CN101820755B - 抗炎化合物及其应用 - Google Patents

抗炎化合物及其应用 Download PDF

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CN101820755B
CN101820755B CN2008801114341A CN200880111434A CN101820755B CN 101820755 B CN101820755 B CN 101820755B CN 2008801114341 A CN2008801114341 A CN 2008801114341A CN 200880111434 A CN200880111434 A CN 200880111434A CN 101820755 B CN101820755 B CN 101820755B
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compounds
sulindac
compound
diseases
inflammation
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CN101820755A (zh
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巴赛尔·雷盖斯
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
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    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2008801114341A 2007-08-10 2008-08-11 抗炎化合物及其应用 Active CN101820755B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95525807P 2007-08-10 2007-08-10
US60/955,258 2007-08-10
US98958407P 2007-11-21 2007-11-21
US60/989,584 2007-11-21
PCT/US2008/072788 WO2009023631A1 (en) 2007-08-10 2008-08-11 Anti-inflammatory compounds and uses thereof

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CN101820755A CN101820755A (zh) 2010-09-01
CN101820755B true CN101820755B (zh) 2013-05-15

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EP (1) EP2180788B1 (https=)
JP (2) JP5707131B2 (https=)
CN (1) CN101820755B (https=)
AU (1) AU2008286954B2 (https=)
CA (1) CA2705463C (https=)
ES (1) ES2618482T3 (https=)
IN (1) IN2010KN00853A (https=)
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CN117417281A (zh) * 2017-09-28 2024-01-19 麦迪康制药公司 抗炎、抗癌和抗血管生成化合物，药物组合物及其制备和使用方法
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PL2180788T3 (pl) 2017-06-30
AU2008286954A1 (en) 2009-02-19
US20160243137A1 (en) 2016-08-25
US20220409638A1 (en) 2022-12-29
CN101820755A (zh) 2010-09-01
HK1147912A1 (en) 2011-08-26
WO2009023631A1 (en) 2009-02-19
ES2618482T3 (es) 2017-06-21
EP2180788B1 (en) 2016-12-21
CA2705463A1 (en) 2009-02-19
US20190307780A1 (en) 2019-10-10
JP5707131B2 (ja) 2015-04-22
IN2010KN00853A (https=) 2015-08-28
US20090099137A1 (en) 2009-04-16
EP2180788A1 (en) 2010-05-05
US20120316139A1 (en) 2012-12-13
US20200237787A1 (en) 2020-07-30
CA2705463C (en) 2014-10-07
JP2014111627A (ja) 2014-06-19
JP2010535817A (ja) 2010-11-25
CA2705463E (en) 2009-02-19
EP2180788A4 (en) 2011-08-24
US8236820B2 (en) 2012-08-07

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