｓ−クロミフェン
JP2014114963A Expired - Fee Related JP5856652B2 (ja) 2007-10-16 2014-06-03 メタボリック症候群用のｔｒａｎｓ−クロミフェン
JP2015241230A Pending JP2016040328A (ja) 2007-10-16 2015-12-10 メタボリック症候群用のｔｒａｎｓ−クロミフェン
JP2017123973A Pending JP2017160273A (ja) 2007-10-16 2017-06-26 メタボリック症候群用のｔｒａｎｓ−クロミフェン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2014114963A Expired - Fee Related JP5856652B2 (ja) 2007-10-16 2014-06-03 メタボリック症候群用のｔｒａｎｓ−クロミフェン
JP2015241230A Pending JP2016040328A (ja) 2007-10-16 2015-12-10 メタボリック症候群用のｔｒａｎｓ−クロミフェン
JP2017123973A Pending JP2017160273A (ja) 2007-10-16 2017-06-26 メタボリック症候群用のｔｒａｎｓ−クロミフェン

Country Status (25)

Country Link
US (2) US8372887B2 (ja)
EP (2) EP2826475B1 (ja)
JP (4) JP5558358B2 (ja)
KR (1) KR101493472B1 (ja)
CN (2) CN102940619A (ja)
AR (1) AR069541A1 (ja)
BR (1) BRPI0818637A2 (ja)
CA (3) CA2702710C (ja)
CL (1) CL2008002999A1 (ja)
CO (1) CO6270215A2 (ja)
CR (1) CR11418A (ja)
EA (2) EA022760B1 (ja)
EC (1) ECSP10010106A (ja)
ES (1) ES2718912T3 (ja)
HK (1) HK1150023A1 (ja)
IL (1) IL205053A (ja)
ME (1) ME00996B (ja)
MX (1) MX2010004195A (ja)
MY (1) MY150082A (ja)
NI (1) NI201000053A (ja)
NZ (2) NZ585389A (ja)
SG (1) SG185311A1 (ja)
TW (1) TW200918093A (ja)
UA (1) UA96076C2 (ja)
WO (1) WO2009051908A1 (ja)

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CN1289075C (zh) 2001-07-09 2006-12-13 佐纳根有限公司 富含反式克罗米酚的克罗米酚组合物的用途
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JP5785680B2 (ja) 2005-03-22 2015-09-30 リプロス セラピューティクス インコーポレイテッド トランス−クロミフェン用の投与レジメン
JP5558358B2 (ja) 2007-10-16 2014-07-23 レプロス セラピューティクス インコーポレイティド メタボリック症候群用のｔｒａｎｓ−クロミフェン
TW201500041A (zh) * 2008-11-07 2015-01-01 Repros Therapeutics Inc 用於代謝症候群與第２型糖尿病的反式氯米芬
ES2784497T3 (es) 2010-09-16 2020-09-28 Shimoda Biotech Pty Ltd Composiciones de fulvestrant y métodos de uso
UA113291C2 (xx) * 2011-08-04 2017-01-10 Метаболіти транскломіфену і їх застосування
AU2013225869B2 (en) * 2012-02-29 2017-06-08 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
MX2015001912A (es) 2012-08-21 2015-06-05 Repros Therapeutics Inc Formulaciones de trans - clomifeno y usos de las mismas.
AU2013338311A1 (en) 2012-11-02 2015-05-14 Repros Therapeutics Inc. Trans-clomiphene for use in cancer therapy
US20160051565A1 (en) * 2014-08-20 2016-02-25 Professional Compounding Centers Of America (Pcca) Transdermal Pharmaceutical Compositions Including Testosterone and an Aromatase Inhibitor
US20160051495A1 (en) * 2014-08-20 2016-02-25 Professional Compounding Centers Of America Oral Transmucosal Compositions including C-SERMs for Low Testosterone Levels in Men
WO2016089904A1 (en) * 2014-12-02 2016-06-09 Repros Therapeutics Inc. Trans-clomiphene and its analogues as agents for treating or preventing filovirus diseases
EP3167869A1 (en) 2015-11-16 2017-05-17 Capsugel Belgium NV Tamperproof oral dosage form
EP3167870B1 (en) * 2015-11-16 2024-01-03 Capsugel Belgium NV Tamperproof oral dosage form
RU2611936C1 (ru) * 2016-02-16 2017-03-01 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Д. Гольдберга" Способ моделирования гипогонадизма, вызванного метаболическими нарушениями
EP3419611A4 (en) * 2016-02-25 2019-10-16 Aspen Park Pharmaceuticals Inc. ORAL DOSAGE FORM OF THE TWO CLOMIPHENE ISOMERS AND METHOD OF USE FOR TREATING SECONDARY HYPOGONADISM
WO2018027175A1 (en) * 2016-08-04 2018-02-08 University Of Iowa Research Foundation Use of swell1 inhibitors and modulators to treat type 2 diabetes and obesity

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