JP2010539082A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010539082A5 JP2010539082A5 JP2010524063A JP2010524063A JP2010539082A5 JP 2010539082 A5 JP2010539082 A5 JP 2010539082A5 JP 2010524063 A JP2010524063 A JP 2010524063A JP 2010524063 A JP2010524063 A JP 2010524063A JP 2010539082 A5 JP2010539082 A5 JP 2010539082A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- complex according
- cyclodextrin
- complex
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97105607P | 2007-09-10 | 2007-09-10 | |
| US60/971,056 | 2007-09-10 | ||
| PCT/US2008/056393 WO2009035718A1 (en) | 2007-09-10 | 2008-03-10 | Tartrate salts or complexes of quinazoline based egfr inhibitors containing a zinc binding moiety |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539082A JP2010539082A (ja) | 2010-12-16 |
| JP2010539082A5 true JP2010539082A5 (enExample) | 2011-03-24 |
| JP5474792B2 JP5474792B2 (ja) | 2014-04-16 |
Family
ID=40452375
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524063A Expired - Fee Related JP5474792B2 (ja) | 2007-09-10 | 2008-03-10 | 亜鉛結合部分を含むキナゾリンベースｅｇｆｒインヒビターの酒石酸塩またはその複合体 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US7846938B2 (enExample) |
| EP (1) | EP2190287B1 (enExample) |
| JP (1) | JP5474792B2 (enExample) |
| AU (1) | AU2008299896B2 (enExample) |
| CA (1) | CA2698944C (enExample) |
| ES (1) | ES2526718T3 (enExample) |
| WO (1) | WO2009035718A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007296746B2 (en) | 2006-09-11 | 2012-07-05 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CN101570516B (zh) * | 2009-04-14 | 2011-01-05 | 重庆威尔德·浩瑞医药化工有限公司 | 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-[3-(4-吗啉基)丙氧基]喹唑啉的方法 |
| CN102452988B (zh) * | 2010-10-27 | 2016-01-27 | 中国科学院化学研究所 | 一种喹唑啉衍生物及其制备方法 |
| WO2012125904A1 (en) | 2011-03-17 | 2012-09-20 | The Trustees Of The University Of Pennsylvania | Mutation mimicking compounds that bind to the kinase domain of egfr |
| EP2685980B1 (en) | 2011-03-17 | 2017-12-06 | The Trustees Of The University Of Pennsylvania | Methods and use of bifunctional enzyme-building clamp-shaped molecules |
| US20140229256A1 (en) | 2013-02-11 | 2014-08-14 | Solutran | Product substantiation using approved product list system and method |
| CN102276500A (zh) * | 2011-05-05 | 2011-12-14 | 西安交通大学 | 水杨酰胺类抗肿瘤化合物及其合成方法和用途 |
| CN103906732A (zh) * | 2011-10-28 | 2014-07-02 | 株式会社钟根堂 | 用作hdac抑制剂的异羟肟酸酯衍生物以及包含所述衍生物的药物组合物 |
| WO2013159698A1 (zh) * | 2012-04-26 | 2013-10-31 | 深圳信立泰药业股份有限公司 | 稠环喹唑啉羟肟酸类化合物及其作为抗肿瘤药物的应用 |
| CN102898315B (zh) * | 2012-11-05 | 2015-01-28 | 上海毕得医药科技有限公司 | 3-乙炔基-4-氟苯胺的制备方法 |
| US10552861B2 (en) | 2013-02-11 | 2020-02-04 | Solutran, Inc. | Dual redemption path with shared benefits system and method |
| RU2017105844A (ru) * | 2014-08-08 | 2018-09-11 | Форсайт Вижн4, Инк. | Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения |
| CN105693630B (zh) * | 2016-03-10 | 2018-02-16 | 田静 | 一种吉非替尼中间体的制备方法 |
| US20220371990A1 (en) * | 2019-09-08 | 2022-11-24 | Hadasit Medical Research Services And Developmect Ltd. | Anti-fibrotic compounds and use thereof |
| US12100049B2 (en) | 2020-06-05 | 2024-09-24 | Soltran, LLC | Filtered POS processing of services |
| CN116710448B (zh) * | 2021-01-20 | 2025-05-16 | 莱托克斯有限公司 | 被保护的hdac(组蛋白脱乙酰酶)抑制剂 |
| US12530346B2 (en) | 2021-12-24 | 2026-01-20 | Solutran, LLC | Data transmission filtering through a customized filter list |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| GB9300059D0 (en) * | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| DE69415391T2 (de) * | 1993-05-26 | 1999-08-26 | Sumitomo Pharmaceuticals Co. | Chinazolinonderivate |
