CN101821235B - 作为雄激素受体调节剂的吡咯烷-2-酮衍生物 - Google Patents
作为雄激素受体调节剂的吡咯烷-2-酮衍生物 Download PDFInfo
- Publication number
- CN101821235B CN101821235B CN2008801105925A CN200880110592A CN101821235B CN 101821235 B CN101821235 B CN 101821235B CN 2008801105925 A CN2008801105925 A CN 2008801105925A CN 200880110592 A CN200880110592 A CN 200880110592A CN 101821235 B CN101821235 B CN 101821235B
- Authority
- CN
- China
- Prior art keywords
- compound
- mixture
- ethyl
- added
- tert
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCOC(C(C)(C)C([C@@](C)NC(OCC1=CC=CCC1)=O)O*(C)(C)C(C)(C)C)=O Chemical compound CCOC(C(C)(C)C([C@@](C)NC(OCC1=CC=CCC1)=O)O*(C)(C)C(C)(C)C)=O 0.000 description 2
- GVAQHXNKGBAPGR-UHFFFAOYSA-N CC(C)C(C(O)=O)Nc(cc1Cl)ccc1C#N Chemical compound CC(C)C(C(O)=O)Nc(cc1Cl)ccc1C#N GVAQHXNKGBAPGR-UHFFFAOYSA-N 0.000 description 1
- XRJRDUTWAOVSEZ-VZJVUDMVSA-N CC(C)C[C@@H]([C@@H]([C@H](C)N1C(CC2)=CC(Cl)=C2C#N)O)C1=O Chemical compound CC(C)C[C@@H]([C@@H]([C@H](C)N1C(CC2)=CC(Cl)=C2C#N)O)C1=O XRJRDUTWAOVSEZ-VZJVUDMVSA-N 0.000 description 1
- DLESROLPOMKFLJ-FQNRMIAFSA-N CCC([C@](C)(C(C)(C)C1=O)O)N1c(cc1)cc(Cl)c1C#N Chemical compound CCC([C@](C)(C(C)(C)C1=O)O)N1c(cc1)cc(Cl)c1C#N DLESROLPOMKFLJ-FQNRMIAFSA-N 0.000 description 1
- WBVYEUYFHRGIHJ-STQMWFEESA-N CCC[C@@H]([C@H](CC1=O)O)N1c(cc1Cl)ccc1C#N Chemical compound CCC[C@@H]([C@H](CC1=O)O)N1c(cc1Cl)ccc1C#N WBVYEUYFHRGIHJ-STQMWFEESA-N 0.000 description 1
- OUVIHEAWVOBSBQ-UHFFFAOYSA-N CCOC(C1(CC1)C(C(C)N(Cc1ccccc1)Cc1ccccc1)=O)=O Chemical compound CCOC(C1(CC1)C(C(C)N(Cc1ccccc1)Cc1ccccc1)=O)=O OUVIHEAWVOBSBQ-UHFFFAOYSA-N 0.000 description 1
- BAQFOCHVQLGTHX-QUBJWBRDSA-N CC[C@@H](C(C1)=O)N(C(CCC2C#N)CC2Cl)C1=O Chemical compound CC[C@@H](C(C1)=O)N(C(CCC2C#N)CC2Cl)C1=O BAQFOCHVQLGTHX-QUBJWBRDSA-N 0.000 description 1
- ONNRRRLKTSGVFD-VKHMYHEASA-N CC[C@@H](C(O1)=O)NC1=O Chemical compound CC[C@@H](C(O1)=O)NC1=O ONNRRRLKTSGVFD-VKHMYHEASA-N 0.000 description 1
- MTOJCSJQNJRUMD-CABZTGNLSA-N CC[C@@H]([C@@H](C)CC1=O)N1c(c(F)c1C)ccc1C#N Chemical compound CC[C@@H]([C@@H](C)CC1=O)N1c(c(F)c1C)ccc1C#N MTOJCSJQNJRUMD-CABZTGNLSA-N 0.000 description 1
- ADZYJUIFVCKFNE-DOTOQJQBSA-O CC[C@@H]([C@@H](CC1=O)O[SH+](C)(C)C(C)(C)C)N1c(c(C)c1Cl)ccc1C#N Chemical compound CC[C@@H]([C@@H](CC1=O)O[SH+](C)(C)C(C)(C)C)N1c(c(C)c1Cl)ccc1C#N ADZYJUIFVCKFNE-DOTOQJQBSA-O 0.000 description 1
- XAIKVKOBEJOTGL-QPUJVOFHSA-N C[C@@H]([C@H](C1(CC1)C1=O)O)N1c(cc1Cl)ccc1C#N Chemical compound C[C@@H]([C@H](C1(CC1)C1=O)O)N1c(cc1Cl)ccc1C#N XAIKVKOBEJOTGL-QPUJVOFHSA-N 0.000 description 1
- XYKGGRQMRGZMND-SUMWQHHRSA-N C[C@@H]([C@H](C1(CC1)C1=O)O[Si+](C)(C)C(C)(C)C)N1c(cc1Cl)ccc1C#N Chemical compound C[C@@H]([C@H](C1(CC1)C1=O)O[Si+](C)(C)C(C)(C)C)N1c(cc1Cl)ccc1C#N XYKGGRQMRGZMND-SUMWQHHRSA-N 0.000 description 1
