JP2010535817A5 - - Google Patents
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- Publication number
- JP2010535817A5 JP2010535817A5 JP2010520344A JP2010520344A JP2010535817A5 JP 2010535817 A5 JP2010535817 A5 JP 2010535817A5 JP 2010520344 A JP2010520344 A JP 2010520344A JP 2010520344 A JP2010520344 A JP 2010520344A JP 2010535817 A5 JP2010535817 A5 JP 2010535817A5
- Authority
- JP
- Japan
- Prior art keywords
- aryl
- group
- aralkyl
- aliphatic
- heteroaliphatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CCC=C(C)[C@@]1C=CC(c2ccccc2)=C(*)C1 Chemical compound CCC=C(C)[C@@]1C=CC(c2ccccc2)=C(*)C1 0.000 description 27
- TYKKUSCFQKUQAN-UHFFFAOYSA-N COCc1cccc(OC(c2ccccc2)=O)c1 Chemical compound COCc1cccc(OC(c2ccccc2)=O)c1 TYKKUSCFQKUQAN-UHFFFAOYSA-N 0.000 description 2
- SYTBZMRGLBWNTM-UHFFFAOYSA-N CC(C(O)=O)c1ccc(-c2ccccc2)c(F)c1 Chemical compound CC(C(O)=O)c1ccc(-c2ccccc2)c(F)c1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- IAEUCHHBPWIKAR-QHHAFSJGSA-N CC(Oc1cccc(C/C=C/c2cc(O)cc(O)c2)c1)=O Chemical compound CC(Oc1cccc(C/C=C/c2cc(O)cc(O)c2)c1)=O IAEUCHHBPWIKAR-QHHAFSJGSA-N 0.000 description 1
- TVQQYNBVXVCSQW-BKUYFWCQSA-N CC1=C(CC(OCCCCO)=O)c(cc(cc2)F)c2/C1=C\c(cc1)ccc1S(C)=O Chemical compound CC1=C(CC(OCCCCO)=O)c(cc(cc2)F)c2/C1=C\c(cc1)ccc1S(C)=O TVQQYNBVXVCSQW-BKUYFWCQSA-N 0.000 description 1
- MYBMIXMHCPDQJR-HMAPJEAMSA-N CC1=C(CC(OCCCCOC)=O)c(cc(cc2)F)c2/C1=C\c(cc1)ccc1S(C)=O Chemical compound CC1=C(CC(OCCCCOC)=O)c(cc(cc2)F)c2/C1=C\c(cc1)ccc1S(C)=O MYBMIXMHCPDQJR-HMAPJEAMSA-N 0.000 description 1
- AOKPKKIFVFRGME-UHFFFAOYSA-N CCOC(C=O)OCc(cc(cc1)OC(c2ccccc2OC(C)=O)=O)c1O Chemical compound CCOC(C=O)OCc(cc(cc1)OC(c2ccccc2OC(C)=O)=O)c1O AOKPKKIFVFRGME-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95525807P | 2007-08-10 | 2007-08-10 | |
| US60/955,258 | 2007-08-10 | ||
| US98958407P | 2007-11-21 | 2007-11-21 | |
| US60/989,584 | 2007-11-21 | ||
| PCT/US2008/072788 WO2009023631A1 (en) | 2007-08-10 | 2008-08-11 | Anti-inflammatory compounds and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014015731A Division JP2014111627A (ja) | 2007-08-10 | 2014-01-30 | 抗炎症性化合物とその用途 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535817A JP2010535817A (ja) | 2010-11-25 |
| JP2010535817A5 true JP2010535817A5 (https=) | 2011-09-22 |
| JP5707131B2 JP5707131B2 (ja) | 2015-04-22 |
Family
ID=40351107
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010520344A Active JP5707131B2 (ja) | 2007-08-10 | 2008-08-11 | 抗炎症性化合物とその用途 |
| JP2014015731A Withdrawn JP2014111627A (ja) | 2007-08-10 | 2014-01-30 | 抗炎症性化合物とその用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014015731A Withdrawn JP2014111627A (ja) | 2007-08-10 | 2014-01-30 | 抗炎症性化合物とその用途 |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US8236820B2 (https=) |
| EP (1) | EP2180788B1 (https=) |
| JP (2) | JP5707131B2 (https=) |
| CN (1) | CN101820755B (https=) |
| AU (1) | AU2008286954B2 (https=) |
| CA (1) | CA2705463C (https=) |
| ES (1) | ES2618482T3 (https=) |
| IN (1) | IN2010KN00853A (https=) |
| PL (1) | PL2180788T3 (https=) |
| WO (1) | WO2009023631A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011094589A1 (en) * | 2010-01-29 | 2011-08-04 | Basil Rigas | Nonsteroidal antiinflammatory derivatives with decreased toxicity and methods of use |
| WO2011133385A2 (en) * | 2010-04-16 | 2011-10-27 | The Research Foundation Of State University Of New York | Novel ether-based compounds and their use |
