JP2011182797A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011182797A5 JP2011182797A5 JP2011095240A JP2011095240A JP2011182797A5 JP 2011182797 A5 JP2011182797 A5 JP 2011182797A5 JP 2011095240 A JP2011095240 A JP 2011095240A JP 2011095240 A JP2011095240 A JP 2011095240A JP 2011182797 A5 JP2011182797 A5 JP 2011182797A5
- Authority
- JP
- Japan
- Prior art keywords
- linked
- vector
- termination sequence
- transcription termination
- influenza virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013598 vector Substances 0.000 claims 63
- 230000005030 transcription termination Effects 0.000 claims 59
- 241000712461 unidentified influenza virus Species 0.000 claims 46
- 239000002299 complementary DNA Substances 0.000 claims 41
- 206010022000 influenza Diseases 0.000 claims 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims 22
- 229920001184 polypeptide Polymers 0.000 claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 claims 21
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 14
- 210000002845 virion Anatomy 0.000 claims 9
- 241000700605 Viruses Species 0.000 claims 7
- 230000003612 virological effect Effects 0.000 claims 7
- 102000017143 RNA Polymerase I Human genes 0.000 claims 6
- 108010013845 RNA Polymerase I Proteins 0.000 claims 6
- 102000004389 Ribonucleoproteins Human genes 0.000 claims 6
- 108010081734 Ribonucleoproteins Proteins 0.000 claims 6
- 208000015181 infectious disease Diseases 0.000 claims 6
- 230000002458 infectious effect Effects 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 5
- 108700029658 influenza virus NS Proteins 0.000 claims 4
- 108700015453 influenza virus PB2 Proteins 0.000 claims 4
- 108010064513 influenza virus polymerase basic protein 1 Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 108091034135 Vault RNA Proteins 0.000 claims 3
- 102000009572 RNA Polymerase II Human genes 0.000 claims 2
- 108010009460 RNA Polymerase II Proteins 0.000 claims 2
- 102000014450 RNA Polymerase III Human genes 0.000 claims 2
- 108010078067 RNA Polymerase III Proteins 0.000 claims 2
- 230000002238 attenuated effect Effects 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- LHEJDBBHZGISGW-UHFFFAOYSA-N 5-fluoro-3-(3-oxo-1h-2-benzofuran-1-yl)-1h-pyrimidine-2,4-dione Chemical compound O=C1C(F)=CNC(=O)N1C1C2=CC=CC=C2C(=O)O1 LHEJDBBHZGISGW-UHFFFAOYSA-N 0.000 claims 1
- 102000053642 Catalytic RNA Human genes 0.000 claims 1
- 108090000994 Catalytic RNA Proteins 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 108091092562 ribozyme Proteins 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12791299P | 1999-04-06 | 1999-04-06 | |
| US60/127,912 | 1999-04-06 | ||
| US13283999P | 1999-05-06 | 1999-05-06 | |
| US60/132,839 | 1999-05-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609542A Division JP5543048B2 (ja) | 1999-04-06 | 2000-04-05 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015071406A Division JP6224645B2 (ja) | 1999-04-06 | 2015-03-31 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011182797A JP2011182797A (ja) | 2011-09-22 |
| JP2011182797A5 true JP2011182797A5 (OSRAM) | 2013-04-04 |
| JP5775351B2 JP5775351B2 (ja) | 2015-09-09 |
Family
ID=26826080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609542A Expired - Lifetime JP5543048B2 (ja) | 1999-04-06 | 2000-04-05 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
| JP2011095240A Expired - Lifetime JP5775351B2 (ja) | 1999-04-06 | 2011-04-21 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
