JP2011500091A5 - - Google Patents
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- JP2011500091A5 JP2011500091A5 JP2010531283A JP2010531283A JP2011500091A5 JP 2011500091 A5 JP2011500091 A5 JP 2011500091A5 JP 2010531283 A JP2010531283 A JP 2010531283A JP 2010531283 A JP2010531283 A JP 2010531283A JP 2011500091 A5 JP2011500091 A5 JP 2011500091A5
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- protein
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- 102000004965 antibodies Human genes 0.000 description 4
- 108090001123 antibodies Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 238000005406 washing Methods 0.000 description 2
- 108091006011 G proteins Proteins 0.000 description 1
- 102000030007 GTP-Binding Proteins Human genes 0.000 description 1
- 108091000058 GTP-Binding Proteins Proteins 0.000 description 1
- 210000002845 Virion Anatomy 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000630 rising Effects 0.000 description 1
Description
下記の表１に示すように、３つの抗体は、立体構造的なエピトープに結合する‐すなわち、それらは重複するペプチドを結合することによっては、マップしない。特異的な配列をマップする本発明の抗体を表１に示す。測定したオンレート及びオフレートから算出してｐＭで示した組み換えＧａタンパク質及びＧｂタンパク質に関する標準的なＢｉａｃｏｒｅアッセイを使用して決定した親和性定数も示す。これら抗体の２つのデータを図６に示す。パネルＡ、Ｂ及びＣ（図６Ａ、６Ｂ、６Ｃ）は、３Ｇ１２の結合データを示し、パネルＤ、Ｅ、およびＦ（図６Ｄ、６Ｅ、６Ｆ）は、３Ｄ３のデータを示す。上段の列は、抗体を用いたバイオセンサーチップのローディングを示し、中段の列は、チップにＧａタンパク質を横切って流した後に、バッファーで洗浄することから上昇するシグナルを示し、下段の列は、Ｇｂタンパク質に関する同様の結果を示す。シグナルの増加（上昇）は、オンレートの算出を許容し、一方では、洗浄中の減少は、オフレートの算出を許容する。オフレートに対するオンレートの割合は、親和性定数、Ｋｄである。
［表１］
＊１３１−２Ｇと同一のエピトープ
［実施例５］
Ｇタンパク質との結合に対するウィルス粒子（Virions）との結合の比較
［表１］
［実施例５］
Ｇタンパク質との結合に対するウィルス粒子（Virions）との結合の比較
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46907P | 2007-10-25 | 2007-10-25 | |
| US61/000,469 | 2007-10-25 | ||
| US8940108P | 2008-08-15 | 2008-08-15 | |
| US61/089,401 | 2008-08-15 | ||
| PCT/US2008/081175 WO2009055711A2 (en) | 2007-10-25 | 2008-10-24 | Anti-rsv g protein antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015006644A Division JP2015078231A (ja) | 2007-10-25 | 2015-01-16 | 抗ｒｓｖｇタンパク質抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500091A JP2011500091A (ja) | 2011-01-06 |
| JP2011500091A5 true JP2011500091A5 (ja) | 2011-10-27 |
| JP5808536B2 JP5808536B2 (ja) | 2015-11-10 |
Family
ID=40580419
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010531283A Active JP5808536B2 (ja) | 2007-10-25 | 2008-10-24 | 抗ｒｓｖｇタンパク質抗体 |
| JP2015006644A Withdrawn JP2015078231A (ja) | 2007-10-25 | 2015-01-16 | 抗ｒｓｖｇタンパク質抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015006644A Withdrawn JP2015078231A (ja) | 2007-10-25 | 2015-01-16 | 抗ｒｓｖｇタンパク質抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7736648B2 (ja) |
| EP (1) | EP2214711B1 (ja) |
| JP (2) | JP5808536B2 (ja) |
| KR (1) | KR101671452B1 (ja) |
| CN (1) | CN101808663B (ja) |
| AU (1) | AU2008316703B2 (ja) |
| BR (1) | BRPI0819210A2 (ja) |
| CA (1) | CA2703667C (ja) |
| IL (1) | IL205257A (ja) |
| MX (1) | MX2010004482A (ja) |
| NZ (1) | NZ585589A (ja) |
| RU (1) | RU2526517C2 (ja) |
| WO (1) | WO2009055711A2 (ja) |
| ZA (1) | ZA201003131B (ja) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4874548B2 (ja) * | 2002-11-26 | 2012-02-15 | ギリアード サイエンシーズ， インコーポレイテッド | 勾配によるリポソームへの薬物充填方法 |
| AU2008316703B2 (en) * | 2007-10-25 | 2012-09-27 | Trellis Bioscience, Inc. | Anti-RSV G protein antibodies |
| US9718876B2 (en) | 2011-11-17 | 2017-08-01 | Aimm Therapeutics B.V. | RSV G protein specific antibodies |
| HUE037186T2 (hu) * | 2011-12-28 | 2018-08-28 | Immunoqure Ag | Eljárás humán antitestek izolálására |
| US10131709B2 (en) | 2011-12-28 | 2018-11-20 | Immunoqure Ag | Nucleic acid molecules encoding monoclonal antibodies specific for IL-22 |
| WO2013119419A1 (en) | 2012-02-08 | 2013-08-15 | North Carolina State University | Treatment of allergic diseases with recombinant antibodies |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| KR102201555B1 (ko) * | 2013-04-15 | 2021-01-12 | 얀센 백신스 앤드 프리벤션 비.브이. | Ｒｓｖ ｇ 단백질에 결합하는 인간 항체 |
| EP2986637A1 (en) * | 2013-04-15 | 2016-02-24 | Crucell Holland B.V. | Human antibodies binding to rsv g protein |
| CN111303278B (zh) * | 2013-04-15 | 2022-09-06 | 扬森疫苗与预防公司 | 结合到rsv g蛋白的人类抗体 |
| KR102378289B1 (ko) * | 2014-02-10 | 2022-03-23 | 아이쥐엠 바이오사이언스 인코포레이티드 | IgA 다중-특이적 결합 분자 |
| CN103911389A (zh) * | 2014-04-09 | 2014-07-09 | 南昌大学 | 一种检测人呼吸道合胞病毒抗体的g和f蛋白的制备方法 |
| LT3227339T (lt) | 2014-12-05 | 2022-01-10 | Memorial Sloan-Kettering Cancer Center | Chimeriniai antigeno receptoriai, nukreipti į receptorių su prijungtu g baltymu ir jų naudojimo būdai |
| EP3227324A4 (en) | 2014-12-05 | 2018-08-29 | Memorial Sloan Kettering Cancer Center | Antibodies targeting g-protein coupled receptor and methods of use |
| CN106496324B (zh) * | 2015-11-30 | 2020-01-14 | 天津昊免生物技术有限公司 | 一种抗呼吸道合胞病毒的全人源抗体 |
| CN105542003B (zh) * | 2016-03-01 | 2019-12-06 | 苏州博泰神州生物技术有限公司 | 一种针对rsv粘附g蛋白表面抗原的全人源单克隆抗体 |
| EP3538558A4 (en) | 2016-11-09 | 2020-07-15 | North Carolina State University | TREATMENT OF ALLERGIC DISEASES WITH A CHIMERAL PROTEIN |
| PE20191404A1 (es) | 2017-01-27 | 2019-10-04 | Ngm Biopharmaceuticals Inc | Proteinas de union al receptor de glucagon y metodos para usarlas |
| JP7445895B2 (ja) * | 2017-10-13 | 2024-03-08 | トレリス・バイオサイエンス・インコーポレーテッド | 呼吸器合胞体ウイルスｇタンパク質中央保存領域の立体構造エピトープ |
| US10961315B2 (en) | 2018-07-27 | 2021-03-30 | Ngm Biopharmaceuticals, Inc. | Method of treating type I diabetes by administering a combination of a glucagon receptor antagonist and an anti-CD3 antibody |
| EP3833677A4 (en) * | 2018-08-08 | 2022-04-27 | Trellis Bioscience, Inc. | IMPROVED PASSIVE AND ACTIVE VACCINES AGAINST RSV |
| EP4031171A1 (en) * | 2019-09-20 | 2022-07-27 | Universiteit Antwerpen | A novel human respiratory syncytial virus strain and its use |
| WO2024027708A1 (zh) * | 2022-08-02 | 2024-02-08 | 诺纳生物（苏州）有限公司 | Msln抗体药物偶联物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5723130A (en) * | 1993-05-25 | 1998-03-03 | Hancock; Gerald E. | Adjuvants for vaccines against respiratory syncytial virus |
| US6020182A (en) * | 1996-07-12 | 2000-02-01 | Connaught Laboratories Limited | Subunit respiratory syncytial virus vaccine preparation |
| FR2766192B1 (fr) * | 1997-07-17 | 2001-07-13 | Pf Medicament | Epitopes du vrs et anticorps les comportant, utiles dans le diagnostic et la therapie |
| US6642062B2 (en) | 1998-09-03 | 2003-11-04 | Trellis Bioinformatics, Inc. | Multihued labels |
| US7083950B2 (en) | 1998-09-25 | 2006-08-01 | Regeneron Pharmaceuticals, Inc. | High affinity fusion proteins and therapeutic and diagnostic methods for use |
| WO2000043040A1 (en) | 1999-01-22 | 2000-07-27 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Methods for the prevention and treatment of diseases caused by an inflammatory response mediated by endogenous substance p by using anti-substance p antibodies |
| ES2316487T5 (es) * | 2000-10-18 | 2019-05-13 | The Government Of The Us Secretary Department Of Health And Human Services | Composiciones y métodos para modular la inmunidad e infección de RSV |
| US7413868B2 (en) | 2003-11-05 | 2008-08-19 | Trellis Bioscience, Inc. | Use of particulate labels in bioanalyte detection methods |
| JP4736037B2 (ja) * | 2005-10-26 | 2011-07-27 | 株式会社イーベック | ヒトｇｍ−ｃｓｆに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| CN1986569A (zh) * | 2005-12-23 | 2007-06-27 | 首都儿科研究所 | 人源抗呼吸道合胞病毒中和性基因工程Fab抗体 |
| JPWO2007094423A1 (ja) | 2006-02-15 | 2009-07-09 | 株式会社イーベック | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
| KR20080113223A (ko) * | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| AU2007272480A1 (en) | 2006-07-12 | 2008-01-17 | Trellis Bioscience, Inc. | Spot bioanalyte detection methods |
| AU2008316703B2 (en) * | 2007-10-25 | 2012-09-27 | Trellis Bioscience, Inc. | Anti-RSV G protein antibodies |
-
2008
- 2008-10-24 AU AU2008316703A patent/AU2008316703B2/en active Active
- 2008-10-24 CN CN200880117420.0A patent/CN101808663B/zh not_active Expired - Fee Related
- 2008-10-24 EP EP08841063.4A patent/EP2214711B1/en active Active
- 2008-10-24 MX MX2010004482A patent/MX2010004482A/es active IP Right Grant
- 2008-10-24 NZ NZ585589A patent/NZ585589A/en not_active IP Right Cessation
- 2008-10-24 BR BRPI0819210-3A patent/BRPI0819210A2/pt not_active IP Right Cessation
- 2008-10-24 JP JP2010531283A patent/JP5808536B2/ja active Active
- 2008-10-24 CA CA2703667A patent/CA2703667C/en active Active
- 2008-10-24 US US12/258,260 patent/US7736648B2/en active Active
- 2008-10-24 RU RU2010120879/10A patent/RU2526517C2/ru not_active IP Right Cessation
- 2008-10-24 KR KR1020107011433A patent/KR101671452B1/ko active IP Right Grant
- 2008-10-24 WO PCT/US2008/081175 patent/WO2009055711A2/en active Application Filing
-
2010
- 2010-04-22 IL IL205257A patent/IL205257A/en not_active IP Right Cessation
- 2010-05-04 ZA ZA2010/03131A patent/ZA201003131B/en unknown
- 2010-05-12 US US12/778,933 patent/US8273354B2/en active Active
-
2012
- 2012-09-25 US US13/626,852 patent/US9321830B2/en active Active
-
2015
- 2015-01-16 JP JP2015006644A patent/JP2015078231A/ja not_active Withdrawn
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