| CN103827310B (zh) * | 2011-07-14 | 2017-09-22 | 财团法人国家卫生研究院 | Map4k3作为自体免疫疾病、癌症、发炎及il‑17相关疾病的生物标记及治疗标的 |
| WO2013130625A1 (en) * | 2012-02-27 | 2013-09-06 | Basil Rigas | Phospho-ester derivatives and uses thereof |
| US9402821B2 (en) | 2012-08-13 | 2016-08-02 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for treatment of cystic fibrosis |
| US20140088044A1 (en) * | 2012-09-21 | 2014-03-27 | Basil Rigas | Product comprising a nicotine-containing material and an anti-cancer agent |
| EP2711006A1 (en) | 2012-09-21 | 2014-03-26 | Basil Rigas | Product Comprising a Nicotine-Containing Material and an Anti-Cancer Agent |
| EP2897621A4 (en) * | 2012-09-21 | 2016-08-10 | Basil Rigas | COMPOUNDS AND COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES, PAIN AND FEVER, SKIN DISEASES, CANCER AND PRECULTURAL INJURIES |
| CN102964250A (zh) * | 2012-11-19 | 2013-03-13 | 吉林大学 | 氟比洛芬丁香酚酯药用化合物及其制剂和制备方法 |
| MX2015006715A (es) | 2012-12-03 | 2015-08-14 | Hoffmann La Roche | Compuestos de acido triazolboronico sustituido. |
| US10023555B2 (en) | 2013-02-07 | 2018-07-17 | Research Foundation Of The City University Of New York | NSAIDs derivatives and uses thereof |
| RU2720180C2 (ru) | 2013-09-24 | 2020-04-27 | Универзитет Цу Кельн | Соединения, применяемые в лечении неопластических заболеваний |
| AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
| WO2015148649A2 (en) * | 2014-03-26 | 2015-10-01 | Basil Rigas | Systems and methods for ameliorating the effects of tobacco products |
| US11510931B2 (en) * | 2016-09-28 | 2022-11-29 | Medicon Pharmaceuticals, Inc. | Compositions and methods for treating ophthalmic conditions |
| HUE062406T2 (hu) | 2016-09-28 | 2023-10-28 | Medicon Pharmaceuticals Inc | Készítmények szemészeti állapotok kezelésére |
| CN109121393B (zh) * | 2017-02-24 | 2021-11-30 | 拉芳家化股份有限公司 | 一种抗炎乳液 |
| JP2020536067A (ja) * | 2017-09-28 | 2020-12-10 | メディコン ファーマシューティカルズ，インコーポレイテッド | 眼の状態を処置するための組成物および方法 |
| CN117417281A (zh) * | 2017-09-28 | 2024-01-19 | 麦迪康制药公司 | 抗炎、抗癌和抗血管生成化合物，药物组合物及其制备和使用方法 |
| CA3087932A1 (en) | 2018-01-09 | 2019-07-18 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
| TWI679279B (zh) * | 2018-05-09 | 2019-12-11 | 臺中榮民總醫院 | 檢測成人發作型史笛兒氏症之罹病風險及預後之方法 |
| EP4272826A3 (en) | 2021-05-24 | 2024-01-17 | Medicon Pharmaceuticals, Inc. | Treating pain associated with diabetic peripheral neuropathy |
| JP2024520463A (ja) | 2021-05-24 | 2024-05-24 | メディコン ファーマシューティカルズ，インコーポレイテッド | 化学療法誘発性末梢神経障害に関連する疼痛の処置 |
| MD4522143T2 (ro) | 2022-11-23 | 2025-11-30 | Medicon Pharmaceuticals Inc | Tratamentul durerii asociate cu sensibilizare centrală |
| WO2025106974A1 (en) * | 2023-11-17 | 2025-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Prodrug moieties and compounds comprising the same |
| WO2025111079A1 (en) | 2023-11-21 | 2025-05-30 | Medicon Pharmaceuticals, Inc. | Isomers of phosphosulindac |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3396193A (en) * | 1965-07-01 | 1968-08-06 | Us Vitamin Pharm Corp | Halogenated cis-cinnamic acids |
| US4006204A (en) * | 1975-04-30 | 1977-02-01 | Nelson Research & Development Company | Phosphoric acid diesters |
| DE3219821A1 (de) * | 1982-05-26 | 1983-12-01 | Bayer Ag, 5090 Leverkusen | Substituierte diphenylether, verfahren zu ihrer herstellung und ihre verwendung als herbizide |
| JPS60101993A (ja) * | 1983-11-08 | 1985-06-06 | 日立化成工業株式会社 | 印刷配線板の製造法 |