| JP2015071406A Expired - Lifetime JP6224645B2 (ja) | 1999-04-06 | 2015-03-31 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609542A Expired - Lifetime JP5543048B2 (ja) | 1999-04-06 | 2000-04-05 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015071406A Expired - Lifetime JP6224645B2 (ja) | 1999-04-06 | 2015-03-31 | ワクチンおよび遺伝子療法用の組換えインフルエンザウイルス |
Country Status (19)
| Country | Link |
|---|---|
| EP (4) | EP1185615B1 (OSRAM) |
| JP (3) | JP5543048B2 (OSRAM) |
| KR (1) | KR100702275B1 (OSRAM) |
| CN (2) | CN101851636B (OSRAM) |
| AT (2) | ATE368729T1 (OSRAM) |
| AU (1) | AU4073300A (OSRAM) |
| BR (1) | BRPI0009580B8 (OSRAM) |
| CA (2) | CA2365526C (OSRAM) |
| CY (2) | CY1108520T1 (OSRAM) |
| DE (6) | DE122008000035I1 (OSRAM) |
| DK (3) | DK1820853T3 (OSRAM) |
| ES (3) | ES2373405T3 (OSRAM) |
| FR (1) | FR11C0027I2 (OSRAM) |
| HK (1) | HK1214298A1 (OSRAM) |
| IL (2) | IL145702A0 (OSRAM) |
| MX (1) | MXPA01010082A (OSRAM) |
| NL (2) | NL300364I2 (OSRAM) |
| PT (2) | PT1185615E (OSRAM) |
| WO (1) | WO2000060050A2 (OSRAM) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| CA2365526C (en) * | 1999-04-06 | 2016-07-05 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
| AU5998400A (en) * | 1999-07-14 | 2001-01-30 | Mount Sinai School Of Medicine Of The City University Of New York, The | In vitro reconstitution of segmented negative-strand rna viruses |
| GB9916794D0 (en) * | 1999-07-16 | 1999-09-22 | Isis Innovation | In vitro virus reconstitution |
| AU2001259211B2 (en) | 2000-04-28 | 2006-07-13 | St. Jude Children's Research Hospital | DNA transfection system for the generation of infectious influenza virus |
| ES2295175T3 (es) * | 2000-06-23 | 2008-04-16 | Wyeth Holdings Corporation | Ensamblaje de particulas similares al virus (vlp) de la gripe de tipo salvaje y quimericas. |
| EP1862550A1 (en) * | 2000-06-23 | 2007-12-05 | Wyeth Holdings Corporation | Assembly of wild-type and chimeric influenza virus-like particles (VLPs) |
| US7211378B2 (en) | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
| JP4430942B2 (ja) * | 2002-02-13 | 2010-03-10 | ウィスコンシン・アルムナイ・リサーチ・ファウンデーション | インフルエンザウイルスベクターのパッケージングのためのシグナル |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| AU2003231083A1 (en) | 2002-04-26 | 2003-11-10 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US20050158342A1 (en) | 2003-12-23 | 2005-07-21 | Medimmune, Inc. | Multi plasmid system for the production of influenza virus |
| US8475806B2 (en) * | 2003-05-28 | 2013-07-02 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines and gene therapy |
| WO2005018539A2 (en) | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| FR2866031B1 (fr) * | 2004-02-11 | 2012-10-19 | David Francois Joseph Millet | Chimere de virus pathogene emergent, medicament la contenant et utilisation en therapie antivirale |
| EP1722815A1 (en) | 2004-03-09 | 2006-11-22 | Chiron Corporation | Influenza virus vaccines |
| ES2393492T3 (es) | 2004-05-25 | 2012-12-21 | Medimmune, Llc | Variantes de hemaglutinina y neuraminidasa de influenza |
| AU2005337178A1 (en) | 2004-11-19 | 2007-04-19 | Wisconsin Alumni Research Foundation | Recombinant influenza vectors with tandem transcription units |
| CN102978169A (zh) | 2004-12-08 | 2013-03-20 | 米迪缪尼有限公司 | 生产流感疫苗组合物的方法 |
| KR101272487B1 (ko) | 2004-12-24 | 2013-06-07 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인플루엔자 바이러스의 구제 |
| EP2471552B1 (en) | 2005-03-08 | 2015-05-06 | MedImmune, LLC | Reassortant influenza viruses |
| US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| CN102755645A (zh) | 2005-11-04 | 2012-10-31 | 诺华疫苗和诊断有限公司 | 佐剂配制的包含细胞因子诱导剂的流感疫苗 |
| EP1945252B1 (en) * | 2005-11-04 | 2013-05-29 | Novartis Vaccines and Diagnostics S.r.l. | Vaccines comprising purified surface antigens prepared from influenza viruses grown in cell culture, adjuvanted with squalene |