- OIVPRZIIQKALPQ-LRDDRELGSA-O C[C@@H]([C@H](CC1=O)O[SH+](C)(C)C(C)(C)C)N1c(cc1Cl)ccc1C#N Chemical compound C[C@@H]([C@H](CC1=O)O[SH+](C)(C)C(C)(C)C)N1c(cc1Cl)ccc1C#N OIVPRZIIQKALPQ-LRDDRELGSA-O 0.000 description 1
- RZUGLLKURVMWKZ-KKMMWDRVSA-N C[C@@H]1NC2OC2C(C)(C)C1=C Chemical compound C[C@@H]1NC2OC2C(C)(C)C1=C RZUGLLKURVMWKZ-KKMMWDRVSA-N 0.000 description 1
- PWAIBFQYNOOUDF-UHFFFAOYSA-N Cc(c(C)c1F)ccc1C#N Chemical compound Cc(c(C)c1F)ccc1C#N PWAIBFQYNOOUDF-UHFFFAOYSA-N 0.000 description 1
- KLJVSSSOHJNLLN-UHFFFAOYSA-N N#Cc(c(Cl)c1)ccc1N(C(CC1CC1)C(O)=C1)C1=O Chemical compound N#Cc(c(Cl)c1)ccc1N(C(CC1CC1)C(O)=C1)C1=O KLJVSSSOHJNLLN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/54—Spiro-condensed
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007205966 | 2007-08-07 | ||
| JP205966/07 | 2007-08-07 | ||
| JP2007299658 | 2007-11-19 | ||
| JP299658/07 | 2007-11-19 | ||
| PCT/JP2008/064500 WO2009020234A2 (en) | 2007-08-07 | 2008-08-06 | Pyrrolidin-2 -one derivatives as androgen receptor modulator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101821235A CN101821235A (zh) | 2010-09-01 |
| CN101821235B true CN101821235B (zh) | 2012-11-14 |
Family
ID=40329363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801105925A Expired - Fee Related CN101821235B (zh) | 2007-08-07 | 2008-08-06 | 作为雄激素受体调节剂的吡咯烷-2-酮衍生物 |
Country Status (34)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008284662B2 (en) * | 2007-08-07 | 2013-07-25 | Takeda Pharmaceutical Company Limited | Pyrrolidin-2 -one derivatives as androgen receptor modulator |
| MX2010009162A (es) | 2008-02-22 | 2010-12-21 | Radius Health Inc | Moduladores selectivos del receptor de androgeno. |
| US8268872B2 (en) * | 2008-02-22 | 2012-09-18 | Radius Health, Inc. | Selective androgen receptor modulators |
| PE20091653A1 (es) * | 2008-03-26 | 2009-11-14 | Takeda Pharmaceutical | Derivados sustituidos de pirazol y su uso |
| CA2788907A1 (en) | 2010-02-04 | 2011-08-11 | Radius Health, Inc. | Selective androgen receptor modulators |
| PT2568806T (pt) | 2010-05-12 | 2016-08-05 | Radius Health Inc | Regimes terapêuticos |
| US8642632B2 (en) | 2010-07-02 | 2014-02-04 | Radius Health, Inc. | Selective androgen receptor modulators |
| ES2550319T3 (es) * | 2010-09-28 | 2015-11-06 | Radius Health, Inc | Moduladores selectivos del receptor de andrógenos |
| US20150057452A1 (en) * | 2012-04-04 | 2015-02-26 | Catylix, Inc. | Selective androgen receptor modulators |
| CN104768544B (zh) | 2012-08-09 | 2017-06-16 | 迪纳米斯治疗公司 | 包括葡甲胺或其盐的组合物在制备减少或预防甘油三酯水平增加的药物中的应用 |
