JP2011168555A - 鑑別方法 - Google Patents
鑑別方法 Download PDFInfo
- Publication number
- JP2011168555A JP2011168555A JP2010035489A JP2010035489A JP2011168555A JP 2011168555 A JP2011168555 A JP 2011168555A JP 2010035489 A JP2010035489 A JP 2010035489A JP 2010035489 A JP2010035489 A JP 2010035489A JP 2011168555 A JP2011168555 A JP 2011168555A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- action
- antibacterial peptide
- administered
- genus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 title claims abstract description 74
- 230000004069 differentiation Effects 0.000 title claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 75
- 239000003910 polypeptide antibiotic agent Substances 0.000 claims abstract description 57
- 238000004519 manufacturing process Methods 0.000 claims abstract description 31
- 101710125314 Beta-defensin 1 Proteins 0.000 claims abstract description 24
- 102100037437 Beta-defensin 1 Human genes 0.000 claims abstract description 24
- 239000000203 mixture Substances 0.000 claims abstract description 24
- 239000002537 cosmetic Substances 0.000 claims abstract description 23
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 19
- 102000044503 Antimicrobial Peptides Human genes 0.000 claims abstract description 12
- 108700042778 Antimicrobial Peptides Proteins 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 10
- 229940079593 drug Drugs 0.000 claims abstract description 6
- 210000003491 skin Anatomy 0.000 claims description 102
- 230000001737 promoting effect Effects 0.000 claims description 100
- 230000031729 antibacterial peptide production Effects 0.000 claims description 57
- 230000009471 action Effects 0.000 claims description 53
- 230000000694 effects Effects 0.000 claims description 48
- 230000014509 gene expression Effects 0.000 claims description 35
- 102000000591 Tight Junction Proteins Human genes 0.000 claims description 26
- 108010002321 Tight Junction Proteins Proteins 0.000 claims description 26
- 210000001578 tight junction Anatomy 0.000 claims description 26
- 230000015572 biosynthetic process Effects 0.000 claims description 21
- 210000000434 stratum corneum Anatomy 0.000 claims description 18
- 206010061218 Inflammation Diseases 0.000 claims description 15
- 230000004054 inflammatory process Effects 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 15
- 230000035945 sensitivity Effects 0.000 claims description 13
- 210000002919 epithelial cell Anatomy 0.000 claims description 11
- 230000007794 irritation Effects 0.000 claims description 11
- 210000001339 epidermal cell Anatomy 0.000 claims description 9
- 210000004927 skin cell Anatomy 0.000 claims description 8
- 230000032798 delamination Effects 0.000 claims description 5
- 101000952040 Homo sapiens Beta-defensin 1 Proteins 0.000 claims description 3
- 206010040880 Skin irritation Diseases 0.000 claims description 3
- 102000046975 human DEFB1 Human genes 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 230000036556 skin irritation Effects 0.000 claims description 3
- 231100000475 skin irritation Toxicity 0.000 claims description 3
- 238000012850 discrimination method Methods 0.000 claims description 2
- 230000000699 topical effect Effects 0.000 claims description 2
- 230000008591 skin barrier function Effects 0.000 abstract description 62
- 230000007246 mechanism Effects 0.000 abstract description 4
- 239000004480 active ingredient Substances 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 30
- 108090000765 processed proteins & peptides Proteins 0.000 description 23
- 238000011156 evaluation Methods 0.000 description 22
- 108020004999 messenger RNA Proteins 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 21
- 241000196324 Embryophyta Species 0.000 description 20
- 230000006872 improvement Effects 0.000 description 20
- 238000012360 testing method Methods 0.000 description 19
- 239000000126 substance Substances 0.000 description 17
- 239000000419 plant extract Substances 0.000 description 16