| NZ568210A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Emulsions with free aqueous-phase surfactant as adjuvants for split influenza vaccines |
| NZ568211A (en) | 2005-11-04 | 2011-11-25 | Novartis Vaccines & Diagnostic | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| SG176468A1 (en) | 2005-12-02 | 2011-12-29 | Sinai School Medicine | Chimeric viruses presenting non-native surface proteins and uses thereof |
| JP6087041B2 (ja) | 2006-01-27 | 2017-03-08 | ノバルティス アーゲー | 血球凝集素およびマトリックスタンパク質を含むインフルエンザウイルスワクチン |
| US20100068223A1 (en) | 2006-03-24 | 2010-03-18 | Hanno Scheffczik | Storage of Influenza Vaccines Without Refrigeration |
| AU2007245192B2 (en) | 2006-03-31 | 2012-04-12 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
| US20090017444A1 (en) * | 2006-06-09 | 2009-01-15 | Wisconsin Alumni Research Foundation | Screening method for modulators of viral transcription or replication |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| EP2049662A4 (en) | 2006-07-21 | 2009-12-30 | Medimmune Llc | METHODS AND COMPOSITIONS FOR INCREASING REPLICATION CAPACITY OF A FLU VIRUS |
| JP2010500034A (ja) | 2006-08-09 | 2010-01-07 | メッドイミューン バクシーンズ，インコーポレイティド | インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体 |
| CA3016948A1 (en) | 2006-09-11 | 2008-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| ES2480491T3 (es) | 2006-12-06 | 2014-07-28 | Novartis Ag | Vacunas incluyendo antígeno de cuatro cepas de virus de la gripe |
| WO2008147496A2 (en) | 2007-05-04 | 2008-12-04 | Warf - Wisconsin Alumni Research Foundation | Neuraminidase-deficient live influenza vaccines |
| US9474798B2 (en) | 2007-06-18 | 2016-10-25 | Wisconsin Alumni Research Foundation | Influenza M2 protein mutant viruses as live influenza attenuated vaccines |
| CA2690196A1 (en) | 2007-06-18 | 2008-12-24 | Medimmune, Llc | Influenza b viruses having alterations in the hemaglutinin polypeptide |
| EP2045323A1 (en) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| EA201070066A1 (ru) | 2007-06-27 | 2010-06-30 | Новартис Аг | Вакцины против гриппа с низким содержанием добавок |
| CN101497877B (zh) * | 2008-01-28 | 2012-09-05 | 河北摩百生物科技有限公司 | 流感全病毒减活疫苗重组体、其构建方法及应用 |
| EP2268309B1 (en) | 2008-03-18 | 2015-01-21 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| CN102149405A (zh) | 2008-07-11 | 2011-08-10 | 米迪缪尼股份有限公司 | 流感血凝素和神经氨酸酶变体 |
| EP2329845A4 (en) | 2008-08-18 | 2013-08-14 | Kitasato Daiichi Sankyo Vaccine Co Ltd | BIRD GRAPEVIRUS ANTIGEN AND BOOSTER IMMUNIZATION PROCEDURE FOR BIRD FLUID VACCINE IN COMBINATION WITH A MUCOSAL ADJUVAN WITH EFFICACY THROUGH ORAL ADMINISTRATION |
| EP2233568A1 (en) | 2009-03-19 | 2010-09-29 | Avir Green Hills Biotechnology Research Development Trade AG | Novel method for generation of RNA virus |
| CA2752041A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccines with increased amounts of h3 antigen |
| US20120093859A1 (en) | 2009-02-10 | 2012-04-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
| EA201500910A1 (ru) | 2009-02-10 | 2016-04-29 | Новартис Аг | Вакцины против гриппа со сниженным количеством сквалена |
| CN102361649A (zh) | 2009-02-12 | 2012-02-22 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
| CA2763816A1 (en) | 2009-04-27 | 2010-11-04 | Novartis Ag | Adjuvanted vaccines for protecting against influenza |
| WO2011030218A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| KR20130115105A (ko) | 2010-06-02 | 2013-10-21 | 박스터 헬쓰케어 에스에이 | Rna 바이러스를 생산하는 방법 및 헬퍼 바이러스 |
