JP2010535704A5 - - Google Patents
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- Publication number
- JP2010535704A5 JP2010535704A5 JP2010504096A JP2010504096A JP2010535704A5 JP 2010535704 A5 JP2010535704 A5 JP 2010535704A5 JP 2010504096 A JP2010504096 A JP 2010504096A JP 2010504096 A JP2010504096 A JP 2010504096A JP 2010535704 A5 JP2010535704 A5 JP 2010535704A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- atom
- halogen atom
- hydroxy
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010504096A JP5292390B2 (ja) | 2007-08-07 | 2008-08-06 | アンドロゲン受容体調節剤としてのピロリジン−２−オン誘導体 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007205966 | 2007-08-07 | ||
| JP2007205966 | 2007-08-07 | ||
| JP2007299658 | 2007-11-19 | ||
| JP2007299658 | 2007-11-19 | ||
| PCT/JP2008/064500 WO2009020234A2 (en) | 2007-08-07 | 2008-08-06 | Pyrrolidin-2 -one derivatives as androgen receptor modulator |
| JP2010504096A JP5292390B2 (ja) | 2007-08-07 | 2008-08-06 | アンドロゲン受容体調節剤としてのピロリジン−２−オン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010535704A JP2010535704A (ja) | 2010-11-25 |
| JP2010535704A5 true JP2010535704A5 (enExample) | 2011-09-22 |
| JP5292390B2 JP5292390B2 (ja) | 2013-09-18 |
Family
ID=40329363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010504096A Expired - Fee Related JP5292390B2 (ja) | 2007-08-07 | 2008-08-06 | アンドロゲン受容体調節剤としてのピロリジン−２−オン誘導体 |
Country Status (34)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY159910A (en) * | 2007-08-07 | 2017-02-15 | Takeda Pharmaceuticals Co | Pyrrolidin-2-one derivatives as androgen receptor modulator |
| BRPI0907844B8 (pt) * | 2008-02-22 | 2021-05-25 | Radius Health Inc | compostos e método para modular um receptor de andrógeno, processos de preparação e composição farmacêutica dos mesmos e seus usos |
| US8268872B2 (en) | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| US20090270361A1 (en) * | 2008-03-26 | 2009-10-29 | Takeda Pharmaceutical Company Limited | Substituted pyrazole derivatives and use thereof |
| JP5964756B2 (ja) | 2010-02-04 | 2016-08-03 | ラジウス ヘルス，インコーポレイテッド | 選択的アンドロゲン受容体モジュレーター |
| PL2568806T3 (pl) | 2010-05-12 | 2017-03-31 | Radius Health, Inc. | Schematy lecznicze |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| AU2011312490B2 (en) * | 2010-09-28 | 2015-06-25 | Radius Pharmaceuticals, Inc. | Selective androgen receptor modulators |
| US20150057452A1 (en) * | 2012-04-04 | 2015-02-26 | Catylix, Inc. | Selective androgen receptor modulators |
| EP3158995B1 (en) | 2012-08-09 | 2018-05-23 | Dynamis Therapeutics, Inc. | Meglumine for reducing high triglyceride levels |
| WO2014044357A1 (de) | 2012-09-21 | 2014-03-27 | Merck Patent Gmbh | Verbindungen mit einer c-c-dreifachbindung und deren verwendung in flüssigkristallmischungen |
| ES2939940T3 (es) | 2014-03-28 | 2023-04-28 | Univ Duke | Tratamiento del cáncer de mama utilizando moduladores selectivos de los receptores de estrógenos |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| KR101597327B1 (ko) | 2014-04-24 | 2016-02-24 | 동아에스티 주식회사 | 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