- 102000004196 processed proteins & peptides Human genes 0.000 description 16
- -1 sucrose fatty acid ester Chemical class 0.000 description 14
- 239000000284 extract Substances 0.000 description 13
- 230000006866 deterioration Effects 0.000 description 12
- 238000005259 measurement Methods 0.000 description 12
- 241000207923 Lamiaceae Species 0.000 description 11
- 239000004615 ingredient Substances 0.000 description 11
- 230000005732 intercellular adhesion Effects 0.000 description 11
- 208000024891 symptom Diseases 0.000 description 11
- 235000018185 Betula X alpestris Nutrition 0.000 description 10
- 235000018212 Betula X uliginosa Nutrition 0.000 description 10
- 235000006886 Zingiber officinale Nutrition 0.000 description 9
- 235000008397 ginger Nutrition 0.000 description 9
- 239000000523 sample Substances 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- 230000011641 antimicrobial peptide production Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 8
- 241000894006 Bacteria Species 0.000 description 7
- 244000126014 Valeriana officinalis Species 0.000 description 7
- 235000013832 Valeriana officinalis Nutrition 0.000 description 7
- 241000234314 Zingiber Species 0.000 description 7
- 235000016788 valerian Nutrition 0.000 description 7
- 241000205585 Aquilegia canadensis Species 0.000 description 6
- 101710125298 Beta-defensin 2 Proteins 0.000 description 6
- 102100038326 Beta-defensin 4A Human genes 0.000 description 6
- 101710176951 Beta-defensin 4A Proteins 0.000 description 6
- 235000002566 Capsicum Nutrition 0.000 description 6
- 240000008574 Capsicum frutescens Species 0.000 description 6
- 102000012265 beta-defensin Human genes 0.000 description 6
- 108050002883 beta-defensin Proteins 0.000 description 6
- 239000001390 capsicum minimum Substances 0.000 description 6
- 238000003752 polymerase chain reaction Methods 0.000 description 6
- 241000269333 Caudata Species 0.000 description 5
- 241000207199 Citrus Species 0.000 description 5
- 241001672694 Citrus reticulata Species 0.000 description 5
- 244000000626 Daucus carota Species 0.000 description 5
- 235000002767 Daucus carota Nutrition 0.000 description 5
- 101710178505 Defensin-1 Proteins 0.000 description 5
- 240000000691 Houttuynia cordata Species 0.000 description 5
- 235000013719 Houttuynia cordata Nutrition 0.000 description 5
- 102100028850 Prolactin-releasing peptide Human genes 0.000 description 5
- 102000006467 TATA-Box Binding Protein Human genes 0.000 description 5
- 108010044281 TATA-Box Binding Protein Proteins 0.000 description 5
- 235000020971 citrus fruits Nutrition 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 210000000440 neutrophil Anatomy 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 238000003757 reverse transcription PCR Methods 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- 244000267823 Hydrangea macrophylla Species 0.000 description 4
- 206010020751 Hypersensitivity Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 244000273928 Zingiber officinale Species 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 230000004888 barrier function Effects 0.000 description 4
- 230000021164 cell adhesion Effects 0.000 description 4
- 239000002299 complementary DNA Substances 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 230000008105 immune reaction Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 235000013599 spices Nutrition 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- WHNFPRLDDSXQCL-UAZQEYIDSA-N α-msh Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(N)=O)NC(=O)[C@H](CO)NC(C)=O)C1=CC=C(O)C=C1 WHNFPRLDDSXQCL-UAZQEYIDSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 3
- 244000183685 Citrus aurantium Species 0.000 description 3
- 235000007716 Citrus aurantium Nutrition 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 241000380130 Ehrharta erecta Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 244000004281 Eucalyptus maculata Species 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 102400000740 Melanocyte-stimulating hormone alpha Human genes 0.000 description 3