| CN102220293B (zh) * | 2011-05-26 | 2012-12-19 | 中国农业科学院上海兽医研究所 | 犬流感重组病毒及其制备方法和应用 |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| EP2751260A2 (en) | 2011-09-02 | 2014-07-09 | Westfälische Wilhelms-Universität Münster | Live attenuated influenza virus |
| EP2768528A1 (en) | 2011-10-20 | 2014-08-27 | Novartis AG | Adjuvanted influenza b virus vaccines for pediatric priming |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| EP3022296B1 (en) | 2013-07-15 | 2022-12-28 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN104450695B (zh) * | 2014-11-26 | 2017-08-25 | 扬州大学 | A型流感病毒基因pcr扩增引物及其快速克隆方法 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| HK1246183A1 (zh) * | 2015-06-10 | 2018-09-07 | Hookipa Biotech Gmbh | Hpv疫苗 |
| EP3313439A2 (en) | 2015-06-26 | 2018-05-02 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| KR102576962B1 (ko) | 2015-07-07 | 2023-09-11 | 세퀴러스 유케이 리미티드 | 인플루엔자 효능 검정 |
| JP2018530314A (ja) * | 2015-08-28 | 2018-10-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ウイルス様粒子からの感染性インフルエンザウイルスの生成 |
| JP2019510481A (ja) | 2016-02-19 | 2019-04-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ワクチン開発のための改善されたｂ型インフルエンザウイルス複製 |
| EP3675834A1 (en) * | 2017-08-28 | 2020-07-08 | Wisconsin Alumini Research Foundation | Nanocapsules for delivering ribonucleoproteins |
| EP3700562A1 (en) | 2017-10-25 | 2020-09-02 | Wisconsin Alumni Research Foundation (WARF) | Recombinant influenza viruses with stabilized ha for replication in eggs |
| CN107964035B (zh) * | 2017-12-06 | 2020-07-24 | 中国科学院微生物研究所 | 一种用于流感病毒的有限复制型黏膜免疫疫苗 |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (en) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (ha) protein |
| CN109097341B (zh) * | 2018-08-28 | 2021-09-24 | 青岛农业大学 | 一种同时表达ha和hef的复制缺陷型重组流感病毒 |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| US11851648B2 (en) | 2019-02-08 | 2023-12-26 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840520A (en) * | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5658772A (en) | 1989-12-22 | 1997-08-19 | E. I. Du Pont De Nemours And Company | Site-specific recombination of DNA in plant cells |
| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| EP0704533A1 (en) * | 1994-09-30 | 1996-04-03 | Bayer Ag | An attenuated vaccination virus, a method to make the virus and a pharmaceutical compositions comprising the virus |
| WO1996010633A1 (en) * | 1994-09-30 | 1996-04-11 | Aviron | Chimeric influenza virus and electroporation method |
| CN1200675A (zh) * | 1995-10-20 | 1998-12-02 | 耶路撒冷希伯来语大学依苏姆研究开发公司 | 流感疫苗 |
| US5994526A (en) * | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| EP1035209A1 (en) * | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| CA2365526C (en) * | 1999-04-06 | 2016-07-05 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
-
2000
- 2000-04-05 CA CA2365526A patent/CA2365526C/en not_active Expired - Lifetime
- 2000-04-05 KR KR1020017012743A patent/KR100702275B1/ko not_active Expired - Lifetime
- 2000-04-05 EP EP00920151A patent/EP1185615B1/en not_active Expired - Lifetime
- 2000-04-05 CN CN201010155623.8A patent/CN101851636B/zh not_active Expired - Lifetime
- 2000-04-05 DE DE122008000035C patent/DE122008000035I1/de active Pending
- 2000-04-05 DK DK07009953.6T patent/DK1820853T3/da active
- 2000-04-05 CA CA2928263A patent/CA2928263A1/en not_active Abandoned
- 2000-04-05 WO PCT/US2000/009021 patent/WO2000060050A2/en not_active Ceased
- 2000-04-05 DE DE122008000061C patent/DE122008000061I1/de active Pending
- 2000-04-05 EP EP14200291.4A patent/EP2910629B1/en not_active Expired - Lifetime
- 2000-04-05 IL IL14570200A patent/IL145702A0/xx unknown
