JP2011057693A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011057693A5 JP2011057693A5 JP2010256651A JP2010256651A JP2011057693A5 JP 2011057693 A5 JP2011057693 A5 JP 2011057693A5 JP 2010256651 A JP2010256651 A JP 2010256651A JP 2010256651 A JP2010256651 A JP 2010256651A JP 2011057693 A5 JP2011057693 A5 JP 2011057693A5
- Authority
- JP
- Japan
- Prior art keywords
- alkynyl
- alkenyl
- alkyl
- alkylsulfinyl
- alkylsulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30554601P | 2001-07-13 | 2001-07-13 | |
| US39574102P | 2002-07-12 | 2002-07-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511780A Division JP2004537544A (ja) | 2001-07-13 | 2002-07-15 | 標的治療活性を有するテトラサイクリン化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011057693A JP2011057693A (ja) | 2011-03-24 |
| JP2011057693A5 true JP2011057693A5 (US20070167479A1-20070719-C00034.png) | 2013-01-24 |
Family
ID=29553007
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511780A Pending JP2004537544A (ja) | 2001-07-13 | 2002-07-15 | 標的治療活性を有するテトラサイクリン化合物 |
| JP2009187938A Expired - Fee Related JP5182956B2 (ja) | 2001-07-13 | 2009-08-14 | 標的治療活性を有するテトラサイクリン化合物 |
| JP2010256651A Pending JP2011057693A (ja) | 2001-07-13 | 2010-11-17 | 標的治療活性を有するテトラサイクリン化合物 |
| JP2010256652A Pending JP2011057694A (ja) | 2001-07-13 | 2010-11-17 | 標的治療活性を有するテトラサイクリン化合物 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003511780A Pending JP2004537544A (ja) | 2001-07-13 | 2002-07-15 | 標的治療活性を有するテトラサイクリン化合物 |
| JP2009187938A Expired - Fee Related JP5182956B2 (ja) | 2001-07-13 | 2009-08-14 | 標的治療活性を有するテトラサイクリン化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010256652A Pending JP2011057694A (ja) | 2001-07-13 | 2010-11-17 | 標的治療活性を有するテトラサイクリン化合物 |
Country Status (5)
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| ES2260051T3 (es) * | 1999-09-14 | 2006-11-01 | Trustees Of Tufts College | Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion. |
| AU3105801A (en) | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| HUP0300082A2 (en) * | 2000-03-31 | 2003-05-28 | Paratek Pharmaceuticals | 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them |
| AU2001259701A1 (en) * | 2000-05-15 | 2001-11-26 | Paratek Pharmaceuticals, Inc | 7-substituted fused ring tetracycline compounds |
| WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| ATE544745T1 (de) | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| WO2002072506A2 (en) * | 2001-03-13 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| MXPA03008165A (es) * | 2001-03-13 | 2003-12-12 | Paratek Pharm Innc | Compuestos tetraciclina sustituidos en la posicion 7,9. |
| JP2005504722A (ja) | 2001-03-14 | 2005-02-17 | パラテック ファーマシューティカルズ インコーポレイテッド | 相乗的抗真菌薬剤としての置換テトラサイクリン化合物 |
| US8088820B2 (en) * | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| EP1404324B2 (en) * | 2001-06-11 | 2011-04-06 | XenoPort, Inc. | Prodrugs of gaba analogs, compositions and uses thereof |
| EP2332548A1 (en) * | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of stroke |
| US20060194773A1 (en) * | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| WO2003055441A2 (en) | 2001-08-02 | 2003-07-10 | Paratek Pharmaceuticals, Inc. | Medicaments |
| EP1894569A3 (en) * | 2001-10-05 | 2008-05-07 | Tetragenex Pharmaceuticals, Inc. | Tetracycline derivatives for treating cancer |
| AU2003235759A1 (en) * | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| WO2003079984A2 (en) * | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| AU2003245295B2 (en) * | 2002-05-20 | 2008-01-03 | Collagenex Pharmaceuticals, Inc. | Methods of treating allergic reactions |
| AU2003256496A1 (en) * | 2002-07-12 | 2004-02-02 | The Research Foundation Of State University Of New York | Method for reducing c-rective protein levels with non-antibacterial tetracycline formulations |
| KR101148415B1 (ko) * | 2002-07-12 | 2012-05-21 | 파라테크 파마슈티컬스, 인크. | 3, 10, 및 12ａ 치환된 테트라시클린 화합물 |
| WO2004014434A1 (en) * | 2002-08-09 | 2004-02-19 | Durkin Helen G | A method for monitoring the effectiveness of tetracycline in the treatment of asthma |
| AU2003287217B2 (en) | 2002-10-24 | 2010-03-04 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate RNA |
| AU2003287218C1 (en) * | 2002-10-24 | 2010-07-15 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| DK2204168T3 (en) * | 2003-04-07 | 2015-04-07 | Supernus Pharmaceuticals Inc | Tetracycline for administration once a day |
| EP2298323A3 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2292590A3 (en) * | 2003-07-09 | 2012-05-02 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CN103040773A (zh) * | 2003-07-25 | 2013-04-17 | 沃纳奇尔科特有限责任公司 | 多西环素金属络合物固体剂型 |
| US20050148553A1 (en) * | 2003-09-05 | 2005-07-07 | Testa Raymond T. | Use of tigecycline, alone, or in combination with rifampin to treat osteomyelitis and/or septic arthritis |
| UA83266C2 (en) * | 2003-12-08 | 2008-06-25 | Уайет | Oxazole derivatives of tetracyclines |
| EP2332904A3 (en) | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
| AU2005244988C1 (en) | 2004-05-21 | 2012-06-28 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| WO2006009840A1 (en) * | 2004-06-21 | 2006-01-26 | Hutchison Medipharma Enterprises Limited | Benzoquinone compounds as a anti-cancer agents |
| TWI261038B (en) * | 2004-08-11 | 2006-09-01 | Bo-Cheng Chen | Bicycle gear-shifting handgrip |
| CA2585248A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP1805134B1 (en) * | 2004-10-25 | 2012-06-20 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| BRPI0517227B8 (pt) | 2004-11-04 | 2021-05-25 | Xenoport Inc | comprimido oral de liberação prolongada do ácido 1-{[alfa-isobutanoiloxietoxi)carbonil]amino metil}-1-cicloexano acético, e, uso do comprimido |
| US8088755B2 (en) * | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| JP2008530123A (ja) * | 2005-02-09 | 2008-08-07 | ジェネンテック・インコーポレーテッド | マトリックスメタロプロテアーゼアンタゴニストを用いたｈｅｒ２のシェディングの阻害 |
| US7879828B2 (en) | 2005-03-14 | 2011-02-01 | Wyeth Llc | Tigecycline compositions and methods of preparation |
| US8211874B2 (en) * | 2005-06-03 | 2012-07-03 | Galderma Laboratories Inc. | Inhibition of thrombin generation |
| US20070093455A1 (en) * | 2005-07-21 | 2007-04-26 | Paul Abato | 10-substituted tetracyclines and methods of use thereof |
| RU2008121238A (ru) * | 2005-12-22 | 2010-01-27 | Вайет (Us) | Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина |
| AU2006331688A1 (en) * | 2005-12-22 | 2007-07-05 | Wyeth | Oral formulations comprising tigecycline |
| US20080027031A1 (en) * | 2006-03-08 | 2008-01-31 | Kinemed, Inc. | Retinoids and Related Compounds for the Treatment of Neuroinflammatory Conditions, Diseases and Disorders |
| AU2007235279B2 (en) | 2006-04-07 | 2012-12-06 | President And Fellows Of Harvard College | Synthesis of tetracyclines and analogues thereof |
| US20070286906A1 (en) * | 2006-04-28 | 2007-12-13 | Hutchison Medipharma Enterprises Limited | Dihydrobenzoquinone compounds |
