JP2006503919A5 - - Google Patents
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- JP2006503919A5 JP2006503919A5 JP2005501762A JP2005501762A JP2006503919A5 JP 2006503919 A5 JP2006503919 A5 JP 2006503919A5 JP 2005501762 A JP2005501762 A JP 2005501762A JP 2005501762 A JP2005501762 A JP 2005501762A JP 2006503919 A5 JP2006503919 A5 JP 2006503919A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- composition
- group
- drug
- topoisomerase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 208000029742 colonic neoplasm Diseases 0.000 claims description 5
- 229960004768 irinotecan Drugs 0.000 claims description 5
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims description 5
- 238000002648 combination therapy Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 201000005787 hematologic cancer Diseases 0.000 claims description 4
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims description 4
- 229960002949 fluorouracil Drugs 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 10
- 229940079593 drug Drugs 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 229940041181 antineoplastic drug Drugs 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 208000020816 lung neoplasm Diseases 0.000 claims 4
- 230000009036 growth inhibition Effects 0.000 claims 3
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 2
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 claims 2
- 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 claims 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 2
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 2
- 239000000365 Topoisomerase I Inhibitor Substances 0.000 claims 2
- 239000000317 Topoisomerase II Inhibitor Substances 0.000 claims 2
- 229940100198 alkylating agent Drugs 0.000 claims 2
- 239000002168 alkylating agent Substances 0.000 claims 2
- 239000012635 anticancer drug combination Substances 0.000 claims 2
- 229940127093 camptothecin Drugs 0.000 claims 2
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 2
- 229960004316 cisplatin Drugs 0.000 claims 2
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 2
- 229940046044 combinations of antineoplastic agent Drugs 0.000 claims 2
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims 2
- 229960004679 doxorubicin Drugs 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000007912 intraperitoneal administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 201000002511 pituitary cancer Diseases 0.000 claims 2
- 229960000575 trastuzumab Drugs 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 3
- PIQCTGMSNWUMAF-UHFFFAOYSA-N chembl522892 Chemical compound C1CN(C)CCN1C1=CC=C(NC(=N2)C=3C(NC4=CC=CC(F)=C4C=3N)=O)C2=C1 PIQCTGMSNWUMAF-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 239000002619 cytotoxin Substances 0.000 description 1
- 229940084651 iressa Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40572902P | 2002-08-23 | 2002-08-23 | |
| US42622602P | 2002-11-13 | 2002-11-13 | |
| US42610702P | 2002-11-13 | 2002-11-13 | |
| US42628202P | 2002-11-13 | 2002-11-13 | |
| US42821002P | 2002-11-21 | 2002-11-21 | |
| US46032803P | 2003-04-03 | 2003-04-03 | |
| US46032703P | 2003-04-03 | 2003-04-03 | |
| US46049303P | 2003-04-03 | 2003-04-03 | |
| US47891603P | 2003-06-16 | 2003-06-16 | |
| US48404803P | 2003-07-01 | 2003-07-01 | |
| PCT/US2003/025990 WO2004018419A2 (en) | 2002-08-23 | 2003-08-19 | Benzimidazole quinolinones and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006503919A JP2006503919A (ja) | 2006-02-02 |
| JP2006503919A5 true JP2006503919A5 (enExample) | 2010-10-28 |
| JP4613130B2 JP4613130B2 (ja) | 2011-01-12 |
Family
ID=31950997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005501762A Expired - Fee Related JP4613130B2 (ja) | 2002-08-23 | 2003-08-19 | ベンゾイミダゾールキノリノンおよびそれらの使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US7470709B2 (enExample) |
| EP (2) | EP1539754A4 (enExample) |
| JP (1) | JP4613130B2 (enExample) |
| KR (1) | KR20050037585A (enExample) |
| AU (1) | AU2003288899B2 (enExample) |
| BR (1) | BR0313743A (enExample) |
| CA (1) | CA2496164C (enExample) |