| JPS60146855A (ja) * | 1984-01-11 | 1985-08-02 | Ono Pharmaceut Co Ltd | アニリン誘導体 |
| JPS62184458A (ja) * | 1986-02-08 | 1987-08-12 | Konishiroku Photo Ind Co Ltd | ハロゲン化銀写真感光材料 |
| US4888328A (en) | 1988-03-10 | 1989-12-19 | Hoeschst-Roussel Incorporated | Alkoxycarbonylalkylphospholipids and alkylaminocarbonylalkylphospholipids |
| ATE188377T1 (de) * | 1993-06-29 | 2000-01-15 | Takeda Chemical Industries Ltd | Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose |
| JPH07261315A (ja) * | 1994-03-23 | 1995-10-13 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料および画像形成方法 |
| IT1270996B (it) | 1994-07-22 | 1997-05-26 | Wilton Licensing Ag | Derivati fosforilati di composti aventi attivita' antiinfiammatoria o analgesica e procedimento per la loro preparazione |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| IT1307928B1 (it) | 1999-01-26 | 2001-11-29 | Nicox Sa | Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. |
| IL137672A0 (en) * | 2000-08-03 | 2001-10-31 | Dpharm Ltd | Derivatives of branched-chain lipophilic molecules and uses thereof |
| US20030060465A1 (en) * | 2000-12-19 | 2003-03-27 | Jilani Jamal A. | Prodrugs of non-steroidal anti-inflammatory and carboxylic acid containing compounds |
| AU2002226225B2 (en) * | 2001-01-18 | 2008-03-20 | Dermavant Sciences GmbH | Novel 1,2-diphenylethene derivatives for treatment of immune diseases |
| ITMI20010985A1 (it) | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| DE20110355U1 (de) | 2001-06-22 | 2001-08-30 | Wella Ag, 64295 Darmstadt | (Dihydroxyphenyl)-acrylamid-Derivate und diese Verbindungen enthaltende Färbemittel |
| ITMI20011744A1 (it) | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| AU2002316231A1 (en) * | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| ITMI20020773A1 (it) | 2002-04-11 | 2003-10-13 | Nicox Sa | Farmaci per il trattamento dell'artrite |
| WO2005065361A2 (en) | 2003-12-31 | 2005-07-21 | Khosrow Kashfi | Compounds and compositions for treating dysproliferative diseases, and methods of use thereof |
| KR100839016B1 (ko) | 2006-12-27 | 2008-06-17 | (주)네오팜 | 세라마이드 유도체 및 그 제조방법과 이를 포함하는 아토피 피부염 치료제 |
-
2008
- 2008-08-11 EP EP08782709.3A patent/EP2180788B1/en active Active
- 2008-08-11 JP JP2010520344A patent/JP5707131B2/ja active Active
- 2008-08-11 PL PL08782709T patent/PL2180788T3/pl unknown
- 2008-08-11 CN CN2008801114341A patent/CN101820755B/zh active Active
- 2008-08-11 ES ES08782709.3T patent/ES2618482T3/es active Active
- 2008-08-11 AU AU2008286954A patent/AU2008286954B2/en active Active
- 2008-08-11 CA CA2705463A patent/CA2705463C/en active Active
- 2008-08-11 WO PCT/US2008/072788 patent/WO2009023631A1/en not_active Ceased
- 2008-08-11 US US12/189,500 patent/US8236820B2/en active Active
-
2010
- 2010-03-05 IN IN853KON2010 patent/IN2010KN00853A/en unknown
-
2012
- 2012-07-27 US US13/559,884 patent/US20120316139A1/en not_active Abandoned
-
2014
- 2014-01-30 JP JP2014015731A patent/JP2014111627A/ja not_active Withdrawn
-
2015
- 2015-09-18 US US14/858,393 patent/US20160243137A1/en not_active Abandoned
-
2018
- 2018-07-13 US US16/034,992 patent/US20190307780A1/en not_active Abandoned
-
2020
- 2020-04-20 US US16/852,777 patent/US20200237787A1/en not_active Abandoned
-
2022
- 2022-06-13 US US17/806,575 patent/US20220409638A1/en not_active Abandoned
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