| EP3056487B1 (en) | 2006-10-11 | 2018-02-21 | President and Fellows of Harvard College | Synthesis of enone intermediate |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| WO2008047340A1 (en) * | 2006-10-19 | 2008-04-24 | Mor Research Applications Ltd. | Combined therapies of antipsychotic drugs and tetracyclines in the treatment of psychiatric disorders |
| CA2673466C (en) * | 2006-12-21 | 2016-06-14 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| CA2892739A1 (en) * | 2006-12-21 | 2008-07-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| CA2679448A1 (en) * | 2007-02-28 | 2008-09-04 | Aciex, Inc. | Methods and compositions for normalizing meibomian gland secretions |
| CA2688725A1 (en) | 2007-04-12 | 2008-10-23 | Paratek Pharmaceuticals, Inc. | Methods for treating spinal muscular atrophy using tetracycline compounds |
| US8518912B2 (en) | 2007-11-29 | 2013-08-27 | Actelion Pharmaceuticals Ltd. | Phosphonic acid derivates and their use as P2Y12 receptor antagonists |
| CN102015602A (zh) * | 2008-03-05 | 2011-04-13 | 帕拉特克药品公司 | 米诺环素化合物及其使用方法 |
| PT2271348T (pt) * | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| EP2307027A4 (en) | 2008-07-11 | 2012-08-15 | Neumedics | TETRACYCLINE DERIVATIVES WITH REDUCED ANTIBIOTIC ACTIVITY AND NEUROPROTECTIVE PROPERTIES |
| SG10201806714PA (en) | 2008-08-08 | 2018-09-27 | Tetraphase Pharmaceuticals Inc | C7-fluoro substituted tetracycline compounds |
| CN102215681A (zh) * | 2008-09-19 | 2011-10-12 | 帕拉特克药品公司 | 用于治疗类风湿性关节炎的四环素化合物和相关的治疗方法 |
| US9073829B2 (en) | 2009-04-30 | 2015-07-07 | President And Fellows Of Harvard College | Synthesis of tetracyclines and intermediates thereto |
| US9315451B2 (en) | 2009-05-08 | 2016-04-19 | Tetraphase Pharmaceuticals, Inc. | Tetracycline compounds |
| NO2470500T3 (US20070167479A1-20070719-C00034.png) | 2009-08-28 | 2018-03-03 | ||
| US9327015B2 (en) * | 2009-10-23 | 2016-05-03 | DePuy Synthes Products, Inc. | Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws |
| CN101967108B (zh) * | 2010-09-13 | 2013-06-19 | 苏春华 | 一种美他环素的衍生物 |
| WO2012068670A1 (en) * | 2010-11-23 | 2012-05-31 | The University Of British Columbia | Binding drugs with nanocrystalline cellulose (ncc) |
| JP6522498B2 (ja) * | 2012-05-30 | 2019-05-29 | パラテック ファーマシューティカルズ インコーポレイテッド | ７−二置換フェニルテトラサイクリン誘導体 |
| JP6301335B2 (ja) | 2012-08-31 | 2018-03-28 | テトラフェース ファーマシューティカルズ，インコーポレイテッド | テトラサイクリン化合物 |
| KR101660815B1 (ko) * | 2013-06-13 | 2016-09-29 | 한국생명공학연구원 | 테트라싸이클린 유도체, 이의 약학적으로 허용가능한 염 또는 이의 입체이성질체를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 |
| WO2014200213A1 (ko) * | 2013-06-13 | 2014-12-18 | 한국생명공학연구원 | 테트라싸이클린 유도체, 이의 약학적으로 허용가능한 염 또는 이의 입체이성질체를 유효성분으로 함유하는 바이러스성 질환의 예방 또는 치료용 약학적 조성물 |
| KR101750834B1 (ko) | 2014-10-07 | 2017-06-26 | 연세대학교 산학협력단 | 알파-시누클레인 응집체의 파괴에 의하여 파킨슨 질환을 치료 또는 예방하기 위한 조성물 |
| MY197627A (en) * | 2016-03-24 | 2023-06-29 | Paratek Pharm Innc | Methods for treating and preventing c. difficile infection |
| AU2017289278A1 (en) | 2016-06-27 | 2019-01-17 | Ohio State Innovation Foundation | Liponucleotide-based therapy for ARDS |
| EP3529236B1 (en) | 2016-10-19 | 2024-02-07 | Tetraphase Pharmaceuticals, Inc. | Crystalline forms of eravacycline |
| RU2019113715A (ru) | 2016-11-01 | 2020-12-03 | Паратек Фармасьютикалс, Инк. | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
| CA3103614C (en) | 2018-06-13 | 2024-05-28 | Texas Tech University System | Modified tetracycline for treatment of alcohol use disorder, pain and other disorders involving potential inflammatory processes |
| WO2020206321A1 (en) * | 2019-04-04 | 2020-10-08 | Cmtx Biotech Inc. | Methods of treating charcot-marie-tooth disease |
| WO2020263484A1 (en) * | 2019-06-28 | 2020-12-30 | Mayo Foundation For Medical Education And Research | Methods and materials for treating neuromyelitis optica spectrum diseases |
| WO2021207441A1 (en) | 2020-04-10 | 2021-10-14 | The Procter & Gamble Company | Cleaning article with preferential rheological solid composition |
| US20220117458A1 (en) | 2020-10-16 | 2022-04-21 | The Procter & Gamble Company | Cleaning article with preferential coating |
| WO2024075662A1 (ja) * | 2022-10-03 | 2024-04-11 | 国立研究開発法人国立循環器病研究センター | 脳卒中の検査方法、及び脳卒中の改善剤 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862225A (en) | 1961-08-18 | 1975-01-21 | Pfizer | D-ring substituted tetracyclines |
| US3326761A (en) * | 1964-11-16 | 1967-06-20 | Pfizer & Co C | 6-demethyl-6-deoxytetracycline, anti-tumor antibiotic |
| US3304227A (en) | 1965-07-15 | 1967-02-14 | Loyal E Loveless | Antibiotic-containing animal feed |
| US4066694A (en) | 1971-02-09 | 1978-01-03 | Pfizer Inc. | 4-hydroxy-4-dedimethylamino-tetracyclines |
| US3622627A (en) | 1967-09-13 | 1971-11-23 | Pfizer | 4-dedimethylaminatetracycline and 5a, 6-anhydro derivatives thereof |
| US4806529A (en) | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US4704383A (en) | 1983-12-29 | 1987-11-03 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4925833A (en) | 1983-12-29 | 1990-05-15 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of osteoporosis |
| US4935412A (en) | 1983-12-29 | 1990-06-19 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same |
| US4666897A (en) | 1983-12-29 | 1987-05-19 | Research Foundation Of State University | Inhibition of mammalian collagenolytic enzymes by tetracyclines |
| USRE34656E (en) | 1983-12-29 | 1994-07-05 | The Research Foundation Of State University Of New York | Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency |
| US5308839A (en) | 1989-12-04 | 1994-05-03 | The Research Foundation Of State University Of New York | Composition comprising non-steroidal anti-inflammatory agent tenidap and effectively non-antibacterial tetracycline |
| JP3016587B2 (ja) | 1989-12-04 | 2000-03-06 | ザ・リサーチ・ファンデーション・オブ・ステート・ユニバーシティ・オブ・ニューヨーク | 非ステロイド抗炎症剤及びテトラサイクリンの配合 |
| FR2660193B1 (fr) | 1990-04-03 | 1994-11-04 | Philippe Maincent | Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules. |
| US5770588A (en) | 1991-02-11 | 1998-06-23 | The Research Foundation Of State University Of New York | Non-antibacterial tetracycline compositions of the prevention and treatment of root caries |
| EP0528810B1 (en) | 1991-03-22 | 1996-02-07 | CARSON, William S. | Container and pickup assembly for collection of recyclable materials |
| US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
| US5281628A (en) | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| DE69232302D1 (de) | 1991-10-04 | 2002-01-31 | American Cyanamid Co | 7-Substituierte-9-substituierte Amino-6-Demethyl-6-Deoxy-Tetracycline |
| US5258371A (en) | 1992-05-29 | 1993-11-02 | Kuraray Co., Ltd. | Method to reduce connective tissue destruction |
| US6043225A (en) | 1992-06-12 | 2000-03-28 | Board Of Regents Of The University Of Washington | Diagnosis and treatment of arterial chlamydial granuloma |
| SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5284963A (en) | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US5442059A (en) | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
| US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5420272A (en) | 1992-08-13 | 1995-05-30 | American Cyanamid Company | 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| DE4227616C2 (de) | 1992-08-20 | 1995-04-13 | Sigma Tau Ind Farmaceuti | 17-(3-Furyl)-und 17-(4-Pyridazinyl)-5beta, 14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammemsetzungen |
| US5362754A (en) * | 1992-11-12 | 1994-11-08 | Univ. Of Tx Md Anderson Cancer Center | M-EDTA pharmaceutical preparations and uses thereof |
| US5688516A (en) * | 1992-11-12 | 1997-11-18 | Board Of Regents, The University Of Texas System | Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices |
| DE69304292T2 (de) | 1992-11-17 | 1997-01-02 | Univ New York | Tetracycline inclusive nicht antimicrobiel wirksame, chemisch modifizierte Tetracycline hemmende exzessive Kollagenquervernetzung bei Diabetes |
| US5523297A (en) | 1993-03-02 | 1996-06-04 | The Research Foundation Of State University Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US6043231A (en) | 1993-03-02 | 2000-03-28 | The Research Foundation Of State Univ. Of New York | Inhibition of excessive phospholipase A2 activity and/or production by non-antimicrobial tetracyclines |
| US5371076A (en) | 1993-04-02 | 1994-12-06 | American Cyanamid Company | 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines |
| US5668122A (en) | 1993-07-28 | 1997-09-16 | Fife; Rose S. | Method to treat cancer with tetracyclines |
| US5834450A (en) | 1994-02-17 | 1998-11-10 | Pfizer Inc. | 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics |
| US5698533A (en) | 1994-07-26 | 1997-12-16 | Kang; Meng-Che | Ophthalmic pharmaceutical composition |
| US5530557A (en) | 1994-09-12 | 1996-06-25 | International Business Machines Corporation | Online placement of video files determined by a function of the bandwidth to space ratio of each of the storage devices in a server environment |
| US5843925A (en) | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5574026A (en) | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| EP0736302A3 (en) * | 1995-03-23 | 1997-06-04 | Stichting Rega V Z W | Protease inhibitors, DNA construction for protease expression and a method for measuring proteases and / or protease inhibitors |
| EP0733369A1 (en) * | 1995-03-23 | 1996-09-25 | Stichting REGA V.Z.W. | Protease inhibitors, a DNA construct for the expression of a protease and a process for measuring proteases and/or protease inhibitors |
| JPH11504916A (ja) | 1995-05-03 | 1999-05-11 | ファイザー・インコーポレーテッド | 新規テトラサイクリン誘導体 |
| US5834449A (en) | 1996-06-13 | 1998-11-10 | The Research Foundation Of State University Of New York | Treatment of aortic and vascular aneurysms with tetracycline compounds |
| US5827840A (en) | 1996-08-01 | 1998-10-27 | The Research Foundation Of State University Of New York | Promotion of wound healing by chemically-modified tetracyclines |
| US5789395A (en) * | 1996-08-30 | 1998-08-04 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds for inhibition of endogenous nitric oxide production |
| US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| US5773430A (en) | 1997-03-13 | 1998-06-30 | Research Foundation Of State University Of New York | Serine proteinase inhibitory activity by hydrophobic tetracycline |
| US5929055A (en) | 1997-06-23 | 1999-07-27 | The Research Foundation Of State University Of New York | Therapeutic method for management of diabetes mellitus |
| US6165484A (en) * | 1997-08-26 | 2000-12-26 | Wake Forest University | EDTA and other chelators with or without antifungal antimicrobial agents for the prevention and treatment of fungal infections |
| JP4733266B2 (ja) | 1997-12-19 | 2011-07-27 | ニューヨーク ユニバーシティ | シクロオキシゲナーゼ−２を阻害する方法および腫瘍壊死因子アルファ |
| AU2203199A (en) | 1997-12-30 | 1999-07-19 | Bioabsorbable Concepts, Inc. | Tetracycline and/or tetracycline derivative(s) for treating, suppressing and preventing of cerebrovascular diseases of nervous system |
| US7189703B2 (en) | 1998-01-09 | 2007-03-13 | Intracell, Llc | Treatment and diagnosis of alzheimer's disease |
| NZ506058A (en) | 1998-01-23 | 2003-04-29 | Tufts College | Antibacterial 9-substituted tetracyclines, and pharmaceuticals and uses thereof |
| US6277061B1 (en) | 1998-03-31 | 2001-08-21 | The Research Foundation Of State University Of New York | Method of inhibiting membrane-type matrix metalloproteinase |
| PT1676579E (pt) * | 1998-05-08 | 2009-03-24 | Univ Miami | Utilização de tetraciclinas sub-antimicrobianas para o tratamento de rosácea ocular |
| US6015804A (en) | 1998-09-11 | 2000-01-18 | The Research Foundation Of State University Of New York | Method of using tetracycline compounds to enhance interleukin-10 production |
| US5977091A (en) | 1998-09-21 | 1999-11-02 | The Research Foundation Of State University Of New York | Method of preventing acute lung injury |
| SE9803710L (sv) * | 1998-09-25 | 2000-03-26 | A & Science Invest Ab | Användning av vissa substanser för behandling av nervrotsskador |
| US5998390A (en) | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| ES2272097T3 (es) | 1998-11-18 | 2007-04-16 | Collagenex Pharmaceuticals, Inc. | Nuevos derivados de 4-desdimetilaminotetraciclina. |
| US6506740B1 (en) * | 1998-11-18 | 2003-01-14 | Robert A. Ashley | 4-dedimethylaminotetracycline derivatives |
| AU3760400A (en) * | 1999-03-19 | 2000-10-09 | Vanderbilt University | Methods and reagents for the diagnosis and treatment of multiple sclerosis |
| EP1171163A1 (en) * | 1999-04-27 | 2002-01-16 | Antibody Systems, Inc. | Compositions containing tetracyclines for treating hemorrhagic virus infections and other disorders |
| ES2260051T3 (es) | 1999-09-14 | 2006-11-01 | Trustees Of Tufts College | Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion. |
| US6231894B1 (en) | 1999-10-21 | 2001-05-15 | Duke University | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase |
| KR20010069066A (ko) * | 2000-01-12 | 2001-07-23 | 이종원 | 저산소 농도하에서 생존이 가능하도록 하는 동물세포의배양방법 |
| AU3105801A (en) | 2000-01-24 | 2001-07-31 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| HUP0300082A2 (en) | 2000-03-31 | 2003-05-28 | Paratek Pharmaceuticals | 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them |
| US7235397B1 (en) * | 2000-04-14 | 2007-06-26 | Gensys, Inc. | Methods and compositions for culturing spirochete and treating spirochetal diseases |
| US6613756B2 (en) | 2000-05-05 | 2003-09-02 | Wisconsin Alumni Research Foundation | Use of tetracycline derivatives in treating multiple sclerosis |
| AU2001259701A1 (en) | 2000-05-15 | 2001-11-26 | Paratek Pharmaceuticals, Inc | 7-substituted fused ring tetracycline compounds |
| AU2000257445A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-n-substituted phenyl tetracycline compounds |