| IL (1) | IL166932A (enExample) |
| TW (1) | TWI345567B (enExample) |
| WO (1) | WO2004018419A2 (enExample) |
Families Citing this family (119)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2334641T3 (es) | 2000-09-01 | 2010-03-15 | Novartis Vaccines And Diagnostics, Inc. | Derivados aza heterociclicos y su uso terapeutico. |
| NZ524717A (en) * | 2000-09-11 | 2004-09-24 | Chiron Corp | Quinolinone derivatives |
| US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
| US20090118139A1 (en) * | 2000-11-07 | 2009-05-07 | Caliper Life Sciences, Inc. | Microfluidic method and system for enzyme inhibition activity screening |
| US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
| US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
| CA2496164C (en) | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
| EP1545529A4 (en) | 2002-09-30 | 2010-03-03 | Bristol Myers Squibb Co | NEW TYROSINE KINASE HEMMER |
| US7838527B2 (en) * | 2002-11-13 | 2010-11-23 | Novartis Vaccines And Diagnostics, Inc. | Methods of treating cancer and related methods |
| US7759336B2 (en) | 2002-12-10 | 2010-07-20 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
| US7893096B2 (en) | 2003-03-28 | 2011-02-22 | Novartis Vaccines And Diagnostics, Inc. | Use of small molecule compounds for immunopotentiation |
| WO2004091485A2 (en) * | 2003-04-11 | 2004-10-28 | Taigen Biotechnology | Aminoquinoline compounds |
| KR20060097105A (ko) * | 2003-07-22 | 2006-09-13 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나아제 저해제로서의 퀴놀리논 유도체 |
| CN1882342A (zh) * | 2003-09-17 | 2006-12-20 | 艾科斯有限公司 | Chk1抑制剂在控制细胞增殖中的应用 |
| KR101224410B1 (ko) * | 2003-11-07 | 2013-01-23 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 퀴놀리논 화합물을 합성하는 방법 |
| EP1699477A2 (en) * | 2003-12-11 | 2006-09-13 | Theravance, Inc. | Compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
| TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
| RU2377988C2 (ru) * | 2004-02-20 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс, Инк. | Модуляция воспалительных и метастатических процессов |
| US20050276765A1 (en) * | 2004-06-10 | 2005-12-15 | Paul Nghiem | Preventing skin damage |
| US7850960B2 (en) * | 2004-12-30 | 2010-12-14 | University Of Washington | Methods for regulation of stem cells |
| KR101387985B1 (ko) * | 2005-01-27 | 2014-04-25 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 전이 종양의 치료 |
| US7893267B2 (en) * | 2005-03-14 | 2011-02-22 | High Point Pharmaceuticals, Llc | Benzazole derivatives, compositions, and methods of use as β-secretase inhibitors |
| UA92164C2 (ru) | 2005-03-29 | 2010-10-11 | Айкос Корпорейшен | Соединения, пригодные для угнетения снк1 |
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| PT1885187E (pt) * | 2005-05-13 | 2013-12-16 | Novartis Ag | Métodos para o tratamento de cancro resistente a fármacos |
| PL1888556T3 (pl) * | 2005-05-17 | 2012-03-30 | Novartis Ag | Metody syntetyzowania związków heterocyklicznych |
| RU2425041C2 (ru) | 2005-05-23 | 2011-07-27 | Новартис Аг | Кристаллические и другие формы солей, образованных из молочной кислоты и 4-амино-5-фтор-3-[6-(4-метилпиперазин-1-ил)-1н-бензимидазол-2-ил]-1н-хинолин-2-она |
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| US8071768B2 (en) | 2005-06-10 | 2011-12-06 | Janssen Pharmaceutica, N.V. | Alkylquinoline and alkylquinazoline kinase modulators |
| MX2007015578A (es) * | 2005-06-10 | 2008-03-06 | Merck & Co Inc | Inhibidores de la actividad akt. |
| US7825244B2 (en) | 2005-06-10 | 2010-11-02 | Janssen Pharmaceutica Nv | Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis |
| JP5301987B2 (ja) * | 2005-06-20 | 2013-09-25 | デコード・ジェネティクス・イーエイチエフ | ２型糖尿病のリスクの診断マーカーとしてのｔｃｆ７ｌ２遺伝子中の遺伝子変異体 |
| EP1743892A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
| US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1757587A1 (en) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
| EP1749523A1 (en) * | 2005-07-29 | 2007-02-07 | Neuropharma, S.A. | GSK-3 inhibitors |
| EP1951234A2 (en) | 2005-10-18 | 2008-08-06 | Janssen Pharmaceutica N.V. | Method of inhibiting flt3 kinase |