| GB9508537D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) * | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| DE69720965T2 (de) * | 1996-02-13 | 2004-02-05 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| PT1154774E (pt) | 1999-02-10 | 2005-10-31 | Astrazeneca Ab | Derivados de quinazolina como inibidores de angiogenese |
| US7230000B1 (en) * | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| UA74803C2 (uk) * | 1999-11-11 | 2006-02-15 | Осі Фармасьютікалз, Інк. | Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування |
| TWI310684B (en) * | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
| ATE340165T1 (de) | 2001-02-26 | 2006-10-15 | Univ Mcgill | Kombi-moleküle, welche eine inhibierende wirkung auf die signalübertragung und dna-schädigende eigenschaften haben |
| WO2004018430A1 (ja) * | 2002-08-23 | 2004-03-04 | Kirin Beer Kabushiki Kaisha | ＴＧＦβ阻害活性を有する化合物およびそれを含んでなる医薬組成物 |
| US7250514B1 (en) * | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2514479A1 (en) * | 2003-01-23 | 2004-08-05 | T.K. Signal Ltd. | Irreversible inhibitors of egf receptor tyrosine kinases and uses thereof |
| PE20040945A1 (es) * | 2003-02-05 | 2004-12-14 | Warner Lambert Co | Preparacion de quinazolinas substituidas |
| GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| WO2005030757A1 (en) * | 2003-09-25 | 2005-04-07 | Astrazeneca Ab | Quinazoline derivatives |
| WO2005097134A2 (en) | 2004-03-31 | 2005-10-20 | The Scripps Research Institute | Quinazoline based protein kinase inhibitors |
| JP5156392B2 (ja) | 2005-02-03 | 2013-03-06 | トポターゲット ユーケー リミテッド | Ｈｄａｃ阻害剤を用いる併用療法 |
| AU2006235487B2 (en) * | 2005-04-12 | 2011-12-22 | Elan Pharma International Limited | Nanoparticulate quinazoline derivative formulations |
| BRPI0609309A2 (pt) | 2005-04-14 | 2010-03-09 | Novartis Vaccines & Diagnostic | 2-amino-quinazolin-5-onas como inibidores hsp90 com utilidade no tratamento de doenças proliferativas |
| ITMI20050729A1 (it) * | 2005-04-22 | 2006-10-23 | Endura Spa | Nuova formulazione biologicamente attiva |
| US20100016435A1 (en) | 2006-05-16 | 2010-01-21 | Mcgill University | Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties |
| EP2061469B8 (en) * | 2006-09-11 | 2014-02-26 | Curis, Inc. | Quinazoline based egfr inhibitors |
| WO2008033747A2 (en) * | 2006-09-11 | 2008-03-20 | Curis, Inc. | Multi-functional small molecules as anti-proliferative agents |
| US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| AU2007296746B2 (en) * | 2006-09-11 | 2012-07-05 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
| CN105481788A (zh) | 2006-10-28 | 2016-04-13 | 梅特希尔基因公司 | 组蛋白脱乙酰酶抑制剂 |
| US8119616B2 (en) | 2007-09-10 | 2012-02-21 | Curis, Inc. | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety |
-
2008
- 2008-03-10 WO PCT/US2008/056393 patent/WO2009035718A1/en not_active Ceased
- 2008-03-10 CA CA2698944A patent/CA2698944C/en not_active Expired - Fee Related
- 2008-03-10 EP EP08743752.1A patent/EP2190287B1/en active Active
- 2008-03-10 AU AU2008299896A patent/AU2008299896B2/en not_active Ceased
- 2008-03-10 JP JP2010524063A patent/JP5474792B2/ja not_active Expired - Fee Related
- 2008-03-10 ES ES08743752.1T patent/ES2526718T3/es active Active
- 2008-09-10 US US12/207,833 patent/US7846938B2/en not_active Expired - Fee Related
-
2010
- 2010-11-08 US US12/941,812 patent/US20110053963A1/en not_active Abandoned
-
2013
- 2013-05-22 US US13/900,165 patent/US8846912B2/en not_active Expired - Fee Related