| WO2001098236A2 (en) | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| AU2000254942A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| ATE544745T1 (de) | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
| CA2415086A1 (en) | 2000-07-07 | 2002-01-17 | Trustees Of Tufts College | 7,8 and 9-substituted tetracycline compounds |
| AU2001271642B2 (en) | 2000-07-07 | 2006-01-05 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
| AU2000265203A1 (en) | 2000-08-04 | 2002-02-18 | Trustees Of Tufts College | 8-substituted tetracycline compounds |
| WO2002020022A1 (en) | 2000-09-06 | 2002-03-14 | Neurotherapeutics, Llc | Method of treating neurologic disorders |
| US20030013692A1 (en) * | 2001-01-19 | 2003-01-16 | Gullans Steven R. | Methods of treating neurological disorders |
| JP2005504722A (ja) * | 2001-03-14 | 2005-02-17 | パラテック ファーマシューティカルズ インコーポレイテッド | 相乗的抗真菌薬剤としての置換テトラサイクリン化合物 |
| CA2457234A1 (en) * | 2001-03-14 | 2002-09-19 | Mark L. Nelson | Substituted tetracycline compounds as antifungal agents |
| DE60235083D1 (de) * | 2001-04-24 | 2010-03-04 | Paratek Pharm Innc | Substituierte tetracyclin-verbindungen zur behandlung von malaria |
| EP2332548A1 (en) * | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Tetracyclines for the treatment of stroke |
| CA2469000A1 (en) * | 2001-12-07 | 2003-06-19 | Johnson & Johnson Consumer Companies, Inc. | Method for reducing acne or improving skin tone |
| AU2003235759A1 (en) * | 2002-01-08 | 2003-07-24 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| AU2003303666A1 (en) * | 2002-01-29 | 2004-08-13 | Protemix Discovery Limited | Suppression of cytotoxic protein conformers |
| EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| DE10228326A1 (de) * | 2002-06-25 | 2004-01-22 | Heribert Dr.med. Bohlen | Verwendung von Macrolid- und/oder Tetracyclin-Verbindungen und/oder Gyrasehemmer enthaltenden Präparationen zur Prophylaxe und therapeutischen Behandlung von Migräne und Migräne-verwandten Erkrankungen |
| JP5706185B2 (ja) | 2011-02-22 | 2015-04-22 | 富士レビオ株式会社 | 測定装置及び測定方法 |
| US9713502B2 (en) | 2014-03-09 | 2017-07-25 | Gyrus Acmi, Inc. | Narrow band imaging with surgical loupes |
-
2002
- 2002-07-15 EP EP10185623A patent/EP2332548A1/en not_active Withdrawn
- 2002-07-15 EP EP10185614A patent/EP2332547A1/en not_active Withdrawn
- 2002-07-15 EP EP10185666A patent/EP2332549A1/en not_active Withdrawn
- 2002-07-15 EP EP10185600A patent/EP2301915A1/en not_active Withdrawn
- 2002-07-15 EP EP10185596A patent/EP2301550A1/en not_active Withdrawn
- 2002-07-15 EP EP10185610A patent/EP2329826A1/en not_active Withdrawn
- 2002-07-15 EP EP10185677A patent/EP2332550A1/en not_active Withdrawn
- 2002-07-15 US US10/196,010 patent/US20040063674A1/en not_active Abandoned
- 2002-07-15 EP EP02748169.6A patent/EP1408987B1/en not_active Expired - Lifetime
- 2002-07-15 EP EP10185627A patent/EP2327409A1/en not_active Withdrawn
- 2002-07-15 JP JP2003511780A patent/JP2004537544A/ja active Pending
- 2002-07-15 WO PCT/US2002/022451 patent/WO2003005971A2/en active Search and Examination
- 2002-07-15 EP EP10185619A patent/EP2329828A1/en not_active Withdrawn
- 2002-07-15 AU AU2002318238A patent/AU2002318238A1/en not_active Abandoned
- 2002-07-15 EP EP10185605A patent/EP2332546A1/en not_active Withdrawn
-
2009
- 2009-08-14 JP JP2009187938A patent/JP5182956B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-17 JP JP2010256651A patent/JP2011057693A/ja active Pending
- 2010-11-17 JP JP2010256652A patent/JP2011057694A/ja active Pending