| WO2007056317A2 (en) * | 2005-11-07 | 2007-05-18 | Novartis Vaccines & Diagnostics, Inc. | Methods for assaying an active pharmaceutical ingredient |
| AR062545A1 (es) | 2005-11-29 | 2008-11-19 | Novartis Ag | Formulaciones estables de quinolinonas |
| RU2008127252A (ru) | 2005-12-08 | 2010-01-20 | Новартис АГ (CH) | Эффекты ингибиторов fgfr3 на транскрипцию генов |
| KR101367645B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제로서의 복소환식 화합물 |
| US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
| KR101367646B1 (ko) | 2006-04-20 | 2014-02-27 | 얀센 파마슈티카 엔.브이. | Ｃ-ｆｍｓ 키나제의 저해제 |
| FR2902100A1 (fr) * | 2006-06-13 | 2007-12-14 | Sanofi Aventis Sa | Molecules duales contenant un derive peroxydique, leur synthese et leurs applications en therapeutique |
| JP5280357B2 (ja) | 2006-07-07 | 2013-09-04 | スティーブン・ピー・ガベック | Ｐｄｅ４の二環式ヘテロアリール阻害剤 |
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| WO2008046757A1 (en) * | 2006-10-19 | 2008-04-24 | F. Hoffmann-La Roche Ag | Aminomethyl-4-imidazoles |
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| JO3240B1 (ar) | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
| GB0800855D0 (en) | 2008-01-17 | 2008-02-27 | Syngenta Ltd | Herbicidal compounds |
| CA2714003A1 (en) * | 2008-02-04 | 2009-08-13 | Dana-Farber Cancer Institute, Inc. | Chk1 suppresses a caspase-2 apoptotic response to dna damage that bypasses p53, bcl-2 and caspase-3 |
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| DE102008022221A1 (de) | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| EP2151234A1 (en) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion |
| US8735424B2 (en) * | 2008-09-02 | 2014-05-27 | Novartis Ag | Bicyclic kinase inhibitors |
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| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| EP2521782B1 (en) | 2010-01-05 | 2019-04-10 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists for the treatment or the prevention of pain disorders |
| JP5734313B2 (ja) | 2010-01-12 | 2015-06-17 | アーべー・シオンス | チアゾールおよびオキサゾールキナーゼ阻害剤 |
| TR201819653T4 (tr) | 2010-04-16 | 2019-01-21 | Novartis Ag | Karaciğer kanserinin tedavisinde kullanılmaya yönelik organik bileşik. |
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| UY33472A (es) | 2010-06-30 | 2012-01-31 | Novartis Ag | ?composiciones farmacéuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1hbencimidazol-2-il]-1h-quinolin-2-ona?. |
| MX2013010581A (es) | 2011-03-17 | 2013-10-03 | Novartis Ag | Receptor del factor de crecimiento de fibroblastos (fgfr) y ligandos del mismo como biomarcadores para cancer de mama en sujetos hr positivos. |
| KR20140023358A (ko) | 2011-05-19 | 2014-02-26 | 노파르티스 아게 | 선양 낭성 암종의 치료에 사용하기 위한 4-아미노-5-플루오로-3-[6-(4-메틸피페라진-1-일)-1h-벤즈이미다졸-2-일]-1h-퀴놀린-2-온 |
| CA2848210A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | Use of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one in the treatment of cancer in moderate hepatic impaired patients |
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2003
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- 2003-08-19 EP EP03781286A patent/EP1539754A4/en not_active Withdrawn
- 2003-08-19 KR KR1020057003112A patent/KR20050037585A/ko not_active Ceased
- 2003-08-19 AU AU2003288899A patent/AU2003288899B2/en not_active Ceased
- 2003-08-19 WO PCT/US2003/025990 patent/WO2004018419A2/en not_active Ceased
- 2003-08-19 JP JP2005501762A patent/JP4613130B2/ja not_active Expired - Fee Related
- 2003-08-19 EP EP12186782.4A patent/EP2573079A3/en not_active Withdrawn
- 2003-08-19 BR BR0313743-0A patent/BR0313743A/pt not_active IP Right Cessation
- 2003-08-22 TW TW092123171A patent/TWI345567B/zh not_active IP Right Cessation
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2004
- 2004-05-05 US US10/839,793 patent/US20050203101A1/en not_active Abandoned
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2005
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2008
- 2008-12-23 US US12/317,493 patent/US20090281100A1/en not_active Abandoned
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