- 2000-04-05 AT AT00920151T patent/ATE368729T1/de active
- 2000-04-05 EP EP07009953A patent/EP1820853B1/en not_active Expired - Lifetime
- 2000-04-05 AU AU40733/00A patent/AU4073300A/en not_active Abandoned
- 2000-04-05 DE DE60035778T patent/DE60035778T2/de not_active Expired - Lifetime
- 2000-04-05 BR BRPI0009580A patent/BRPI0009580B8/pt not_active IP Right Cessation
- 2000-04-05 MX MXPA01010082A patent/MXPA01010082A/es active IP Right Grant
- 2000-04-05 AT AT07009953T patent/ATE525461T1/de active
- 2000-04-05 PT PT00920151T patent/PT1185615E/pt unknown
- 2000-04-05 ES ES07009953T patent/ES2373405T3/es not_active Expired - Lifetime
- 2000-04-05 CN CN00807495XA patent/CN1350578B/zh not_active Expired - Lifetime
- 2000-04-05 DK DK00920151T patent/DK1185615T3/da active
- 2000-04-05 ES ES00920151T patent/ES2290024T3/es not_active Expired - Lifetime
- 2000-04-05 ES ES10011896.7T patent/ES2533622T3/es not_active Expired - Lifetime
- 2000-04-05 DK DK10011896.7T patent/DK2345716T3/en active
- 2000-04-05 DE DE122008000058C patent/DE122008000058I1/de active Pending
- 2000-04-05 JP JP2000609542A patent/JP5543048B2/ja not_active Expired - Lifetime
- 2000-04-05 DE DE200812000014 patent/DE122008000014I1/de active Pending
- 2000-04-05 EP EP10011896.7A patent/EP2345716B1/en not_active Expired - Lifetime
- 2000-04-05 PT PT07009953T patent/PT1820853E/pt unknown
-
2001
- 2001-09-30 IL IL145702A patent/IL145702A/en not_active IP Right Cessation
-
2007
- 2007-10-08 CY CY20071101295T patent/CY1108520T1/el unknown
-
2008
- 2008-11-13 NL NL300364C patent/NL300364I2/nl unknown
- 2008-11-13 NL NL300365C patent/NL300365I2/nl unknown
-
2011
- 2011-04-21 JP JP2011095240A patent/JP5775351B2/ja not_active Expired - Lifetime
- 2011-07-26 FR FR11C0027C patent/FR11C0027I2/fr active Active
- 2011-07-26 DE DE201112100037 patent/DE122011100037I1/de active Pending
- 2011-12-12 CY CY20111101234T patent/CY1112140T1/el unknown
-
2015
- 2015-03-31 JP JP2015071406A patent/JP6224645B2/ja not_active Expired - Lifetime
-
2016
- 2016-02-25 HK HK16102164.8A patent/HK1214298A1/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011182797A5 (OSRAM) | ||
| EP1631663B1 (en) | High titer recombinant influenza viruses for vaccines and gene therapy | |
| US7723094B2 (en) | Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy | |
| JP2015119730A5 (OSRAM) | ||
| JP5438065B2 (ja) | 突然変異した膜タンパク質をコードするウイルス | |
| EP2010557B1 (en) | High titer recombinant influenza viruses for vaccines | |
| JP2020010711A (ja) | Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス | |
| JP2022172369A (ja) | 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス | |
| US20060134138A1 (en) | Recombinant influenza viruses for vaccines and gene therapy | |
| RU2008101367A (ru) | Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках | |
| JP2012511579A5 (OSRAM) | ||
| CA2406100A1 (en) | Dna transfection system for the generation of infectious influenza virus | |
| CN114929269A (zh) | 用于疫苗开发的改进的流感病毒复制 | |
| JP2016521553A5 (OSRAM) | ||
| CN1350578A (zh) | 用于疫苗和基因治疗的重组流感病毒 | |
| JP2017522907A5 (OSRAM) | ||
| JP2004500842A5 (OSRAM) | ||
| WO2008156681A2 (en) | Adenoviral vectors for influenza virus production | |
| JP2016501020A5 (OSRAM) | ||
| CN104195154B (zh) | 新城疫病毒Mukteswar中等毒力疫苗株反向遗传操作系统及其应用 | |
| CN111363728A (zh) | 携带乙型肝炎病毒基因的重组甲型流感病毒、宿主细胞及其制备方法与应用 | |
| CN116144612B (zh) | 重组乙型流感病毒及其制备方法与应用 | |
| Elderfield et al. | Using reverse genetics to improve influenza vaccines | |
| HK1082769B (en) | High titer recombinant influenza viruses for vaccines and gene therapy | |
| Kawaoka et al. | Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy |