ES2526718T3 - Inhibidores de EGFR basados en sales de tartrato o complejos de quinazolina que contienen un resto que se une al cinc - Google Patents

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Publication number

ES2526718T3

ES2526718T3 ES08743752.1T ES08743752T ES2526718T3 ES 2526718 T3 ES2526718 T3 ES 2526718T3 ES 08743752 T ES08743752 T ES 08743752T ES 2526718 T3 ES2526718 T3 ES 2526718T3

Authority

ES

Spain

Prior art keywords

compound

mmol

pharmaceutical composition

cyclodextrin

cancer

Prior art date

2007-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229940121647 egfr inhibitor Drugs 0.000 title description 3
• 229910052725 zinc Inorganic materials 0.000 title description 3
• 239000011701 zinc Substances 0.000 title description 3
• 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 569
• 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 63
• FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract description 35
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 35
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• 239000011975 tartaric acid Substances 0.000 claims abstract description 29
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• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 2
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