JP2011500598A5 - - Google Patents
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- Publication number
- JP2011500598A5 JP2011500598A5 JP2010529091A JP2010529091A JP2011500598A5 JP 2011500598 A5 JP2011500598 A5 JP 2011500598A5 JP 2010529091 A JP2010529091 A JP 2010529091A JP 2010529091 A JP2010529091 A JP 2010529091A JP 2011500598 A5 JP2011500598 A5 JP 2011500598A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- ring
- aliphatic
- cor
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 CC1(*)C=NN=CN=C1 Chemical compound CC1(*)C=NN=CN=C1 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97925807P | 2007-10-11 | 2007-10-11 | |
| US60/979,258 | 2007-10-11 | ||
| PCT/US2008/079542 WO2009049180A2 (en) | 2007-10-11 | 2008-10-10 | Heteroaryl amides useful as inhibitors of voltage-gated sodium channels |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500598A JP2011500598A (ja) | 2011-01-06 |
| JP2011500598A5 true JP2011500598A5 (https=) | 2012-11-15 |
| JP5555169B2 JP5555169B2 (ja) | 2014-07-23 |
Family
ID=40429979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529091A Expired - Fee Related JP5555169B2 (ja) | 2007-10-11 | 2008-10-10 | 電位開口型ナトリウムチャネルの阻害剤として有用なヘテロアリールアミド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8519137B2 (https=) |
| EP (1) | EP2227453B1 (https=) |
| JP (1) | JP5555169B2 (https=) |
| CN (1) | CN101883760A (https=) |
| AU (1) | AU2008310660A1 (https=) |
| CA (1) | CA2701946A1 (https=) |
| MX (1) | MX2010003866A (https=) |
| NZ (1) | NZ584475A (https=) |
| WO (1) | WO2009049180A2 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5855095B2 (ja) | 2010-06-07 | 2016-02-09 | ノボメディックス, エルエルシーNovomedix, Llc | フラニル化合物およびその使用 |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9212209B2 (en) | 2012-07-13 | 2015-12-15 | Indiana University Research And Technology Corporation | Screening methods for spinal muscular atrophy |
| CA2898653C (en) | 2013-01-31 | 2021-09-28 | Vertex Pharmaceuticals Incorporated | Amides as modulators of sodium channels |
| RU2683788C2 (ru) | 2013-01-31 | 2019-04-02 | Вертекс Фармасьютикалз Инкорпорейтед | Амиды хинолина и хиназолина, полезные в качестве модуляторов натриевых каналов |
| RS56015B1 (sr) | 2013-01-31 | 2017-09-29 | Vertex Pharma | Piridon amidi kao modulatori natrijumovih kanala |
| UA119147C2 (uk) | 2013-07-19 | 2019-05-10 | Вертекс Фармасьютікалз Інкорпорейтед | Сульфонаміди як модулятори натрієвих каналів |
| CA2931550C (en) | 2013-12-13 | 2023-09-26 | Vertex Pharmaceuticals Incorporated | Prodrugs of pyridone amides useful as modulators of sodium channels |
| JP2017538676A (ja) | 2014-11-05 | 2017-12-28 | ザ ユニバーシティ オブ カンザス | ミトコンドリア透過性遷移孔（ｍｔＰＴＰ）の小分子阻害剤 |
| JP6930916B2 (ja) * | 2015-02-12 | 2021-09-01 | ユニヴァーシティ オブ サザン カリフォルニアＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｓｏｕｔｈｅｒｎ Ｃａｌｉｆｏｒｎｉａ | 疾患予防および治療における成長ホルモン受容体の遮断剤 |
| EP3625214B1 (en) | 2017-05-16 | 2022-07-06 | Vertex Pharmaceuticals Incorporated | Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels |
| AU2018300150A1 (en) | 2017-07-11 | 2020-01-30 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| CN108863970A (zh) | 2017-08-14 | 2018-11-23 | 四川省中医药转化医学中心 | 新化合物及其在治疗炎症或炎症相关疾病方面的应用 |
| US11529337B2 (en) | 2018-02-12 | 2022-12-20 | Vertex Pharmaceuticals Incorporated | Method of treating pain |
| AU2019302534B2 (en) | 2018-07-09 | 2024-10-03 | Lieber Institute, Inc. | Pyridazine compounds for inhibiting NaV1.8 |
| CA3105657A1 (en) * | 2018-07-09 | 2020-01-16 | Lieber Institute, Inc. | Pyridine carboxamide compounds for inhibiting nav1.8 |
| MA53488A (fr) * | 2018-08-31 | 2021-12-08 | Xenon Pharmaceuticals Inc | Composés de sulfonamide substitués par hétéroaryle et leur utilisation en tant qu'inhibiteurs de canaux sodiques |
| US12344595B2 (en) | 2018-11-02 | 2025-07-01 | Merck Sharp & Dohme Llc | 2-amino-n-phenyl-nicotinamides as NAV1.8 inhibitors |
| JP7288051B2 (ja) | 2018-11-02 | 2023-06-06 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎａｖ１．８阻害薬としての２－アミノ－Ｎ－ヘテロアリール－ニコチンアミド類 |
| WO2020146682A1 (en) | 2019-01-10 | 2020-07-16 | Vertex Pharmaceuticals Incorporated | Carboxamides as modulators of sodium channels |
| US12440481B2 (en) | 2019-01-10 | 2025-10-14 | Vertex Pharmaceuticals Incorporated | Esters and carbamates as modulators of sodium channels |
| WO2020199683A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海海雁医药科技有限公司 | 氮杂环取代的磺酰基苯甲酰胺衍生物、其制法与医药上的用途 |
| CN112390745B (zh) * | 2019-08-19 | 2022-10-21 | 江苏恒瑞医药股份有限公司 | 吡啶烟酰胺类衍生物、其制备方法及其在医药上的应用 |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| US11802122B2 (en) | 2020-06-17 | 2023-10-31 | Merck Sharp & Dohme Llc | 2-oxoimidazolidine-4-carboxamides as NAv1.8 inhibitors |
| US12516046B2 (en) | 2020-06-17 | 2026-01-06 | Merck Sharp & Dohme Llc | 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors |
| GEP20257795B (en) | 2021-05-07 | 2025-09-25 | Merck Sharp & Dohme Llc | Cycloalkyl 3-oxopiperazine carboxamides and cycloheteroalkyl 3-oxopiperazine carboxamides as nav1.8 inhibitors |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| TW202317520A (zh) | 2021-06-15 | 2023-05-01 | 德商歌林達有限公司 | 經取代之吡唑醯胺 |
| US20250154109A1 (en) * | 2022-02-04 | 2025-05-15 | Latigo Biotherapeutics, Inc | Sodium channel blocking compounds, derivatives thereof, and methods of their use |
| CN116655497B (zh) * | 2022-02-25 | 2025-06-03 | 中国科学院上海药物研究所 | 脒类衍生化合物及其制备方法和用途 |
| CN116789644B (zh) * | 2022-03-17 | 2025-11-11 | 中国科学院上海药物研究所 | 酰胺类化合物及其制备方法和用途 |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| EP4385980A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Indazoles as inhibitors of nav1.8 |
| AR131345A1 (es) | 2022-12-14 | 2025-03-12 | Gruenenthal Gmbh | SULFOXIMINAS COMO INHIBIDORES DE NaV1.8 |
| EP4385979A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Multicyclic inhibitors of nav1.8 |
| EP4385984A1 (en) | 2022-12-14 | 2024-06-19 | Grünenthal GmbH | Pyridine-n-oxides as inhibitors of nav1.8 |
| CN119285621B (zh) * | 2024-12-13 | 2025-07-18 | 嘉兴安帝康生物科技有限公司 | 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE568114A (https=) * | 1957-05-29 | 1900-01-01 | ||
| ES482591A1 (es) * | 1978-07-20 | 1980-04-01 | Basf Ag | Procedimiento para la obtencion de n-arilsulfonilpirroles. |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| HUP0103622A3 (en) * | 1998-08-20 | 2003-01-28 | Agouron Pharmaceuticals Inc La | Non-peptide gnrh agents, methods and intermediates for their preparation and medicaments containing them |
| ATE299499T1 (de) * | 1998-11-09 | 2005-07-15 | Black James Foundation | Gastrin und cholecystokinin rezeptor ligande |
| US6620849B2 (en) * | 2000-07-26 | 2003-09-16 | Icafen, Inc. | Potassium channel inhibitors |
| US6995162B2 (en) * | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| WO2003037274A2 (en) | 2001-11-01 | 2003-05-08 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| SE0203752D0 (sv) * | 2002-12-17 | 2002-12-17 | Astrazeneca Ab | New compounds |
| WO2004106324A1 (en) * | 2003-05-27 | 2004-12-09 | E.I. Dupont De Nemours And Company | Azolecarboxamide herbicides |
| EP1673357A2 (en) | 2003-08-08 | 2006-06-28 | Vertex Pharmaceuticals Incorporated | Heteroarylaminosulfonylphenyl derivatives for use as sodium or calcium channel blockers in the treatment of pain |
| AU2004285053B2 (en) * | 2003-10-28 | 2010-10-21 | Vertex Pharmaceuticals, Incorporated | Benzimidazoles useful as modulators of ion channels |
| WO2006053227A2 (en) * | 2004-11-10 | 2006-05-18 | Synta Pharmaceuticals Corp. | Il-12 modulatory compounds |
| DOP2006000210A (es) * | 2005-10-04 | 2007-06-15 | Aventis Pharma Inc | Compuestos de pirimidina amida como inhibidores de pgds |
| JP5182088B2 (ja) * | 2006-04-19 | 2013-04-10 | アステラス製薬株式会社 | アゾールカルボキサミド誘導体 |
-
2008
- 2008-10-10 AU AU2008310660A patent/AU2008310660A1/en not_active Abandoned
- 2008-10-10 NZ NZ584475A patent/NZ584475A/en not_active IP Right Cessation
- 2008-10-10 EP EP08838105.8A patent/EP2227453B1/en active Active
- 2008-10-10 JP JP2010529091A patent/JP5555169B2/ja not_active Expired - Fee Related
- 2008-10-10 WO PCT/US2008/079542 patent/WO2009049180A2/en not_active Ceased
- 2008-10-10 CA CA2701946A patent/CA2701946A1/en not_active Abandoned
- 2008-10-10 MX MX2010003866A patent/MX2010003866A/es not_active Application Discontinuation
- 2008-10-10 CN CN2008801180521A patent/CN101883760A/zh active Pending
- 2008-10-10 US US12/249,230 patent/US8519137B2/en active Active
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