| CN103951688B (zh) * | 2014-05-06 | 2016-04-20 | 成都安斯利生物医药有限公司 | 一种制备3,5-二氟-4-甲基苯硼酸的方法 |
| WO2017223115A1 (en) | 2016-06-22 | 2017-12-28 | Radius Health, Inc. | Ar+ breast cancer treatment methods |
| EP3565542B1 (en) | 2017-01-05 | 2024-04-10 | Radius Pharmaceuticals, Inc. | Polymorphic forms of rad1901-2hcl |
| SG11202013177WA (en) | 2018-07-04 | 2021-01-28 | Radius Pharmaceuticals Inc | Polymorphic forms of rad 1901-2hcl |
| WO2020144375A1 (en) | 2019-01-11 | 2020-07-16 | Grünenthal GmbH | Substituted pyrrolidine amides iii |
| US12441745B2 (en) | 2019-02-12 | 2025-10-14 | Radius Pharmaceuticals, Inc. | Processes and compounds |
| CN110204505B (zh) * | 2019-05-31 | 2023-02-03 | 荆门医药工业技术研究院 | (s)-3-苄氧羰基-4-异丙基-2,5-恶唑烷二酮的制备工艺 |
| US20230012570A1 (en) * | 2019-11-20 | 2023-01-19 | Medshine Discovery Inc. | Bicyclic compound used as selective androgen receptor modulator |
| CA3251059A1 (en) | 2022-05-02 | 2023-11-09 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions, systems and methods for modulating a target gene |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4141399A1 (de) | 1991-12-16 | 1993-06-17 | Bayer Ag | 4-(substituierte)amino-3-arylpyrrolinon-derivate |
| WO2000017163A1 (en) * | 1998-09-22 | 2000-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Cyanophenyl derivatives |
| US6258833B1 (en) | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| JP2002088073A (ja) * | 2000-09-08 | 2002-03-27 | Yamanouchi Pharmaceut Co Ltd | 抗アンドロゲン剤 |
| FR2817472B1 (fr) | 2000-12-06 | 2003-01-03 | Oreal | Composition de teinture d'oxydation a base de 1-(4-aminophenyl)pyrrolidines substituees au moins en position 2 et 3 et procede de teinture de mise en oeuvre |
| PT1463497E (pt) | 2001-12-06 | 2011-12-20 | Gtx Inc | Tratamento do desgaste muscular com moduladores selectivos do receptor de androgénios |
| JP4316232B2 (ja) | 2001-12-28 | 2009-08-19 | 武田薬品工業株式会社 | アンドロゲン受容体拮抗剤 |
| CA2471754A1 (en) | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Androgen receptor antagonist |
| AU2003241583B2 (en) | 2002-06-17 | 2009-05-21 | University Of Tennessee Research Foundation | N-bridged selective androgen receptor modulators and methods of use thereof |
| NZ538713A (en) | 2002-08-12 | 2007-01-26 | Takeda Chemical Industries Ltd | Fused benzene derivative and use |
| GB0402492D0 (en) | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Pharmaceutically active compounds |
| US8519158B2 (en) | 2004-03-12 | 2013-08-27 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| MXPA06013115A (es) * | 2004-05-11 | 2007-02-28 | Pfizer Prod Inc | Derivados de benzonitrilo para tratar la fragilidad musculoesqueletica. |
| EP1756101A2 (en) | 2004-05-17 | 2007-02-28 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
| DK2289872T3 (en) | 2004-06-07 | 2017-10-09 | Univ Tennessee Res Found | Medical use of a selective androgen receptor modulator |
| NZ555974A (en) | 2005-01-10 | 2010-11-26 | Acadia Pharm Inc | Aminophenyl derivatives as selective androgen receptor modulators |
| TW200724139A (en) * | 2005-05-05 | 2007-07-01 | Warner Lambert Co | Androgen modulators |
| DE602006003432D1 (de) | 2005-05-13 | 2008-12-11 | Lilly Co Eli | Latoren des androgenrezeptors |
| WO2007015567A1 (ja) | 2005-08-01 | 2007-02-08 | Takeda Pharmaceutical Company Limited | 環状アミン化合物 |
| JPWO2007097289A1 (ja) | 2006-02-20 | 2009-07-16 | 武田薬品工業株式会社 | 新規医薬 |
| WO2008011072A2 (en) | 2006-07-19 | 2008-01-24 | Osurf (Ohio State University Research Foundation) | Selective androgen receptor modulators, analogs and derivatives thereof and uses thereof |
| RU2009106214A (ru) | 2006-07-26 | 2010-09-10 | Новартис АГ (CH) | Ингибиторы ундекапренилпирофосфатсинтазы |
| CA2670976C (en) | 2006-11-30 | 2015-01-27 | Atsushi Hasuoka | Cyclic amine compound |
| MY159910A (en) | 2007-08-07 | 2017-02-15 | Takeda Pharmaceuticals Co | Pyrrolidin-2-one derivatives as androgen receptor modulator |
-
2008
- 2008-08-06 MY MYPI2010000564A patent/MY159910A/en unknown
- 2008-08-06 GE GEAP200811715A patent/GEP20125571B/en unknown
- 2008-08-06 PT PT87924304T patent/PT2176220E/pt unknown
- 2008-08-06 CN CN2008801105925A patent/CN101821235B/zh not_active Expired - Fee Related
- 2008-08-06 CL CL2008002313A patent/CL2008002313A1/es unknown
- 2008-08-06 AU AU2008284662A patent/AU2008284662B2/en not_active Ceased
- 2008-08-06 US US12/672,516 patent/US8420694B2/en not_active Expired - Fee Related
- 2008-08-06 EA EA201070246A patent/EA017429B1/ru unknown
- 2008-08-06 RS RS20130235A patent/RS52812B/sr unknown
- 2008-08-06 CA CA2695852A patent/CA2695852C/en active Active
- 2008-08-06 US US12/221,739 patent/US7834051B2/en active Active
- 2008-08-06 DK DK08792430.4T patent/DK2176220T3/da active
- 2008-08-06 HR HRP20130374AT patent/HRP20130374T1/hr unknown
- 2008-08-06 PE PE2008001314A patent/PE20090899A1/es not_active Application Discontinuation
- 2008-08-06 KR KR1020107005062A patent/KR20100049644A/ko not_active Abandoned
- 2008-08-06 ES ES08792430T patent/ES2406685T3/es active Active
- 2008-08-06 JP JP2010504096A patent/JP5292390B2/ja not_active Expired - Fee Related
- 2008-08-06 BR BRPI0814957A patent/BRPI0814957B8/pt not_active IP Right Cessation
- 2008-08-06 AR ARP080103428A patent/AR067823A1/es unknown
- 2008-08-06 ME MEP-2013-64A patent/ME01579B/me unknown
- 2008-08-06 NZ NZ583624A patent/NZ583624A/en not_active IP Right Cessation
- 2008-08-06 EP EP08792430A patent/EP2176220B1/en active Active
- 2008-08-06 TW TW097129774A patent/TWI418543B/zh not_active IP Right Cessation
- 2008-08-06 SI SI200830941T patent/SI2176220T1/sl unknown
- 2008-08-06 WO PCT/JP2008/064500 patent/WO2009020234A2/en not_active Ceased
- 2008-08-06 MX MX2010001484A patent/MX2010001484A/es active IP Right Grant
- 2008-08-06 PL PL08792430T patent/PL2176220T3/pl unknown
- 2008-08-09 JO JO2008353A patent/JO2864B1/en active
-
2010
- 2010-02-05 DO DO2010000053A patent/DOP2010000053A/es unknown
- 2010-02-05 TN TNP2010000062A patent/TN2010000062A1/fr unknown
- 2010-02-12 CR CR11266A patent/CR11266A/es unknown
- 2010-02-23 ZA ZA2010/01289A patent/ZA201001289B/en unknown
- 2010-02-26 MA MA32657A patent/MA31639B1/fr unknown
- 2010-03-05 CO CO10026475A patent/CO6160326A2/es unknown
-
2013
- 2013-06-21 CY CY20131100507T patent/CY1114067T1/el unknown
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