JP2011093893A - 抗アレルギー剤 - Google Patents
抗アレルギー剤 Download PDFInfo
- Publication number
- JP2011093893A JP2011093893A JP2010220332A JP2010220332A JP2011093893A JP 2011093893 A JP2011093893 A JP 2011093893A JP 2010220332 A JP2010220332 A JP 2010220332A JP 2010220332 A JP2010220332 A JP 2010220332A JP 2011093893 A JP2011093893 A JP 2011093893A
- Authority
- JP
- Japan
- Prior art keywords
- apolactoferrin
- products
- lactoferrin
- pollen
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
【解決手段】本発明は、アポラクトフェリンを含む抗アレルギー剤を提供する。この抗アレルギー剤は、眼科用製品、鼻腔用製品、口腔用製品などに用いられ得る。また、アレルギー予防に用いられ得る製品(例えば、マスク)に処理を施すことによっても用いられ得る。
【選択図】なし
Description
アポラクトフェリンとは、ラクフェリン分子中に結合されている鉄が遊離した糖蛋白分子である。本発明で使用するアポラクトフェリンは特に限定されないが、以下の特性を有することが好ましい。
アポラクトフェリンは、アレルゲン(例えば、スギ花粉、ブタクサ花粉、イヌアレルゲン、ネコアレルゲン、およびダニアレルゲン)との結合能を有するアレルゲン結合剤、または花粉などのアレルゲンとの接触を防止し得る抗アレルギー剤として利用可能である。アポラクトフェリンは、アレルギーの予防(これは、症状の発症の防止および症状の抑制を含み得る)に有効な成分として利用され得る。アレルギーとしては、特に、スギ花粉、ブタクサ花粉などの花粉に起因する花粉症、イヌアレルギー、ネコアレルギー、またはダニアレルギーの予防に有用であり得るがこれに限定されない。アポラクトフェリンは、アレルギーの予防に有効な量で組成物に含まれ得る。アポラクトフェリンをアレルギーの予防に有効な成分として含む組成物を、本明細書中では、アレルギー予防用組成物ともいう。アポラクトフェリンを含む抗アレルギー剤は、任意の公知のアレルギー症状抑制剤と併用してもよく、アレルギー予防用組成物は、任意の公知のアレルギー症状抑制剤をさらに含み得る。
マイクローザUFラボテスト機(LX−22001;旭化成ケミカルズ株式会社)に、同社製のUFモジュールであるLOV(中空糸モジュール:膜内径0.8mm、有効膜面積41m2、膜素材:ポリアクリロニトリル、公称分画分子量:50,000)を組み込んだ限外濾過装置を用いて、以下のようにアポラクトフェリンを製造した。
株式会社デルタ・インターナショナル(東京)から購入したカリフォルニア産アーモンドの種皮および仁を一緒に細かく裁断し凍結乾燥機で乾燥させ、十分に乾燥を終えた後、粉砕機で粉砕した。粉砕サンプル1gを100mLのビーカーに測り取り、20〜25℃の超純水20mLを入れ、超音波で約5分処理した後、4℃にて一晩攪拌した。撹拌後の液状物を、4℃にて20分間、3000rpmで遠心分離し、上清を回収した。この遠心分離による沈澱を10mLの超純水で洗い、もう一度、同条件で遠心分離を行い、上清を回収した。回収した2つの上清を合わせて凍結乾燥、粉末化した(以下、「アーモンド水抽出物」)。
摘果ぶどう(品種:巨峰)を福岡県久留米市のぶどう園にて採取し、実および皮部分を一緒に細かく裁断し凍結乾燥機で乾燥させ、十分に乾燥を終えた後、粉砕機で粉砕した。粉砕サンプル1gを100mLのビーカーに測り取り、20〜25℃の超純水20mLを入れ、超音波で約5分処理した後、4℃にて一晩攪拌した。攪拌後の液状物を、4℃にて20分間、3000rpmで遠心分離し、上清を回収した。この遠心分離による沈澱を10mLの超純水で洗い、もう一度、同条件で遠心分離を行い、上清を回収した。回収した2つの上清を合わせて凍結乾燥、粉末化した(以下、「摘果ぶどう(実)水抽出物」)。
日本スギ花粉(生化学バイオビジネス株式会社から購入)、すなわち、日本スギ(Cryptomeria japonica)の成熟雄花から採取した花粉を、分子間相互作用定量水晶天秤(QCM)装置「AFFINIXQ」(型番:QCM2000;株式会社イニシアム)の専用センサーチップに、100μg/mL濃度で1μL滴下し、十分に風乾した後に、超純水でチップを洗浄した。日本スギ花粉を固定したチップを上記装置に装着し、8mLの超純水、あるいは50mM、100mM、150mM、200mM、250mMのNaClあるいはCaCl2の水溶液を入れた試験容器に挿入した。次いで、調製例1で製造したアポラクトフェリンの凍結乾燥物を超純水で1mg/mLとしたアポラクトフェリン溶液8μLを、試験容器に添加した。装置のディスプレイ上でチップ上のスギ花粉とアポラクトフェリンとの結合が安定になったことを確認し、上記アポラクトフェリン溶液8μLを更に添加した。この操作を更に3回繰り返し、日本スギ花粉とアポラクトフェリンとの相互作用を示す平衡曲線(吸着曲線)を作成した。次に、上記測定過程において、花粉を結合させていない当該専用センサーチップについて同様の測定を行い、ブランクとして先の測定値より差し引いた。結果は、装置に内蔵した専用測定解析ソフトウェアで解析し、解離定数の逆数として結合定数を算出した。
専用センサーチップに、日本スギ花粉の代わりに、スギ花粉抗原SBP(生化学バイオビジネス株式会社から購入)を固定し、そしてアポラクトフェリン溶液を添加する前の試験容器には超純水を入れたこと以外は、実施例1と同様の操作を行った。スギ花粉抗原SBPは、日本スギ(Cryptomeria japonica)花粉を炭酸水素ナトリウム溶液により抽出および精製して得られる糖タンパク質で主要アレルゲンである、Cryj 1およびCryj 2を含む。実施例1の8mLの超純水を試験容器に入れた場合のスギ花粉の結果を比較に用いた。
不織布マスク(ディスポーザーマスク;ケンコーコム社製;ポリプロピレン100%;W175×H94)を集塵機(株式会社千代田テクノル社製;MODEL: TH-D5101)の吸入口に固定した。吸入口を被覆する部分(被覆部)以外にはガムテープで目張りした。不織布マスクを固定した集塵機を、日本スギ花粉(生化学バイオビジネス株式会社から購入)1gを入れた1m×1m×1mの6面体アクリルボックスに入れ、電源コード部分を除いて密閉した。集塵機を30分間稼働した。稼動終了後、被覆部上に付着したスギ花粉をマスクから振動によるふるい落としで回収し、秤量した。付着していた花粉量(質量)をアクリルボックスに入れた1gで除して、花粉捕捉率とした。なお、マスクから回収したスギ花粉にマスクの繊維が混入していないかを、回収プレート上の無作為に抽出した3箇所について、顕微鏡下で確認を行った。
専用センサーチップに、日本スギ花粉の代わりに、スギ花粉抗原SBP(Purified Sugi Basic Protein;Japanese Cedar Pollen Allergen;生化学バイオビジネス株式会社から購入)、ブタクサ花粉(Ragweed pollen;株式会社ビオスタから購入)、イヌアレルゲン粗抽出物(株式会社東京環境アレルギー研究所から購入)、ネコ粗抽出物(株式会社東京環境アレルギー研究所から購入)、およびダニ(Dp)粗抽出物(株式会社東京環境アレルギー研究所から購入)のいずれかを50μg/ml(スギ花粉抗原SBP、ブタクサ花粉)または10μg/ml(イヌアレルゲン粗抽出物、ネコ粗抽出物、およびダニ粗抽出物)で固定し、そしてアポラクトフェリン溶液を添加する前の試験容器には超純水を入れたこと以外は、実施例1と同様の操作を行った。
アポラクトフェリン溶液の代わりに、カルシウムカゼネート(株式会社アップウェルより購入)、ラクトペルオキシダーゼ(タツア・ジャパン株式会社より購入)、カゼインタンパク質加水分解物(HCP105:軽度に加水分解したカゼインタンパク質;分子量10000-20000が30-40%;タツア・ジャパン株式会社より購入)を超純水で1mg/mLとした溶液を用いたこと以外は、実施例4と同様の操作を行った。
アポラクトフェリン溶液の代わりに、調製例2で調製したアーモンド抽出物(水抽出物または熱水抽出物)あるいは調製例3で調製した摘果ぶどう(実または枝)抽出物(水抽出物または熱水抽出物)を超純水で1mg/mLとした溶液を用いたこと以外は、実施例4と同様の操作を行った。
Claims (2)
- アポラクトフェリンを含む抗アレルギー剤。
- アポラクトフェリンを有効成分として含有するアレルギー予防用組成物。
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EP2692355A1 (en) | 2012-08-01 | 2014-02-05 | Biagio Biancardi | Apolactoferrin for the treatment of iron accumulation diseases |
IT202000009430A1 (it) | 2020-04-29 | 2021-10-29 | Tdc Tech Dedicated To Care Srl | Composizione per la prevenzione e/o il trattamento delle infezioni delle vie respiratorie |
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IT202000009430A1 (it) | 2020-04-29 | 2021-10-29 | Tdc Tech Dedicated To Care Srl | Composizione per la prevenzione e/o il trattamento delle infezioni delle vie respiratorie |
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