- 101710200814 Melanotropin alpha Proteins 0.000 description 3
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 3
- 235000004347 Perilla Nutrition 0.000 description 3
- 244000124853 Perilla frutescens Species 0.000 description 3
- 241000218201 Ranunculaceae Species 0.000 description 3
- 230000000843 anti-fungal effect Effects 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229940106189 ceramide Drugs 0.000 description 3
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 230000010534 mechanism of action Effects 0.000 description 3
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 3
- 239000012264 purified product Substances 0.000 description 3
- 235000002020 sage Nutrition 0.000 description 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 244000097863 Grifola umbellata Species 0.000 description 2
- 235000002897 Grifola umbellata Nutrition 0.000 description 2
- 102000006492 Histatins Human genes 0.000 description 2
- 108010019494 Histatins Proteins 0.000 description 2
- 101000830386 Homo sapiens Neutrophil defensin 3 Proteins 0.000 description 2
- 101000929203 Homo sapiens Neutrophil defensin 4 Proteins 0.000 description 2
- 101000743264 Homo sapiens RNA-binding protein 6 Proteins 0.000 description 2
- 235000014486 Hydrangea macrophylla Nutrition 0.000 description 2
- 241000832224 Hypericaceae Species 0.000 description 2
- 241000546188 Hypericum Species 0.000 description 2
- 206010055171 Hypertensive nephropathy Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 102100024761 Neutrophil defensin 3 Human genes 0.000 description 2
- 102100036348 Neutrophil defensin 4 Human genes 0.000 description 2
- 241000218657 Picea Species 0.000 description 2
- 108010087786 Prolactin-Releasing Hormone Proteins 0.000 description 2
- 235000002634 Solanum Nutrition 0.000 description 2
- 241000207763 Solanum Species 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 241001222097 Xenocypris argentea Species 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 210000002867 adherens junction Anatomy 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 102000018568 alpha-Defensin Human genes 0.000 description 2
- 108050007802 alpha-defensin Proteins 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 229960005188 collagen Drugs 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 230000008260 defense mechanism Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000009610 hypersensitivity Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 210000004692 intercellular junction Anatomy 0.000 description 2
- 239000006166 lysate Substances 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 239000002877 prolactin releasing hormone Substances 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 1
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- JYZLSYFPFQTNNO-UHFFFAOYSA-N 2-octyldecan-1-ol Chemical compound CCCCCCCCC(CO)CCCCCCCC JYZLSYFPFQTNNO-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 102100026887 Beta-defensin 103 Human genes 0.000 description 1
- 102100026886 Beta-defensin 104 Human genes 0.000 description 1
- 101710125296 Beta-defensin 3 Proteins 0.000 description 1
- 101710125300 Beta-defensin 4 Proteins 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 244000260524 Chrysanthemum balsamita Species 0.000 description 1
- 235000005633 Chrysanthemum balsamita Nutrition 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 102000000541 Defensins Human genes 0.000 description 1
- 108010002069 Defensins Proteins 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 244000166124 Eucalyptus globulus Species 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000577765 Homo sapiens Prolactin-releasing peptide Proteins 0.000 description 1
- 241000243251 Hydra Species 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000000637 Melanocyte-Stimulating Hormone Substances 0.000 description 1
- 108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 description 1
- 101800001751 Melanocyte-stimulating hormone alpha Proteins 0.000 description 1
- 241000219926 Myrtaceae Species 0.000 description 1
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
- 240000008881 Oenanthe javanica Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010072574 Periodontal inflammation Diseases 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 241000218206 Ranunculus Species 0.000 description 1
- 241000245165 Rhododendron ponticum Species 0.000 description 1
- 235000017276 Salvia Nutrition 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 241000207929 Scutellaria Species 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000208292 Solanaceae Species 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 108700026226 TATA Box Proteins 0.000 description 1
- 240000001949 Taraxacum officinale Species 0.000 description 1
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 229940024546 aluminum hydroxide gel Drugs 0.000 description 1
- SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000017455 cell-cell adhesion Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000004665 defense response Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 125000005131 dialkylammonium group Chemical group 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 210000003038 endothelium Anatomy 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000010413 gardening Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000003864 humus Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002434 immunopotentiative effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229940114937 microcrystalline wax Drugs 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000010899 nucleation Methods 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000008008 oral excipient Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000010330 ougon Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 235000021067 refined food Nutrition 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 101150023847 tbp gene Proteins 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 230000036572 transepidermal water loss Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
Images
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010035489A JP2011168555A (ja) | 2010-02-22 | 2010-02-22 | 鑑別方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010035489A JP2011168555A (ja) | 2010-02-22 | 2010-02-22 | 鑑別方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011168555A true JP2011168555A (ja) | 2011-09-01 |
| JP2011168555A5 JP2011168555A5 (enExample) | 2012-07-05 |
Family
ID=44683053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010035489A Pending JP2011168555A (ja) | 2010-02-22 | 2010-02-22 | 鑑別方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2011168555A (enExample) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014055127A (ja) * | 2012-08-10 | 2014-03-27 | Shiseido Co Ltd | フィラグリン遺伝子発現促進剤 |
| JP2016513808A (ja) * | 2013-03-15 | 2016-05-16 | ザ プロクター アンド ギャンブル カンパニー | 微生物からの自然防御の客観的尺度として皮膚から抗微生物ペプチドを測定するための非侵襲的方法 |
| JP2016135761A (ja) * | 2015-01-14 | 2016-07-28 | 御木本製薬株式会社 | ディフェンシン産生促進剤、カテリシジン産生促進剤、抗菌剤 |
| JP2017100987A (ja) * | 2015-12-01 | 2017-06-08 | 株式会社ナールスコーポレーション | フィラグリン遺伝子発現促進剤 |
| JP2017132758A (ja) * | 2016-01-25 | 2017-08-03 | 御木本製薬株式会社 | クローディン産生促進剤、オクルディン産生促進剤、タイトジャンクション機能強化剤 |
| JP2021159046A (ja) * | 2020-04-03 | 2021-10-11 | 花王株式会社 | 皮膚情報提供方法 |
| JP2023052021A (ja) * | 2018-02-19 | 2023-04-11 | 株式会社ファンケル | 抗炎症剤および肌荒れ防止剤 |
| JP2023070539A (ja) * | 2021-11-09 | 2023-05-19 | 学校法人順天堂 | オートファジー活性化剤 |
| WO2025013795A1 (ja) * | 2023-07-07 | 2025-01-16 | 丸善製薬株式会社 | β－ディフェンシン－３ ｍＲＮＡ発現促進剤 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005172654A (ja) * | 2003-12-12 | 2005-06-30 | Pola Chem Ind Inc | 肌状態の分析結果の表示方法 |
| JP2006022007A (ja) * | 2004-07-06 | 2006-01-26 | Kao Corp | 敏感肌改善用内服剤 |
| JP2007174931A (ja) * | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 表皮角化細胞層膜及び該表皮角化細胞層膜の利用 |
| JP2008019264A (ja) * | 2002-08-02 | 2008-01-31 | Engelhard Lyon | ２型又は３型ヒトβ−デフェンシンを刺激する活性成分とその活性成分を含有する化粧用組成物及び医薬組成物 |
-
2010
- 2010-02-22 JP JP2010035489A patent/JP2011168555A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008019264A (ja) * | 2002-08-02 | 2008-01-31 | Engelhard Lyon | ２型又は３型ヒトβ−デフェンシンを刺激する活性成分とその活性成分を含有する化粧用組成物及び医薬組成物 |
| JP2005172654A (ja) * | 2003-12-12 | 2005-06-30 | Pola Chem Ind Inc | 肌状態の分析結果の表示方法 |
| JP2006022007A (ja) * | 2004-07-06 | 2006-01-26 | Kao Corp | 敏感肌改善用内服剤 |
| JP2007174931A (ja) * | 2005-12-27 | 2007-07-12 | Pola Chem Ind Inc | 表皮角化細胞層膜及び該表皮角化細胞層膜の利用 |
Non-Patent Citations (1)
| Title |
|---|
| JPN6014003691; Ｊｏｕｒｎａｌ ｏｆ Ｉｎｖｅｓｔｉｇａｔｉｖｅ Ｄｅｒｍａｔｏｌｏｇｙ Ｖｏｌ．１２８, 2008, ｐ．Ｓ１０９ * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9827187B2 (en) | 2012-08-10 | 2017-11-28 | Shiseido Company, Ltd. | Filaggrin gene expression promoter |
| JP2014055127A (ja) * | 2012-08-10 | 2014-03-27 | Shiseido Co Ltd | フィラグリン遺伝子発現促進剤 |
| JP2016513808A (ja) * | 2013-03-15 | 2016-05-16 | ザ プロクター アンド ギャンブル カンパニー | 微生物からの自然防御の客観的尺度として皮膚から抗微生物ペプチドを測定するための非侵襲的方法 |
| JP2016135761A (ja) * | 2015-01-14 | 2016-07-28 | 御木本製薬株式会社 | ディフェンシン産生促進剤、カテリシジン産生促進剤、抗菌剤 |
| JP2018087212A (ja) * | 2015-01-14 | 2018-06-07 | 御木本製薬株式会社 | ディフェンシン産生促進剤、カテリシジン産生促進剤、抗菌剤 |
| JP2017100987A (ja) * | 2015-12-01 | 2017-06-08 | 株式会社ナールスコーポレーション | フィラグリン遺伝子発現促進剤 |
| JP2017132758A (ja) * | 2016-01-25 | 2017-08-03 | 御木本製薬株式会社 | クローディン産生促進剤、オクルディン産生促進剤、タイトジャンクション機能強化剤 |
| JP2023052021A (ja) * | 2018-02-19 | 2023-04-11 | 株式会社ファンケル | 抗炎症剤および肌荒れ防止剤 |
| JP2021159046A (ja) * | 2020-04-03 | 2021-10-11 | 花王株式会社 | 皮膚情報提供方法 |
| JP2024169560A (ja) * | 2020-04-03 | 2024-12-05 | 花王株式会社 | 皮膚情報提供方法 |
| JP7775403B2 (ja) | 2020-04-03 | 2025-11-25 | 花王株式会社 | 皮膚情報提供方法 |
| JP2023070539A (ja) * | 2021-11-09 | 2023-05-19 | 学校法人順天堂 | オートファジー活性化剤 |
| WO2025013795A1 (ja) * | 2023-07-07 | 2025-01-16 | 丸善製薬株式会社 | β－ディフェンシン－３ ｍＲＮＡ発現促進剤 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100910747B1 (ko) | 항균, 항여드름, 피부진정, 보습 및 피지 조절 활성이 우수한 생약 혼합 추출물 | |
| JP2011168555A (ja) | 鑑別方法 | |
| JP2011168555A5 (enExample) | ||
| JP5791879B2 (ja) | ＮＦ−κＢ活性化抑制剤ならびに毛穴ケア剤 | |
| KR101425031B1 (ko) | 유자씨 및 망고씨 혼합오일을 함유하는 피부 자극완화 및 피부보습용 화장료 조성물 | |
| KR102348042B1 (ko) | 산수국 추출물을 포함하는 피부 상태 개선용 조성물 | |
| KR101591872B1 (ko) | 항염, 항알러지 및 항산화 효능이 우수한 Ge-8 혼합물을 함유하는 화장료 조성물 | |
| WO2009145345A1 (ja) | 冬虫夏草菌セミタケを含む外用剤 | |
| KR20130030032A (ko) | 허브 추출물을 포함하는 화장료 조성물 | |
| KR102096703B1 (ko) | 무화과잎 주정 추출물을 포함하는 화장료 조성물 | |
| Garg et al. | Exploring the potential of Moringa oleifera Lam in skin disorders and cosmetics: nutritional analysis, phytochemistry, geographical distribution, ethnomedicinal uses, dermatological studies and cosmetic formulations | |
| KR102002894B1 (ko) | 천연 복합추출물을 함유하는 화장료 조성물 | |
| JP2011088845A (ja) | インボルクリン発現抑制剤 | |
| Asseleih et al. | Ethnobotany, pharmacology and chemistry of medicinal orchids from Veracruz | |
| Mansour-Djaalab et al. | In vitro evaluation of antifungal effects of Lawsonia inermis, Pistacia lentiscus and Juglans regia. | |
| KR102150927B1 (ko) | 조릿대 추출물 및 우레아를 포함하는 화장료 및 약학적 조성물 | |
| KR101981678B1 (ko) | 모발 성장 촉진 및 두피 및 모발 개선용 복합 항산화 추출물 및 화장료 조성물 | |
| KR101039532B1 (ko) | 연잎, 지부자, 지골피 추출물로 구성되는 천연항균복합체를 함유하는 여드름 개선용 화장료 조성물 | |
| KR101582971B1 (ko) | 딱총나무 및 으아리 추출물을 유효성분으로 함유하는 주름개선용 화장료 조성물 | |
| KR102760310B1 (ko) | 보스웰리아 추출물, 레몬 머틀 잎 추출물, 만주자작나무 싹 추출물 및 에버라스팅 추출물을 포함하는 항염증 및 항여드름용 화장료 조성물 | |
| KR20230081343A (ko) | 천연 발효 추출물을 성분으로 하는 모발 및 두피 개선용 조성물 | |
| KR100712249B1 (ko) | 생약재 추출물을 함유하는 지성피부 개선용 화장료 조성물및 그 제조방법 | |
| KR100829832B1 (ko) | 두릅나무 에탄올 추출물을 유효성분으로 포함하는 피부 주름개선용 화장료 조성물 | |
| KR102512376B1 (ko) | 생약 혼합물로부터 저온 숙성 공정을 이용하여 얻은 추출물을 포함하는 화장료 조성물 | |
| KR102270290B1 (ko) | 진주 복합추출물을 유효성분으로 포함하는 피부 개선용 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120518 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20120518 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140204 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140407 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20150331 |