| EP2898045B1 (de) | 2012-09-21 | 2018-10-24 | Merck Patent GmbH | Verbindungen mit einer c-c-dreifachbindung und deren verwendung in flüssigkristallmischungen |
| RS67458B1 (sr) | 2014-03-28 | 2025-12-31 | Univ Duke | Lečenje kancera dojke pozitivnog na receptor estrogena upotrebom selektivnih modulatora receptora estrogena |
| US9421264B2 (en) | 2014-03-28 | 2016-08-23 | Duke University | Method of treating cancer using selective estrogen receptor modulators |
| KR101597327B1 (ko) * | 2014-04-24 | 2016-02-24 | 동아에스티 주식회사 | 옥사졸리딘계 화합물 및 이를 포함하는 선택적 안드로겐 수용체 효능제 |
| CN103951688B (zh) * | 2014-05-06 | 2016-04-20 | 成都安斯利生物医药有限公司 | 一种制备3,5-二氟-4-甲基苯硼酸的方法 |
| RS63311B1 (sr) | 2016-06-22 | 2022-07-29 | Ellipses Pharma Ltd | Ar+ metode lečenja raka dojke |
| KR102881465B1 (ko) | 2017-01-05 | 2025-11-04 | 래디어스 파마슈티컬스, 인코포레이티드 | Rad1901-2hcl의 다형 형태 |
| CN112423844B (zh) | 2018-07-04 | 2024-08-13 | 雷迪厄斯制药公司 | Rad1901-2hcl的多晶型形式 |
| CN113382990B (zh) | 2019-01-11 | 2024-11-19 | 格吕伦塔尔有限公司 | 取代的吡咯烷酰胺iii |
| JOP20210218A1 (ar) | 2019-02-12 | 2023-01-30 | Radius Pharmaceuticals Inc | عمليات ومركبات |
| CN110204505B (zh) * | 2019-05-31 | 2023-02-03 | 荆门医药工业技术研究院 | (s)-3-苄氧羰基-4-异丙基-2,5-恶唑烷二酮的制备工艺 |
| US20230012570A1 (en) * | 2019-11-20 | 2023-01-19 | Medshine Discovery Inc. | Bicyclic compound used as selective androgen receptor modulator |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319091A (zh) * | 1998-09-22 | 2001-10-24 | 山之内制药株式会社 | 氰基苯基衍生物 |
| WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| WO2005108351A1 (en) * | 2004-05-11 | 2005-11-17 | Pfizer Products Inc. | Benzonitrile derivatives to treat musculoskeletal frailty |
| WO2006117677A1 (en) * | 2005-05-05 | 2006-11-09 | Warner-Lambert Company Llc | Androgen modulators |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4141399A1 (de) * | 1991-12-16 | 1993-06-17 | Bayer Ag | 4-(substituierte)amino-3-arylpyrrolinon-derivate |
| US6258833B1 (en) | 1999-12-23 | 2001-07-10 | Icos Corporation | Cyclic AMP-specific phosphodiesterase inhibitors |
| US7026500B2 (en) | 2000-08-24 | 2006-04-11 | University Of Tennessee Research Foundation | Halogenated selective androgen receptor modulators and methods of use thereof |
| JP2002088073A (ja) * | 2000-09-08 | 2002-03-27 | Yamanouchi Pharmaceut Co Ltd | 抗アンドロゲン剤 |
| FR2817472B1 (fr) | 2000-12-06 | 2003-01-03 | Oreal | Composition de teinture d'oxydation a base de 1-(4-aminophenyl)pyrrolidines substituees au moins en position 2 et 3 et procede de teinture de mise en oeuvre |
| ATE526959T1 (de) | 2001-12-06 | 2011-10-15 | Gtx Inc | Behandlung von muskelschwund mit selektiven androgenrezeptormodulatoren |
| JP4316232B2 (ja) | 2001-12-28 | 2009-08-19 | 武田薬品工業株式会社 | アンドロゲン受容体拮抗剤 |
| WO2003057669A1 (fr) * | 2001-12-28 | 2003-07-17 | Takeda Chemical Industries, Ltd. | Antagonistes du recepteur androgene |
| MXPA04013001A (es) | 2002-06-17 | 2005-09-12 | Univ Tennessee Res Foundation | Moduladores del receptor de androgneo selectivo en fuente n y metodos de uso de los mismos. |
| MXPA05001631A (es) * | 2002-08-12 | 2005-08-19 | Takeda Pharmaceutical | Derivado de benceno fusionado y su uso. |
| GB0402492D0 (en) | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Pharmaceutically active compounds |
| AU2005247405A1 (en) | 2004-05-17 | 2005-12-08 | Acadia Pharmaceuticals Inc. | Androgen receptor modulators and method of treating disease using the same |
| EP1753417B1 (en) | 2004-06-07 | 2012-04-04 | University Of Tennessee Research Foundation | A selective androgen receptor modulator and medical uses thereof |
| RU2007130558A (ru) | 2005-01-10 | 2009-02-20 | Акэдиа Фармасьютикалз Инк. (Us) | Производные аминофенола в качестве селективных модуляторов андрогеновых рецепторов |
| PT1891038E (pt) | 2005-05-13 | 2008-12-02 | Lilly Co Eli | N-arilpirrolidinas substituídas como moduladores selectivos do receptor de androgénio |
| CA2617256C (en) | 2005-08-01 | 2014-07-15 | Takeda Pharmaceutical Company Limited | Cyclic amine compound |
| EP1987827A1 (en) * | 2006-02-20 | 2008-11-05 | Takeda Pharmaceutical Company Limited | Novel pharmaceutical |
| KR20090030345A (ko) * | 2006-07-19 | 2009-03-24 | 더 오하이오 스테이트 유니버시티 리서치 파운데이션 | 선택적인 안드로겐 수용체 모듈레이터, 그 유사체와 유도체, 및 그의 용도 |
| EP2049103A2 (en) * | 2006-07-26 | 2009-04-22 | Novartis AG | Inhibitors of undecaprenyl pyrophosphate synthase |
| CA2670976C (en) | 2006-11-30 | 2015-01-27 | Atsushi Hasuoka | Cyclic amine compound |
| AU2008284662B2 (en) * | 2007-08-07 | 2013-07-25 | Takeda Pharmaceutical Company Limited | Pyrrolidin-2 -one derivatives as androgen receptor modulator |
-
2008
- 2008-08-06 AU AU2008284662A patent/AU2008284662B2/en not_active Ceased
- 2008-08-06 US US12/672,516 patent/US8420694B2/en not_active Expired - Fee Related
- 2008-08-06 AR ARP080103428A patent/AR067823A1/es unknown
- 2008-08-06 EA EA201070246A patent/EA017429B1/ru unknown
- 2008-08-06 NZ NZ583624A patent/NZ583624A/en not_active IP Right Cessation
- 2008-08-06 KR KR1020107005062A patent/KR20100049644A/ko not_active Abandoned
- 2008-08-06 US US12/221,739 patent/US7834051B2/en active Active
- 2008-08-06 ME MEP-2013-64A patent/ME01579B/me unknown
- 2008-08-06 MY MYPI2010000564A patent/MY159910A/en unknown
- 2008-08-06 DK DK08792430.4T patent/DK2176220T3/da active
- 2008-08-06 EP EP08792430A patent/EP2176220B1/en active Active
- 2008-08-06 SI SI200830941T patent/SI2176220T1/sl unknown
- 2008-08-06 JP JP2010504096A patent/JP5292390B2/ja not_active Expired - Fee Related
- 2008-08-06 PE PE2008001314A patent/PE20090899A1/es not_active Application Discontinuation
- 2008-08-06 CA CA2695852A patent/CA2695852C/en active Active
- 2008-08-06 GE GEAP200811715A patent/GEP20125571B/en unknown
- 2008-08-06 CL CL2008002313A patent/CL2008002313A1/es unknown
- 2008-08-06 CN CN2008801105925A patent/CN101821235B/zh not_active Expired - Fee Related
- 2008-08-06 ES ES08792430T patent/ES2406685T3/es active Active
- 2008-08-06 WO PCT/JP2008/064500 patent/WO2009020234A2/en not_active Ceased
- 2008-08-06 PL PL08792430T patent/PL2176220T3/pl unknown
- 2008-08-06 PT PT87924304T patent/PT2176220E/pt unknown
- 2008-08-06 MX MX2010001484A patent/MX2010001484A/es active IP Right Grant
- 2008-08-06 HR HRP20130374AT patent/HRP20130374T1/hr unknown
- 2008-08-06 RS RS20130235A patent/RS52812B/sr unknown
- 2008-08-06 TW TW097129774A patent/TWI418543B/zh not_active IP Right Cessation
- 2008-08-06 BR BRPI0814957A patent/BRPI0814957B8/pt not_active IP Right Cessation
- 2008-08-09 JO JO2008353A patent/JO2864B1/en active
-
2010
- 2010-02-05 DO DO2010000053A patent/DOP2010000053A/es unknown
- 2010-02-05 TN TNP2010000062A patent/TN2010000062A1/fr unknown
- 2010-02-12 CR CR11266A patent/CR11266A/es unknown
- 2010-02-23 ZA ZA2010/01289A patent/ZA201001289B/en unknown
- 2010-02-26 MA MA32657A patent/MA31639B1/fr unknown
- 2010-03-05 CO CO10026475A patent/CO6160326A2/es unknown
-
2013
- 2013-06-21 CY CY20131100507T patent/CY1114067T1/el unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1319091A (zh) * | 1998-09-22 | 2001-10-24 | 山之内制药株式会社 | 氰基苯基衍生物 |
| WO2005090282A1 (en) * | 2004-03-12 | 2005-09-29 | Ligand Pharmaceuticals Incorporated | Androgen receptor modulator compounds and methods |
| WO2005108351A1 (en) * | 2004-05-11 | 2005-11-17 | Pfizer Products Inc. | Benzonitrile derivatives to treat musculoskeletal frailty |
| WO2006117677A1 (en) * | 2005-05-05 | 2006-11-09 | Warner-Lambert Company Llc | Androgen modulators |
Non-Patent Citations (1)
| Title |
|---|
| JP特开2002-88073A 2002.03.27 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101821235A (zh) | 作为雄激素受体调节剂的吡咯烷-2-酮衍生物 | |
| EP1911743B1 (en) | Cyclic amine compound | |
| WO2009133861A1 (ja) | 環状アミン化合物 | |
| WO2007097289A1 (ja) | 新規医薬 | |
| TWI458482B (zh) | Ｃ型肝炎病毒抑制劑 | |
| TW202330513A (zh) | )抑制劑及其使用方法 | |
| JP5241507B2 (ja) | 環状アミン化合物 | |
| HK1143972B (en) | Pyrrolidin-2-one derivatives as androgen receptor modulator | |
| CA3118438A1 (en) | Novel imidazole compounds, process for the synthesis and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121114 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |